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U.S. Genome Variation Estimates

NAT2 Allele and Genotype Frequencies

 

Available polymorphism(s)

rs number

Common Designations

Nucleotide change                  Amino acid

Genotyping method

rs1041983

Ex2+288C>T

Tyr94Tyr

TaqMan

rs1208

Ex2-367A>G

Lys268Arg

TaqMan

rs1799930

Ex2-580G>A

Arg197Gln

TaqMan

rs1801279

Ex2+197G>A

Arg64Gln

TaqMan

rs1801280

Ex2+347T>C

Ile114Thr

TaqMan




Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity 

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1041983 C T   CC CT TT    
Non-Hispanic White 64.6 (62.9, 66.2) 35.4 (33.8, 37.1) <0.001 41.4 (38.9, 43.9) 46.3 (43.8, 48.9) 12.3 (10.8, 13.8) <0.001 0.77
Non-Hispanic Black 53.9 (52.4, 55.4) 46.1 (44.6, 47.6) 30.8 (28.9, 32.8) 46.2 (43.8, 48.5) 23.0 (21.2, 24.9) 0.03
Mexican American 68.1 (65.6, 70.6) 31.9 (29.4, 34.4) 46.7 (43.4, 50.1) 42.8 (40.1, 45.6) 10.5 (8.4, 12.9) 0.66
Total* 63.6 (62.1, 65.0) 36.4 (35.0, 37.9)   40.4 (38.4, 42.4) 46.3 (44.6, 48.1) 13.3 (12.0, 14.7)    
rs1208 A G   AA AG GG    
Non-Hispanic White 59.0 (57.7, 60.1) 41.0 (39.9, 42.3) <0.001 34.5 (33.1, 36.0) 48.9 (47.3, 50.4) 16.6 (15.2, 18.1) <0.001 0.67
Non-Hispanic Black 61.7 (60.3, 63.1) 38.3 (36.9, 39.7) 39.3 (37.3, 41.2) 44.9 (42.7, 47.2) 15.8 (14.2, 17.5) 0.06
Mexican American 64.3 (62.1, 66.5) 35.7 (33.5, 37.9) 41.2 (38.2, 44.4) 46.2 (43.5, 48.9) 12.6 (10.8, 14.6) 0.68
Total* 60.6 (59.8, 61.5) 39.4 (38.5, 40.2)   37.2 (35.9, 38.5) 46.8 (45.4, 48.2) 15.9 (15.1, 16.8)    
rs1799930 A G   AA AG GG    
Non-Hispanic White 32.3 (30.5, 34.1) 67.7 (65.9, 69.5) <0.001 10.1 (8.7, 11.7) 44.4 (42.0, 46.7) 45.5 (42.8, 48.2) <0.001 0.83
Non-Hispanic Black 28.0 (25.8, 30.3) 72.0 (69.7, 74.2) 8.7 (7.1, 10.5) 38.6 (35.6, 41.8) 52.7 (49.2, 56.2) 0.04
