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U.S. Genome Variation Estimates

NQO1 Allele and Genotype Frequencies

 

Available polymorphism(s)

rs number

Common Designations

Nucleotide change                  Amino acid

Genotyping method

rs10517

Ex6-457C>T

 

TaqMan

rs1800566

Ex6+40C>T
609C>T

Pro187Ser
Pro149Ser
Pro153Ser

TaqMan

rs34755915

IVS3+20G>A

 

TaqMan

rs689452

IVS1-27C>G

 

TaqMan

rs689453

Ex2+65G>A

Glu24Glu

TaqMan



Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs10517 C T   CC CT TT    
Non-Hispanic White 86.8 (85.7, 87.9) 13.2 (12.1, 14.3) <0.001 75.5 (73.5, 77.3) 22.8 (21.0, 24.7) 1.8 (1.2, 2.6) 0.001 0.65
Non-Hispanic Black 86.1 (84.6, 87.5) 13.9 (12.5, 15.4) 73.9 (71.4, 76.3) 24.3 (22.2, 26.6) 1.7 (1.1, 2.7) 0.65
Mexican American 93.5 (91.7, 94.9) 6.5 (5.1, 8.3) 87.2 (83.8, 90.0) 12.6 (9.8, 16.0) 0.2 (0.1, 0.5) 0.20
Total* 86.4 (85.1, 87.7) 13.6 (12.3, 14.9)   75.0 (73.0, 77.0) 22.9 (21.4, 24.4) 2.1 (1.5, 3.0)    
rs1800566 C T   CC CT TT    
Non-Hispanic White 80.6 (78.7, 82.4) 19.4 (17.6, 21.3) <0.001 64.7 (61.2, 68.0) 31.8 (28.7, 35.1) 3.5 (2.8, 4.3) <0.001 0.51
Non-Hispanic Black 81.2 (80.0, 82.3) 18.8 (17.7, 20.0) 65.8 (64.1, 67.5) 30.7 (29.1, 32.3) 3.5 (2.7, 4.6) 0.93
Mexican American 63.2 (61.2, 65.1) 36.8 (34.9, 38.8) 40.4 (37.5, 43.4) 45.6 (42.8, 48.4) 14.0 (12.4, 15.8) 0.93
Total* 78.5 (76.8, 80.2) 21.5 (19.8, 23.2)   61.8 (58.8, 64.7) 33.4 (30.8, 36.2) 4.8 (4.1, 5.6)    
rs34755915 A G   AA AG GG    
                 
