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U.S. Genome Variation Estimates

MBL2 Allele and Genotype Frequencies

 

Available polymorphism(s)

rs number

Common Designations

Nucleotide change                  Amino acid

Genotyping method

rs11003125

-618G>C
-550G>C

 

TaqMan

rs1800450

Ex1-27G>A

Gly54Asp

TaqMan

rs1800451

Ex1-18G>A

Gly57Glu

TaqMan

rs5030737

Ex1-34C>T

Arg52Cys

TaqMan

rs7096206

-289G<C
-221G>C

 

TaqMan



Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity 

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs11003125 C G   CC CG GG    
Non-Hispanic White 63.6 (61.9, 65.3) 36.4 (34.7, 38.1) <0.001 40.9 (38.6, 43.2) 45.6 (42.5, 48.6) 13.6 (11.4, 16.1) <0.001 0.76
Non-Hispanic Black 87.2 (86.0, 88.3) 12.8 (11.7, 14.0) 76.2 (73.9, 78.3) 21.9 (19.8, 24.3) 1.9 (1.3, 2.7) 0.71
Mexican American 49.0 (46.9, 51.1) 51.0 (48.9, 53.1) 25.0 (22.3, 27.8) 48.1 (46.3, 50.0) 26.9 (25.2, 28.7) 0.44
Total* 65.1 (63.3, 66.8) 34.9 (33.2, 36.7)   43.2 (41.0, 45.4) 43.8 (41.3, 46.2) 13.1 (11.2, 15.2)    
rs1800450 A G   AA AG GG    
Non-Hispanic White 14.6 (13.1, 16.2) 85.4 (83.8, 86.9) <0.001 2.8 (2.1, 3.7) 23.5 (21.1, 26.1) 73.7 (70.8, 76.3) <0.001 0.01
Non-Hispanic Black 4.0 (3.3, 4.9) 96.0 (95.1, 96.7) 0.4 (0.2, 0.8) 7.4 (6.0, 9.0) 92.3 (90.6, 93.6) 0.02
Mexican American 14.6 (12.9, 16.6) 85.4 (83.4, 87.1) 2.0 (1.3, 3.2) 25.1 (22.8, 27.6) 72.8 (69.7, 75.7) 0.66
Total* 13.5 (12.3, 14.7) 86.5 (85.3, 87.7)   2.4 (1.9, 3.1) 22.1 (20.3, 24.0) 75.5 (73.4, 77.5)    
rs1800451 A G   AA AG GG    
Non-Hispanic White 2.0 (1.6, 2.4) 98.0 (97.6, 98.4) <0.001 0.1 (0.0, 0.3) 3.8 (3.1, 4.7) 96.1 (95.2, 96.9) <0.001 0.16
Non-Hispanic Black 23.3 (21.7, 25.0) 76.7 (75.0, 78.3) 6.1 (4.6, 7.9) 34.4 (32.3, 36.7) 59.5 (57.2, 61.8) 0.12
Mexican American 2.5 (1.9, 3.3) 97.5 (96.7, 98.1) 0.0 (NA) 5.1 (3.9, 6.6) 94.9 (93.4, 96.1) 0.23
Total* 4.6 (3.9, 5.5) 95.4 (94.5, 96.1)   0.8 (0.6, 1.2) 7.6 (6.3, 9.2) 91.6 (90.0, 93.0)    
rs5030737 C T   CC CT TT    
Non-Hispanic White 92.6 (91.5, 93.6) 7.4 (6.4, 8.5) <0.001 85.9 (83.7, 87.9) 13.3 (11.3, 15.6) 0.8 (0.4, 1.3) <0.001 0.27
Non-Hispanic Black 98.9 (98.5, 99.2) 1.1 (0.8, 1.5) 97.7 (97.0, 98.3) 2.3 (1.7, 3.0) 0.0 (NA) 0.63
Mexican American 97.1 (96.5, 97.6) 2.9 (2.4, 3.5) 94.4 (93.2, 95.3) 5.5 (4.6, 6.5) 0.2 (0.1, 0.4) <0.01
Total* 93.9 (92.9, 94.7) 6.1 (5.3, 7.1)   88.3 (86.5, 89.9) 11.1 (9.6, 12.9) 0.6 (0.3, 1.0)    
rs7096206 C G   CC CG GG    
Non-Hispanic White 22.4 (20.4, 24.5) 77.6 (75.5, 79.6) <0.001 5.2 (4.1, 6.5) 34.4 (31.2, 37.6) 60.4 (56.9, 63.8) <0.001 0.41
Non-Hispanic Black 15.1 (13.7, 16.7) 84.9 (83.3, 86.3) 2.2 (1.6, 3.0) 25.8 (23.3, 28.5) 71.9 (69.1, 74.6) 0.97
Mexican American 11.4 (9.5, 13.5) 88.6 (86.5, 90.5) 2.2 (1.5, 3.4) 18.3 (15.8, 21.1) 79.5 (76.0, 82.5) <0.01
Total* 20.4 (18.9, 22.0) 79.6 (78.0, 81.1)   4.4 (3.6, 5.3) 32.0 (29.7, 34.4) 63.6 (61.0, 66.2)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*


Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs11003125 C G   CC CG GG  
12-19 65.6 (61.6, 69.4) 34.4 (30.6, 38.4) 0.838 44.9 (39.9, 50.1) 41.3 (36.5, 46.3) 13.7 (10.2, 18.2) 0.130
20-39 64.8 (61.6, 67.8) 35.2 (32.2, 38.4)   43.8 (40.5, 47.2) 41.9 (38.8, 45.2) 14.2 (10.9, 18.3)  
40-59 65.7 (63.6, 67.7) 34.3 (32.3, 36.4)   42.0 (38.6, 45.4) 47.4 (42.9, 52.0) 10.6 (8.2, 13.5)  
>=60 64.3 (61.5, 67.1) 35.7 (32.9, 38.5)   42.4 (38.4, 46.5) 43.9 (40.8, 47.0) 13.7 (12.0, 15.7)  
Total 65.1 (63.3, 66.8) 34.9 (33.2, 36.7)   43.2 (41.0, 45.4) 43.8 (41.3, 46.2) 13.1 (11.2, 15.2)  
rs1800450 A G   AA AG GG  
12-19 13.8 (11.1, 17.0) 86.2 (83.0, 88.9) 0.604 3.1 (1.7, 5.6) 21.4 (16.7, 26.9) 75.5 (69.9, 80.3) 0.286
20-39 12.7 (11.3, 14.3) 87.3 (85.7, 88.7)   2.3 (1.7, 3.1) 20.8 (18.2, 23.6) 76.9 (73.9, 79.6)  
40-59 14.0 (11.8, 16.5) 86.0 (83.5, 88.2)   1.6 (1.0, 2.6) 24.7 (20.8, 29.1) 73.7 (69.1, 77.8)  
>=60 13.9 (12.5, 15.4) 86.1 (84.6, 87.5)   3.2 (1.9, 5.1) 21.5 (18.9, 24.4) 75.3 (72.9, 77.6)  
Total 13.5 (12.3, 14.7) 86.5 (85.3, 87.7)   2.4 (1.9, 3.1) 22.1 (20.3, 24.0) 75.5 (73.4, 77.5)  
rs1800451 A G   AA AG GG  
12-19 5.6 (3.7, 8.5) 94.4 (91.5, 96.3) 0.085 1.3 (0.6, 2.9) 8.6 (5.6, 13.0) 90.1 (85.2, 93.5) 0.125
20-39 5.1 (4.1, 6.2) 94.9 (93.8, 95.9)   0.8 (0.6, 1.2) 8.5 (6.8, 10.6) 90.7 (88.5, 92.5)  
40-59 3.7 (3.0, 4.7) 96.3 (95.3, 97.0)   0.7 (0.5, 1.1) 6.1 (4.5, 8.0) 93.2 (91.3, 94.8)  
>=60 4.3 (3.4, 5.3) 95.7 (94.7, 96.6)   0.6 (0.3, 1.2) 7.3 (6.1, 8.8) 92.1 (90.4, 93.5)  
Total 4.6 (3.9, 5.5) 95.4 (94.5, 96.1)   0.8 (0.6, 1.2) 7.6 (6.3, 9.2) 91.6 (90.0, 93.0)  
rs5030737 C T   CC CT TT  
12-19 92.8 (89.5, 95.1) 7.2 (4.9, 10.5) 0.487 86.4 (80.8, 90.6) 12.7 (9.0, 17.7) 0.8 (0.2, 3.3) 0.269
20-39 93.5 (91.7, 94.9) 6.5 (5.1, 8.3)   87.7 (84.3, 90.5) 11.5 (8.8, 15.0) 0.8 (0.3, 1.7)  
40-59 94.5 (92.8, 95.8) 5.5 (4.2, 7.2)   89.2 (86.1, 91.7) 10.6 (8.2, 13.6) 0.2 (0.1, 0.9)  
>=60 94.4 (93.1, 95.5) 5.6 (4.5, 6.9)   89.4 (86.7, 91.6) 10.0 (7.8, 12.8) 0.5 (0.3, 1.1)  
Total 93.9 (92.9, 94.7) 6.1 (5.3, 7.1)   88.3 (86.5, 89.9) 11.1 (9.6, 12.9) 0.6 (0.3, 1.0)  
rs7096206 C G   CC CG GG  
12-19 19.5 (17.1, 22.1) 80.5 (77.9, 82.9) 0.304 3.7 (2.0, 6.7) 31.7 (27.1, 36.7) 64.6 (60.2, 68.9) 0.493
20-39 19.3 (17.0, 21.8) 80.7 (78.2, 83.0)   4.4 (3.4, 5.8) 29.7 (25.8, 33.9) 65.8 (61.4, 70.0)  
40-59 21.8 (18.7, 25.3) 78.2 (74.7, 81.3)   4.3 (2.7, 6.7) 35.1 (30.6, 39.8) 60.6 (55.2, 65.9)  
>=60 21.1 (19.2, 23.2) 78.9 (76.8, 80.8)   4.9 (3.3, 7.3) 32.4 (29.2, 35.8) 62.6 (59.5, 65.7)  
Total 20.4 (18.9, 22.0) 79.6 (78.0, 81.1)   4.4 (3.6, 5.3) 32.0 (29.7, 34.4) 63.6 (61.0, 66.2)  