Mexican American 18.0 (16.0, 20.1) 82.0 (79.9, 84.0) 3.2 (2.2, 4.7) 29.5 (26.0, 33.2) 67.3 (63.5, 70.9) 0.70
Total* 30.2 (28.9, 31.5) 69.8 (68.5, 71.1)   8.9 (7.9, 10.1) 42.6 (40.8, 44.5) 48.5 (46.5, 50.5)    
rs1801279 A G   AA AG GG    
Non-Hispanic White 0.0 (0.0, 0.1) 100.0 (99.9, 100.0) <0.001 0.0 (NA) 0.1 (0.0, 0.3) 99.9 (99.7, 100.0) <0.001 0.97
Non-Hispanic Black 7.8 (6.9, 8.8) 92.2 (91.2, 93.1) 0.4 (0.2, 0.9) 14.9 (13.1, 16.8) 84.7 (82.8, 86.5) 0.05
Mexican American 0.5 (0.3, 0.9) 99.5 (99.1, 99.7) 0.0 (0.0, 0.1) 1.0 (0.6, 1.8) 99.0 (98.2, 99.4) <0.01
Total* 1.0 (0.8, 1.3) 99.0 (98.7, 99.2)   0.0 (0.0, 0.1) 2.0 (1.5, 2.6) 98.0 (97.4, 98.4)    
rs1801280 C T   CC CT TT    
Non-Hispanic White 42.1 (40.9, 43.3) 57.9 (56.7, 59.1) <0.001 17.5 (15.9, 19.2) 49.3 (47.4, 51.3) 33.2 (31.8, 34.7) <0.001 0.85
Non-Hispanic Black 29.3 (27.7, 30.9) 70.7 (69.1, 72.3) 9.1 (7.8, 10.7) 40.3 (37.5, 43.1) 50.6 (48.0, 53.3) 0.65
Mexican American 32.4 (29.5, 35.3) 67.6 (64.7, 70.5) 10.1 (7.9, 12.9) 44.4 (41.5, 47.4) 45.4 (41.6, 49.3) 0.60
Total* 38.9 (37.8, 40.0) 61.1 (60.0, 62.2)   15.7 (14.5, 16.8) 46.5 (44.7, 48.2) 37.9 (36.2, 39.6)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1041983 C T   CC CT TT  
12-19 62.6 (58.6, 66.5) 37.4 (33.5, 41.4) 0.841 38.6 (33.5, 43.8) 48.2 (42.1, 54.4) 13.3 (9.1, 18.9) 0.909
20-39 63.3 (61.0, 65.5) 36.7 (34.5, 39.0) 40.3 (37.4, 43.3) 45.9 (43.3, 48.6) 13.7 (11.7, 16.1)
40-59 63.9 (61.1, 66.6) 36.1 (33.4, 38.9) 40.2 (35.9, 44.7) 47.4 (42.4, 52.4) 12.4 (9.8, 15.6)
>=60 64.3 (61.8, 66.7) 35.7 (33.3, 38.2) 42.2 (38.0, 46.5) 44.2 (39.6, 48.8) 13.6 (11.7, 15.8)
Total 63.6 (62.1, 65.0) 36.4 (35.0, 37.9)   40.4 (38.4, 42.4) 46.3 (44.6, 48.1) 13.3 (12.0, 14.7)  
rs1208 A G   AA AG GG  
12-19 61.2 (57.6, 64.8) 38.8 (35.2, 42.4) 0.876 38.2 (33.1, 43.6) 46.1 (41.8, 50.5) 15.7 (13.0, 18.8) 0.989
20-39 60.6 (58.5, 62.7) 39.4 (37.3, 41.5) 37.3 (33.6, 41.1) 46.7 (42.4, 51.0) 16.1 (14.3, 18.0)