Non-Hispanic White 1.8 (1.5, 2.3) 98.2 (97.7, 98.5) <0.001 0.0 (0.0, 0.4) 3.5 (2.9, 4.4) 96.4 (95.6, 97.1) <0.001 0.81
Non-Hispanic Black 0.4 (0.2, 0.8) 99.6 (99.2, 99.8) 0.0 (NA) 0.8 (0.4, 1.6) 99.2 (98.4, 99.6) 0.88
Mexican American 0.5 (0.3, 0.9) 99.5 (99.1, 99.7) 0.0 (NA) 1.1 (0.6, 1.8) 98.9 (98.2, 99.4) 0.82
Total* 1.4 (1.1, 1.8) 98.6 (98.2, 98.9)   0.0 (0.0, 0.3) 2.8 (2.2, 3.5) 97.2 (96.5, 97.8)    
rs689452 C G   CC CG GG    
Non-Hispanic White 88.1 (87.1, 89.0) 11.9 (11.0, 12.9) <0.001 77.5 (75.7, 79.3) 21.1 (19.4, 23.0) 1.3 (0.9, 2.0) <0.001 0.23
Non-Hispanic Black 86.3 (84.7, 87.7) 13.7 (12.3, 15.3) 74.2 (71.7, 76.6) 24.1 (21.9, 26.4) 1.7 (1.1, 2.6) 0.63
Mexican American 93.7 (91.8, 95.1) 6.3 (4.9, 8.2) 87.5 (83.9, 90.4) 12.3 (9.4, 15.8) 0.2 (0.1, 0.5) 0.25
Total* 87.5 (86.3, 88.6) 12.5 (11.4, 13.7)   76.6 (74.8, 78.4) 21.6 (20.2, 23.2) 1.7 (1.2, 2.5)    
rs689453 A G   AA AG GG    
Non-Hispanic White 7.9 (6.7, 9.2) 92.1 (90.8, 93.3) <0.001 0.5 (0.2, 1.1) 14.7 (12.7, 17.0) 84.8 (82.4, 86.9) 0.005 0.23
Non-Hispanic Black 5.1 (4.2, 6.2) 94.9 (93.8, 95.8) 0.4 (0.1, 1.1) 9.5 (7.5, 11.9) 90.2 (87.9, 92.1) 0.25
Mexican American 5.2 (3.8, 7.0) 94.8 (93.0, 96.2) 0.6 (0.3, 1.3) 9.2 (7.1, 12.0) 90.2 (87.0, 92.6) 0.21
Total* 7.0 (6.1, 8.1) 93.0 (91.9, 93.9)   0.4 (0.2, 0.9) 13.2 (11.4, 15.1) 86.4 (84.4, 88.2)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs10517 C T   CC CT TT  
12-19 85.7 (83.4, 87.8) 14.3 (12.2, 16.6) 0.894 74.3 (70.3, 77.8) 22.9 (19.2, 27.1) 2.8 (1.4, 5.4) 0.864
20-39 86.7 (84.3, 88.7) 13.3 (11.3, 15.7) 75.2 (71.4, 78.7) 22.9 (20.0, 26.1) 1.9 (1.2, 3.0)
40-59 86.3 (84.4, 88.1) 13.7 (11.9, 15.6) 74.7 (71.4, 77.8) 23.2 (20.2, 26.6) 2.0 (1.2, 3.6)
>=60 86.6 (84.7, 88.3) 13.4 (11.7, 15.3) 75.5 (72.4, 78.4) 22.2 (19.5, 25.2) 2.3 (1.2, 4.1)
Total 86.4 (85.1, 87.7) 13.6 (12.3, 14.9)   75.0 (73.0, 77.0) 22.9 (21.4, 24.4) 2.1 (1.5, 3.0)  
rs1800566 C T   CC CT TT  
