Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

U.S. Genome Variation Estimates

IL4 Allele and Genotype Frequencies

Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs2243248

-1098T>G

TaqMan

rs2243250

-588C>T
-524C>T
-590C>T

TaqMan

rs2243270

IVS2-1297A>G

TaqMan



Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs2243248GTGGGTTT
Non-Hispanic White7.5 (6.7, 8.4)92.5 (91.6, 93.3)<0.0010.4 (0.2, 0.8)14.1 (12.7, 15.7)85.4 (83.7, 87.0)<0.0010.68
Non-Hispanic Black15.7 (14.3, 17.3)84.3 (82.7, 85.7)2.5 (1.7, 3.5)26.6 (24.3, 29.0)71.0 (68.3, 73.5)0.46
Mexican American12.0 (10.0, 14.4)88.0 (85.6, 90.0)1.9 (1.3, 2.8)20.3 (17.1, 23.9)77.8 (73.7, 81.4)0.03
Total*9.0 (8.1, 9.9)91.0 (90.1, 91.9)0.8 (0.6, 1.1)16.3 (14.8, 18.0)82.9 (81.1, 84.5)
rs2243250CTCCCTTT
Non-Hispanic White84.0 (82.7, 85.2)16.0 (14.8, 17.3)<0.00170.8 (68.9, 72.6)26.4 (24.9, 28.0)2.8 (2.0, 4.0)<0.0010.53
Non-Hispanic Black36.0 (34.2, 37.9)64.0 (62.1, 65.8)14.1 (12.3, 16.2)43.8 (41.0, 46.7)42.0 (39.4, 44.7)0.03
Mexican American57.7 (55.6, 59.8)42.3 (40.2, 44.4)34.3 (30.9, 37.8)46.9 (43.3, 50.5)18.9 (17.1, 20.7)0.07
Total*74.5 (72.7, 76.2)25.5 (23.8, 27.3)58.9 (56.6, 61.1)31.2 (29.6, 32.9)9.9 (8.6, 11.4)
rs2243270AGAAAGGG
Non-Hispanic White83.6 (82.4, 84.8)16.4 (15.2, 17.6)<0.00169.9 (68.1, 71.7)27.4 (25.8, 29.1)2.6 (1.8, 3.8)<0.0010.71
Non-Hispanic Black36.3 (34.6, 38.1)63.7 (61.9, 65.4)14.5 (13.4, 15.8)43.5 (40.4, 46.7)41.9 (38.9, 45.0)0.01
Mexican American58.2 (55.7, 60.7)41.8 (39.3, 44.3)34.9 (31.5, 38.6)46.6 (43.3, 49.9)18.5 (16.2, 21.0)0.08
Total*74.3 (72.4, 76.0)25.7 (24.0, 27.6)58.3 (55.9, 60.7)31.8 (30.1, 33.6)9.8 (8.4, 11.4)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

Top of Page


By Age*


VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs2243248GTGGGTTT
12-199.9 (8.1, 11.9)90.1 (88.1, 91.9)0.1141.1 (0.4, 3.2)17.5 (15.1, 20.1)81.4 (78.2, 84.2)0.045
20-399.5 (7.9, 11.2)90.5 (88.8, 92.1)0.7 (0.5, 1.0)17.4 (14.6, 20.7)81.8 (78.5, 84.8)
40-599.2 (7.6, 11.0)90.8 (89.0, 92.4)0.9 (0.5, 1.8)16.4 (13.6, 19.7)82.6 (79.3, 85.6)
>=607.2 (6.0, 8.5)92.8 (91.5, 94.0)0.5 (0.2, 1.2)13.2 (11.2, 15.6)86.2 (83.8, 88.3)
Total9.0 (8.1, 9.9)91.0 (90.1, 91.9)0.8 (0.6, 1.1)16.3 (14.8, 18.0)82.9 (81.1, 84.5)
rs2243250CTCCCTTT
12-1971.7 (67.8, 75.4)28.3 (24.6, 32.2)0.01554.9 (49.9, 59.9)33.6 (29.6, 37.8)11.5 (8.4, 15.5)0.079
20-3973.0 (70.0, 75.9)27.0 (24.1, 30.0)57.3 (53.1, 61.4)31.5 (28.5, 34.8)11.2 (9.2, 13.6)
40-5976.1 (73.4, 78.5)23.9 (21.5, 26.6)61.2 (57.1, 65.1)29.8 (26.1, 33.7)9.0 (7.2, 11.4)
>=6077.1 (75.3, 78.7)22.9 (21.3, 24.7)61.5 (58.9, 64.1)31.1 (28.3, 33.9)7.4 (5.9, 9.2)
Total74.5 (72.7, 76.2)25.5 (23.8, 27.3)58.9 (56.6, 61.1)31.2 (29.6, 32.9)9.9 (8.6, 11.4)
rs2243270AGAAAGGG
12-1971.4 (67.5, 75.0)28.6 (25.0, 32.5)0.01654.3 (49.5, 59.0)34.3 (30.4, 38.4)11.4 (8.2, 15.7)0.100
20-3972.8 (69.5, 75.8)27.2 (24.2, 30.5)56.9 (52.4, 61.2)31.7 (28.7, 34.9)11.4 (9.3, 13.9)
40-5976.0 (73.3, 78.5)24.0 (21.5, 26.7)60.7 (56.2, 65.1)30.5 (26.2, 35.3)8.8 (6.9, 11.1)
>=6076.8 (74.9, 78.6)23.2 (21.4, 25.1)60.7 (57.7, 63.6)32.2 (29.3, 35.3)7.1 (5.5, 8.9)
Total74.3 (72.4, 76.0)25.7 (24.0, 27.6)58.3 (55.9, 60.7)31.8 (30.1, 33.6)9.8 (8.4, 11.4)

