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U.S. Genome Variation Estimates

NOS3 Allele and Genotype Frequencies

 

Available polymorphism(s)

rs number

Common Designations

Nucleotide change                  Amino acid

Genotyping method

rs1799983

Ex8-63G>T

Glu298Asp

TaqMan

rs2070744

IVS1-762T>C
 -786T>C

 

TaqMan




Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity 

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1799983 G T   GG GT TT    
Non-Hispanic White 67.5 (65.6, 69.3) 32.5 (30.7, 34.4) <0.001 45.5 (42.4, 48.6) 43.9 (40.8, 47.1) 10.6 (9.2, 12.1) <0.001 0.35
Non-Hispanic Black 86.9 (85.3, 88.3) 13.1 (11.7, 14.7) 74.9 (71.8, 77.7) 24.0 (21.2, 27.1) 1.1 (0.7, 1.6) 0.10
Mexican American 80.4 (78.4, 82.3) 19.6 (17.7, 21.6) 65.0 (61.6, 68.2) 30.8 (27.9, 33.9) 4.2 (3.2, 5.4) 0.11
Total* 71.5 (70.3, 72.6) 28.5 (27.4, 29.7)   51.5 (49.4, 53.6) 39.9 (37.6, 42.2) 8.6 (7.7, 9.7)    
rs2070744 C T   CC CT TT    
Non-Hispanic White 39.1 (37.1, 41.1) 60.9 (58.9, 62.9) <0.001 15.3 (13.5, 17.3) 47.6 (45.3, 49.9) 37.1 (34.5, 39.8) <0.001 0.31
Non-Hispanic Black 15.1 (13.8, 16.5) 84.9 (83.5, 86.2) 1.6 (1.2, 2.0) 27.2 (24.6, 29.9) 71.3 (68.5, 73.8) 0.07
Mexican American 25.1 (22.9, 27.5) 74.9 (72.5, 77.1) 7.3 (6.0, 8.8) 35.7 (32.3, 39.2) 57.0 (53.2, 60.8) 0.01
Total* 34.2 (32.2, 36.3) 65.8 (63.7, 67.8)   12.6 (11.1, 14.2) 43.3 (40.8, 45.8) 44.1 (41.1, 47.2)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1799983 G T   GG GT TT  
12-19 72.5 (68.4, 76.2) 27.5 (23.8, 31.6) 0.222 52.9 (46.9, 58.8) 39.2 (33.3, 45.4) 7.9 (5.1, 12.2) 0.249
20-39 70.8 (68.8, 72.7) 29.2 (27.3, 31.2) 50.7 (47.6, 53.9) 40.1 (36.5, 43.7) 9.2 (7.4, 11.4)
40-59 72.9 (70.8, 75.0) 27.1 (25.0, 29.2) 54.0 (50.4, 57.6) 37.9 (33.5, 42.5) 8.1 (6.0, 10.9)
>=60 70.1 (68.8, 71.4) 29.9 (28.6, 31.2) 48.7 (46.1, 51.4) 42.7 (39.2, 46.2) 8.6 (7.1, 10.3)
Total 71.5 (70.3, 72.6) 28.5 (27.4, 29.7)   51.5 (49.4, 53.6) 39.9 (37.6, 42.2) 8.6 (7.7, 9.7)  
rs2070744 C T   CC CT TT  
12-19 30.8 (26.9, 35.0) 69.2 (65.0, 73.1) 0.182 10.9 (7.8, 15.0) 39.8 (35.6, 44.2) 49.3 (43.9, 54.7) 0.149
20-39 34.7 (32.2, 37.2) 65.3 (62.8, 67.8) 12.8 (10.4, 15.6) 43.7 (40.3, 47.2) 43.5 (40.1, 46.9)
40-59 34.2 (30.6, 38.1) 65.8 (61.9, 69.4) 12.2 (9.6, 15.4) 44.1 (40.7, 47.5) 43.7 (38.8, 48.8)
>=60 35.7 (33.4, 38.0) 64.3 (62.0, 66.6) 13.8 (11.6, 16.3) 43.7 (41.0, 46.5) 42.4 (39.5, 45.5)
Total 34.2 (32.2, 36.3) 65.8 (63.7, 67.8)   12.6 (11.1, 14.2) 43.3 (40.8, 45.8) 44.1 (41.1, 47.2)  

* Includes all participants, regardless of race/ethnicity.