12-19 76.1 (72.2, 79.5) 23.9 (20.5, 27.8) 0.108 57.5 (50.9, 63.9) 37.1 (31.0, 43.6) 5.4 (3.8, 7.6) 0.185
20-39 77.9 (75.5, 80.1) 22.1 (19.9, 24.5) 61.1 (57.2, 65.0) 33.5 (30.1, 37.1) 5.4 (4.3, 6.7)
40-59 80.1 (77.3, 82.6) 19.9 (17.4, 22.7) 64.2 (59.3, 68.7) 31.9 (27.5, 36.6) 4.0 (2.8, 5.6)
>=60 79.3 (77.1, 81.4) 20.7 (18.6, 22.9) 62.9 (59.2, 66.5) 32.9 (29.5, 36.4) 4.2 (3.2, 5.6)
Total 78.5 (76.8, 80.2) 21.5 (19.8, 23.2)   61.8 (58.8, 64.7) 33.4 (30.8, 36.2) 4.8 (4.1, 5.6)  
rs34755915 A G   AA AG GG  
12-19 1.4 (0.7, 2.8) 98.6 (97.2, 99.3) 0.969 0.0 (NA) 2.7 (1.3, 5.6) 97.3 (94.4, 98.7) 0.976
20-39 1.4 (0.9, 2.2) 98.6 (97.8, 99.1) 0.0 (NA) 2.8 (1.8, 4.4) 97.2 (95.6, 98.2)
40-59 1.4 (0.9, 2.1) 98.6 (97.9, 99.1) 0.0 (NA) 2.8 (1.8, 4.2) 97.2 (95.8, 98.2)
>=60 1.5 (1.0, 2.4) 98.5 (97.6, 99.0) 0.2 (0.0, 1.5) 2.7 (1.9, 3.9) 97.1 (95.7, 98.0)
Total 1.4 (1.1, 1.8) 98.6 (98.2, 98.9)   0.0 (0.0, 0.3) 2.8 (2.2, 3.5) 97.2 (96.5, 97.8)  
rs689452 C G   CC CG GG  
12-19 86.9 (84.9, 88.7) 13.1 (11.3, 15.1) 0.923 76.2 (72.8, 79.3) 21.3 (17.9, 25.2) 2.5 (1.2, 5.1) 0.867
20-39 87.6 (85.5, 89.5) 12.4 (10.5, 14.5) 76.6 (73.2, 79.7) 22.0 (19.4, 24.7) 1.4 (0.8, 2.5)
40-59 87.4 (85.7, 89.0) 12.6 (11.0, 14.3) 76.6 (73.4, 79.5) 21.7 (18.8, 25.0) 1.7 (0.9, 3.2)
>=60 87.6 (85.7, 89.3) 12.4 (10.7, 14.3) 77.1 (73.8, 80.1) 21.1 (18.3, 24.3) 1.8 (1.0, 3.2)
Total 87.5 (86.3, 88.6) 12.5 (11.4, 13.7)   76.6 (74.8, 78.4) 21.6 (20.2, 23.2) 1.7 (1.2, 2.5)  
rs689453 A G   AA AG GG  
12-19 7.4 (5.2, 10.3) 92.6 (89.7, 94.8) 0.205 0.8 (0.2, 2.5) 13.2 (9.2, 18.6) 86.0 (80.6, 90.1) 0.090
20-39 6.2 (5.2, 7.5) 93.8 (92.5, 94.8) 0.3 (0.1, 1.0) 11.8 (9.7, 14.3) 87.9 (85.4, 89.9)
40-59 7.6 (6.5, 9.0) 92.4 (91.0, 93.5) 0.3 (0.1, 1.0) 14.7 (12.6, 17.1) 85.0 (82.5, 87.2)
>=60 7.5 (6.2, 9.0) 92.5 (91.0, 93.8) 0.7 (0.3, 1.4) 13.6 (11.1, 16.6) 85.7 (82.8, 88.2)
Total 7.0 (6.1, 8.1) 93.0 (91.9, 93.9)   0.4 (0.2, 0.9) 13.2 (11.4, 15.1) 86.4 (84.4, 88.2)  