* Includes all participants, regardless of race/ethnicity.

Top of Page


By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs2243248GTGGGTTT
Male9.3 (8.3, 10.6)90.7 (89.4, 91.7)0.2020.7 (0.4, 1.2)17.3 (15.1, 19.7)82.0 (79.6, 84.2)0.315
Female8.6 (7.6, 9.7)91.4 (90.3, 92.4)0.9 (0.5, 1.6)15.4 (13.8, 17.2)83.7 (81.7, 85.4)
Total9.0 (8.1, 9.9)91.0 (90.1, 91.9)0.8 (0.6, 1.1)16.3 (14.8, 18.0)82.9 (81.1, 84.5)
rs2243250CTCCCTTT
Male75.2 (72.9, 77.3)24.8 (22.7, 27.1)0.11259.7 (56.3, 63.0)31.0 (28.5, 33.8)9.3 (7.9, 10.9)0.095
Female73.8 (72.2, 75.4)26.2 (24.6, 27.8)58.1 (55.7, 60.5)31.4 (29.0, 33.9)10.5 (9.0, 12.2)
Total74.5 (72.7, 76.2)25.5 (23.8, 27.3)58.9 (56.6, 61.1)31.2 (29.6, 32.9)9.9 (8.6, 11.4)
rs2243270AGAAAGGG
Male74.9 (72.6, 77.2)25.1 (22.8, 27.4)0.15659.2 (55.6, 62.6)31.6 (28.8, 34.4)9.3 (7.9, 10.9)0.217
Female73.6 (71.9, 75.3)26.4 (24.7, 28.1)57.6 (55.2, 60.0)32.1 (29.8, 34.5)10.3 (8.7, 12.2)
Total74.3 (72.4, 76.0)25.7 (24.0, 27.6)58.3 (55.9, 60.7)31.8 (30.1, 33.6)9.8 (8.4, 11.4)

* Includes all participants, regardless of race/ethnicity.

