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U.S. Genome Variation Estimates

NOS3 Allele and Genotype Frequencies

Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs1799983

Ex8-63G>T

Glu298Asp

TaqMan

rs2070744

IVS1-762T>C
-786T>C

TaqMan




Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1799983GTGGGTTT
Non-Hispanic White67.5 (65.6, 69.3)32.5 (30.7, 34.4)<0.00145.5 (42.4, 48.6)43.9 (40.8, 47.1)10.6 (9.2, 12.1)<0.0010.35
Non-Hispanic Black86.9 (85.3, 88.3)13.1 (11.7, 14.7)74.9 (71.8, 77.7)24.0 (21.2, 27.1)1.1 (0.7, 1.6)0.10
Mexican American80.4 (78.4, 82.3)19.6 (17.7, 21.6)65.0 (61.6, 68.2)30.8 (27.9, 33.9)4.2 (3.2, 5.4)0.11
Total*71.5 (70.3, 72.6)28.5 (27.4, 29.7)51.5 (49.4, 53.6)39.9 (37.6, 42.2)8.6 (7.7, 9.7)
rs2070744CTCCCTTT
Non-Hispanic White39.1 (37.1, 41.1)60.9 (58.9, 62.9)<0.00115.3 (13.5, 17.3)47.6 (45.3, 49.9)37.1 (34.5, 39.8)<0.0010.31
Non-Hispanic Black15.1 (13.8, 16.5)84.9 (83.5, 86.2)1.6 (1.2, 2.0)27.2 (24.6, 29.9)71.3 (68.5, 73.8)0.07
Mexican American25.1 (22.9, 27.5)74.9 (72.5, 77.1)7.3 (6.0, 8.8)35.7 (32.3, 39.2)57.0 (53.2, 60.8)0.01
Total*34.2 (32.2, 36.3)65.8 (63.7, 67.8)12.6 (11.1, 14.2)43.3 (40.8, 45.8)44.1 (41.1, 47.2)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1799983GTGGGTTT
12-1972.5 (68.4, 76.2)27.5 (23.8, 31.6)0.22252.9 (46.9, 58.8)39.2 (33.3, 45.4)7.9 (5.1, 12.2)0.249
20-3970.8 (68.8, 72.7)29.2 (27.3, 31.2)50.7 (47.6, 53.9)40.1 (36.5, 43.7)9.2 (7.4, 11.4)
40-5972.9 (70.8, 75.0)27.1 (25.0, 29.2)54.0 (50.4, 57.6)37.9 (33.5, 42.5)8.1 (6.0, 10.9)
>=6070.1 (68.8, 71.4)29.9 (28.6, 31.2)48.7 (46.1, 51.4)42.7 (39.2, 46.2)8.6 (7.1, 10.3)
Total71.5 (70.3, 72.6)28.5 (27.4, 29.7)51.5 (49.4, 53.6)39.9 (37.6, 42.2)8.6 (7.7, 9.7)
rs2070744CTCCCTTT
12-1930.8 (26.9, 35.0)69.2 (65.0, 73.1)0.18210.9 (7.8, 15.0)39.8 (35.6, 44.2)49.3 (43.9, 54.7)0.149
20-3934.7 (32.2, 37.2)65.3 (62.8, 67.8)12.8 (10.4, 15.6)43.7 (40.3, 47.2)43.5 (40.1, 46.9)
40-5934.2 (30.6, 38.1)65.8 (61.9, 69.4)12.2 (9.6, 15.4)44.1 (40.7, 47.5)43.7 (38.8, 48.8)
>=6035.7 (33.4, 38.0)64.3 (62.0, 66.6)13.8 (11.6, 16.3)43.7 (41.0, 46.5)42.4 (39.5, 45.5)
Total34.2 (32.2, 36.3)65.8 (63.7, 67.8)12.6 (11.1, 14.2)43.3 (40.8, 45.8)44.1 (41.1, 47.2)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1799983GTGGGTTT
Male71.5 (69.1, 73.8)28.5 (26.2, 30.9)0.97452.0 (48.2, 55.7)39.0 (35.3, 42.8)9.0 (7.1, 11.3)0.674
Female71.4 (69.6, 73.2)28.6 (26.8, 30.4)51.1 (48.5, 53.7)40.6 (38.3, 43.1)8.2 (6.7, 10.1)
Total71.5 (70.3, 72.6)28.5 (27.4, 29.7)51.5 (49.4, 53.6)39.9 (37.6, 42.2)8.6 (7.7, 9.7)
rs2070744CTCCCTTT
