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U.S. Genome Variation Estimates

ITGB3 Allele and Genotype Frequencies

Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs5918

Ex3+11T>C

Leu59Pro

MGB Eclipse



Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs5918CTCCCTTT
Non-Hispanic White16.3 (15.0, 17.6)83.7 (82.4, 85.0)<0.0012.7 (1.8, 4.0)27.2 (25.1, 29.4)70.1 (67.9, 72.2)<0.0010.81
Non-Hispanic Black10.1 (9.2, 11.0)89.9 (89.0, 90.8)1.1 (0.7, 1.7)18.0 (16.3, 19.8)81.0 (79.2, 82.6)0.59
Mexican American9.7 (8.2, 11.3)90.3 (88.7, 91.8)1.3 (0.8, 2.1)16.8 (14.8, 19.0)81.9 (79.2, 84.4)0.22
Total*14.4 (13.3, 15.6)85.6 (84.4, 86.7)2.2 (1.5, 3.3)24.4 (22.7, 26.2)73.4 (71.4, 75.2)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs5918CTCCCTTT
12-1912.6 (10.2, 15.4)87.4 (84.6, 89.8)0.3061.7 (0.7, 4.4)21.7 (18.3, 25.7)76.5 (72.1, 80.4)0.629
20-3914.4 (12.7, 16.4)85.6 (83.6, 87.3)2.4 (1.3, 4.4)24.0 (21.5, 26.7)73.6 (70.7, 76.3)
40-5915.3 (13.4, 17.3)84.7 (82.7, 86.6)2.2 (1.2, 3.9)26.2 (22.5, 30.4)71.6 (67.8, 75.2)
>=6014.5 (13.3, 15.9)85.5 (84.1, 86.7)2.3 (1.7, 3.1)24.5 (22.4, 26.7)73.2 (70.9, 75.5)
Total14.4 (13.3, 15.6)85.6 (84.4, 86.7)2.2 (1.5, 3.3)24.4 (22.7, 26.2)73.4 (71.4, 75.2)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs5918CTCCCTTT
Male14.3 (12.6, 16.1)85.7 (83.9, 87.4)0.7622.7 (1.8, 4.1)23.1 (20.3, 26.2)74.2 (71.0, 77.1)0.069
Female14.6 (13.3, 16.0)85.4 (84.0, 86.7)1.8 (1.1, 2.9)25.6 (23.7, 27.5)72.6 (70.4, 74.8)
Total14.4 (13.3, 15.6)85.6 (84.4, 86.7)2.2 (1.5, 3.3)24.4 (22.7, 26.2)73.4 (71.4, 75.2)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs5918CTCCCTTT
Non-Hispanic White12-1914.3 (11.1, 18.1)85.7 (81.9, 88.9)1.7 (0.5, 5.2)25.1 (19.7, 31.6)73.2 (66.6, 78.9)
20-3916.8 (14.7, 19.2)83.2 (80.8, 85.3)3.1 (1.6, 6.0)27.4 (24.4, 30.6)69.5 (66.1, 72.6)
40-5916.8 (14.7, 19.0)83.2 (81.0, 85.3)2.6 (1.3, 5.0)28.4 (24.5, 32.8)69.0 (65.0, 72.7)
>=6015.8 (14.3, 17.4)84.2 (82.6, 85.7)2.6 (1.8, 3.7)26.4 (24.2, 28.7)71.0 (68.4, 73.5)
Non-Hispanic Black12-199.2 (7.6, 11.1)90.8 (88.9, 92.4)1.0 (0.5, 1.7)16.4 (13.6, 19.7)82.6 (79.1, 85.6)
20-3910.1 (8.7, 11.8)89.9 (88.2, 91.3)0.9 (0.4, 1.9)18.4 (15.5, 21.9)80.6 (77.4, 83.6)
40-5910.9 (9.1, 13.2)89.1 (86.8, 90.9)1.6 (0.7, 3.4)18.7 (15.5, 22.4)79.7 (75.9, 83.0)
>=609.4 (6.8, 12.7)90.6 (87.3, 93.2)0.8 (0.2, 3.2)17.2 (12.2, 23.7)82.0 (75.6, 87.0)
Mexican American12-197.5 (4.9, 11.5)92.5 (88.5, 95.1)0.0 (NA)15.1 (9.7, 22.7)84.9 (77.3, 90.3)
20-3910.9 (9.3, 12.8)89.1 (87.2, 90.7)2.0 (1.1, 3.7)17.8 (15.4, 20.5)80.2 (77.2, 82.9)
40-598.6 (6.9, 10.7)91.4 (89.3, 93.1)0.6 (0.2, 2.1)16.1 (13.3, 19.2)83.3 (79.8, 86.4)
>=6010.0 (6.5, 15.0)90.0 (85.0, 93.5)1.6 (0.2, 10.3)16.8 (11.7, 23.7)81.6 (74.1, 87.3)

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By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs5918CTCCCTTT
Non-Hispanic WhiteMale16.3 (14.3, 18.5)83.7 (81.5, 85.7)3.2 (2.1, 4.9)26.2 (22.7, 30.0)70.6 (66.8, 74.1)
Female16.3 (14.7, 18.0)83.7 (82.0, 85.3)2.2 (1.3, 3.6)28.2 (25.8, 30.7)69.7 (66.9, 72.3)
Non-Hispanic BlackMale9.6 (8.5, 10.8)90.4 (89.2, 91.5)1.0 (0.5, 2.0)17.1 (15.2, 19.2)81.9 (79.7, 83.8)
Female10.5 (9.4, 11.7)89.5 (88.3, 90.6)1.1 (0.6, 2.1)18.7 (16.4, 21.2)80.2 (77.9, 82.3)
Mexican AmericanMale10.2 (8.7, 11.8)89.8 (88.2, 91.3)1.4 (0.7, 2.7)17.5 (14.9, 20.5)81.1 (78.1, 83.7)
Female9.1 (7.2, 11.5)90.9 (88.5, 92.8)1.1 (0.5, 2.4)16.0 (12.8, 19.9)82.9 (78.7, 86.3)


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