40-59 60.9 (59.1, 62.7) 39.1 (37.3, 40.9) 37.1 (34.1, 40.3) 47.5 (42.9, 52.2) 15.3 (12.7, 18.3)
>=60 59.9 (57.8, 62.0) 40.1 (38.0, 42.2) 36.6 (34.5, 38.7) 46.6 (44.2, 49.1) 16.8 (14.2, 19.7)
Total 60.6 (59.8, 61.5) 39.4 (38.5, 40.2)   37.2 (35.9, 38.5) 46.8 (45.4, 48.2) 15.9 (15.1, 16.8)  
rs1799930 A G   AA AG GG  
12-19 30.2 (26.7, 34.1) 69.8 (65.9, 73.3) 0.823 8.7 (6.1, 12.4) 43.0 (38.0, 48.2) 48.2 (42.7, 53.8) 0.574
20-39 29.6 (27.5, 31.9) 70.4 (68.1, 72.5) 8.9 (7.1, 11.1) 41.5 (38.7, 44.3) 49.6 (46.5, 52.8)
40-59 30.5 (28.3, 32.8) 69.5 (67.2, 71.7) 8.1 (6.0, 11.0) 44.7 (40.1, 49.4) 47.1 (43.3, 50.9)
>=60 30.9 (29.2, 32.7) 69.1 (67.3, 70.8) 10.2 (8.6, 12.1) 41.5 (37.4, 45.7) 48.3 (45.0, 51.7)
Total 30.2 (28.9, 31.5) 69.8 (68.5, 71.1)   8.9 (7.9, 10.1) 42.6 (40.8, 44.5) 48.5 (46.5, 50.5)  
rs1801279 A G   AA AG GG  
12-19 1.3 (0.9, 1.9) 98.7 (98.1, 99.1) 0.147 0.1 (0.0, 0.7) 2.4 (1.7, 3.3) 97.5 (96.4, 98.3) 0.197
20-39 1.1 (0.8, 1.6) 98.9 (98.4, 99.2) 0.1 (0.0, 0.2) 2.1 (1.4, 3.0) 97.9 (97.0, 98.5)
40-59 1.1 (0.8, 1.5) 98.9 (98.5, 99.2) 0.0 (0.0, 0.2) 2.1 (1.5, 3.0) 97.9 (97.0, 98.5)
>=60 0.7 (0.4, 1.1) 99.3 (98.9, 99.6) 0.0 (0.0, 0.1) 1.3 (0.8, 2.1) 98.7 (97.9, 99.1)
Total 1.0 (0.8, 1.3) 99.0 (98.7, 99.2)   0.0 (0.0, 0.1) 2.0 (1.5, 2.6) 98.0 (97.4, 98.4)  
rs1801280 C T   CC CT TT  
12-19 37.6 (34.3, 41.0) 62.4 (59.0, 65.7) 0.540 13.4 (10.5, 16.9) 48.5 (43.4, 53.6) 38.2 (33.3, 43.3) 0.591
20-39 38.7 (36.2, 41.2) 61.3 (58.8, 63.8) 15.7 (13.8, 17.7) 46.0 (42.3, 49.8) 38.3 (34.5, 42.3)
40-59 38.7 (37.0, 40.5) 61.3 (59.5, 63.0) 15.3 (12.6, 18.5) 46.8 (42.5, 51.1) 37.9 (35.4, 40.5)
>=60 40.5 (37.9, 43.1) 59.5 (56.9, 62.1) 17.8 (14.8, 21.2) 45.4 (42.2, 48.6) 36.8 (34.0, 39.8)
Total 38.9 (37.8, 40.0) 61.1 (60.0, 62.2)   15.7 (14.5, 16.8) 46.5 (44.7, 48.2) 37.9 (36.2, 39.6)  