* Includes all participants, regardless of race/ethnicity.

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By Sex* 

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs10517 C T CC CT TT
Male 86.1 (84.2, 87.7) 13.9 (12.3, 15.8) 0.500 74.1 (71.2, 76.9) 23.8 (21.3, 26.5) 2.0 (1.1, 3.6) 0.696
Female 86.8 (85.0, 88.4) 13.2 (11.6, 15.0)   75.8 (72.6, 78.8) 22.0 (19.2, 25.0) 2.2 (1.7, 2.9)  
Total 86.4 (85.1, 87.7) 13.6 (12.3, 14.9)   75.0 (73.0, 77.0) 22.9 (21.4, 24.4) 2.1 (1.5, 3.0)  
rs1800566 C T CC CT TT
Male 78.7 (76.2, 81.0) 21.3 (19.0, 23.8) 0.770 61.8 (57.5, 65.9) 33.8 (29.8, 38.1) 4.4 (3.2, 6.0) 0.694
Female 78.4 (76.7, 79.9) 21.6 (20.1, 23.3)   61.9 (59.0, 64.7) 33.0 (30.3, 35.9) 5.1 (4.3, 6.0)  
Total 78.5 (76.8, 80.2) 21.5 (19.8, 23.2)   61.8 (58.8, 64.7) 33.4 (30.8, 36.2) 4.8 (4.1, 5.6)  
rs34755915 A G AA AG GG
Male 1.6 (1.2, 2.1) 98.4 (97.9, 98.8) 0.320 0.0 (NA) 3.1 (2.4, 4.2) 96.9 (95.8, 97.6) 0.206
Female 1.3 (0.9, 1.8) 98.7 (98.2, 99.1)   0.1 (0.0, 0.5) 2.4 (1.8, 3.3) 97.5 (96.5, 98.2)  
Total 1.4 (1.1, 1.8) 98.6 (98.2, 98.9)   0.0 (0.0, 0.3) 2.8 (2.2, 3.5) 97.2 (96.5, 97.8)  
rs689452 C G CC CG GG
Male 87.2 (85.5, 88.7) 12.8 (11.3, 14.5) 0.545 76.0 (73.4, 78.5) 22.3 (20.1, 24.6) 1.7 (0.9, 3.1) 0.815
Female 87.8 (86.2, 89.2) 12.2 (10.8, 13.8)   77.2 (74.4, 79.9) 21.1 (18.5, 23.9) 1.7 (1.2, 2.5)  
Total 87.5 (86.3, 88.6) 12.5 (11.4, 13.7)   76.6 (74.8, 78.4) 21.6 (20.2, 23.2) 1.7 (1.2, 2.5)  
rs689453 A G AA AG GG
Male 7.6 (6.2, 9.3) 92.4 (90.7, 93.8) 0.086 0.6 (0.3, 1.5) 13.9 (11.4, 16.9) 85.4 (82.3, 88.1) 0.252
Female 6.5 (5.7, 7.3) 93.5 (92.7, 94.3)   0.3 (0.1, 0.6) 12.4 (10.9, 14.1) 87.3 (85.6, 88.9)  
Total 7.0 (6.1, 8.1) 93.0 (91.9, 93.9)   0.4 (0.2, 0.9) 13.2 (11.4, 15.1) 86.4 (84.4, 88.2)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs10517 C T CC CT TT
Non-Hispanic White 12-19 85.9 (82.3, 88.9) 14.1 (11.1, 17.7) 74.5 (68.6, 79.5) 23.0 (18.6, 28.1) 2.6 (1.3, 5.0)
20-39 86.7 (84.1, 89.0) 13.3 (11.0, 15.9) 74.8 (70.0, 79.1) 23.8 (19.7, 28.5) 1.4 (0.9, 2.1)
40-59 87.0 (84.4, 89.2) 13.0 (10.8, 15.6) 76.0 (72.1, 79.6) 22.0 (18.9, 25.4) 2.0 (0.9, 4.4)
