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U.S. Genome Variation Estimates

IL10 Allele and Genotype Frequencies

 

Available polymorphism(s)

rs number

Common Designations

Nucleotide change                  Amino acid

Genotyping method

rs1800871

-853C>T
-819C>T

 

TaqMan

rs1800872

-626C>A
-592C>A

 

TaqMan

rs1800896

-1116A>G
-1082A>G

 

TaqMan



Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity 

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1800871 C T   CC CT TT    
Non-Hispanic White 75.8 (73.8, 77.7) 24.2 (22.3, 26.2) <0.001 58.4 (55.6, 61.1) 34.9 (32.4, 37.5) 6.7 (5.1, 8.9) <0.001 0.06
Non-Hispanic Black 60.4 (58.5, 62.2) 39.6 (37.8, 41.5) 36.3 (33.5, 39.3) 48.1 (45.3, 50.9) 15.6 (14.0, 17.2) 0.66
Mexican American 61.9 (58.4, 65.3) 38.1 (34.7, 41.6) 39.2 (35.2, 43.4) 45.4 (43.2, 47.6) 15.4 (12.5, 18.8) 0.02
Total* 71.0 (69.1, 72.9) 29.0 (27.1, 30.9)   52.2 (49.5, 54.8) 37.7 (35.3, 40.3) 10.1 (8.4, 12.0)    
rs1800872 A G   AA AC CC    
Non-Hispanic White 24.3 (22.4, 26.4) 75.7 (73.6, 77.6) <0.001 6.9 (5.1, 9.2) 35.0 (32.3, 37.7) 58.2 (55.4, 60.9) <0.001 0.06
Non-Hispanic Black 39.3 (37.4, 41.2) 60.7 (58.8, 62.6) 15.0 (13.4, 16.8) 48.5 (45.4, 51.6) 36.5 (33.5, 39.5) 0.98
Mexican American 37.9 (34.6, 41.4) 62.1 (58.6, 65.4) 15.1 (12.3, 18.5) 45.6 (43.0, 48.3) 39.3 (35.2, 43.4) 0.03
Total* 29.0 (27.1, 31.0) 71.0 (69.0, 72.9)   10.1 (8.4, 12.1) 37.9 (35.3, 40.5) 52.1 (49.4, 54.8)    
rs1800896 A G   AA AG GG    
Non-Hispanic White 53.1 (50.7, 55.5) 46.9 (44.5, 49.3) <0.001 28.6 (25.6, 31.8) 49.0 (46.4, 51.6) 22.4 (20.1, 24.8) <0.001 0.89
Non-Hispanic Black 64.4 (62.5, 66.2) 35.6 (33.8, 37.5) 40.6 (37.4, 43.8) 47.6 (44.3, 50.9) 11.8 (10.4, 13.4) 0.35
Mexican American 69.5 (66.7, 72.2) 30.5 (27.8, 33.3) 48.7 (43.9, 53.4) 41.7 (37.0, 46.5) 9.6 (7.8, 11.8) 0.36
Total* 57.7 (56.0, 59.4) 42.3 (40.6, 44.0)   34.4 (32.3, 36.6) 46.6 (44.3, 48.9) 19.0 (17.2, 20.9)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800871 C T   CC CT TT  
12-19 69.4 (63.9, 74.4) 30.6 (25.6, 36.1) 0.164 53.1 (45.9, 60.1) 32.7 (27.2, 38.7) 14.2 (10.3, 19.3) 0.081
20-39 69.6 (66.8, 72.4) 30.4 (27.6, 33.2)   49.9 (45.8, 54.1) 39.4 (35.1, 43.9) 10.7 (8.1, 13.9)  
40-59 73.3 (70.5, 75.8) 26.7 (24.2, 29.5)   54.2 (49.8, 58.6) 38.1 (34.2, 42.1) 7.7 (6.3, 9.4)  
>=60 71.9 (69.2, 74.4) 28.1 (25.6, 30.8)   53.1 (49.5, 56.8) 37.5 (34.4, 40.8) 9.3 (7.3, 11.8)  
Total 71.0 (69.1, 72.9) 29.0 (27.1, 30.9)   52.2 (49.5, 54.8) 37.7 (35.3, 40.3) 10.1 (8.4, 12.0)  
rs1800872 A C   AA AC CC  
12-19 30.7 (25.7, 36.2) 69.3 (63.8, 74.3) 0.182 14.2 (10.4, 19.2) 32.9 (27.5, 38.9) 52.8 (45.6, 59.9) 0.074
20-39 30.4 (27.6, 33.4) 69.6 (66.6, 72.4)   10.7 (8.1, 14.0) 39.5 (35.1, 44.0) 49.8 (45.6, 54.1)  
40-59 27.0 (24.3, 29.8) 73.0 (70.2, 75.7)   7.9 (6.4, 9.7) 38.1 (34.5, 42.0) 54.0 (49.5, 58.4)  
>=60 27.9 (25.4, 30.4) 72.1 (69.6, 74.6)   9.0 (7.0, 11.4) 37.8 (34.2, 41.4) 53.3 (49.5, 57.0)  
Total 29.0 (27.1, 31.0) 71.0 (69.0, 72.9)   10.1 (8.4, 12.1) 37.9 (35.3, 40.5) 52.1 (49.4, 54.8)  
rs1800896 A G   AA AG GG  
12-19 58.0 (54.2, 61.7) 42.0 (38.3, 45.8) 0.127 35.8 (30.5, 41.5) 44.4 (38.8, 50.1) 19.8 (16.4, 23.7) 0.188
20-39 59.5 (57.0, 62.0) 40.5 (38.0, 43.0)   37.3 (33.8, 40.8) 44.5 (40.8, 48.3) 18.2 (15.6, 21.1)  
40-59 55.8 (52.6, 58.9) 44.2 (41.1, 47.4)   31.8 (27.5, 36.3) 48.0 (43.2, 52.9) 20.2 (16.8, 24.0)  
>=60 56.6 (54.2, 59.0) 43.4 (41.0, 45.8)   31.5 (28.2, 34.9) 50.3 (46.9, 53.6) 18.3 (16.0, 20.8)  
Total 57.7 (56.0, 59.4) 42.3 (40.6, 44.0)   34.4 (32.3, 36.6) 46.6 (44.3, 48.9) 19.0 (17.2, 20.9)  

