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U.S. Genome Variation Estimates

NOS2A Allele and Genotype Frequencies

 

Available polymorphism(s)

rs number

Common Designations

Nucleotide change                  Amino acid

Genotyping method

rs1800482

G>C in promoter

 

MGB Eclipse

rs9282799

-2892C>T
-1173C>T

 

MGB Eclipse




Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity 

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1800482 C G   CC CG GG    
Non-Hispanic White 0.1 (0.0, 0.1) 99.9 (99.9, 100.0) <0.001 0.0 (NA) 0.1 (0.0, 0.3) 99.9 (99.7, 100.0) <0.001 0.96
Non-Hispanic Black 6.3 (5.0, 7.8) 93.7 (92.2, 95.0) 0.5 (0.3, 1.0) 11.5 (9.2, 14.2) 88.0 (85.1, 90.4) 0.81
Mexican American 0.3 (0.1, 0.7) 99.7 (99.3, 99.9) 0.1 (0.0, 0.7) 0.4 (0.2, 0.9) 99.5 (98.9, 99.8) <0.01
Total* 1.0 (0.7, 1.3) 99.0 (98.7, 99.3)   0.1 (0.0, 0.1) 1.8 (1.3, 2.5) 98.2 (97.5, 98.7)    
rs9282799 C T   CC CT TT    
Non-Hispanic White 100.0 (99.9, 100.0) 0.0 (0.0, 0.1) <0.001 99.9 (99.7, 100.0) 0.1 (0.0, 0.3) 0.0 (NA) <0.001 0.96
Non-Hispanic Black 95.5 (94.9, 96.1) 4.5 (3.9, 5.1) 91.2 (90.1, 92.3) 8.5 (7.5, 9.6) 0.2 (0.1, 0.6) 0.65
Mexican American 99.6 (99.3, 99.8) 0.4 (0.2, 0.7) 99.2 (98.5, 99.6) 0.8 (0.4, 1.5) 0.0 (NA) 0.89
Total* 99.3 (99.1, 99.5) 0.7 (0.5, 0.9)   98.7 (98.2, 99.1) 1.3 (0.9, 1.8) 0.0 (0.0, 0.1)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800482 C G   CC CG GG  
12-19 0.9 (0.5, 1.5) 99.1 (98.5, 99.5) 0.500 0.0 (NA) 1.8 (1.1, 2.9) 98.2 (97.1, 98.9) 0.020
20-39 1.1 (0.7, 1.7) 98.9 (98.3, 99.3) 0.1 (0.0, 0.2) 2.1 (1.4, 3.2) 97.9 (96.7, 98.6)
40-59 0.9 (0.6, 1.5) 99.1 (98.5, 99.4) 0.1 (0.0, 0.3) 1.7 (1.0, 2.8) 98.2 (97.1, 98.9)
>=60 0.8 (0.5, 1.2) 99.2 (98.8, 99.5) 0.1 (0.0, 0.3) 1.4 (0.9, 2.1) 98.6 (97.7, 99.1)
Total 1.0 (0.7, 1.3) 99.0 (98.7, 99.3)   0.1 (0.0, 0.1) 1.8 (1.3, 2.5) 98.2 (97.5, 98.7)  
rs9282799 C T   CC CT TT  
12-19 99.2 (98.7, 99.5) 0.8 (0.5, 1.3) 0.021 98.6 (97.6, 99.1) 1.3 (0.8, 2.1) 0.1 (0.0, 0.4) 0.230
20-39 99.1 (98.6, 99.5) 0.9 (0.5, 1.4) 98.3 (97.3, 99.0) 1.7 (1.0, 2.7) 0.0 (0.0, 0.1)
40-59 99.4 (99.2, 99.6) 0.6 (0.4, 0.8) 98.9 (98.4, 99.2) 1.1 (0.8, 1.6) 0.0 (NA)
>=60 99.7 (99.4, 99.8) 0.3 (0.2, 0.6) 99.4 (98.9, 99.6) 0.6 (0.4, 1.1) 0.0 (NA)
Total 99.3 (99.1, 99.5) 0.7 (0.5, 0.9)   98.7 (98.2, 99.1) 1.3 (0.9, 1.8) 0.0 (0.0, 0.1)  

* Includes all participants, regardless of race/ethnicity.