>=60 87.3 (85.7, 88.8) 12.7 (11.2, 14.3) 76.4 (73.4, 79.1) 22.0 (19.2, 24.9) 1.7 (0.9, 3.1)
Non-Hispanic Black 12-19 85.9 (82.8, 88.5) 14.1 (11.5, 17.2) 73.9 (68.6, 78.5) 24.0 (19.3, 29.4) 2.1 (0.8, 5.6)
20-39 86.2 (84.1, 88.1) 13.8 (11.9, 15.9) 74.1 (70.4, 77.5) 24.2 (20.8, 28.0) 1.7 (0.8, 3.6)
40-59 86.5 (84.2, 88.5) 13.5 (11.5, 15.8) 73.9 (69.7, 77.7) 25.3 (21.7, 29.3) 0.8 (0.3, 2.1)
>=60 85.4 (81.5, 88.7) 14.6 (11.3, 18.5) 73.7 (66.5, 79.7) 23.6 (17.6, 30.8) 2.8 (1.4, 5.2)
Mexican American 12-19 94.5 (90.5, 96.8) 5.5 (3.2, 9.5) 89.5 (82.3, 94.0) 9.9 (5.6, 16.8) 0.6 (0.1, 2.6)
20-39 93.8 (92.3, 95.1) 6.2 (4.9, 7.7) 87.7 (84.7, 90.1) 12.3 (9.9, 15.3) 0.0 (NA)
40-59 92.2 (89.6, 94.2) 7.8 (5.8, 10.4) 84.5 (79.4, 88.4) 15.4 (11.4, 20.5) 0.1 (0.0, 1.0)
>=60 92.5 (90.1, 94.4) 7.5 (5.6, 9.9) 85.9 (82.0, 89.1) 13.2 (10.3, 16.8) 0.8 (0.2, 3.4)
rs1800566 C T CC CT TT
Non-Hispanic White 12-19 78.1 (73.4, 82.1) 21.9 (17.9, 26.6) 60.2 (52.4, 67.5) 35.7 (28.9, 43.2) 4.1 (2.1, 7.6)
20-39 80.9 (78.1, 83.3) 19.1 (16.7, 21.9) 64.6 (59.6, 69.3) 32.5 (28.1, 37.2) 2.9 (2.2, 3.9)
40-59 81.4 (78.0, 84.4) 18.6 (15.6, 22.0) 66.8 (60.8, 72.3) 29.1 (23.8, 35.0) 4.1 (2.7, 6.1)
>=60 80.6 (78.0, 83.0) 19.4 (17.0, 22.0) 64.5 (60.0, 68.7) 32.2 (28.5, 36.2) 3.3 (2.4, 4.6)
Non-Hispanic Black 12-19 82.5 (80.2, 84.5) 17.5 (15.5, 19.8) 67.8 (63.6, 71.8) 29.2 (24.6, 34.3) 2.9 (1.5, 5.6)
20-39 79.4 (77.6, 81.2) 20.6 (18.8, 22.4) 63.1 (59.7, 66.3) 32.7 (29.2, 36.4) 4.2 (3.0, 6.0)
40-59 82.8 (79.5, 85.7) 17.2 (14.3, 20.5) 68.1 (62.2, 73.4) 29.5 (24.4, 35.1) 2.5 (1.4, 4.4)
>=60 81.9 (78.6, 84.7) 18.1 (15.3, 21.4) 67.6 (62.6, 72.3) 28.5 (24.1, 33.3) 3.9 (2.1, 7.0)
Mexican American 12-19 60.6 (56.1, 64.9) 39.4 (35.1, 43.9) 39.4 (32.9, 46.3) 42.3 (35.5, 49.4) 18.3 (14.4, 22.9)
20-39 64.5 (62.3, 66.7) 35.5 (33.3, 37.7) 42.4 (39.3, 45.6) 44.3 (41.5, 47.2) 13.3 (11.5, 15.3)
40-59 61.9 (58.8, 64.8) 38.1 (35.2, 41.2) 36.2 (31.6, 41.1) 51.4 (45.4, 57.2) 12.4 (9.3, 16.5)
>=60 64.7 (60.8, 68.4) 35.3 (31.6, 39.2) 41.5 (35.7, 47.6) 46.4 (40.5, 52.4) 12.1 (9.2, 15.9)
rs34755915 A G AA AG GG
Non-Hispanic White 12-19 2.0 (0.9, 4.2) 98.0 (95.8, 99.1) 0.0 (NA) 4.0 (1.9, 8.4) 96.0 (91.6, 98.1)