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By Sex* 

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1799983 G T GG GT TT
Male 71.5 (69.1, 73.8) 28.5 (26.2, 30.9) 0.974 52.0 (48.2, 55.7) 39.0 (35.3, 42.8) 9.0 (7.1, 11.3) 0.674
Female 71.4 (69.6, 73.2) 28.6 (26.8, 30.4) 51.1 (48.5, 53.7) 40.6 (38.3, 43.1) 8.2 (6.7, 10.1)
Total 71.5 (70.3, 72.6) 28.5 (27.4, 29.7)   51.5 (49.4, 53.6) 39.9 (37.6, 42.2) 8.6 (7.7, 9.7)  
rs2070744 C T CC CT TT
Male 33.2 (30.2, 36.4) 66.8 (63.6, 69.8) 0.164 11.7 (9.5, 14.4) 43.0 (39.1, 46.9) 45.3 (40.8, 49.9) 0.375
Female 35.1 (33.3, 37.0) 64.9 (63.0, 66.7) 13.4 (11.7, 15.2) 43.6 (40.6, 46.6) 43.1 (40.2, 46.0)
Total 34.2 (32.2, 36.3) 65.8 (63.7, 67.8)   12.6 (11.1, 14.2) 43.3 (40.8, 45.8) 44.1 (41.1, 47.2)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs1799983 G T GG GT TT
Non-Hispanic White 12-19 67.8 (62.7, 72.4) 32.2 (27.6, 37.3) 46.1 (38.5, 53.9) 43.4 (35.3, 51.8) 10.5 (6.8, 16.1)
20-39 65.5 (62.6, 68.3) 34.5 (31.7, 37.4) 43.4 (39.4, 47.5) 44.3 (40.0, 48.6) 12.4 (9.6, 15.7)
40-59 69.7 (67.3, 72.0) 30.3 (28.0, 32.7) 48.6 (44.0, 53.2) 42.3 (36.9, 47.8) 9.2 (7.1, 11.7)
>=60 67.8 (65.9, 69.6) 32.2 (30.4, 34.1) 44.9 (41.6, 48.1) 45.8 (41.9, 49.7) 9.3 (7.6, 11.4)
Non-Hispanic Black 12-19 86.6 (84.5, 88.5) 13.4 (11.5, 15.5) 74.1 (70.0, 77.8) 25.0 (21.3, 29.2) 0.9 (0.4, 2.1)
20-39 86.6 (84.1, 88.7) 13.4 (11.3, 15.9) 74.4 (69.8, 78.6) 24.3 (20.2, 29.0) 1.3 (0.6, 2.7)
40-59 88.4 (85.7, 90.6) 11.6 (9.4, 14.3) 77.0 (71.6, 81.6) 22.8 (18.1, 28.2) 0.3 (0.0, 1.9)
>=60 85.6 (83.2, 87.7) 14.4 (12.3, 16.8) 73.5 (69.1, 77.4) 24.2 (19.6, 29.5) 2.3 (0.9, 6.0)
Mexican American 12-19 80.1 (77.3, 82.6) 19.9 (17.4, 22.7) 65.4 (61.0, 69.6) 29.4 (24.7, 34.6) 5.2 (3.1, 8.8)
20-39 81.1 (77.8, 84.1) 18.9 (15.9, 22.2) 65.7 (59.8, 71.0) 30.9 (26.0, 36.3) 3.4 (2.4, 5.0)
40-59 80.7 (77.3, 83.7) 19.3 (16.3, 22.7) 65.8 (60.0, 71.1) 29.9 (24.7, 35.8) 4.3 (2.5, 7.3)
>=60 75.9 (72.3, 79.2) 24.1 (20.8, 27.7) 57.8 (50.7, 64.6) 36.3 (28.7, 44.6) 5.9 (3.9, 8.9)
rs2070744 C T CC CT TT
Non-Hispanic White 12-19 36.4 (32.0, 41.0) 63.6 (59.0, 68.0) 14.3 (10.3, 19.6) 44.1 (39.4, 49.0) 41.5 (36.1, 47.2)
20-39 40.8 (37.9, 43.8) 59.2 (56.2, 62.1) 16.2 (13.0, 20.1) 49.2 (45.5, 52.9) 34.6 (31.2, 38.1)
40-59 38.0 (33.7, 42.4) 62.0 (57.6, 66.3) 14.2 (11.1, 18.1) 47.5 (43.9, 51.1) 38.3 (32.8, 44.1)