* Includes all participants, regardless of race/ethnicity.

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By Sex* 

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs11003125 C G CC CG GG
Male 65.0 (62.8, 67.1) 35.0 (32.9, 37.2) 0.890 42.1 (39.5, 44.7) 45.8 (43.5, 48.0) 12.2 (10.1, 14.6) 0.066
Female 65.2 (62.8, 67.4) 34.8 (32.6, 37.2)   44.2 (41.2, 47.3) 41.9 (38.6, 45.2) 13.9 (11.5, 16.7)  
Total 65.1 (63.3, 66.8) 34.9 (33.2, 36.7)   43.2 (41.0, 45.4) 43.8 (41.3, 46.2) 13.1 (11.2, 15.2)  
rs1800450 A G AA AG GG
Male 13.4 (11.8, 15.2) 86.6 (84.8, 88.2) 0.882 2.2 (1.6, 3.1) 22.3 (19.3, 25.5) 75.5 (72.1, 78.5) 0.811
Female 13.5 (12.4, 14.7) 86.5 (85.3, 87.6)   2.5 (1.8, 3.5) 21.9 (20.3, 23.6) 75.5 (73.6, 77.4)  
Total 13.5 (12.3, 14.7) 86.5 (85.3, 87.7)   2.4 (1.9, 3.1) 22.1 (20.3, 24.0) 75.5 (73.4, 77.5)  
rs1800451 A G AA AG GG
Male 4.1 (3.3, 4.9) 95.9 (95.1, 96.7) 0.021 0.9 (0.5, 1.5) 6.3 (5.1, 7.8) 92.8 (91.3, 94.1) 0.008
Female 5.1 (4.2, 6.3) 94.9 (93.7, 95.8)   0.8 (0.5, 1.1) 8.8 (7.0, 11.0) 90.5 (88.2, 92.3)  
Total 4.6 (3.9, 5.5) 95.4 (94.5, 96.1)   0.8 (0.6, 1.2) 7.6 (6.3, 9.2) 91.6 (90.0, 93.0)  
rs5030737 C T CC CT TT
Male 94.1 (92.7, 95.2) 5.9 (4.8, 7.3) 0.410 88.4 (85.7, 90.7) 11.4 (9.2, 14.1) 0.2 (0.1, 0.8) 0.140
Female 93.6 (92.9, 94.3) 6.4 (5.7, 7.1)   88.2 (86.6, 89.6) 10.9 (9.3, 12.8) 0.9 (0.5, 1.7)  
Total 93.9 (92.9, 94.7) 6.1 (5.3, 7.1)   88.3 (86.5, 89.9) 11.1 (9.6, 12.9) 0.6 (0.3, 1.0)  
rs7096206 C G CC CG GG
Male 20.0 (18.2, 21.9) 80.0 (78.1, 81.8) 0.434 3.7 (2.4, 5.6) 32.6 (28.4, 37.2) 63.7 (59.9, 67.4) 0.459
Female 20.8 (19.0, 22.7) 79.2 (77.3, 81.0)   5.1 (3.9, 6.6) 31.4 (28.6, 34.4) 63.5 (60.4, 66.5)  
Total 20.4 (18.9, 22.0) 79.6 (78.0, 81.1)   4.4 (3.6, 5.3) 32.0 (29.7, 34.4) 63.6 (61.0, 66.2)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs11003125 C G CC CG GG