Male33.2 (30.2, 36.4)66.8 (63.6, 69.8)0.16411.7 (9.5, 14.4)43.0 (39.1, 46.9)45.3 (40.8, 49.9)0.375
Female35.1 (33.3, 37.0)64.9 (63.0, 66.7)13.4 (11.7, 15.2)43.6 (40.6, 46.6)43.1 (40.2, 46.0)
Total34.2 (32.2, 36.3)65.8 (63.7, 67.8)12.6 (11.1, 14.2)43.3 (40.8, 45.8)44.1 (41.1, 47.2)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs1799983GTGGGTTT
Non-Hispanic White12-1967.8 (62.7, 72.4)32.2 (27.6, 37.3)46.1 (38.5, 53.9)43.4 (35.3, 51.8)10.5 (6.8, 16.1)
20-3965.5 (62.6, 68.3)34.5 (31.7, 37.4)43.4 (39.4, 47.5)44.3 (40.0, 48.6)12.4 (9.6, 15.7)
40-5969.7 (67.3, 72.0)30.3 (28.0, 32.7)48.6 (44.0, 53.2)42.3 (36.9, 47.8)9.2 (7.1, 11.7)
>=6067.8 (65.9, 69.6)32.2 (30.4, 34.1)44.9 (41.6, 48.1)45.8 (41.9, 49.7)9.3 (7.6, 11.4)
Non-Hispanic Black12-1986.6 (84.5, 88.5)13.4 (11.5, 15.5)74.1 (70.0, 77.8)25.0 (21.3, 29.2)0.9 (0.4, 2.1)
20-3986.6 (84.1, 88.7)13.4 (11.3, 15.9)74.4 (69.8, 78.6)24.3 (20.2, 29.0)1.3 (0.6, 2.7)
40-5988.4 (85.7, 90.6)11.6 (9.4, 14.3)77.0 (71.6, 81.6)22.8 (18.1, 28.2)0.3 (0.0, 1.9)
>=6085.6 (83.2, 87.7)14.4 (12.3, 16.8)73.5 (69.1, 77.4)24.2 (19.6, 29.5)2.3 (0.9, 6.0)
Mexican American12-1980.1 (77.3, 82.6)19.9 (17.4, 22.7)65.4 (61.0, 69.6)29.4 (24.7, 34.6)5.2 (3.1, 8.8)
20-3981.1 (77.8, 84.1)18.9 (15.9, 22.2)65.7 (59.8, 71.0)30.9 (26.0, 36.3)3.4 (2.4, 5.0)
40-5980.7 (77.3, 83.7)19.3 (16.3, 22.7)65.8 (60.0, 71.1)29.9 (24.7, 35.8)4.3 (2.5, 7.3)
>=6075.9 (72.3, 79.2)24.1 (20.8, 27.7)57.8 (50.7, 64.6)36.3 (28.7, 44.6)5.9 (3.9, 8.9)
rs2070744CTCCCTTT
Non-Hispanic White12-1936.4 (32.0, 41.0)63.6 (59.0, 68.0)14.3 (10.3, 19.6)44.1 (39.4, 49.0)41.5 (36.1, 47.2)
20-3940.8 (37.9, 43.8)59.2 (56.2, 62.1)16.2 (13.0, 20.1)49.2 (45.5, 52.9)34.6 (31.2, 38.1)
40-5938.0 (33.7, 42.4)62.0 (57.6, 66.3)14.2 (11.1, 18.1)47.5 (43.9, 51.1)38.3 (32.8, 44.1)
>=6039.2 (36.6, 41.9)60.8 (58.1, 63.4)15.7 (12.9, 18.9)47.0 (44.0, 50.0)37.3 (34.3, 40.4)
Non-Hispanic Black12-1913.0 (10.8, 15.6)87.0 (84.4, 89.2)1.6 (0.8, 3.1)22.9 (19.2, 27.1)75.5 (71.0, 79.6)
20-3915.8 (14.1, 17.6)84.2 (82.4, 85.9)1.8 (1.0, 3.2)27.9 (24.7, 31.4)70.3 (66.9, 73.4)
40-5915.6 (12.6, 19.0)84.4 (81.0, 87.4)0.9 (0.3, 2.4)29.4 (24.4, 35.0)69.7 (63.6, 75.2)
>=6015.3 (12.1, 19.3)84.7 (80.7, 87.9)2.1 (1.2, 3.4)26.5 (20.5, 33.6)71.4 (64.2, 77.7)
Mexican American12-1927.5 (23.0, 32.5)72.5 (67.5, 77.0)8.9 (5.3, 14.6)37.3 (30.4, 44.7)53.8 (46.7, 60.8)
20-3924.3 (22.2, 26.4)75.7 (73.6, 77.8)6.6 (5.3, 8.3)35.2 (31.6, 39.0)58.1 (54.4, 61.7)
40-5923.6 (20.7, 26.7)76.4 (73.3, 79.3)5.8 (4.0, 8.3)35.6 (29.9, 41.6)58.7 (53.0, 64.1)
>=6028.6 (24.9, 32.7)71.4 (67.3, 75.1)11.1 (8.8, 13.9)35.1 (30.0, 40.6)53.8 (47.6, 59.9)