* Includes all participants, regardless of race/ethnicity.

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By Sex* 

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1041983 C T CC CT TT
Male 64.1 (62.1, 66.0) 35.9 (34.0, 37.9) 0.239 41.2 (38.8, 43.6) 45.8 (43.9, 47.7) 13.0 (11.2, 15.1) 0.419
Female 63.1 (61.6, 64.6) 36.9 (35.4, 38.4) 39.7 (37.5, 41.9) 46.8 (44.6, 48.9) 13.5 (12.2, 15.0)
Total 63.6 (62.1, 65.0) 36.4 (35.0, 37.9)   40.4 (38.4, 42.4) 46.3 (44.6, 48.1) 13.3 (12.0, 14.7)  
rs1208 A G AA AG GG
Male 59.8 (58.2, 61.3) 40.2 (38.7, 41.8) 0.108 35.8 (33.6, 38.1) 47.8 (45.2, 50.5) 16.3 (14.6, 18.2) 0.245
Female 61.5 (60.2, 62.7) 38.5 (37.3, 39.8) 38.5 (36.6, 40.5) 45.9 (43.5, 48.4) 15.6 (14.1, 17.1)
Total 60.6 (59.8, 61.5) 39.4 (38.5, 40.2)   37.2 (35.9, 38.5) 46.8 (45.4, 48.2) 15.9 (15.1, 16.8)  
rs1799930 A G AA AG GG
Male 29.7 (28.0, 31.4) 70.3 (68.6, 72.0) 0.154 8.2 (7.0, 9.6) 42.9 (40.5, 45.3) 48.9 (46.3, 51.5) 0.128
Female 30.7 (29.4, 32.0) 69.3 (68.0, 70.6) 9.5 (8.4, 10.9) 42.3 (40.0, 44.7) 48.1 (46.0, 50.3)
Total 30.2 (28.9, 31.5) 69.8 (68.5, 71.1)   8.9 (7.9, 10.1) 42.6 (40.8, 44.5) 48.5 (46.5, 50.5)  
rs1801279 A G AA AG GG
Male 0.9 (0.7, 1.1) 99.1 (98.9, 99.3) 0.053 0.0 (0.0, 0.2) 1.7 (1.3, 2.2) 98.3 (97.8, 98.7) 0.191
Female 1.2 (0.9, 1.6) 98.8 (98.4, 99.1) 0.1 (0.0, 0.2) 2.3 (1.6, 3.2) 97.7 (96.8, 98.3)
Total 1.0 (0.8, 1.3) 99.0 (98.7, 99.2)   0.0 (0.0, 0.1) 2.0 (1.5, 2.6) 98.0 (97.4, 98.4)  
rs1801280 C T CC CT TT
Male 39.8 (38.1, 41.6) 60.2 (58.4, 61.9) 0.092 16.2 (14.5, 18.0) 47.2 (44.7, 49.8) 36.6 (34.1, 39.2) 0.281
Female 38.0 (36.7, 39.4) 62.0 (60.6, 63.3) 15.2 (13.8, 16.7) 45.7 (43.1, 48.4) 39.1 (36.9, 41.4)
Total 38.9 (37.8, 40.0) 61.1 (60.0, 62.2)   15.7 (14.5, 16.8) 46.5 (44.7, 48.2) 37.9 (36.2, 39.6)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs1041983 C T CC CT TT
Non-Hispanic White 12-19 62.6 (58.1, 66.9) 37.4 (33.1, 41.9) 37.4 (29.6, 46.0) 50.3 (39.5, 61.2) 12.2 (7.7, 18.9)
20-39 64.5 (61.9, 67.1) 35.5 (32.9, 38.1) 41.7 (38.3, 45.2) 45.7 (42.4, 49.0) 12.6 (10.1, 15.6)
40-59 65.1 (61.7, 68.3) 34.9 (31.7, 38.3) 41.5 (36.7, 46.5) 47.1 (41.6, 52.6) 11.4 (8.2, 15.7)
>=60 65.1 (62.3, 67.7) 34.9 (32.3, 37.7) 42.9 (38.2, 47.8) 44.2 (39.1, 49.5) 12.8 (10.8, 15.2)