Non-Hispanic White 12-19 63.1 (58.5, 67.5) 36.9 (32.5, 41.5) 41.3 (36.1, 46.7) 43.6 (37.7, 49.7) 15.1 (10.4, 21.5)
20-39 63.5 (59.7, 67.2) 36.5 (32.8, 40.3) 42.3 (38.4, 46.2) 42.5 (38.3, 46.9) 15.2 (11.1, 20.5)
40-59 64.7 (62.1, 67.3) 35.3 (32.7, 37.9) 39.9 (35.6, 44.4) 49.6 (44.0, 55.1) 10.5 (7.8, 14.0)
>=60 62.7 (59.7, 65.5) 37.3 (34.5, 40.3) 39.5 (35.4, 43.7) 46.4 (43.2, 49.6) 14.1 (12.1, 16.5)
Non-Hispanic Black 12-19 87.8 (84.5, 90.5) 12.2 (9.5, 15.5) 77.3 (71.7, 82.0) 21.1 (16.9, 26.1) 1.6 (0.7, 3.5)
20-39 87.9 (86.1, 89.5) 12.1 (10.5, 13.9) 76.7 (72.9, 80.1) 22.4 (18.7, 26.6) 0.9 (0.3, 2.3)
40-59 83.8 (80.3, 86.8) 16.2 (13.2, 19.7) 71.2 (65.8, 76.0) 25.4 (21.2, 30.0) 3.5 (1.9, 6.3)
>=60 89.9 (88.3, 91.3) 10.1 (8.7, 11.7) 82.1 (79.1, 84.8) 15.5 (12.1, 19.6) 2.4 (1.1, 5.1)
Mexican American 12-19 50.0 (45.3, 54.8) 50.0 (45.2, 54.7) 26.4 (21.1, 32.4) 47.3 (41.8, 52.8) 26.3 (21.3, 32.0)
20-39 47.7 (44.6, 50.8) 52.3 (49.2, 55.4) 23.0 (19.8, 26.5) 49.3 (46.9, 51.8) 27.7 (24.5, 31.1)
40-59 50.0 (45.5, 54.5) 50.0 (45.5, 54.5) 27.1 (20.7, 34.7) 45.8 (39.0, 52.7) 27.1 (23.5, 31.1)
>=60 52.5 (47.5, 57.4) 47.5 (42.6, 52.5) 27.9 (23.2, 33.2) 49.1 (43.8, 54.4) 23.0 (17.4, 29.7)
rs1800450 A G AA AG GG
Non-Hispanic White 12-19 15.6 (12.1, 19.9) 84.4 (80.1, 87.9) 3.9 (1.9, 7.6) 23.5 (17.1, 31.4) 72.6 (65.1, 79.0)
20-39 13.7 (11.6, 16.0) 86.3 (84.0, 88.4) 2.8 (2.1, 3.9) 21.7 (18.1, 25.7) 75.5 (71.3, 79.3)
40-59 15.1 (12.6, 18.1) 84.9 (81.9, 87.4) 1.8 (1.1, 3.1) 26.6 (22.2, 31.5) 71.6 (66.3, 76.3)
>=60 14.7 (13.2, 16.4) 85.3 (83.6, 86.8) 3.5 (2.2, 5.8) 22.4 (19.4, 25.8) 74.0 (71.3, 76.6)
Non-Hispanic Black 12-19 6.2 (4.4, 8.6) 93.8 (91.4, 95.6) 0.7 (0.2, 2.5) 11.0 (7.7, 15.4) 88.4 (83.9, 91.7)
20-39 3.4 (2.5, 4.5) 96.6 (95.5, 97.5) 0.3 (0.1, 0.9) 6.2 (4.6, 8.2) 93.5 (91.5, 95.1)
