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U.S. Genome Variation Estimates

IL1B Allele and Genotype Frequencies

 

Available polymorphism(s)

rs number

Common Designations

Nucleotide change                  Amino acid

Genotyping method

rs1143623

-2022G>C

 

TaqMan



Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity  

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1143623 C G   CC CG GG    
Non-Hispanic White 28.5 (26.0, 31.1) 71.5 (68.9, 74.0) <0.001 9.0 (7.2, 11.1) 39.1 (36.8, 41.4) 52.0 (48.5, 55.4) <0.001 0.76
Non-Hispanic Black 11.2 (10.0, 12.7) 88.8 (87.3, 90.0) 1.1 (0.6, 1.9) 20.3 (18.4, 22.3) 78.6 (76.3, 80.8) 0.58
Mexican American 42.9 (40.5, 45.4) 57.1 (54.6, 59.5) 19.4 (16.9, 22.2) 47.1 (44.1, 50.2) 33.5 (30.4, 36.8) 0.44
Total* 28.7 (26.5, 31.0) 71.3 (69.0, 73.5)   9.6 (7.9, 11.6) 38.1 (36.4, 39.9) 52.2 (49.4, 55.0)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1143623 C G   CC CG GG  
12-19 29.0 (23.4, 35.4) 71.0 (64.6, 76.6) 0.386 10.0 (6.0, 16.3) 38.0 (31.3, 45.1) 52.0 (43.6, 60.3) 0.362
20-39 28.9 (26.9, 31.0) 71.1 (69.0, 73.1) 9.8 (7.4, 12.9) 38.3 (35.6, 41.1) 51.9 (49.7, 54.0)
40-59 29.9 (26.3, 33.8) 70.1 (66.2, 73.7) 11.0 (8.3, 14.3) 37.9 (33.7, 42.3) 51.1 (45.7, 56.5)
>=60 26.3 (23.5, 29.3) 73.7 (70.7, 76.5) 7.1 (5.3, 9.6) 38.2 (34.3, 42.3) 54.6 (50.1, 59.1)
Total 28.7 (26.5, 31.0) 71.3 (69.0, 73.5)   9.6 (7.9, 11.6) 38.1 (36.4, 39.9) 52.2 (49.4, 55.0)  

* Includes all participants, regardless of race/ethnicity.

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By Sex* 

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1143623 C G   CC CG GG  
Male 29.6 (26.8, 32.6) 70.4 (67.4, 73.2) 0.115 10.3 (8.3, 12.8) 38.6 (35.5, 41.8) 51.1 (47.0, 55.2) 0.338
Female 27.9 (25.8, 30.0) 72.1 (70.0, 74.2) 9.0 (7.0, 11.4) 37.7 (35.3, 40.2) 53.3 (50.7, 55.9)
Total 28.7 (26.5, 31.0) 71.3 (69.0, 73.5)   9.6 (7.9, 11.6) 38.1 (36.4, 39.9) 52.2 (49.4, 55.0)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs1143623 C G CC CG GG
Non-Hispanic White 12-19 30.0 (23.7, 37.2) 70.0 (62.8, 76.3) 9.4 (5.3, 16.1) 41.2 (31.8, 51.2) 49.4 (39.0, 59.9)
20-39 27.8 (25.5, 30.3) 72.2 (69.7, 74.5) 8.7 (6.2, 12.0) 38.3 (35.3, 41.5) 53.0 (50.2, 55.8)
40-59 30.1 (25.9, 34.8) 69.9 (65.2, 74.1) 10.3 (7.5, 13.8) 39.8 (34.0, 45.9) 50.0 (43.1, 56.8)
>=60 26.6 (23.3, 30.1) 73.4 (69.9, 76.7) 7.5 (5.3, 10.4) 38.2 (34.1, 42.5) 54.3 (49.3, 59.3)
Non-Hispanic Black 12-19 12.0 (9.5, 15.0) 88.0 (85.0, 90.5) 0.8 (0.4, 1.6) 22.4 (17.5, 28.1) 76.9 (71.1, 81.8)
20-39 12.2 (10.2, 14.6) 87.8 (85.4, 89.8) 1.4 (0.8, 2.6) 21.7 (18.4, 25.4) 76.9 (72.9, 80.5)
40-59 9.6 (7.1, 12.9) 90.4 (87.1, 92.9) 1.1 (0.3, 3.8) 17.0 (13.0, 22.0) 81.9 (76.4, 86.3)
>=60 10.1 (7.5, 13.4) 89.9 (86.6, 92.5) 0.4 (0.1, 3.6) 19.2 (13.6, 26.5) 80.3 (73.5, 85.7)
Mexican American 12-19 39.3 (36.5, 42.2) 60.7 (57.8, 63.5) 17.9 (14.8, 21.4) 42.9 (36.4, 49.7) 39.2 (34.1, 44.6)
20-39 44.9 (41.2, 48.6) 55.1 (51.4, 58.8) 20.9 (17.1, 25.3) 47.9 (44.5, 51.3) 31.2 (27.3, 35.3)
40-59 42.9 (37.3, 48.8) 57.1 (51.2, 62.7) 19.1 (13.8, 25.7) 47.7 (40.1, 55.5) 33.2 (25.9, 41.4)
>=60 40.0 (37.1, 43.0) 60.0 (57.0, 62.9) 14.6 (10.9, 19.3) 50.9 (44.6, 57.1) 34.5 (30.2, 39.2)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs1143623 C G CC CG GG
Non-Hispanic White Male 28.9 (25.9, 32.0) 71.1 (68.0, 74.1) 9.3 (7.4, 11.7) 39.1 (35.1, 43.2) 51.6 (46.9, 56.3)
Female 28.1 (25.3, 31.2) 71.9 (68.8, 74.7) 8.6 (6.3, 11.7) 39.0 (35.9, 42.3) 52.3 (48.4, 56.2)
Non-Hispanic Black Male 11.3 (9.9, 12.8) 88.7 (87.2, 90.1) 1.2 (0.5, 2.9) 20.1 (18.0, 22.4) 78.7 (76.2, 80.9)
Female 11.2 (9.6, 13.1) 88.8 (86.9, 90.4) 1.0 (0.5, 1.9) 20.5 (17.8, 23.4) 78.6 (75.3, 81.5)
Mexican American Male 44.5 (40.9, 48.2) 55.5 (51.8, 59.1) 21.6 (17.9, 25.7) 46.0 (40.8, 51.3) 32.5 (27.7, 37.7)
Female 41.2 (39.1, 43.4) 58.8 (56.6, 60.9) 17.1 (14.6, 19.9) 48.3 (44.7, 51.9) 34.6 (31.8, 37.5)


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