Non-Hispanic Black 12-19 53.8 (48.4, 59.1) 46.2 (40.9, 51.6) 30.6 (24.8, 37.2) 46.3 (41.6, 51.1) 23.1 (18.0, 29.0)
20-39 53.6 (51.7, 55.6) 46.4 (44.4, 48.3) 30.5 (28.1, 32.9) 46.3 (43.1, 49.7) 23.2 (20.6, 26.0)
40-59 54.2 (49.5, 58.8) 45.8 (41.2, 50.5) 31.1 (25.8, 36.8) 46.2 (41.8, 50.7) 22.7 (18.3, 27.9)
>=60 54.5 (47.9, 60.9) 45.5 (39.1, 52.1) 31.8 (24.8, 39.8) 45.3 (38.6, 52.2) 22.9 (16.4, 30.9)
Mexican American 12-19 69.8 (64.0, 75.0) 30.2 (25.0, 36.0) 50.6 (42.2, 58.9) 38.4 (30.3, 47.2) 11.0 (6.9, 17.1)
20-39 68.1 (64.9, 71.1) 31.9 (28.9, 35.1) 46.8 (42.5, 51.2) 42.6 (38.8, 46.4) 10.6 (8.1, 13.7)
40-59 67.8 (63.9, 71.4) 32.2 (28.6, 36.1) 44.9 (39.2, 50.7) 45.7 (40.2, 51.3) 9.4 (6.7, 13.0)
>=60 65.1 (61.7, 68.4) 34.9 (31.6, 38.3) 41.6 (35.6, 47.8) 47.2 (40.6, 53.8) 11.3 (8.9, 14.2)
rs1208 A G AA AG GG
Non-Hispanic White 12-19 60.4 (56.5, 64.2) 39.6 (35.8, 43.5) 36.4 (30.3, 43.0) 48.1 (41.3, 54.8) 15.5 (12.3, 19.4)
20-39 58.5 (55.4, 61.6) 41.5 (38.4, 44.6) 33.5 (28.6, 38.9) 49.9 (44.9, 55.0) 16.5 (14.3, 19.0)
40-59 58.7 (55.9, 61.5) 41.3 (38.5, 44.1) 34.3 (30.2, 38.7) 48.8 (42.8, 54.9) 16.9 (13.2, 21.2)
>=60 59.2 (56.8, 61.5) 40.8 (38.5, 43.2) 35.4 (33.5, 37.4) 47.5 (44.6, 50.4) 17.1 (14.0, 20.7)
Non-Hispanic Black 12-19 61.8 (56.4, 67.0) 38.2 (33.0, 43.6) 40.0 (33.7, 46.6) 43.7 (39.3, 48.2) 16.3 (12.0, 21.8)
20-39 61.7 (59.6, 63.7) 38.3 (36.3, 40.4) 40.0 (36.7, 43.3) 43.4 (39.6, 47.3) 16.6 (14.4, 19.0)
40-59 62.2 (58.8, 65.4) 37.8 (34.6, 41.2) 39.3 (34.5, 44.2) 45.8 (40.7, 51.0) 14.9 (11.8, 18.7)
>=60 60.9 (56.3, 65.4) 39.1 (34.6, 43.7) 36.1 (29.2, 43.6) 49.7 (41.8, 57.6) 14.2 (10.3, 19.4)
Mexican American 12-19 64.8 (60.6, 68.7) 35.2 (31.3, 39.4) 40.9 (36.5, 45.6) 47.6 (41.0, 54.3) 11.4 (6.8, 18.7)
20-39 63.2 (59.9, 66.5) 36.8 (33.5, 40.1) 39.7 (34.7, 45.0) 47.0 (42.5, 51.6) 13.3 (11.0, 15.9)
40-59 67.3 (65.0, 69.5) 32.7 (30.5, 35.0) 44.8 (40.1, 49.5) 45.1 (38.9, 51.4) 10.2 (7.7, 13.3)
>=60 62.3 (56.6, 67.7) 37.7 (32.3, 43.4) 42.1 (36.8, 47.5) 40.5 (35.0, 46.3) 17.4 (11.5, 25.6)
rs1799930 A G AA AG GG
Non-Hispanic White 12-19 33.7 (28.9, 38.9) 66.3 (61.1, 71.1) 10.7 (7.1, 15.8) 46.0 (37.2, 55.1) 43.3 (35.0, 52.0)