Top of Page


By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs2243248GTGGGTTT
Non-Hispanic White12-198.3 (5.9, 11.6)91.7 (88.4, 94.1)0.8 (0.1, 7.1)15.1 (12.1, 18.6)84.2 (79.5, 87.9)
20-397.5 (5.9, 9.4)92.5 (90.6, 94.1)0.3 (0.1, 0.7)14.4 (11.3, 18.1)85.3 (81.6, 88.4)
40-598.6 (6.9, 10.7)91.4 (89.3, 93.1)0.5 (0.1, 2.1)16.2 (13.1, 19.9)83.3 (79.5, 86.5)
>=605.7 (4.7, 6.8)94.3 (93.2, 95.3)0.4 (0.1, 1.3)10.4 (8.7, 12.5)89.1 (87.0, 90.9)
Non-Hispanic Black12-1916.1 (12.2, 21.1)83.9 (78.9, 87.8)2.7 (1.3, 5.3)26.9 (21.4, 33.2)70.4 (62.6, 77.2)
20-3916.7 (15.4, 18.0)83.3 (82.0, 84.6)2.5 (1.7, 3.7)28.3 (26.0, 30.7)69.2 (66.9, 71.4)
40-5913.7 (11.1, 16.9)86.3 (83.1, 88.9)2.7 (1.1, 6.1)22.2 (18.0, 27.1)75.2 (70.2, 79.5)
>=6016.0 (12.5, 20.1)84.0 (79.9, 87.5)1.7 (0.5, 5.1)28.6 (22.3, 35.9)69.7 (62.4, 76.2)
Mexican American12-1910.4 (6.8, 15.5)89.6 (84.5, 93.2)1.8 (0.8, 3.9)17.1 (11.4, 24.8)81.1 (72.4, 87.5)
20-3913.7 (10.8, 17.1)86.3 (82.9, 89.2)1.7 (0.7, 4.2)23.9 (20.0, 28.3)74.4 (69.0, 79.1)
40-5911.2 (8.5, 14.5)88.8 (85.5, 91.5)2.5 (1.0, 6.0)17.4 (14.2, 21.2)80.1 (75.4, 84.1)
>=608.4 (6.1, 11.5)91.6 (88.5, 93.9)1.6 (0.8, 3.3)13.7 (10.0, 18.3)84.7 (79.5, 88.8)
rs2243250CTCCCTTT
Non-Hispanic White12-1983.4 (79.5, 86.6)16.6 (13.4, 20.5)69.4 (62.4, 75.6)27.9 (21.7, 35.2)2.7 (1.2, 5.9)
20-3984.3 (82.1, 86.3)15.7 (13.7, 17.9)72.1 (68.6, 75.4)24.4 (21.0, 28.1)3.5 (2.1, 5.8)
40-5984.2 (81.4, 86.6)15.8 (13.4, 18.6)70.5 (65.9, 74.7)27.4 (23.7, 31.5)2.1 (1.2, 3.9)
>=6083.6 (81.3, 85.6)16.4 (14.4, 18.7)69.8 (65.8, 73.5)27.6 (24.2, 31.4)2.6 (1.7, 3.9)
Non-Hispanic Black12-1938.2 (34.6, 42.0)61.8 (58.0, 65.4)16.7 (13.6, 20.4)43.0 (37.2, 49.1)40.2 (34.6, 46.1)
20-3935.5 (32.9, 38.2)64.5 (61.8, 67.1)13.1 (10.6, 16.0)44.9 (40.4, 49.4)42.0 (38.0, 46.2)
40-5934.9 (31.7, 38.1)65.1 (61.9, 68.3)13.6 (10.4, 17.7)42.5 (37.8, 47.3)43.9 (39.7, 48.2)
>=6036.8 (31.9, 42.0)63.2 (58.0, 68.1)14.7 (9.9, 21.2)44.2 (38.9, 49.7)41.1 (35.3, 47.1)
Mexican American12-1960.0 (56.8, 63.2)40.0 (36.8, 43.2)36.5 (32.9, 40.3)47.1 (39.5, 54.8)16.4 (11.2, 23.5)
20-3956.3 (52.5, 60.0)43.7 (40.0, 47.5)32.5 (26.3, 39.5)47.5 (41.3, 53.7)20.0 (18.2, 21.9)
40-5958.6 (54.1, 63.0)41.4 (37.0, 45.9)35.5 (28.8, 42.8)46.2 (37.3, 55.3)18.3 (13.3, 24.6)
>=6058.5 (53.6, 63.3)41.5 (36.7, 46.4)36.3 (31.0, 42.0)44.5 (37.8, 51.3)19.2 (13.7, 26.4)
rs2243270AGAAAGGG
Non-Hispanic White12-1983.3 (79.6, 86.4)16.7 (13.6, 20.4)68.9 (61.8, 75.2)28.7 (22.0, 36.5)2.4 (1.0, 5.6)
20-3983.9 (81.7, 85.8)16.1 (14.2, 18.3)71.1 (67.9, 74.1)25.5 (22.6, 28.6)3.4 (2.0, 5.7)
40-5983.9 (81.0, 86.4)16.1 (13.6, 19.0)69.8 (64.6, 74.5)28.1 (23.6, 33.2)2.0 (1.2, 3.5)
>=6083.2 (80.6, 85.5)16.8 (14.5, 19.4)68.6 (64.3, 72.6)29.1 (25.5, 32.9)2.3 (1.3, 4.0)
Non-Hispanic Black12-1936.9 (33.4, 40.7)63.1 (59.3, 66.6)14.8 (11.6, 18.8)44.3 (39.4, 49.2)40.9 (36.0, 46.1)
20-3935.8 (32.8, 38.9)64.2 (61.1, 67.2)14.7 (12.7, 16.8)42.2 (38.4, 46.2)43.1 (38.5, 47.8)
40-5935.7 (32.7, 38.9)64.3 (61.1, 67.3)13.5 (10.8, 16.6)44.5 (37.2, 52.1)42.0 (35.9, 48.3)
>=6038.2 (33.5, 43.1)61.8 (56.9, 66.5)15.8 (11.2, 21.8)44.8 (36.9, 53.0)39.4 (32.5, 46.8)
Mexican American12-1960.5 (57.4, 63.5)39.5 (36.5, 42.6)37.1 (34.1, 40.2)46.8 (39.7, 54.0)16.1 (11.0, 22.9)
20-3957.0 (53.1, 60.9)43.0 (39.1, 46.9)33.4 (27.3, 40.2)47.2 (41.6, 52.8)19.4 (17.5, 21.4)
40-5959.0 (54.3, 63.6)41.0 (36.4, 45.7)35.9 (29.1, 43.2)46.3 (38.1, 54.7)17.9 (13.2, 23.8)
>=6058.1 (52.7, 63.3)41.9 (36.7, 47.3)36.6 (31.3, 42.3)43.1 (34.8, 51.8)20.4 (13.5, 29.4)