40-59 3.8 (2.4, 5.8) 96.2 (94.2, 97.6) 0.4 (0.1, 1.9) 6.6 (4.4, 9.9) 92.9 (89.4, 95.3)
>=60 3.8 (2.5, 5.7) 96.2 (94.3, 97.5) 0.0 (NA) 7.5 (4.9, 11.4) 92.5 (88.6, 95.1)
Mexican American 12-19 13.3 (9.8, 17.9) 86.7 (82.1, 90.2) 1.5 (0.7, 3.3) 23.7 (17.9, 30.6) 74.9 (67.1, 81.3)
20-39 14.2 (11.9, 16.9) 85.8 (83.1, 88.1) 1.9 (0.9, 4.1) 24.6 (20.7, 28.9) 73.5 (68.9, 77.6)
40-59 15.9 (14.0, 18.0) 84.1 (82.0, 86.0) 2.7 (1.3, 5.4) 26.5 (21.8, 31.6) 70.9 (66.7, 74.7)
>=60 16.8 (14.2, 19.8) 83.2 (80.2, 85.8) 2.5 (1.5, 4.0) 28.7 (23.6, 34.4) 68.9 (63.2, 74.0)
rs1800451 A G AA AG GG
Non-Hispanic White 12-19 1.4 (0.8, 2.3) 98.6 (97.7, 99.2) 0.0 (NA) 2.7 (1.6, 4.7) 97.3 (95.3, 98.4)
20-39 2.4 (1.7, 3.3) 97.6 (96.7, 98.3) 0.1 (0.0, 0.6) 4.5 (3.3, 6.2) 95.4 (93.6, 96.7)
40-59 1.2 (0.8, 2.0) 98.8 (98.0, 99.2) 0.0 (NA) 2.5 (1.5, 4.1) 97.5 (95.9, 98.5)
>=60 2.6 (2.1, 3.2) 97.4 (96.8, 97.9) 0.2 (0.0, 1.1) 4.8 (3.9, 6.0) 94.9 (93.8, 95.9)
Non-Hispanic Black 12-19 23.0 (19.4, 27.0) 77.0 (73.0, 80.6) 5.6 (3.6, 8.6) 34.8 (29.0, 41.2) 59.6 (53.0, 65.9)
20-39 23.2 (21.5, 25.0) 76.8 (75.0, 78.5) 6.2 (4.2, 8.9) 34.1 (29.5, 39.0) 59.7 (56.3, 63.1)
40-59 23.4 (20.9, 26.3) 76.6 (73.7, 79.1) 6.8 (4.4, 10.2) 33.4 (29.5, 37.5) 59.9 (56.0, 63.6)
>=60 23.6 (19.6, 28.2) 76.4 (71.8, 80.4) 5.2 (3.0, 9.0) 36.8 (30.2, 43.9) 58.0 (50.6, 65.0)
Mexican American 12-19 2.1 (1.4, 3.1) 97.9 (96.9, 98.6) 0.0 (NA) 4.3 (2.9, 6.2) 95.7 (93.8, 97.1)
20-39 2.3 (1.5, 3.6) 97.7 (96.4, 98.5) 0.0 (NA) 4.7 (3.0, 7.2) 95.3 (92.8, 97.0)
40-59 3.2 (2.2, 4.6) 96.8 (95.4, 97.8) 0.0 (NA) 6.4 (4.4, 9.2) 93.6 (90.8, 95.6)
>=60 3.0 (2.0, 4.5) 97.0 (95.5, 98.0) 0.0 (NA) 6.0 (4.0, 8.9) 94.0 (91.1, 96.0)
rs5030737 C T CC CT TT
Non-Hispanic White 12-19 90.9 (85.9, 94.3) 9.1 (5.7, 14.1) 83.1 (74.5, 89.2) 15.7 (10.1, 23.6) 1.2 (0.3, 4.9)
