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U.S. Genome Variation Estimates

PON1 Allele and Genotype Frequencies

Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs662

Ex6+78A>G

Gln192Arg

TaqMan

rs854560

Ex3+18T>A

Leu55Met

TaqMan



Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs662AGAAAGGG
Non-Hispanic White68.5 (66.8, 70.3)31.5 (29.7, 33.2)<0.00147.3 (44.4, 50.3)42.4 (39.4, 45.4)10.3 (9.0, 11.7)<0.0010.37
Non-Hispanic Black32.9 (31.2, 34.6)67.1 (65.4, 68.8)11.3 (9.9, 12.8)43.2 (41.5, 44.9)45.5 (43.3, 47.7)0.98
Mexican American53.5 (51.9, 55.0)46.5 (45.0, 48.1)28.6 (25.4, 32.1)49.6 (45.4, 53.9)21.7 (20.1, 23.4)0.90
Total*61.5 (59.4, 63.6)38.5 (36.4, 40.6)40.0 (37.3, 42.8)43.0 (40.8, 45.2)17.0 (15.2, 19.0)
rs854560ATAAATTT
Non-Hispanic White35.6 (33.6, 37.7)64.4 (62.3, 66.4)<0.00113.5 (12.2, 14.9)44.3 (41.4, 47.2)42.2 (39.0, 45.6)<0.0010.40
Non-Hispanic Black17.9 (16.5, 19.3)82.1 (80.7, 83.5)2.9 (2.3, 3.7)30.0 (27.7, 32.3)67.1 (64.6, 69.5)0.30
Mexican American23.0 (21.3, 24.8)77.0 (75.2, 78.7)5.0 (4.0, 6.1)36.1 (33.2, 39.2)58.9 (55.8, 61.9)0.55
Total*31.5 (29.4, 33.6)68.5 (66.4, 70.6)11.1 (10.0, 12.2)40.8 (38.2, 43.5)48.1 (44.8, 51.5)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs662AGAAAGGG
12-1962.6 (58.9, 66.2)37.4 (33.8, 41.1)0.04440.2 (35.0, 45.6)44.8 (39.8, 50.0)15.0 (11.9, 18.7)0.015
20-3959.5 (56.8, 62.1)40.5 (37.9, 43.2)37.6 (34.2, 41.1)43.8 (40.5, 47.2)18.6 (16.0, 21.5)
40-5961.8 (58.3, 65.1)38.2 (34.9, 41.7)41.1 (36.5, 45.9)41.3 (36.9, 45.7)17.6 (14.7, 21.0)
>=6064.3 (61.7, 66.8)35.7 (33.2, 38.3)43.1 (39.5, 46.8)42.4 (38.5, 46.4)14.5 (12.0, 17.5)
Total61.5 (59.4, 63.6)38.5 (36.4, 40.6)40.0 (37.3, 42.8)43.0 (40.8, 45.2)17.0 (15.2, 19.0)
rs854560ATAAATTT
12-1931.7 (26.8, 37.1)68.3 (62.9, 73.2)0.33010.4 (6.7, 15.9)42.6 (36.9, 48.4)47.0 (40.1, 54.0)0.092
20-3929.9 (26.5, 33.5)70.1 (66.5, 73.5)10.6 (8.4, 13.4)38.6 (34.6, 42.7)50.8 (45.6, 55.9)
40-5932.0 (28.9, 35.3)68.0 (64.7, 71.1)11.3 (9.0, 14.1)41.5 (37.5, 45.7)47.2 (42.5, 51.9)
>=6033.6 (31.9, 35.4)66.4 (64.6, 68.1)12.1 (10.1, 14.5)43.0 (39.3, 46.9)44.9 (41.9, 47.8)
Total31.5 (29.4, 33.6)68.5 (66.4, 70.6)11.1 (10.0, 12.2)40.8 (38.2, 43.5)48.1 (44.8, 51.5)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs662AGAAAGGG
Male61.9 (58.7, 65.0)38.1 (35.0, 41.3)0.60440.0 (35.5, 44.7)43.8 (40.2, 47.5)16.2 (14.0, 18.6)0.268
Female61.1 (58.9, 63.3)38.9 (36.7, 41.1)40.0 (37.4, 42.7)42.2 (39.9, 44.4)17.8 (15.7, 20.2)
Total61.5 (59.4, 63.6)38.5 (36.4, 40.6)40.0 (37.3, 42.8)43.0 (40.8, 45.2)17.0 (15.2, 19.0)
rs854560ATAAATTT