20-39 32.4 (29.7, 35.3) 67.6 (64.7, 70.3) 10.4 (8.0, 13.5) 44.0 (40.6, 47.4) 45.6 (41.9, 49.4)
40-59 31.8 (29.1, 34.6) 68.2 (65.4, 70.9) 9.0 (6.3, 12.7) 45.5 (39.9, 51.3) 45.4 (40.8, 50.1)
>=60 32.0 (30.0, 34.1) 68.0 (65.9, 70.0) 10.7 (8.9, 12.9) 42.6 (38.1, 47.2) 46.7 (42.9, 50.5)
Non-Hispanic Black 12-19 28.1 (23.3, 33.5) 71.9 (66.5, 76.7) 9.8 (6.6, 14.5) 36.6 (30.8, 42.9) 53.6 (46.1, 60.9)
20-39 27.9 (25.3, 30.7) 72.1 (69.3, 74.7) 8.9 (6.7, 11.6) 38.1 (35.5, 40.9) 53.0 (49.5, 56.5)
40-59 26.9 (23.1, 31.1) 73.1 (68.9, 76.9) 6.2 (4.4, 8.6) 41.4 (34.2, 49.0) 52.4 (44.9, 59.7)
>=60 29.8 (25.4, 34.6) 70.2 (65.4, 74.6) 10.9 (6.9, 16.8) 37.8 (30.7, 45.5) 51.3 (44.6, 58.0)
Mexican American 12-19 16.8 (13.1, 21.3) 83.2 (78.7, 86.9) 3.2 (1.7, 5.8) 27.3 (20.5, 35.2) 69.6 (61.5, 76.6)
20-39 17.8 (15.6, 20.2) 82.2 (79.8, 84.4) 2.9 (1.6, 5.3) 29.8 (25.7, 34.2) 67.3 (63.1, 71.2)
40-59 18.2 (14.9, 22.0) 81.8 (78.0, 85.1) 3.4 (1.5, 7.5) 29.6 (24.2, 35.6) 67.0 (60.9, 72.7)
>=60 21.0 (17.1, 25.6) 79.0 (74.4, 82.9) 4.7 (2.8, 7.6) 32.6 (25.0, 41.3) 62.7 (54.3, 70.3)
rs1801279 A G AA AG GG
Non-Hispanic White 12-19 0.0 (NA) 100.0 (NA) 0.0 (NA) 0.0 (NA) 100.0 (NA)
20-39 0.0 (NA) 100.0 (NA) 0.0 (NA) 0.0 (NA) 100.0 (NA)
40-59 0.1 (0.0, 0.5) 99.9 (99.5, 100.0) 0.0 (NA) 0.1 (0.0, 1.0) 99.9 (99.0, 100.0)
>=60 0.1 (0.0, 0.3) 99.9 (99.7, 100.0) 0.0 (NA) 0.2 (0.1, 0.7) 99.8 (99.3, 99.9)
Non-Hispanic Black 12-19 7.7 (5.3, 11.2) 92.3 (88.8, 94.7) 0.6 (0.1, 3.9) 14.3 (10.6, 19.0) 85.1 (79.5, 89.4)
20-39 7.8 (6.6, 9.3) 92.2 (90.7, 93.4) 0.4 (0.1, 1.5) 14.8 (12.4, 17.5) 84.8 (82.1, 87.2)
40-59 8.6 (6.9, 10.6) 91.4 (89.4, 93.1) 0.2 (0.0, 1.5) 16.7 (13.1, 21.0) 83.1 (78.9, 86.6)
>=60 6.6 (5.4, 8.2) 93.4 (91.8, 94.6) 0.2 (0.0, 2.1) 12.8 (10.1, 16.1) 87.0 (83.8, 89.6)
Mexican American 12-19 0.6 (0.2, 1.7) 99.4 (98.3, 99.8) 0.0 (NA) 1.2 (0.5, 3.3) 98.8 (96.7, 99.5)
20-39 0.4 (0.2, 0.9) 99.6 (99.1, 99.8) 0.0 (NA) 0.7 (0.3, 1.8) 99.3 (98.2, 99.7)
40-59 0.7 (0.3, 1.9) 99.3 (98.1, 99.7) 0.0 (NA) 1.5 (0.5, 3.8) 98.5 (96.2, 99.5)
>=60 0.5 (0.2, 1.2) 99.5 (98.8, 99.8) 0.1 (0.0, 0.7) 0.8 (0.2, 3.6) 99.1 (97.2, 99.7)
rs1801280 C T CC CT TT
Non-Hispanic White 12-19 40.4 (36.7, 44.2) 59.6 (55.8, 63.3) 14.1 (10.1, 19.2) 52.7 (45.2, 60.0) 33.3 (27.5, 39.5)