20-39 91.6 (89.5, 93.4) 8.4 (6.6, 10.5) 84.4 (80.3, 87.7) 14.6 (11.2, 18.8) 1.1 (0.5, 2.3)
40-59 93.6 (91.5, 95.2) 6.4 (4.8, 8.5) 87.5 (83.5, 90.7) 12.2 (9.2, 16.1) 0.3 (0.1, 1.1)
>=60 93.7 (92.1, 95.0) 6.3 (5.0, 7.9) 88.0 (84.8, 90.6) 11.4 (8.8, 14.7) 0.6 (0.3, 1.2)
Non-Hispanic Black 12-19 98.6 (97.6, 99.2) 1.4 (0.8, 2.4) 97.2 (95.3, 98.3) 2.8 (1.7, 4.7) 0.0 (NA)
20-39 98.8 (98.0, 99.3) 1.2 (0.7, 2.0) 97.7 (95.9, 98.7) 2.3 (1.3, 4.1) 0.0 (NA)
40-59 98.8 (98.1, 99.3) 1.2 (0.7, 1.9) 97.7 (96.2, 98.6) 2.3 (1.4, 3.8) 0.0 (NA)
>=60 99.3 (97.8, 99.8) 0.7 (0.2, 2.2) 98.7 (95.6, 99.6) 1.3 (0.4, 4.4) 0.0 (NA)
Mexican American 12-19 95.8 (94.3, 96.9) 4.2 (3.1, 5.7) 91.9 (89.6, 93.8) 7.7 (6.1, 9.7) 0.4 (0.1, 1.9)
20-39 97.5 (96.3, 98.3) 2.5 (1.7, 3.7) 95.1 (92.9, 96.6) 4.8 (3.3, 6.9) 0.1 (0.0, 0.6)
40-59 97.2 (95.8, 98.2) 2.8 (1.8, 4.2) 94.4 (91.6, 96.4) 5.6 (3.6, 8.4) 0.0 (NA)
>=60 97.7 (95.8, 98.8) 2.3 (1.2, 4.2) 95.8 (92.4, 97.7) 3.8 (2.0, 7.1) 0.4 (0.1, 2.4)
rs7096206 C G CC CG GG
Non-Hispanic White 12-19 22.0 (18.2, 26.3) 78.0 (73.7, 81.8) 4.7 (2.1, 10.0) 34.7 (28.3, 41.7) 60.7 (54.0, 67.0)
20-39 21.6 (18.7, 24.8) 78.4 (75.2, 81.3) 5.7 (4.3, 7.6) 31.7 (26.4, 37.5) 62.6 (56.8, 68.0)
40-59 23.7 (19.8, 28.1) 76.3 (71.9, 80.2) 4.8 (2.8, 8.1) 37.8 (32.4, 43.4) 57.4 (50.8, 63.8)
>=60 22.3 (20.2, 24.4) 77.7 (75.6, 79.8) 5.2 (3.4, 7.8) 34.1 (30.6, 37.9) 60.7 (57.3, 63.9)
Non-Hispanic Black 12-19 15.1 (13.0, 17.4) 84.9 (82.6, 87.0) 2.0 (1.2, 3.3) 26.1 (21.6, 31.2) 71.9 (67.2, 76.2)
20-39 15.1 (12.8, 17.6) 84.9 (82.4, 87.2) 1.9 (1.1, 3.2) 26.3 (22.9, 30.1) 71.8 (67.5, 75.7)
40-59 15.4 (13.6, 17.3) 84.6 (82.7, 86.4) 3.0 (1.7, 5.3) 24.7 (21.7, 27.9) 72.3 (69.2, 75.2)
>=60 15.2 (12.1, 18.9) 84.8 (81.1, 87.9) 2.2 (0.9, 5.1) 26.0 (20.3, 32.7) 71.8 (65.2, 77.6)