Male32.4 (29.1, 35.8)67.6 (64.2, 70.9)0.28912.2 (10.4, 14.4)40.3 (36.4, 44.2)47.5 (42.4, 52.7)0.222
Female30.7 (28.9, 32.5)69.3 (67.5, 71.1)10.0 (8.6, 11.6)41.4 (38.9, 43.9)48.7 (46.0, 51.4)
Total31.5 (29.4, 33.6)68.5 (66.4, 70.6)11.1 (10.0, 12.2)40.8 (38.2, 43.5)48.1 (44.8, 51.5)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs662AGAAAGGG
Non-Hispanic White12-1972.6 (68.0, 76.7)27.4 (23.3, 32.0)51.8 (44.1, 59.4)41.6 (33.8, 49.8)6.7 (4.0, 10.8)
20-3967.7 (65.4, 70.0)32.3 (30.0, 34.6)45.5 (41.5, 49.6)44.4 (39.9, 48.9)10.1 (8.1, 12.4)
40-5967.0 (63.5, 70.4)33.0 (29.6, 36.5)46.8 (41.8, 51.9)40.4 (35.5, 45.5)12.7 (9.8, 16.5)
>=6069.7 (66.7, 72.5)30.3 (27.5, 33.3)48.6 (44.0, 53.2)42.1 (37.6, 46.8)9.3 (7.1, 12.1)
Non-Hispanic Black12-1934.4 (31.5, 37.4)65.6 (62.6, 68.5)12.6 (9.7, 16.2)43.6 (38.7, 48.7)43.8 (39.4, 48.3)
20-3932.4 (30.2, 34.6)67.6 (65.4, 69.8)11.0 (8.3, 14.4)42.7 (40.0, 45.5)46.3 (44.2, 48.4)
40-5933.6 (30.0, 37.4)66.4 (62.6, 70.0)11.7 (8.7, 15.7)43.7 (38.8, 48.6)44.6 (39.5, 49.9)
>=6031.2 (27.4, 35.2)68.8 (64.8, 72.6)9.6 (5.9, 15.3)43.2 (36.9, 49.7)47.2 (41.8, 52.7)
Mexican American12-1954.0 (50.0, 58.1)46.0 (41.9, 50.0)25.7 (20.0, 32.3)56.8 (50.1, 63.2)17.6 (13.8, 22.1)
20-3952.7 (50.1, 55.2)47.3 (44.8, 49.9)27.9 (23.5, 32.8)49.5 (44.5, 54.6)22.6 (20.5, 24.8)
40-5955.5 (50.8, 60.1)44.5 (39.9, 49.2)32.8 (27.7, 38.4)45.3 (39.9, 50.8)21.9 (16.9, 27.8)
>=6051.5 (47.4, 55.5)48.5 (44.5, 52.6)29.4 (24.3, 35.1)44.1 (36.8, 51.7)26.5 (21.2, 32.5)
rs854560ATAAATTT
Non-Hispanic White12-1938.7 (33.2, 44.6)61.3 (55.4, 66.8)13.9 (9.1, 20.6)49.7 (43.0, 56.5)36.4 (29.3, 44.1)
20-3934.7 (30.3, 39.3)65.3 (60.7, 69.7)13.5 (10.3, 17.6)42.3 (37.3, 47.4)44.2 (37.9, 50.6)
40-5935.1 (31.4, 38.9)64.9 (61.1, 68.6)13.1 (10.3, 16.5)44.0 (38.4, 49.7)42.9 (37.2, 48.9)
>=6036.2 (34.4, 38.1)63.8 (61.9, 65.6)13.7 (11.7, 16.1)45.0 (41.6, 48.5)41.3 (38.5, 44.1)
Non-Hispanic Black12-1917.3 (14.6, 20.3)82.7 (79.7, 85.4)2.9 (1.8, 4.5)28.9 (23.7, 34.6)68.3 (62.6, 73.4)
20-3918.0 (16.3, 19.9)82.0 (80.1, 83.7)3.1 (2.0, 4.8)29.8 (27.0, 32.8)67.1 (64.1, 70.0)
40-5918.0 (15.1, 21.4)82.0 (78.6, 84.9)2.6 (1.3, 5.2)30.9 (25.4, 37.0)66.5 (60.5, 72.0)
>=6018.1 (16.0, 20.4)81.9 (79.6, 84.0)2.9 (1.6, 5.2)30.4 (25.7, 35.5)66.7 (62.2, 70.9)
Mexican American12-1924.9 (21.6, 28.6)75.1 (71.4, 78.4)5.6 (3.3, 9.3)38.7 (34.0, 43.5)55.7 (50.4, 60.9)
20-3921.3 (18.7, 24.1)78.7 (75.9, 81.3)4.3 (2.9, 6.3)34.1 (30.1, 38.3)61.6 (57.0, 66.0)
40-5924.8 (20.6, 29.5)75.2 (70.5, 79.4)5.4 (3.4, 8.4)38.9 (33.2, 44.9)55.8 (48.6, 62.7)
>=6024.3 (21.5, 27.5)75.7 (72.5, 78.5)6.8 (3.6, 12.2)35.2 (30.2, 40.4)58.1 (54.2, 61.8)

