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U.S. Genome Variation Estimates

OGG1 Allele and Genotype Frequencies

 

Available polymorphism(s)

rs number

Common Designations

Nucleotide change                  Amino acid

Genotyping method

rs1052133

Ex6-315C>G

Ser326Cys
Pro332Ala

TaqMan



 

Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1052133 C G   CC CG GG    
Non-Hispanic White 78.5 (76.5, 80.5) 21.5 (19.5, 23.5) <0.001 61.3 (57.9, 64.6) 34.4 (31.5, 37.5) 4.3 (3.3, 5.5) <0.001 0.11
Non-Hispanic Black 83.6 (82.2, 84.8) 16.4 (15.2, 17.8) 69.6 (67.3, 71.8) 28.0 (25.8, 30.3) 2.5 (1.6, 3.7) 0.14
Mexican American 67.0 (64.8, 69.2) 33.0 (30.8, 35.2) 44.3 (40.8, 47.8) 45.5 (42.6, 48.4) 10.2 (9.0, 11.6) 0.12
Total* 77.0 (75.3, 78.7) 23.0 (21.3, 24.7)   59.6 (56.8, 62.4) 34.8 (32.5, 37.1) 5.6 (4.7, 6.6)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1052133 C G   CC CG GG  
12-19 76.9 (73.5, 80.0) 23.1 (20.0, 26.5) 0.955 58.6 (53.7, 63.4) 36.6 (32.6, 40.8) 4.8 (2.9, 7.7) 0.728
20-39 77.0 (74.4, 79.4) 23.0 (20.6, 25.6) 59.5 (55.5, 63.5) 34.9 (31.6, 38.4) 5.6 (4.3, 7.2)
40-59 77.5 (74.4, 80.3) 22.5 (19.7, 25.6) 61.2 (56.5, 65.6) 32.6 (28.2, 37.4) 6.2 (4.0, 9.5)
>=60 76.6 (73.9, 79.1) 23.4 (20.9, 26.1) 58.4 (53.9, 62.7) 36.4 (32.4, 40.5) 5.2 (3.8, 7.1)
Total 77.0 (75.3, 78.7) 23.0 (21.3, 24.7)   59.6 (56.8, 62.4) 34.8 (32.5, 37.1) 5.6 (4.7, 6.6)  

* Includes all participants, regardless of race/ethnicity.

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By Sex* 

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1052133 C G CC CG GG
Male 77.3 (74.9, 79.5) 22.7 (20.5, 25.1) 0.683 59.9 (56.4, 63.3) 34.8 (32.2, 37.4) 5.3 (4.1, 6.9) 0.876
Female 76.8 (74.9, 78.6) 23.2 (21.4, 25.1) 59.4 (56.3, 62.4) 34.8 (32.1, 37.6) 5.8 (4.7, 7.1)
Total 77.0 (75.3, 78.7) 23.0 (21.3, 24.7)   59.6 (56.8, 62.4) 34.8 (32.5, 37.1) 5.6 (4.7, 6.6)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs1052133 C G CC CG GG
Non-Hispanic White 12-19 78.8 (74.4, 82.7) 21.2 (17.3, 25.6) 60.9 (54.1, 67.4) 35.8 (30.2, 41.7) 3.3 (1.5, 7.0)
20-39 79.1 (75.6, 82.2) 20.9 (17.8, 24.4) 62.1 (56.4, 67.5) 33.9 (29.3, 38.8) 4.0 (2.7, 5.8)
40-59 78.5 (74.8, 81.9) 21.5 (18.1, 25.2) 62.0 (56.2, 67.5) 33.0 (27.7, 38.8) 4.9 (2.7, 8.7)
>=60 77.5 (74.7, 80.1) 22.5 (19.9, 25.3) 59.3 (54.7, 63.7) 36.4 (32.3, 40.6) 4.3 (2.9, 6.3)
Non-Hispanic Black 12-19 84.4 (81.8, 86.7) 15.6 (13.3, 18.2) 70.8 (65.8, 75.4) 27.2 (22.2, 32.8) 2.0 (0.8, 4.6)
20-39 82.4 (79.9, 84.6) 17.6 (15.4, 20.1) 67.4 (62.9, 71.6) 30.0 (25.8, 34.6) 2.6 (1.5, 4.5)
40-59 86.0 (83.3, 88.3) 14.0 (11.7, 16.7) 74.8 (70.9, 78.3) 22.3 (18.9, 26.2) 2.9 (1.3, 6.5)
>=60 81.6 (78.7, 84.2) 18.4 (15.8, 21.3) 65.1 (59.9, 70.1) 33.0 (28.3, 38.1) 1.9 (1.1, 3.2)
Mexican American 12-19 70.0 (64.7, 74.8) 30.0 (25.2, 35.3) 47.7 (40.5, 54.9) 44.7 (39.5, 50.0) 7.7 (4.9, 11.9)
20-39 66.5 (63.7, 69.1) 33.5 (30.9, 36.3) 44.3 (39.6, 49.0) 44.4 (39.9, 49.0) 11.4 (9.6, 13.4)
40-59 65.4 (61.3, 69.3) 34.6 (30.7, 38.7) 40.7 (36.1, 45.5) 49.4 (45.5, 53.2) 9.9 (6.4, 14.9)
>=60 67.4 (63.8, 70.9) 32.6 (29.1, 36.2) 45.4 (39.6, 51.4) 44.0 (37.9, 50.3) 10.5 (7.9, 13.9)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs1052133 C G CC CG GG
Non-Hispanic White Male 78.5 (76.0, 80.8) 21.5 (19.2, 24.0) 61.1 (57.1, 64.9) 34.8 (31.6, 38.2) 4.1 (2.9, 5.6)
Female 78.6 (76.4, 80.6) 21.4 (19.4, 23.6) 61.6 (57.8, 65.2) 34.0 (30.4, 37.8) 4.4 (3.2, 6.1)
Non-Hispanic Black Male 83.9 (82.1, 85.5) 16.1 (14.5, 17.9) 70.3 (67.6, 72.9) 27.1 (24.5, 29.8) 2.6 (1.5, 4.6)
Female 83.3 (81.2, 85.2) 16.7 (14.8, 18.8) 68.9 (65.1, 72.5) 28.7 (25.1, 32.6) 2.3 (1.3, 4.1)
Mexican American Male 68.0 (65.5, 70.3) 32.0 (29.7, 34.5) 45.6 (41.3, 49.9) 44.8 (40.4, 49.2) 9.7 (8.2, 11.4)
Female 66.1 (63.2, 68.8) 33.9 (31.2, 36.8) 42.9 (38.7, 47.3) 46.3 (42.9, 49.7) 10.8 (9.2, 12.6)


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