Mexican American 12-19 12.7 (9.1, 17.6) 87.3 (82.4, 90.9) 3.7 (1.7, 8.2) 18.0 (13.6, 23.3) 78.3 (71.4, 83.9)
20-39 11.1 (9.0, 13.7) 88.9 (86.3, 91.0) 1.9 (1.1, 3.5) 18.4 (14.8, 22.6) 79.7 (75.2, 83.5)
40-59 9.8 (7.3, 12.9) 90.2 (87.1, 92.7) 1.6 (0.6, 4.2) 16.2 (12.2, 21.3) 82.1 (76.8, 86.5)
>=60 13.8 (11.5, 16.4) 86.2 (83.6, 88.5) 2.0 (0.9, 4.7) 23.5 (19.6, 27.8) 74.5 (70.1, 78.5)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs11003125 C G CC CG GG
Non-Hispanic White Male 64.2 (62.2, 66.2) 35.8 (33.8, 37.8) 40.4 (37.9, 42.9) 47.7 (45.2, 50.3) 11.9 (9.8, 14.3)
Female 63.1 (60.7, 65.4) 36.9 (34.6, 39.3) 41.3 (38.1, 44.7) 43.5 (39.1, 48.0) 15.2 (12.3, 18.6)
Non-Hispanic Black Male 86.3 (84.3, 88.0) 13.7 (12.0, 15.7) 74.6 (70.9, 77.9) 23.4 (19.9, 27.2) 2.1 (1.2, 3.4)
Female 87.9 (86.3, 89.3) 12.1 (10.7, 13.7) 77.5 (74.3, 80.4) 20.8 (17.7, 24.3) 1.7 (1.1, 2.7)
Mexican American Male 48.3 (45.1, 51.5) 51.7 (48.5, 54.9) 24.1 (20.2, 28.4) 48.6 (46.0, 51.1) 27.4 (24.8, 30.1)
Female 49.8 (47.7, 51.8) 50.2 (48.2, 52.3) 25.9 (22.9, 29.2) 47.7 (44.1, 51.3) 26.4 (24.2, 28.7)
rs1800450 A G AA AG GG
Non-Hispanic White Male 14.3 (12.4, 16.6) 85.7 (83.4, 87.6) 2.7 (1.9, 3.7) 23.4 (19.8, 27.5) 74.0 (69.9, 77.7)
Female 14.8 (13.2, 16.5) 85.2 (83.5, 86.8) 3.0 (2.1, 4.3) 23.6 (21.4, 25.9) 73.4 (70.8, 75.9)
Non-Hispanic Black Male 4.5 (3.6, 5.7) 95.5 (94.3, 96.4) 0.3 (0.1, 1.1) 8.4 (6.7, 10.5) 91.3 (89.1, 93.0)
Female 3.6 (2.6, 5.0) 96.4 (95.0, 97.4) 0.4 (0.1, 1.0) 6.5 (4.8, 8.8) 93.1 (90.7, 95.0)
Mexican American Male 14.8 (13.0, 16.8) 85.2 (83.2, 87.0) 2.4 (1.4, 4.1) 24.9 (22.4, 27.6) 72.7 (69.7, 75.6)
Female 14.4 (12.0, 17.1) 85.6 (82.9, 88.0) 1.7 (0.9, 3.0) 25.4 (21.6, 29.7) 72.9 (68.2, 77.2)
rs1800451 A G AA AG GG
Non-Hispanic White Male 1.7 (1.2, 2.4) 98.3 (97.6, 98.8) 0.1 (0.0, 0.6) 3.2 (2.2, 4.7) 96.7 (95.3, 97.7)