>=60 39.2 (36.6, 41.9) 60.8 (58.1, 63.4) 15.7 (12.9, 18.9) 47.0 (44.0, 50.0) 37.3 (34.3, 40.4)
Non-Hispanic Black 12-19 13.0 (10.8, 15.6) 87.0 (84.4, 89.2) 1.6 (0.8, 3.1) 22.9 (19.2, 27.1) 75.5 (71.0, 79.6)
20-39 15.8 (14.1, 17.6) 84.2 (82.4, 85.9) 1.8 (1.0, 3.2) 27.9 (24.7, 31.4) 70.3 (66.9, 73.4)
40-59 15.6 (12.6, 19.0) 84.4 (81.0, 87.4) 0.9 (0.3, 2.4) 29.4 (24.4, 35.0) 69.7 (63.6, 75.2)
>=60 15.3 (12.1, 19.3) 84.7 (80.7, 87.9) 2.1 (1.2, 3.4) 26.5 (20.5, 33.6) 71.4 (64.2, 77.7)
Mexican American 12-19 27.5 (23.0, 32.5) 72.5 (67.5, 77.0) 8.9 (5.3, 14.6) 37.3 (30.4, 44.7) 53.8 (46.7, 60.8)
20-39 24.3 (22.2, 26.4) 75.7 (73.6, 77.8) 6.6 (5.3, 8.3) 35.2 (31.6, 39.0) 58.1 (54.4, 61.7)
40-59 23.6 (20.7, 26.7) 76.4 (73.3, 79.3) 5.8 (4.0, 8.3) 35.6 (29.9, 41.6) 58.7 (53.0, 64.1)
>=60 28.6 (24.9, 32.7) 71.4 (67.3, 75.1) 11.1 (8.8, 13.9) 35.1 (30.0, 40.6) 53.8 (47.6, 59.9)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs1799983 G T GG GT TT
Non-Hispanic White Male 67.8 (64.2, 71.1) 32.2 (28.9, 35.8) 46.2 (41.1, 51.4) 43.2 (38.3, 48.2) 10.7 (8.0, 14.1)
Female 67.2 (65.0, 69.3) 32.8 (30.7, 35.0) 44.9 (41.8, 48.0) 44.7 (41.7, 47.7) 10.5 (8.7, 12.5)
Non-Hispanic Black Male 86.8 (85.2, 88.3) 13.2 (11.7, 14.8) 74.8 (71.5, 77.8) 24.2 (21.0, 27.6) 1.1 (0.6, 2.0)
Female 86.9 (84.5, 89.0) 13.1 (11.0, 15.5) 75.0 (70.6, 78.9) 24.0 (20.3, 28.1) 1.1 (0.6, 1.9)
Mexican American Male 79.6 (76.9, 82.1) 20.4 (17.9, 23.1) 64.5 (60.0, 68.7) 30.3 (26.4, 34.4) 5.2 (4.0, 6.9)
Female 81.2 (79.1, 83.1) 18.8 (16.9, 20.9) 65.5 (62.0, 68.8) 31.4 (28.5, 34.6) 3.1 (2.2, 4.3)
rs2070744 C T CC CT TT
Non-Hispanic White Male 37.8 (34.6, 41.1) 62.2 (58.9, 65.4) 14.0 (11.1, 17.5) 47.5 (43.3, 51.7) 38.5 (34.1, 43.0)
Female 40.3 (38.3, 42.5) 59.7 (57.5, 61.7) 16.5 (14.4, 18.8) 47.7 (44.6, 50.8) 35.8 (32.9, 38.9)
Non-Hispanic Black Male 15.6 (13.8, 17.6) 84.4 (82.4, 86.2) 1.8 (1.2, 2.8) 27.5 (24.3, 31.0) 70.6 (67.0, 74.0)
Female 14.8 (12.8, 17.0) 85.2 (83.0, 87.2) 1.3 (0.9, 2.0) 26.9 (23.0, 31.1) 71.8 (67.5, 75.7)
Mexican American Male 25.7 (23.2, 28.3) 74.3 (71.7, 76.8) 8.3 (6.9, 10.0) 34.7 (30.8, 38.7) 57.0 (52.6, 61.3)
Female 24.6 (22.1, 27.2) 75.4 (72.8, 77.9) 6.2 (4.6, 8.2) 36.8 (32.6, 41.2) 57.0 (52.6, 61.4)


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