20-39 42.5 (39.3, 45.7) 57.5 (54.3, 60.7) 17.3 (14.8, 20.1) 50.3 (46.3, 54.3) 32.4 (28.0, 37.2)
40-59 42.2 (39.4, 45.0) 57.8 (55.0, 60.6) 17.8 (14.1, 22.1) 48.8 (43.6, 54.1) 33.4 (29.8, 37.2)
>=60 42.4 (39.6, 45.3) 57.6 (54.7, 60.4) 19.2 (15.6, 23.4) 46.5 (42.8, 50.3) 34.3 (31.5, 37.2)
Non-Hispanic Black 12-19 28.8 (24.4, 33.5) 71.2 (66.5, 75.6) 9.0 (6.1, 12.9) 39.6 (34.7, 44.7) 51.5 (44.9, 58.0)
20-39 30.2 (28.3, 32.2) 69.8 (67.8, 71.7) 10.5 (8.3, 13.2) 39.4 (35.9, 43.0) 50.1 (47.2, 53.0)
40-59 28.3 (25.7, 31.1) 71.7 (68.9, 74.3) 8.6 (6.3, 11.5) 39.5 (33.9, 45.5) 51.9 (46.9, 56.9)
>=60 28.7 (25.8, 31.8) 71.3 (68.2, 74.2) 6.1 (3.0, 12.1) 45.2 (36.4, 54.4) 48.7 (42.3, 55.0)
Mexican American 12-19 32.1 (27.3, 37.4) 67.9 (62.6, 72.7) 9.1 (4.5, 17.5) 46.1 (40.8, 51.5) 44.8 (39.7, 50.0)
20-39 33.2 (30.1, 36.6) 66.8 (63.4, 69.9) 10.7 (8.2, 13.8) 45.1 (40.8, 49.6) 44.2 (39.5, 49.1)
40-59 30.1 (26.0, 34.6) 69.9 (65.4, 74.0) 8.5 (5.8, 12.3) 43.2 (37.4, 49.1) 48.3 (41.7, 55.0)
>=60 33.5 (28.8, 38.5) 66.5 (61.5, 71.2) 13.8 (9.3, 19.8) 39.3 (34.2, 44.7) 46.9 (41.1, 52.7)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs1041983 C T CC CT TT
Non-Hispanic White Male 65.2 (63.3, 67.1) 34.8 (32.9, 36.7) 42.0 (39.4, 44.7) 46.4 (43.7, 49.1) 11.6 (9.7, 13.7)
Female 63.9 (61.9, 65.9) 36.1 (34.1, 38.1) 40.8 (37.6, 44.1) 46.2 (43.1, 49.4) 12.9 (11.4, 14.7)
Non-Hispanic Black Male 53.6 (50.2, 56.9) 46.4 (43.1, 49.8) 31.1 (27.0, 35.5) 45.0 (41.3, 48.9) 23.9 (20.6, 27.5)
Female 54.2 (52.6, 55.7) 45.8 (44.3, 47.4) 30.6 (28.7, 32.6) 47.1 (44.4, 49.8) 22.3 (20.2, 24.5)
Mexican American Male 67.7 (64.7, 70.6) 32.3 (29.4, 35.3) 45.6 (41.6, 49.8) 44.2 (41.1, 47.3) 10.2 (8.0, 12.8)
Female 68.5 (65.8, 71.2) 31.5 (28.8, 34.2) 47.9 (44.1, 51.6) 41.3 (37.7, 45.1) 10.8 (8.4, 13.8)
rs1208 A G AA AG GG
Non-Hispanic White Male 58.4 (56.5, 60.2) 41.6 (39.8, 43.5) 33.4 (30.5, 36.4) 50.0 (46.7, 53.2) 16.6 (14.8, 18.7)
Female 59.5 (57.7, 61.3) 40.5 (38.7, 42.3) 35.6 (33.7, 37.6) 47.8 (44.9, 50.7) 16.6 (14.2, 19.4)
Non-Hispanic Black Male 61.9 (59.5, 64.4) 38.1 (35.6, 40.5) 39.9 (36.3, 43.7) 44.1 (39.9, 48.3) 16.0 (13.5, 18.9)