Female 2.2 (1.6, 3.1) 97.8 (96.9, 98.4) 0.1 (0.0, 0.4) 4.3 (3.1, 5.9) 95.6 (94.0, 96.8)
Non-Hispanic Black Male 22.5 (19.8, 25.3) 77.5 (74.7, 80.2) 6.4 (4.5, 9.2) 32.0 (28.6, 35.7) 61.5 (57.5, 65.4)
Female 24.0 (21.9, 26.1) 76.0 (73.9, 78.1) 5.8 (4.2, 7.8) 36.4 (33.8, 39.1) 57.8 (54.8, 60.8)
Mexican American Male 2.4 (1.7, 3.3) 97.6 (96.7, 98.3) 0.0 (NA) 4.8 (3.4, 6.7) 95.2 (93.3, 96.6)
Female 2.7 (2.1, 3.5) 97.3 (96.5, 97.9) 0.0 (NA) 5.4 (4.1, 6.9) 94.6 (93.1, 95.9)
rs5030737 C T CC CT TT
Non-Hispanic White Male 93.0 (91.1, 94.5) 7.0 (5.5, 8.9) 86.2 (82.6, 89.1) 13.6 (10.7, 17.1) 0.2 (0.0, 1.2)
Female 92.2 (91.2, 93.1) 7.8 (6.9, 8.8) 85.6 (83.8, 87.3) 13.1 (11.2, 15.3) 1.3 (0.7, 2.4)
Non-Hispanic Black Male 99.2 (98.6, 99.5) 0.8 (0.5, 1.4) 98.3 (97.3, 99.0) 1.7 (1.0, 2.7) 0.0 (NA)
Female 98.6 (98.0, 99.1) 1.4 (0.9, 2.0) 97.3 (95.9, 98.2) 2.7 (1.8, 4.1) 0.0 (NA)
Mexican American Male 97.3 (96.3, 98.1) 2.7 (1.9, 3.7) 94.9 (92.9, 96.3) 5.0 (3.6, 6.8) 0.2 (0.1, 0.3)
Female 96.8 (95.8, 97.6) 3.2 (2.4, 4.2) 93.8 (91.9, 95.3) 6.0 (4.5, 7.9) 0.2 (0.0, 0.7)
rs7096206 C G CC CG GG
Non-Hispanic White Male 21.8 (19.7, 24.0) 78.2 (76.0, 80.3) 4.3 (2.5, 7.0) 35.1 (30.1, 40.4) 60.7 (56.3, 64.9)
Female 22.9 (20.5, 25.6) 77.1 (74.4, 79.5) 6.1 (4.7, 8.0) 33.7 (29.6, 38.0) 60.2 (55.8, 64.5)
Non-Hispanic Black Male 14.2 (12.3, 16.3) 85.8 (83.7, 87.7) 1.9 (1.1, 3.2) 24.5 (21.2, 28.2) 73.5 (69.8, 77.0)
Female 15.9 (14.0, 18.1) 84.1 (81.9, 86.0) 2.5 (1.7, 3.7) 26.9 (23.5, 30.6) 70.6 (66.7, 74.2)
Mexican American Male 10.4 (8.6, 12.7) 89.6 (87.3, 91.4) 2.4 (1.5, 3.9) 16.1 (13.5, 19.1) 81.5 (77.9, 84.6)
Female 12.4 (10.1, 15.1) 87.6 (84.9, 89.9) 2.1 (1.2, 3.6) 20.5 (16.9, 24.8) 77.4 (72.7, 81.4)


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