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U.S. Genome Variation Estimates

NOS2A Allele and Genotype Frequencies

Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs1800482

G>C in promoter

MGB Eclipse

rs9282799

-2892C>T
-1173C>T

MGB Eclipse




Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1800482CGCCCGGG
Non-Hispanic White0.1 (0.0, 0.1)99.9 (99.9, 100.0)<0.0010.0 (NA)0.1 (0.0, 0.3)99.9 (99.7, 100.0)<0.0010.96
Non-Hispanic Black6.3 (5.0, 7.8)93.7 (92.2, 95.0)0.5 (0.3, 1.0)11.5 (9.2, 14.2)88.0 (85.1, 90.4)0.81
Mexican American0.3 (0.1, 0.7)99.7 (99.3, 99.9)0.1 (0.0, 0.7)0.4 (0.2, 0.9)99.5 (98.9, 99.8)<0.01
Total*1.0 (0.7, 1.3)99.0 (98.7, 99.3)0.1 (0.0, 0.1)1.8 (1.3, 2.5)98.2 (97.5, 98.7)
rs9282799CTCCCTTT
Non-Hispanic White100.0 (99.9, 100.0)0.0 (0.0, 0.1)<0.00199.9 (99.7, 100.0)0.1 (0.0, 0.3)0.0 (NA)<0.0010.96
Non-Hispanic Black95.5 (94.9, 96.1)4.5 (3.9, 5.1)91.2 (90.1, 92.3)8.5 (7.5, 9.6)0.2 (0.1, 0.6)0.65
Mexican American99.6 (99.3, 99.8)0.4 (0.2, 0.7)99.2 (98.5, 99.6)0.8 (0.4, 1.5)0.0 (NA)0.89
Total*99.3 (99.1, 99.5)0.7 (0.5, 0.9)98.7 (98.2, 99.1)1.3 (0.9, 1.8)0.0 (0.0, 0.1)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800482CGCCCGGG
12-190.9 (0.5, 1.5)99.1 (98.5, 99.5)0.5000.0 (NA)1.8 (1.1, 2.9)98.2 (97.1, 98.9)0.020
20-391.1 (0.7, 1.7)98.9 (98.3, 99.3)0.1 (0.0, 0.2)2.1 (1.4, 3.2)97.9 (96.7, 98.6)
40-590.9 (0.6, 1.5)99.1 (98.5, 99.4)0.1 (0.0, 0.3)1.7 (1.0, 2.8)98.2 (97.1, 98.9)
>=600.8 (0.5, 1.2)99.2 (98.8, 99.5)0.1 (0.0, 0.3)1.4 (0.9, 2.1)98.6 (97.7, 99.1)
Total1.0 (0.7, 1.3)99.0 (98.7, 99.3)0.1 (0.0, 0.1)1.8 (1.3, 2.5)98.2 (97.5, 98.7)
rs9282799CTCCCTTT
12-1999.2 (98.7, 99.5)0.8 (0.5, 1.3)0.02198.6 (97.6, 99.1)1.3 (0.8, 2.1)0.1 (0.0, 0.4)0.230
20-3999.1 (98.6, 99.5)0.9 (0.5, 1.4)98.3 (97.3, 99.0)1.7 (1.0, 2.7)0.0 (0.0, 0.1)
40-5999.4 (99.2, 99.6)0.6 (0.4, 0.8)98.9 (98.4, 99.2)1.1 (0.8, 1.6)0.0 (NA)
>=6099.7 (99.4, 99.8)0.3 (0.2, 0.6)99.4 (98.9, 99.6)0.6 (0.4, 1.1)0.0 (NA)
Total99.3 (99.1, 99.5)0.7 (0.5, 0.9)98.7 (98.2, 99.1)1.3 (0.9, 1.8)0.0 (0.0, 0.1)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800482CGCCCGGG
Male1.2 (0.8, 1.6)98.8 (98.4, 99.2)0.0010.1 (0.0, 0.2)2.2 (1.6, 3.1)97.7 (96.8, 98.4)0.008
Female0.8 (0.5, 1.1)99.2 (98.9, 99.5)0.1 (0.0, 0.1)1.4 (1.0, 2.0)98.5 (97.9, 99.0)
Total1.0 (0.7, 1.3)99.0 (98.7, 99.3)0.1 (0.0, 0.1)1.8 (1.3, 2.5)98.2 (97.5, 98.7)
rs9282799CTCCCTTT
Male99.4 (99.1, 99.5)0.6 (0.5, 0.9)0.84698.7 (98.3, 99.1)1.2 (0.9, 1.7)0.0 (0.0, 0.1)0.945
Female99.3 (98.8, 99.6)0.7 (0.4, 1.2)98.7 (97.7, 99.2)1.3 (0.7, 2.2)0.0 (0.0, 0.1)
Total99.3 (99.1, 99.5)0.7 (0.5, 0.9)98.7 (98.2, 99.1)1.3 (0.9, 1.8)0.0 (0.0, 0.1)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs1800482CGCCCGGG
Non-Hispanic White12-190.1 (0.0, 0.9)99.9 (99.1, 100.0)0.0 (NA)0.2 (0.0, 1.8)99.8 (98.2, 100.0)
20-390.0 (NA)100.0 (NA)0.0 (NA)0.0 (NA)100.0 (NA)
40-590.0 (NA)100.0 (NA)0.0 (NA)0.0 (NA)100.0 (NA)
>=600.2 (0.0, 0.6)99.8 (99.4, 100.0)0.0 (NA)0.3 (0.1, 1.1)99.7 (98.9, 99.9)
Non-Hispanic Black12-194.9 (3.2, 7.3)95.1 (92.7, 96.8)0.0 (NA)9.7 (6.4, 14.5)90.3 (85.5, 93.6)
20-396.0 (4.5, 7.9)94.0 (92.1, 95.5)0.5 (0.1, 1.5)11.0 (8.5, 14.1)88.6 (85.1, 91.3)
40-597.5 (5.6, 10.1)92.5 (89.9, 94.4)0.7 (0.2, 3.0)13.6 (10.1, 18.2)85.6 (81.0, 89.3)
>=606.7 (5.1, 8.7)93.3 (91.3, 94.9)0.9 (0.2, 3.4)11.6 (8.9, 14.9)87.5 (84.1, 90.3)
Mexican American12-190.1 (0.0, 0.9)99.9 (99.1, 100.0)0.0 (NA)0.2 (0.0, 1.7)99.8 (98.3, 100.0)
20-390.3 (0.1, 0.8)99.7 (99.2, 99.9)0.0 (NA)0.7 (0.3, 1.5)99.3 (98.5, 99.7)
40-590.4 (0.1, 3.2)99.6 (96.8, 99.9)0.4 (0.1, 3.2)0.0 (NA)99.6 (96.8, 99.9)
>=600.0 (0.0, 0.3)100.0 (99.7, 100.0)0.0 (NA)0.1 (0.0, 0.5)99.9 (99.5, 100.0)
rs9282799CTCCCTTT
Non-Hispanic White12-19100.0 (NA)0.0 (NA)100.0 (NA)0.0 (NA)0.0 (NA)
20-39100.0 (NA)0.0 (NA)100.0 (NA)0.0 (NA)0.0 (NA)
40-59100.0 (99.7, 100.0)0.0 (0.0, 0.3)99.9 (99.4, 100.0)0.1 (0.0, 0.6)0.0 (NA)
>=6099.9 (99.5, 100.0)0.1 (0.0, 0.5)99.8 (99.0, 99.9)0.2 (0.1, 1.0)0.0 (NA)
Non-Hispanic Black12-1995.5 (93.1, 97.0)4.5 (3.0, 6.9)91.7 (87.6, 94.5)7.5 (5.0, 11.3)0.8 (0.2, 2.5)
20-3994.9 (93.9, 95.8)5.1 (4.2, 6.1)90.1 (88.1, 91.8)9.7 (8.0, 11.7)0.2 (0.1, 0.9)
40-5995.1 (94.0, 96.0)4.9 (4.0, 6.0)90.2 (88.1, 92.0)9.8 (8.0, 11.9)0.0 (NA)
>=6097.9 (96.7, 98.7)2.1 (1.3, 3.3)95.8 (93.3, 97.4)4.2 (2.6, 6.7)0.0 (NA)
Mexican American12-1999.2 (98.0, 99.7)0.8 (0.3, 2.0)98.4 (96.0, 99.4)1.6 (0.6, 4.0)0.0 (NA)
20-3999.6 (99.0, 99.9)0.4 (0.1, 1.0)99.2 (98.0, 99.7)0.8 (0.3, 2.0)0.0 (NA)
40-59100.0 (NA)0.0 (NA)100.0 (NA)0.0 (NA)0.0 (NA)
>=6099.5 (96.5, 99.9)0.5 (0.1, 3.5)99.0 (93.2, 99.9)1.0 (0.1, 6.8)0.0 (NA)