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By Sex* 

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800482 C G CC CG GG
Male 1.2 (0.8, 1.6) 98.8 (98.4, 99.2) 0.001 0.1 (0.0, 0.2) 2.2 (1.6, 3.1) 97.7 (96.8, 98.4) 0.008
Female 0.8 (0.5, 1.1) 99.2 (98.9, 99.5) 0.1 (0.0, 0.1) 1.4 (1.0, 2.0) 98.5 (97.9, 99.0)
Total 1.0 (0.7, 1.3) 99.0 (98.7, 99.3)   0.1 (0.0, 0.1) 1.8 (1.3, 2.5) 98.2 (97.5, 98.7)  
rs9282799 C T CC CT TT
Male 99.4 (99.1, 99.5) 0.6 (0.5, 0.9) 0.846 98.7 (98.3, 99.1) 1.2 (0.9, 1.7) 0.0 (0.0, 0.1) 0.945
Female 99.3 (98.8, 99.6) 0.7 (0.4, 1.2) 98.7 (97.7, 99.2) 1.3 (0.7, 2.2) 0.0 (0.0, 0.1)
Total 99.3 (99.1, 99.5) 0.7 (0.5, 0.9)   98.7 (98.2, 99.1) 1.3 (0.9, 1.8) 0.0 (0.0, 0.1)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs1800482 C G CC CG GG
Non-Hispanic White 12-19 0.1 (0.0, 0.9) 99.9 (99.1, 100.0) 0.0 (NA) 0.2 (0.0, 1.8) 99.8 (98.2, 100.0)
20-39 0.0 (NA) 100.0 (NA) 0.0 (NA) 0.0 (NA) 100.0 (NA)
40-59 0.0 (NA) 100.0 (NA) 0.0 (NA) 0.0 (NA) 100.0 (NA)
>=60 0.2 (0.0, 0.6) 99.8 (99.4, 100.0) 0.0 (NA) 0.3 (0.1, 1.1) 99.7 (98.9, 99.9)
Non-Hispanic Black 12-19 4.9 (3.2, 7.3) 95.1 (92.7, 96.8) 0.0 (NA) 9.7 (6.4, 14.5) 90.3 (85.5, 93.6)
20-39 6.0 (4.5, 7.9) 94.0 (92.1, 95.5) 0.5 (0.1, 1.5) 11.0 (8.5, 14.1) 88.6 (85.1, 91.3)
40-59 7.5 (5.6, 10.1) 92.5 (89.9, 94.4) 0.7 (0.2, 3.0) 13.6 (10.1, 18.2) 85.6 (81.0, 89.3)
>=60 6.7 (5.1, 8.7) 93.3 (91.3, 94.9) 0.9 (0.2, 3.4) 11.6 (8.9, 14.9) 87.5 (84.1, 90.3)
Mexican American 12-19 0.1 (0.0, 0.9) 99.9 (99.1, 100.0) 0.0 (NA) 0.2 (0.0, 1.7) 99.8 (98.3, 100.0)
20-39 0.3 (0.1, 0.8) 99.7 (99.2, 99.9) 0.0 (NA) 0.7 (0.3, 1.5) 99.3 (98.5, 99.7)
40-59 0.4 (0.1, 3.2) 99.6 (96.8, 99.9) 0.4 (0.1, 3.2) 0.0 (NA) 99.6 (96.8, 99.9)
>=60 0.0 (0.0, 0.3) 100.0 (99.7, 100.0) 0.0 (NA) 0.1 (0.0, 0.5) 99.9 (99.5, 100.0)
rs9282799 C T CC CT TT
Non-Hispanic White 12-19 100.0 (NA) 0.0 (NA) 100.0 (NA) 0.0 (NA) 0.0 (NA)
20-39 100.0 (NA) 0.0 (NA) 100.0 (NA) 0.0 (NA) 0.0 (NA)
40-59 100.0 (99.7, 100.0) 0.0 (0.0, 0.3) 99.9 (99.4, 100.0) 0.1 (0.0, 0.6) 0.0 (NA)