20-39 1.8 (1.2, 2.8) 98.2 (97.2, 98.8) 0.0 (NA) 3.7 (2.4, 5.6) 96.3 (94.4, 97.6)
40-59 1.7 (1.1, 2.6) 98.3 (97.4, 98.9) 0.0 (NA) 3.4 (2.2, 5.3) 96.6 (94.7, 97.8)
>=60 1.8 (1.2, 2.8) 98.2 (97.2, 98.8) 0.2 (0.0, 1.8) 3.2 (2.3, 4.5) 96.6 (95.0, 97.7)
Non-Hispanic Black 12-19 0.1 (0.0, 0.7) 99.9 (99.3, 100.0) 0.0 (NA) 0.2 (0.0, 1.4) 99.8 (98.6, 100.0)
20-39 0.6 (0.2, 1.7) 99.4 (98.3, 99.8) 0.0 (NA) 1.2 (0.4, 3.3) 98.8 (96.7, 99.6)
40-59 0.3 (0.1, 1.0) 99.7 (99.0, 99.9) 0.0 (NA) 0.7 (0.2, 2.0) 99.3 (98.0, 99.8)
>=60 0.3 (0.1, 1.4) 99.7 (98.6, 99.9) 0.0 (NA) 0.6 (0.2, 2.7) 99.4 (97.3, 99.8)
Mexican American 12-19 0.5 (0.1, 2.2) 99.5 (97.8, 99.9) 0.0 (NA) 1.0 (0.2, 4.3) 99.0 (95.7, 99.8)
20-39 0.6 (0.3, 1.2) 99.4 (98.8, 99.7) 0.0 (NA) 1.2 (0.6, 2.3) 98.8 (97.7, 99.4)
40-59 0.5 (0.2, 1.6) 99.5 (98.4, 99.8) 0.0 (NA) 1.0 (0.3, 3.2) 99.0 (96.8, 99.7)
>=60 0.5 (0.2, 1.3) 99.5 (98.7, 99.8) 0.0 (NA) 0.9 (0.3, 2.7) 99.1 (97.3, 99.7)
rs689452 C G CC CG GG
Non-Hispanic White 12-19 87.3 (84.0, 90.0) 12.7 (10.0, 16.0) 76.6 (71.3, 81.2) 21.3 (17.2, 26.1) 2.0 (0.9, 4.5)
20-39 88.0 (85.5, 90.1) 12.0 (9.9, 14.5) 77.0 (72.4, 80.9) 22.1 (18.3, 26.3) 1.0 (0.5, 1.8)
40-59 88.3 (86.0, 90.2) 11.7 (9.8, 14.0) 78.1 (74.5, 81.4) 20.3 (17.3, 23.7) 1.6 (0.6, 4.1)
>=60 88.5 (86.8, 90.0) 11.5 (10.0, 13.2) 78.2 (75.0, 81.1) 20.5 (17.7, 23.7) 1.2 (0.7, 2.3)
Non-Hispanic Black 12-19 85.7 (82.6, 88.3) 14.3 (11.7, 17.4) 73.6 (68.3, 78.2) 24.3 (19.6, 29.7) 2.1 (0.8, 5.7)
20-39 86.3 (84.4, 87.9) 13.7 (12.1, 15.6) 74.2 (70.8, 77.3) 24.2 (20.9, 27.8) 1.6 (0.8, 3.5)
40-59 86.9 (84.5, 89.0) 13.1 (11.0, 15.5) 74.7 (70.3, 78.6) 24.5 (20.7, 28.6) 0.8 (0.3, 2.1)
>=60 85.8 (81.8, 89.1) 14.2 (10.9, 18.2) 74.4 (67.0, 80.5) 22.9 (16.9, 30.2) 2.8 (1.4, 5.2)
Mexican American 12-19 94.6 (90.8, 96.9) 5.4 (3.1, 9.2) 89.9 (82.9, 94.2) 9.5 (5.4, 16.1) 0.6 (0.1, 2.6)
20-39 93.9 (92.2, 95.3) 6.1 (4.7, 7.8) 87.8 (84.4, 90.6) 12.2 (9.4, 15.6) 0.0 (NA)
40-59 92.4 (89.9, 94.4) 7.6 (5.6, 10.1) 85.0 (80.1, 88.9) 14.9 (11.0, 19.8) 0.1 (0.0, 1.0)
>=60 92.8 (90.0, 94.8) 7.2 (5.2, 10.0) 86.4 (81.7, 90.1) 12.7 (9.3, 17.1) 0.8 (0.2, 3.4)
rs689453 A G AA AG GG