Top of Page


By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs2243248GTGGGTTT
Non-Hispanic WhiteMale8.5 (7.4, 9.7)91.5 (90.3, 92.6)0.5 (0.2, 1.3)16.0 (13.6, 18.7)83.5 (81.0, 85.8)
Female6.6 (5.8, 7.5)93.4 (92.5, 94.2)0.4 (0.1, 1.4)12.3 (10.9, 14.0)87.2 (85.6, 88.7)
Non-Hispanic BlackMale15.8 (14.2, 17.6)84.2 (82.4, 85.8)2.5 (1.5, 4.1)26.7 (23.8, 29.8)70.8 (67.8, 73.7)
Female15.7 (13.9, 17.7)84.3 (82.3, 86.1)2.5 (1.6, 3.9)26.4 (23.3, 29.7)71.1 (67.7, 74.3)
Mexican AmericanMale12.0 (10.2, 14.2)88.0 (85.8, 89.8)1.4 (0.9, 2.2)21.2 (18.2, 24.6)77.3 (73.6, 80.7)
Female12.0 (9.4, 15.2)88.0 (84.8, 90.6)2.4 (1.4, 4.1)19.3 (15.6, 23.7)78.3 (73.1, 82.7)
rs2243250CTCCCTTT
Non-Hispanic WhiteMale84.4 (82.4, 86.1)15.6 (13.9, 17.6)71.4 (68.3, 74.4)25.8 (22.9, 29.0)2.7 (1.6, 4.7)
Female83.7 (82.0, 85.2)16.3 (14.8, 18.0)70.2 (67.4, 72.8)27.0 (24.5, 29.6)2.9 (1.9, 4.2)
Non-Hispanic BlackMale35.2 (31.6, 38.9)64.8 (61.1, 68.4)13.4 (10.4, 16.9)43.6 (39.7, 47.6)43.0 (38.3, 47.9)
Female36.8 (34.3, 39.3)63.2 (60.7, 65.7)14.8 (12.5, 17.3)44.0 (40.3, 47.8)41.2 (37.5, 45.0)
Mexican AmericanMale57.1 (54.2, 60.0)42.9 (40.0, 45.8)32.6 (27.4, 38.2)49.0 (43.1, 54.9)18.4 (16.2, 20.9)
Female58.4 (56.7, 60.1)41.6 (39.9, 43.3)36.1 (33.9, 38.3)44.6 (42.1, 47.2)19.3 (17.4, 21.4)
rs2243270AGAAAGGG
Non-Hispanic WhiteMale84.0 (82.1, 85.9)16.0 (14.1, 17.9)70.8 (67.5, 73.8)26.5 (23.4, 29.9)2.7 (1.5, 4.8)
Female83.2 (81.7, 84.7)16.8 (15.3, 18.3)69.1 (66.5, 71.6)28.3 (25.9, 30.8)2.6 (1.8, 3.8)
Non-Hispanic BlackMale35.0 (32.0, 38.1)65.0 (61.9, 68.0)13.4 (11.1, 16.0)43.3 (39.0, 47.7)43.3 (38.7, 48.1)
Female37.4 (35.2, 39.6)62.6 (60.4, 64.8)15.5 (13.6, 17.7)43.7 (40.4, 47.1)40.8 (37.5, 44.1)
Mexican AmericanMale57.7 (54.3, 61.1)42.3 (38.9, 45.7)33.5 (28.5, 38.9)48.5 (43.7, 53.3)18.0 (15.5, 20.9)
Female58.8 (56.7, 60.8)41.2 (39.2, 43.3)36.5 (34.1, 39.0)44.6 (41.9, 47.2)18.9 (16.6, 21.5)


Top of Page

Top