Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

U.S. Genome Variation Estimates

ITGB3 Allele and Genotype Frequencies

 

Available polymorphism(s)

rs number

Common Designations

Nucleotide change                  Amino acid

Genotyping method

rs5918

Ex3+11T>C

Leu59Pro

MGB Eclipse



Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity 

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs5918 C T   CC CT TT    
Non-Hispanic White 16.3 (15.0, 17.6) 83.7 (82.4, 85.0) <0.001 2.7 (1.8, 4.0) 27.2 (25.1, 29.4) 70.1 (67.9, 72.2) <0.001 0.81
Non-Hispanic Black 10.1 (9.2, 11.0) 89.9 (89.0, 90.8) 1.1 (0.7, 1.7) 18.0 (16.3, 19.8) 81.0 (79.2, 82.6) 0.59
Mexican American 9.7 (8.2, 11.3) 90.3 (88.7, 91.8) 1.3 (0.8, 2.1) 16.8 (14.8, 19.0) 81.9 (79.2, 84.4) 0.22
Total* 14.4 (13.3, 15.6) 85.6 (84.4, 86.7)   2.2 (1.5, 3.3) 24.4 (22.7, 26.2) 73.4 (71.4, 75.2)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

Top of Page


 

By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs5918 C T   CC CT TT  
12-19 12.6 (10.2, 15.4) 87.4 (84.6, 89.8) 0.306 1.7 (0.7, 4.4) 21.7 (18.3, 25.7) 76.5 (72.1, 80.4) 0.629
20-39 14.4 (12.7, 16.4) 85.6 (83.6, 87.3) 2.4 (1.3, 4.4) 24.0 (21.5, 26.7) 73.6 (70.7, 76.3)
40-59 15.3 (13.4, 17.3) 84.7 (82.7, 86.6) 2.2 (1.2, 3.9) 26.2 (22.5, 30.4) 71.6 (67.8, 75.2)
>=60 14.5 (13.3, 15.9) 85.5 (84.1, 86.7) 2.3 (1.7, 3.1) 24.5 (22.4, 26.7) 73.2 (70.9, 75.5)
Total 14.4 (13.3, 15.6) 85.6 (84.4, 86.7)   2.2 (1.5, 3.3) 24.4 (22.7, 26.2) 73.4 (71.4, 75.2)  

* Includes all participants, regardless of race/ethnicity.

Top of Page


 

By Sex* 

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs5918 C T CC CT TT
Male 14.3 (12.6, 16.1) 85.7 (83.9, 87.4) 0.762 2.7 (1.8, 4.1) 23.1 (20.3, 26.2) 74.2 (71.0, 77.1) 0.069
Female 14.6 (13.3, 16.0) 85.4 (84.0, 86.7) 1.8 (1.1, 2.9) 25.6 (23.7, 27.5) 72.6 (70.4, 74.8)
Total 14.4 (13.3, 15.6) 85.6 (84.4, 86.7)   2.2 (1.5, 3.3) 24.4 (22.7, 26.2) 73.4 (71.4, 75.2)  

* Includes all participants, regardless of race/ethnicity.

Top of Page


 

By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs5918 C T CC CT TT
Non-Hispanic White 12-19 14.3 (11.1, 18.1) 85.7 (81.9, 88.9) 1.7 (0.5, 5.2) 25.1 (19.7, 31.6) 73.2 (66.6, 78.9)
20-39 16.8 (14.7, 19.2) 83.2 (80.8, 85.3) 3.1 (1.6, 6.0) 27.4 (24.4, 30.6) 69.5 (66.1, 72.6)
40-59 16.8 (14.7, 19.0) 83.2 (81.0, 85.3) 2.6 (1.3, 5.0) 28.4 (24.5, 32.8) 69.0 (65.0, 72.7)
>=60 15.8 (14.3, 17.4) 84.2 (82.6, 85.7) 2.6 (1.8, 3.7) 26.4 (24.2, 28.7) 71.0 (68.4, 73.5)
Non-Hispanic Black 12-19 9.2 (7.6, 11.1) 90.8 (88.9, 92.4) 1.0 (0.5, 1.7) 16.4 (13.6, 19.7) 82.6 (79.1, 85.6)
20-39 10.1 (8.7, 11.8) 89.9 (88.2, 91.3) 0.9 (0.4, 1.9) 18.4 (15.5, 21.9) 80.6 (77.4, 83.6)
40-59 10.9 (9.1, 13.2) 89.1 (86.8, 90.9) 1.6 (0.7, 3.4) 18.7 (15.5, 22.4) 79.7 (75.9, 83.0)
>=60 9.4 (6.8, 12.7) 90.6 (87.3, 93.2) 0.8 (0.2, 3.2) 17.2 (12.2, 23.7) 82.0 (75.6, 87.0)
Mexican American 12-19 7.5 (4.9, 11.5) 92.5 (88.5, 95.1) 0.0 (NA) 15.1 (9.7, 22.7) 84.9 (77.3, 90.3)
20-39 10.9 (9.3, 12.8) 89.1 (87.2, 90.7) 2.0 (1.1, 3.7) 17.8 (15.4, 20.5) 80.2 (77.2, 82.9)
40-59 8.6 (6.9, 10.7) 91.4 (89.3, 93.1) 0.6 (0.2, 2.1) 16.1 (13.3, 19.2) 83.3 (79.8, 86.4)
>=60 10.0 (6.5, 15.0) 90.0 (85.0, 93.5) 1.6 (0.2, 10.3) 16.8 (11.7, 23.7) 81.6 (74.1, 87.3)

Top of Page


 

By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs5918 C T CC CT TT
Non-Hispanic White Male 16.3 (14.3, 18.5) 83.7 (81.5, 85.7) 3.2 (2.1, 4.9) 26.2 (22.7, 30.0) 70.6 (66.8, 74.1)
Female 16.3 (14.7, 18.0) 83.7 (82.0, 85.3) 2.2 (1.3, 3.6) 28.2 (25.8, 30.7) 69.7 (66.9, 72.3)
Non-Hispanic Black Male 9.6 (8.5, 10.8) 90.4 (89.2, 91.5) 1.0 (0.5, 2.0) 17.1 (15.2, 19.2) 81.9 (79.7, 83.8)
Female 10.5 (9.4, 11.7) 89.5 (88.3, 90.6) 1.1 (0.6, 2.1) 18.7 (16.4, 21.2) 80.2 (77.9, 82.3)
Mexican American Male 10.2 (8.7, 11.8) 89.8 (88.2, 91.3) 1.4 (0.7, 2.7) 17.5 (14.9, 20.5) 81.1 (78.1, 83.7)
Female 9.1 (7.2, 11.5) 90.9 (88.5, 92.8) 1.1 (0.5, 2.4) 16.0 (12.8, 19.9) 82.9 (78.7, 86.3)


Top of Page

 
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30333, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO
A-Z Index
  1. A
  2. B
  3. C
  4. D
  5. E
  6. F
  7. G
  8. H
  9. I
  10. J
  11. K
  12. L
  13. M
  14. N
  15. O
  16. P
  17. Q
  18. R
  19. S
  20. T
  21. U
  22. V
  23. W
  24. X
  25. Y
  26. Z
  27. #