>=60 99.9 (99.5, 100.0) 0.1 (0.0, 0.5) 99.8 (99.0, 99.9) 0.2 (0.1, 1.0) 0.0 (NA)
Non-Hispanic Black 12-19 95.5 (93.1, 97.0) 4.5 (3.0, 6.9) 91.7 (87.6, 94.5) 7.5 (5.0, 11.3) 0.8 (0.2, 2.5)
20-39 94.9 (93.9, 95.8) 5.1 (4.2, 6.1) 90.1 (88.1, 91.8) 9.7 (8.0, 11.7) 0.2 (0.1, 0.9)
40-59 95.1 (94.0, 96.0) 4.9 (4.0, 6.0) 90.2 (88.1, 92.0) 9.8 (8.0, 11.9) 0.0 (NA)
>=60 97.9 (96.7, 98.7) 2.1 (1.3, 3.3) 95.8 (93.3, 97.4) 4.2 (2.6, 6.7) 0.0 (NA)
Mexican American 12-19 99.2 (98.0, 99.7) 0.8 (0.3, 2.0) 98.4 (96.0, 99.4) 1.6 (0.6, 4.0) 0.0 (NA)
20-39 99.6 (99.0, 99.9) 0.4 (0.1, 1.0) 99.2 (98.0, 99.7) 0.8 (0.3, 2.0) 0.0 (NA)
40-59 100.0 (NA) 0.0 (NA) 100.0 (NA) 0.0 (NA) 0.0 (NA)
>=60 99.5 (96.5, 99.9) 0.5 (0.1, 3.5) 99.0 (93.2, 99.9) 1.0 (0.1, 6.8) 0.0 (NA)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs1800482 C G CC CG GG
Non-Hispanic White Male 0.1 (0.0, 0.3) 99.9 (99.7, 100.0) 0.0 (NA) 0.2 (0.1, 0.6) 99.8 (99.4, 99.9)
Female 0.0 (0.0, 0.1) 100.0 (99.9, 100.0) 0.0 (NA) 0.0 (0.0, 0.2) 100.0 (99.8, 100.0)
Non-Hispanic Black Male 7.0 (5.3, 9.2) 93.0 (90.8, 94.7) 0.6 (0.2, 1.9) 12.7 (9.9, 16.3) 86.6 (82.8, 89.7)
Female 5.6 (4.4, 7.1) 94.4 (92.9, 95.6) 0.4 (0.2, 0.9) 10.5 (8.1, 13.5) 89.1 (86.2, 91.5)
Mexican American Male 0.2 (0.1, 0.6) 99.8 (99.4, 99.9) 0.0 (NA) 0.4 (0.2, 1.1) 99.6 (98.9, 99.8)
Female 0.3 (0.1, 1.3) 99.7 (98.7, 99.9) 0.2 (0.0, 1.4) 0.3 (0.1, 1.5) 99.5 (98.3, 99.9)
rs9282799 C T CC CT TT
Non-Hispanic White Male 100.0 (99.9, 100.0) 0.0 (0.0, 0.1) 99.9 (99.8, 100.0) 0.1 (0.0, 0.2) 0.0 (NA)
Female 100.0 (99.8, 100.0) 0.0 (0.0, 0.2) 99.9 (99.6, 100.0) 0.1 (0.0, 0.4) 0.0 (NA)
Non-Hispanic Black Male 94.6 (93.4, 95.7) 5.4 (4.3, 6.6) 89.5 (87.0, 91.6) 10.3 (8.2, 12.9) 0.2 (0.1, 0.9)
Female 96.2 (95.3, 97.0) 3.8 (3.0, 4.7) 92.7 (90.7, 94.2) 7.1 (5.4, 9.2) 0.3 (0.1, 0.9)
Mexican American Male 99.7 (99.0, 99.9) 0.3 (0.1, 1.0) 99.4 (98.0, 99.8) 0.6 (0.2, 2.0) 0.0 (NA)
Female 99.5 (99.1, 99.7) 0.5 (0.3, 0.9) 99.0 (98.2, 99.5) 1.0 (0.5, 1.8) 0.0 (NA)


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