Non-Hispanic White 12-19 8.6 (5.5, 13.0) 91.4 (87.0, 94.5) 1.1 (0.3, 3.8) 14.9 (9.3, 23.0) 84.0 (75.8, 89.8)
20-39 6.9 (5.6, 8.5) 93.1 (91.5, 94.4) 0.4 (0.1, 1.3) 13.1 (10.5, 16.2) 86.5 (83.5, 89.1)
40-59 8.5 (7.0, 10.4) 91.5 (89.6, 93.0) 0.3 (0.1, 1.5) 16.5 (13.8, 19.8) 83.2 (79.8, 86.1)
>=60 8.2 (6.7, 10.0) 91.8 (90.0, 93.3) 0.7 (0.3, 1.6) 15.0 (12.0, 18.5) 84.3 (80.9, 87.2)
Non-Hispanic Black 12-19 5.5 (4.1, 7.3) 94.5 (92.7, 95.9) 0.3 (0.1, 1.1) 10.4 (7.6, 14.0) 89.3 (85.8, 92.1)
20-39 4.3 (3.3, 5.5) 95.7 (94.5, 96.7) 0.2 (0.0, 0.7) 8.2 (6.3, 10.8) 91.6 (89.1, 93.6)
40-59 5.3 (3.8, 7.5) 94.7 (92.5, 96.2) 0.5 (0.1, 3.6) 9.7 (6.6, 14.1) 89.8 (85.7, 92.9)
>=60 6.6 (4.7, 9.2) 93.4 (90.8, 95.3) 0.8 (0.2, 3.4) 11.5 (7.5, 17.1) 87.7 (82.5, 91.5)
Mexican American 12-19 5.0 (2.7, 9.1) 95.0 (90.9, 97.3) 0.0 (NA) 10.1 (5.4, 18.0) 89.9 (82.0, 94.6)
20-39 5.5 (4.0, 7.5) 94.5 (92.5, 96.0) 0.7 (0.3, 1.8) 9.5 (7.1, 12.6) 89.8 (86.3, 92.5)
40-59 5.6 (4.0, 7.8) 94.4 (92.2, 96.0) 0.8 (0.2, 3.1) 9.5 (6.6, 13.6) 89.7 (85.7, 92.6)
>=60 3.1 (2.5, 3.9) 96.9 (96.1, 97.5) 0.6 (0.1, 3.8) 5.0 (3.2, 7.8) 94.4 (92.7, 95.7)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs10517 C T CC CT TT
Non-Hispanic White Male 86.6 (84.8, 88.1) 13.4 (11.9, 15.2) 74.5 (71.0, 77.8) 24.1 (20.6, 28.0) 1.4 (0.8, 2.5)
Female 87.1 (85.1, 88.8) 12.9 (11.2, 14.9) 76.3 (73.0, 79.4) 21.5 (18.8, 24.5) 2.1 (1.4, 3.2)
Non-Hispanic Black Male 85.2 (82.9, 87.2) 14.8 (12.8, 17.1) 72.0 (67.9, 75.8) 26.3 (22.7, 30.3) 1.7 (0.9, 3.2)
Female 86.9 (84.5, 89.0) 13.1 (11.0, 15.5) 75.5 (71.6, 79.1) 22.7 (19.5, 26.3) 1.7 (0.8, 3.7)
Mexican American Male 93.8 (91.2, 95.7) 6.2 (4.3, 8.8) 87.7 (82.6, 91.5) 12.2 (8.4, 17.3) 0.1 (0.0, 0.7)
Female 93.2 (91.5, 94.5) 6.8 (5.5, 8.5) 86.7 (83.5, 89.3) 13.0 (10.4, 16.1) 0.3 (0.1, 0.8)
rs1800566 C T CC CT TT
Non-Hispanic White Male 81.2 (78.7, 83.4) 18.8 (16.6, 21.3) 65.1 (60.3, 69.6) 32.2 (27.6, 37.3) 2.7 (1.8, 4.2)
Female 80.1 (78.0, 82.0) 19.9 (18.0, 22.0) 64.3 (60.8, 67.7) 31.5 (28.2, 35.0) 4.2 (3.1, 5.7)
Non-Hispanic Black Male 80.6 (78.0, 82.9) 19.4 (17.1, 22.0) 65.2 (61.6, 68.5) 30.9 (28.0, 33.9) 4.0 (2.3, 6.8)
