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U.S. Genome Variation Estimates

OGG1 Allele and Genotype Frequencies

Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs1052133

Ex6-315C>G

Ser326Cys
Pro332Ala

TaqMan



Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1052133CGCCCGGG
Non-Hispanic White78.5 (76.5, 80.5)21.5 (19.5, 23.5)<0.00161.3 (57.9, 64.6)34.4 (31.5, 37.5)4.3 (3.3, 5.5)<0.0010.11
Non-Hispanic Black83.6 (82.2, 84.8)16.4 (15.2, 17.8)69.6 (67.3, 71.8)28.0 (25.8, 30.3)2.5 (1.6, 3.7)0.14
Mexican American67.0 (64.8, 69.2)33.0 (30.8, 35.2)44.3 (40.8, 47.8)45.5 (42.6, 48.4)10.2 (9.0, 11.6)0.12
Total*77.0 (75.3, 78.7)23.0 (21.3, 24.7)59.6 (56.8, 62.4)34.8 (32.5, 37.1)5.6 (4.7, 6.6)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1052133CGCCCGGG
12-1976.9 (73.5, 80.0)23.1 (20.0, 26.5)0.95558.6 (53.7, 63.4)36.6 (32.6, 40.8)4.8 (2.9, 7.7)0.728
20-3977.0 (74.4, 79.4)23.0 (20.6, 25.6)59.5 (55.5, 63.5)34.9 (31.6, 38.4)5.6 (4.3, 7.2)
40-5977.5 (74.4, 80.3)22.5 (19.7, 25.6)61.2 (56.5, 65.6)32.6 (28.2, 37.4)6.2 (4.0, 9.5)
>=6076.6 (73.9, 79.1)23.4 (20.9, 26.1)58.4 (53.9, 62.7)36.4 (32.4, 40.5)5.2 (3.8, 7.1)
Total77.0 (75.3, 78.7)23.0 (21.3, 24.7)59.6 (56.8, 62.4)34.8 (32.5, 37.1)5.6 (4.7, 6.6)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1052133CGCCCGGG
Male77.3 (74.9, 79.5)22.7 (20.5, 25.1)0.68359.9 (56.4, 63.3)34.8 (32.2, 37.4)5.3 (4.1, 6.9)0.876
Female76.8 (74.9, 78.6)23.2 (21.4, 25.1)59.4 (56.3, 62.4)34.8 (32.1, 37.6)5.8 (4.7, 7.1)
Total77.0 (75.3, 78.7)23.0 (21.3, 24.7)59.6 (56.8, 62.4)34.8 (32.5, 37.1)5.6 (4.7, 6.6)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs1052133CGCCCGGG
Non-Hispanic White12-1978.8 (74.4, 82.7)21.2 (17.3, 25.6)60.9 (54.1, 67.4)35.8 (30.2, 41.7)3.3 (1.5, 7.0)
20-3979.1 (75.6, 82.2)20.9 (17.8, 24.4)62.1 (56.4, 67.5)33.9 (29.3, 38.8)4.0 (2.7, 5.8)
40-5978.5 (74.8, 81.9)21.5 (18.1, 25.2)62.0 (56.2, 67.5)33.0 (27.7, 38.8)4.9 (2.7, 8.7)
>=6077.5 (74.7, 80.1)22.5 (19.9, 25.3)59.3 (54.7, 63.7)36.4 (32.3, 40.6)4.3 (2.9, 6.3)
Non-Hispanic Black12-1984.4 (81.8, 86.7)15.6 (13.3, 18.2)70.8 (65.8, 75.4)27.2 (22.2, 32.8)2.0 (0.8, 4.6)
20-3982.4 (79.9, 84.6)17.6 (15.4, 20.1)67.4 (62.9, 71.6)30.0 (25.8, 34.6)2.6 (1.5, 4.5)
40-5986.0 (83.3, 88.3)14.0 (11.7, 16.7)74.8 (70.9, 78.3)22.3 (18.9, 26.2)2.9 (1.3, 6.5)
>=6081.6 (78.7, 84.2)18.4 (15.8, 21.3)65.1 (59.9, 70.1)33.0 (28.3, 38.1)1.9 (1.1, 3.2)
Mexican American12-1970.0 (64.7, 74.8)30.0 (25.2, 35.3)47.7 (40.5, 54.9)44.7 (39.5, 50.0)7.7 (4.9, 11.9)
20-3966.5 (63.7, 69.1)33.5 (30.9, 36.3)44.3 (39.6, 49.0)44.4 (39.9, 49.0)11.4 (9.6, 13.4)
40-5965.4 (61.3, 69.3)34.6 (30.7, 38.7)40.7 (36.1, 45.5)49.4 (45.5, 53.2)9.9 (6.4, 14.9)
>=6067.4 (63.8, 70.9)32.6 (29.1, 36.2)45.4 (39.6, 51.4)44.0 (37.9, 50.3)10.5 (7.9, 13.9)

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By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs1052133CGCCCGGG
Non-Hispanic WhiteMale78.5 (76.0, 80.8)21.5 (19.2, 24.0)61.1 (57.1, 64.9)34.8 (31.6, 38.2)4.1 (2.9, 5.6)
Female78.6 (76.4, 80.6)21.4 (19.4, 23.6)61.6 (57.8, 65.2)34.0 (30.4, 37.8)4.4 (3.2, 6.1)
Non-Hispanic BlackMale83.9 (82.1, 85.5)16.1 (14.5, 17.9)70.3 (67.6, 72.9)27.1 (24.5, 29.8)2.6 (1.5, 4.6)
Female83.3 (81.2, 85.2)16.7 (14.8, 18.8)68.9 (65.1, 72.5)28.7 (25.1, 32.6)2.3 (1.3, 4.1)
Mexican AmericanMale68.0 (65.5, 70.3)32.0 (29.7, 34.5)45.6 (41.3, 49.9)44.8 (40.4, 49.2)9.7 (8.2, 11.4)
Female66.1 (63.2, 68.8)33.9 (31.2, 36.8)42.9 (38.7, 47.3)46.3 (42.9, 49.7)10.8 (9.2, 12.6)


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