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By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs1799983GTGGGTTT
Non-Hispanic WhiteMale67.8 (64.2, 71.1)32.2 (28.9, 35.8)46.2 (41.1, 51.4)43.2 (38.3, 48.2)10.7 (8.0, 14.1)
Female67.2 (65.0, 69.3)32.8 (30.7, 35.0)44.9 (41.8, 48.0)44.7 (41.7, 47.7)10.5 (8.7, 12.5)
Non-Hispanic BlackMale86.8 (85.2, 88.3)13.2 (11.7, 14.8)74.8 (71.5, 77.8)24.2 (21.0, 27.6)1.1 (0.6, 2.0)
Female86.9 (84.5, 89.0)13.1 (11.0, 15.5)75.0 (70.6, 78.9)24.0 (20.3, 28.1)1.1 (0.6, 1.9)
Mexican AmericanMale79.6 (76.9, 82.1)20.4 (17.9, 23.1)64.5 (60.0, 68.7)30.3 (26.4, 34.4)5.2 (4.0, 6.9)
Female81.2 (79.1, 83.1)18.8 (16.9, 20.9)65.5 (62.0, 68.8)31.4 (28.5, 34.6)3.1 (2.2, 4.3)
rs2070744CTCCCTTT
Non-Hispanic WhiteMale37.8 (34.6, 41.1)62.2 (58.9, 65.4)14.0 (11.1, 17.5)47.5 (43.3, 51.7)38.5 (34.1, 43.0)
Female40.3 (38.3, 42.5)59.7 (57.5, 61.7)16.5 (14.4, 18.8)47.7 (44.6, 50.8)35.8 (32.9, 38.9)
Non-Hispanic BlackMale15.6 (13.8, 17.6)84.4 (82.4, 86.2)1.8 (1.2, 2.8)27.5 (24.3, 31.0)70.6 (67.0, 74.0)
Female14.8 (12.8, 17.0)85.2 (83.0, 87.2)1.3 (0.9, 2.0)26.9 (23.0, 31.1)71.8 (67.5, 75.7)
Mexican AmericanMale25.7 (23.2, 28.3)74.3 (71.7, 76.8)8.3 (6.9, 10.0)34.7 (30.8, 38.7)57.0 (52.6, 61.3)
Female24.6 (22.1, 27.2)75.4 (72.8, 77.9)6.2 (4.6, 8.2)36.8 (32.6, 41.2)57.0 (52.6, 61.4)


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