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By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs1800482CGCCCGGG
Non-Hispanic WhiteMale0.1 (0.0, 0.3)99.9 (99.7, 100.0)0.0 (NA)0.2 (0.1, 0.6)99.8 (99.4, 99.9)
Female0.0 (0.0, 0.1)100.0 (99.9, 100.0)0.0 (NA)0.0 (0.0, 0.2)100.0 (99.8, 100.0)
Non-Hispanic BlackMale7.0 (5.3, 9.2)93.0 (90.8, 94.7)0.6 (0.2, 1.9)12.7 (9.9, 16.3)86.6 (82.8, 89.7)
Female5.6 (4.4, 7.1)94.4 (92.9, 95.6)0.4 (0.2, 0.9)10.5 (8.1, 13.5)89.1 (86.2, 91.5)
Mexican AmericanMale0.2 (0.1, 0.6)99.8 (99.4, 99.9)0.0 (NA)0.4 (0.2, 1.1)99.6 (98.9, 99.8)
Female0.3 (0.1, 1.3)99.7 (98.7, 99.9)0.2 (0.0, 1.4)0.3 (0.1, 1.5)99.5 (98.3, 99.9)
rs9282799CTCCCTTT
Non-Hispanic WhiteMale100.0 (99.9, 100.0)0.0 (0.0, 0.1)99.9 (99.8, 100.0)0.1 (0.0, 0.2)0.0 (NA)
Female100.0 (99.8, 100.0)0.0 (0.0, 0.2)99.9 (99.6, 100.0)0.1 (0.0, 0.4)0.0 (NA)
Non-Hispanic BlackMale94.6 (93.4, 95.7)5.4 (4.3, 6.6)89.5 (87.0, 91.6)10.3 (8.2, 12.9)0.2 (0.1, 0.9)
Female96.2 (95.3, 97.0)3.8 (3.0, 4.7)92.7 (90.7, 94.2)7.1 (5.4, 9.2)0.3 (0.1, 0.9)
Mexican AmericanMale99.7 (99.0, 99.9)0.3 (0.1, 1.0)99.4 (98.0, 99.8)0.6 (0.2, 2.0)0.0 (NA)
Female99.5 (99.1, 99.7)0.5 (0.3, 0.9)99.0 (98.2, 99.5)1.0 (0.5, 1.8)0.0 (NA)


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