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U.S. Genome Variation Estimates

IL1B Allele and Genotype Frequencies

Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs1143623

-2022G>C

TaqMan



Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1143623CGCCCGGG
Non-Hispanic White28.5 (26.0, 31.1)71.5 (68.9, 74.0)<0.0019.0 (7.2, 11.1)39.1 (36.8, 41.4)52.0 (48.5, 55.4)<0.0010.76
Non-Hispanic Black11.2 (10.0, 12.7)88.8 (87.3, 90.0)1.1 (0.6, 1.9)20.3 (18.4, 22.3)78.6 (76.3, 80.8)0.58
Mexican American42.9 (40.5, 45.4)57.1 (54.6, 59.5)19.4 (16.9, 22.2)47.1 (44.1, 50.2)33.5 (30.4, 36.8)0.44
Total*28.7 (26.5, 31.0)71.3 (69.0, 73.5)9.6 (7.9, 11.6)38.1 (36.4, 39.9)52.2 (49.4, 55.0)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1143623CGCCCGGG
12-1929.0 (23.4, 35.4)71.0 (64.6, 76.6)0.38610.0 (6.0, 16.3)38.0 (31.3, 45.1)52.0 (43.6, 60.3)0.362
20-3928.9 (26.9, 31.0)71.1 (69.0, 73.1)9.8 (7.4, 12.9)38.3 (35.6, 41.1)51.9 (49.7, 54.0)
40-5929.9 (26.3, 33.8)70.1 (66.2, 73.7)11.0 (8.3, 14.3)37.9 (33.7, 42.3)51.1 (45.7, 56.5)
>=6026.3 (23.5, 29.3)73.7 (70.7, 76.5)7.1 (5.3, 9.6)38.2 (34.3, 42.3)54.6 (50.1, 59.1)
Total28.7 (26.5, 31.0)71.3 (69.0, 73.5)9.6 (7.9, 11.6)38.1 (36.4, 39.9)52.2 (49.4, 55.0)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1143623CGCCCGGG
Male29.6 (26.8, 32.6)70.4 (67.4, 73.2)0.11510.3 (8.3, 12.8)38.6 (35.5, 41.8)51.1 (47.0, 55.2)0.338
Female27.9 (25.8, 30.0)72.1 (70.0, 74.2)9.0 (7.0, 11.4)37.7 (35.3, 40.2)53.3 (50.7, 55.9)
Total28.7 (26.5, 31.0)71.3 (69.0, 73.5)9.6 (7.9, 11.6)38.1 (36.4, 39.9)52.2 (49.4, 55.0)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs1143623CGCCCGGG
Non-Hispanic White12-1930.0 (23.7, 37.2)70.0 (62.8, 76.3)9.4 (5.3, 16.1)41.2 (31.8, 51.2)49.4 (39.0, 59.9)
20-3927.8 (25.5, 30.3)72.2 (69.7, 74.5)8.7 (6.2, 12.0)38.3 (35.3, 41.5)53.0 (50.2, 55.8)
40-5930.1 (25.9, 34.8)69.9 (65.2, 74.1)10.3 (7.5, 13.8)39.8 (34.0, 45.9)50.0 (43.1, 56.8)
>=6026.6 (23.3, 30.1)73.4 (69.9, 76.7)7.5 (5.3, 10.4)38.2 (34.1, 42.5)54.3 (49.3, 59.3)
Non-Hispanic Black12-1912.0 (9.5, 15.0)88.0 (85.0, 90.5)0.8 (0.4, 1.6)22.4 (17.5, 28.1)76.9 (71.1, 81.8)
20-3912.2 (10.2, 14.6)87.8 (85.4, 89.8)1.4 (0.8, 2.6)21.7 (18.4, 25.4)76.9 (72.9, 80.5)
40-599.6 (7.1, 12.9)90.4 (87.1, 92.9)1.1 (0.3, 3.8)17.0 (13.0, 22.0)81.9 (76.4, 86.3)
>=6010.1 (7.5, 13.4)89.9 (86.6, 92.5)0.4 (0.1, 3.6)19.2 (13.6, 26.5)80.3 (73.5, 85.7)
Mexican American12-1939.3 (36.5, 42.2)60.7 (57.8, 63.5)17.9 (14.8, 21.4)42.9 (36.4, 49.7)39.2 (34.1, 44.6)
20-3944.9 (41.2, 48.6)55.1 (51.4, 58.8)20.9 (17.1, 25.3)47.9 (44.5, 51.3)31.2 (27.3, 35.3)
40-5942.9 (37.3, 48.8)57.1 (51.2, 62.7)19.1 (13.8, 25.7)47.7 (40.1, 55.5)33.2 (25.9, 41.4)
>=6040.0 (37.1, 43.0)60.0 (57.0, 62.9)14.6 (10.9, 19.3)50.9 (44.6, 57.1)34.5 (30.2, 39.2)

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By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs1143623CGCCCGGG
Non-Hispanic WhiteMale28.9 (25.9, 32.0)71.1 (68.0, 74.1)9.3 (7.4, 11.7)39.1 (35.1, 43.2)51.6 (46.9, 56.3)
Female28.1 (25.3, 31.2)71.9 (68.8, 74.7)8.6 (6.3, 11.7)39.0 (35.9, 42.3)52.3 (48.4, 56.2)
Non-Hispanic BlackMale11.3 (9.9, 12.8)88.7 (87.2, 90.1)1.2 (0.5, 2.9)20.1 (18.0, 22.4)78.7 (76.2, 80.9)
Female11.2 (9.6, 13.1)88.8 (86.9, 90.4)1.0 (0.5, 1.9)20.5 (17.8, 23.4)78.6 (75.3, 81.5)
Mexican AmericanMale44.5 (40.9, 48.2)55.5 (51.8, 59.1)21.6 (17.9, 25.7)46.0 (40.8, 51.3)32.5 (27.7, 37.7)
Female41.2 (39.1, 43.4)58.8 (56.6, 60.9)17.1 (14.6, 19.9)48.3 (44.7, 51.9)34.6 (31.8, 37.5)


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