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By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs662AGAAAGGG
Non-Hispanic WhiteMale68.1 (65.0, 71.1)31.9 (28.9, 35.0)46.4 (41.2, 51.6)43.5 (38.7, 48.4)10.2 (8.4, 12.2)
Female68.9 (66.6, 71.2)31.1 (28.8, 33.4)48.3 (44.5, 52.0)41.4 (37.8, 45.1)10.4 (8.8, 12.2)
Non-Hispanic BlackMale32.6 (30.4, 34.9)67.4 (65.1, 69.6)11.1 (9.1, 13.6)43.0 (39.9, 46.1)45.9 (42.8, 49.1)
Female33.1 (30.8, 35.5)66.9 (64.5, 69.2)11.4 (9.6, 13.5)43.4 (40.5, 46.3)45.2 (41.9, 48.6)
Mexican AmericanMale54.2 (51.5, 56.8)45.8 (43.2, 48.5)28.7 (24.2, 33.7)50.9 (45.5, 56.3)20.4 (18.0, 23.0)
Female52.7 (50.5, 54.9)47.3 (45.1, 49.5)28.6 (24.9, 32.5)48.3 (42.7, 53.9)23.1 (20.0, 26.6)
rs854560ATAAATTT
Non-Hispanic WhiteMale35.9 (32.1, 40.0)64.1 (60.0, 67.9)14.5 (12.0, 17.4)42.8 (38.7, 47.0)42.7 (37.1, 48.4)
Female35.3 (33.5, 37.2)64.7 (62.8, 66.5)12.5 (10.7, 14.5)45.6 (42.7, 48.6)41.9 (39.1, 44.6)
Non-Hispanic BlackMale16.9 (14.5, 19.6)83.1 (80.4, 85.5)2.4 (1.6, 3.6)28.9 (24.8, 33.4)68.7 (63.9, 73.1)
Female18.8 (17.2, 20.4)81.2 (79.6, 82.8)3.3 (2.4, 4.7)30.9 (28.3, 33.6)65.8 (63.1, 68.5)
Mexican AmericanMale24.8 (22.8, 26.9)75.2 (73.1, 77.2)5.7 (4.5, 7.2)38.2 (34.4, 42.2)56.1 (52.3, 59.8)
Female21.2 (19.4, 23.1)78.8 (76.9, 80.6)4.2 (3.4, 5.3)34.0 (31.1, 37.0)61.8 (58.6, 65.0)


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