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U.S. Genome Variation Estimates

MTRR Allele and Genotype Frequencies

Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs1801394

Ex2-64A>G

Ile22Met
Ile49Met

TaqMan




Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1801394AGAAAGGG
Non-Hispanic White47.2 (45.9, 48.5)52.8 (51.5, 54.1)<0.00122.6 (20.9, 24.4)49.1 (47.1, 51.1)28.3 (26.7, 29.9)<0.0010.74
Non-Hispanic Black71.3 (69.1, 73.3)28.7 (26.7, 30.9)50.7 (47.8, 53.6)41.1 (39.2, 43.1)8.2 (6.8, 9.8)0.82
Mexican American73.9 (72.0, 75.8)26.1 (24.2, 28.0)55.0 (51.8, 58.1)37.9 (34.7, 41.3)7.1 (5.7, 8.9)0.04
Total*53.1 (51.5, 54.7)46.9 (45.3, 48.5)29.8 (27.7, 31.9)46.7 (45.0, 48.5)23.5 (22.0, 25.0)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801394AGAAAGGG
12-1957.3 (51.0, 63.3)42.7 (36.7, 49.0)0.01534.2 (27.9, 41.2)46.1 (41.6, 50.6)19.7 (14.0, 27.0)0.060
20-3953.8 (51.4, 56.2)46.2 (43.8, 48.6)29.5 (26.0, 33.2)48.6 (45.0, 52.2)21.9 (19.7, 24.3)
40-5953.9 (50.7, 57.2)46.1 (42.8, 49.3)32.1 (27.5, 37.1)43.7 (38.2, 49.3)24.2 (20.7, 28.1)
>=6047.8 (45.2, 50.3)52.2 (49.7, 54.8)23.9 (20.8, 27.4)47.7 (44.4, 50.9)28.4 (25.7, 31.2)
Total53.1 (51.5, 54.7)46.9 (45.3, 48.5)29.8 (27.7, 31.9)46.7 (45.0, 48.5)23.5 (22.0, 25.0)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801394AGAAAGGG
Male53.5 (50.7, 56.3)46.5 (43.7, 49.3)0.60429.3 (26.3, 32.6)48.4 (45.5, 51.2)22.3 (19.3, 25.5)0.335
Female52.8 (51.4, 54.2)47.2 (45.8, 48.6)30.2 (28.2, 32.4)45.2 (42.3, 48.0)24.6 (22.8, 26.6)
Total53.1 (51.5, 54.7)46.9 (45.3, 48.5)29.8 (27.7, 31.9)46.7 (45.0, 48.5)23.5 (22.0, 25.0)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs1801394AGAAAGGG
Non-Hispanic White12-1949.7 (42.6, 56.8)50.3 (43.2, 57.4)25.4 (18.5, 33.8)48.6 (42.1, 55.1)26.0 (18.8, 34.8)
20-3946.5 (43.6, 49.5)53.5 (50.5, 56.4)20.1 (15.9, 25.0)52.9 (47.8, 57.9)27.0 (24.0, 30.3)
40-5949.8 (45.9, 53.7)50.2 (46.3, 54.1)27.2 (21.7, 33.6)45.1 (38.7, 51.7)27.6 (23.8, 31.9)
>=6043.5 (40.9, 46.0)56.5 (54.0, 59.1)19.4 (16.4, 22.7)48.2 (44.6, 51.9)32.4 (29.4, 35.6)
Non-Hispanic Black12-1970.1 (66.5, 73.5)29.9 (26.5, 33.5)50.9 (46.2, 55.5)38.5 (34.7, 42.4)10.6 (7.8, 14.4)
20-3969.6 (66.5, 72.5)30.4 (27.5, 33.5)47.2 (42.8, 51.8)44.7 (40.8, 48.6)8.1 (6.1, 10.7)
40-5974.0 (69.5, 78.0)26.0 (22.0, 30.5)56.1 (49.7, 62.3)35.8 (30.9, 41.0)8.2 (5.5, 11.9)
>=6073.1 (70.1, 76.0)26.9 (24.0, 29.9)51.5 (47.6, 55.3)43.3 (39.5, 47.3)5.2 (2.8, 9.4)
Mexican American12-1973.8 (68.5, 78.5)26.2 (21.5, 31.5)54.2 (46.5, 61.7)39.2 (32.5, 46.4)6.6 (3.5, 12.1)
20-3974.6 (72.1, 76.9)25.4 (23.1, 27.9)55.8 (50.9, 60.6)37.6 (32.2, 43.3)6.6 (5.0, 8.8)
40-5972.8 (69.8, 75.6)27.2 (24.4, 30.2)54.6 (50.9, 58.4)36.4 (32.8, 40.1)9.0 (6.3, 12.6)
>=6073.1 (69.7, 76.3)26.9 (23.7, 30.3)52.8 (48.1, 57.4)40.7 (36.1, 45.6)6.5 (3.8, 10.9)

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By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs1801394AGAAAGGG
Non-Hispanic WhiteMale48.0 (45.7, 50.3)52.0 (49.7, 54.3)22.3 (19.9, 24.9)51.4 (47.9, 54.9)26.3 (23.3, 29.6)
Female46.4 (44.6, 48.3)53.6 (51.7, 55.4)23.0 (21.0, 25.1)46.9 (43.4, 50.5)30.1 (27.2, 33.1)
Non-Hispanic BlackMale71.0 (68.0, 73.9)29.0 (26.1, 32.0)50.3 (45.8, 54.9)41.4 (37.8, 45.1)8.3 (6.5, 10.4)
Female71.5 (69.2, 73.6)28.5 (26.4, 30.8)51.0 (48.0, 54.0)40.9 (38.5, 43.4)8.1 (6.4, 10.1)
Mexican AmericanMale74.3 (71.0, 77.4)25.7 (22.6, 29.0)55.5 (49.6, 61.3)37.6 (32.0, 43.5)6.9 (5.4, 8.8)
Female73.5 (71.4, 75.5)26.5 (24.5, 28.6)54.4 (51.7, 57.1)38.2 (36.0, 40.5)7.4 (5.7, 9.5)


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