Female 61.5 (59.9, 63.2) 38.5 (36.8, 40.1) 38.7 (36.4, 41.1) 45.7 (43.3, 48.0) 15.6 (14.0, 17.4)
Mexican American Male 64.7 (61.4, 67.9) 35.3 (32.1, 38.6) 41.4 (37.2, 45.6) 46.7 (43.1, 50.4) 11.9 (9.1, 15.5)
Female 63.9 (61.6, 66.1) 36.1 (33.9, 38.4) 41.1 (37.8, 44.5) 45.6 (42.7, 48.6) 13.3 (11.6, 15.2)
rs1799930 A G AA AG GG
Non-Hispanic White Male 31.7 (29.9, 33.6) 68.3 (66.4, 70.1) 9.2 (7.6, 11.0) 45.1 (42.4, 47.8) 45.7 (43.0, 48.5)
Female 32.9 (30.7, 35.1) 67.1 (64.9, 69.3) 11.0 (9.4, 12.9) 43.7 (40.7, 46.7) 45.3 (42.0, 48.6)
Non-Hispanic Black Male 28.7 (25.4, 32.3) 71.3 (67.7, 74.6) 9.6 (7.5, 12.2) 38.2 (33.5, 43.2) 52.2 (46.6, 57.7)
Female 27.4 (25.8, 29.0) 72.6 (71.0, 74.2) 7.9 (6.5, 9.6) 38.9 (35.8, 42.1) 53.2 (50.4, 55.9)
Mexican American Male 18.1 (16.2, 20.3) 81.9 (79.7, 83.8) 3.1 (1.8, 5.2) 30.1 (26.7, 33.9) 66.8 (63.2, 70.2)
Female 17.8 (14.9, 21.1) 82.2 (78.9, 85.1) 3.4 (2.0, 5.7) 28.8 (24.8, 33.1) 67.8 (62.7, 72.6)
rs1801279 A G AA AG GG
Non-Hispanic White Male 0.0 (0.0, 0.3) 100.0 (99.7, 100.0) 0.0 (NA) 0.1 (0.0, 0.6) 99.9 (99.4, 100.0)
Female 0.0 (0.0, 0.1) 100.0 (99.9, 100.0) 0.0 (NA) 0.1 (0.0, 0.3) 99.9 (99.7, 100.0)
Non-Hispanic Black Male 7.5 (6.6, 8.5) 92.5 (91.5, 93.4) 0.3 (0.1, 1.6) 14.4 (12.6, 16.4) 85.3 (83.4, 87.1)
Female 8.1 (6.9, 9.5) 91.9 (90.5, 93.1) 0.4 (0.1, 1.2) 15.3 (12.8, 18.3) 84.3 (81.4, 86.7)
Mexican American Male 0.5 (0.2, 1.2) 99.5 (98.8, 99.8) 0.0 (0.0, 0.1) 1.1 (0.5, 2.4) 98.9 (97.6, 99.5)
Female 0.5 (0.2, 1.0) 99.5 (99.0, 99.8) 0.0 (NA) 0.9 (0.4, 2.0) 99.1 (98.0, 99.6)
rs1801280 C T CC CT TT
Non-Hispanic White Male 42.5 (40.5, 44.5) 57.5 (55.5, 59.5) 17.5 (15.6, 19.6) 50.0 (46.8, 53.3) 32.5 (29.5, 35.6)
Female 41.8 (40.0, 43.5) 58.2 (56.5, 60.0) 17.4 (15.0, 20.1) 48.7 (45.6, 51.8) 33.9 (31.9, 36.0)
Non-Hispanic Black Male 30.2 (28.1, 32.5) 69.8 (67.5, 71.9) 10.2 (8.7, 11.9) 40.0 (36.2, 44.0) 49.8 (46.0, 53.5)
Female 28.5 (26.5, 30.5) 71.5 (69.5, 73.5) 8.2 (6.5, 10.4) 40.4 (37.6, 43.3) 51.3 (48.4, 54.2)
Mexican American Male 31.6 (28.2, 35.2) 68.4 (64.8, 71.8) 9.7 (7.0, 13.2) 43.8 (41.1, 46.5) 46.5 (42.2, 50.9)
Female 33.2 (30.3, 36.2) 66.8 (63.8, 69.7) 10.6 (8.6, 13.1) 45.1 (40.9, 49.4) 44.3 (39.7, 48.9)


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