Female 81.6 (80.4, 82.8) 18.4 (17.2, 19.6) 66.4 (64.3, 68.5) 30.5 (28.5, 32.6) 3.1 (2.5, 3.9)
Mexican American Male 62.1 (59.6, 64.6) 37.9 (35.4, 40.4) 38.8 (35.6, 42.1) 46.7 (43.7, 49.7) 14.5 (12.1, 17.3)
Female 64.3 (61.8, 66.7) 35.7 (33.3, 38.2) 42.1 (38.2, 46.0) 44.4 (40.8, 48.2) 13.5 (11.7, 15.5)
rs34755915 A G AA AG GG
Non-Hispanic White Male 2.0 (1.5, 2.6) 98.0 (97.4, 98.5) 0.0 (NA) 4.0 (3.0, 5.3) 96.0 (94.7, 97.0)
Female 1.7 (1.2, 2.3) 98.3 (97.7, 98.8) 0.1 (0.0, 0.7) 3.1 (2.3, 4.2) 96.8 (95.6, 97.6)
Non-Hispanic Black Male 0.5 (0.2, 1.3) 99.5 (98.7, 99.8) 0.0 (NA) 0.9 (0.4, 2.5) 99.1 (97.5, 99.6)
Female 0.3 (0.2, 0.7) 99.7 (99.3, 99.8) 0.0 (NA) 0.7 (0.3, 1.4) 99.3 (98.6, 99.7)
Mexican American Male 0.6 (0.3, 1.3) 99.4 (98.7, 99.7) 0.0 (NA) 1.3 (0.6, 2.5) 98.7 (97.5, 99.4)
Female 0.4 (0.3, 0.7) 99.6 (99.3, 99.7) 0.0 (NA) 0.9 (0.5, 1.4) 99.1 (98.6, 99.5)
rs689452 C G CC CG GG
Non-Hispanic White Male 87.9 (86.1, 89.4) 12.1 (10.6, 13.9) 76.9 (73.4, 80.0) 22.0 (18.8, 25.5) 1.2 (0.7, 2.0)
Female 88.3 (86.6, 89.8) 11.7 (10.2, 13.4) 78.2 (75.2, 80.9) 20.3 (17.8, 23.1) 1.5 (0.9, 2.6)
Non-Hispanic Black Male 85.1 (82.7, 87.3) 14.9 (12.7, 17.3) 72.0 (67.6, 75.9) 26.4 (22.5, 30.6) 1.7 (0.9, 3.2)
Female 87.2 (84.8, 89.3) 12.8 (10.7, 15.2) 76.1 (72.2, 79.6) 22.2 (19.1, 25.7) 1.7 (0.8, 3.6)
Mexican American Male 93.8 (91.2, 95.7) 6.2 (4.3, 8.8) 87.8 (82.6, 91.6) 12.1 (8.4, 17.3) 0.1 (0.0, 0.7)
Female 93.5 (91.7, 94.9) 6.5 (5.1, 8.3) 87.3 (83.8, 90.1) 12.4 (9.6, 15.9) 0.3 (0.1, 0.8)
rs689453 A G AA AG GG
Non-Hispanic White Male 8.7 (7.0, 10.8) 91.3 (89.2, 93.0) 0.8 (0.3, 1.8) 15.9 (12.9, 19.5) 83.3 (79.5, 86.5)
Female 7.0 (6.2, 8.0) 93.0 (92.0, 93.8) 0.3 (0.1, 0.7) 13.6 (11.8, 15.5) 86.2 (84.2, 87.9)
Non-Hispanic Black Male 4.5 (3.4, 5.9) 95.5 (94.1, 96.6) 0.2 (0.0, 1.0) 8.5 (6.2, 11.6) 91.3 (88.3, 93.6)
Female 5.6 (4.4, 7.0) 94.4 (93.0, 95.6) 0.5 (0.1, 1.4) 10.2 (7.8, 13.3) 89.3 (86.4, 91.6)
Mexican American Male 5.3 (3.6, 7.6) 94.7 (92.4, 96.4) 0.9 (0.3, 2.4) 8.7 (6.2, 12.1) 90.4 (86.5, 93.3)
Female 5.2 (3.9, 6.7) 94.8 (93.3, 96.1) 0.3 (0.1, 1.1) 9.8 (7.5, 12.7) 89.9 (87.0, 92.3)


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