* Includes all participants, regardless of race/ethnicity.

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By Sex*

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800871 C T   CC CT TT  
Male 71.4 (68.7, 74.0) 28.6 (26.0, 31.3) 0.574 52.7 (49.0, 56.5) 37.3 (34.4, 40.3) 10.0 (8.0, 12.3) 0.839
Female 70.7 (68.9, 72.5) 29.3 (27.5, 31.1)   51.6 (48.7, 54.5) 38.2 (34.7, 41.8) 10.2 (8.3, 12.5)  
Total 71.0 (69.1, 72.9) 29.0 (27.1, 30.9)   52.2 (49.5, 54.8) 37.7 (35.3, 40.3) 10.1 (8.4, 12.0)  
rs1800872 A C   AA AC CC  
Male 28.7 (26.1, 31.5) 71.3 (68.5, 73.9) 0.647 9.9 (7.9, 12.4) 37.6 (34.6, 40.7) 52.5 (48.7, 56.2) 0.898
Female 29.3 (27.5, 31.1) 70.7 (68.9, 72.5)   10.2 (8.2, 12.6) 38.2 (34.5, 41.9) 51.7 (48.7, 54.7)  
Total 29.0 (27.1, 31.0) 71.0 (69.0, 72.9)   10.1 (8.4, 12.1) 37.9 (35.3, 40.5) 52.1 (49.4, 54.8)  
rs1800896 A G   AA AG GG  
Male 58.2 (56.2, 60.2) 41.8 (39.8, 43.8) 0.353 34.8 (31.6, 38.1) 46.8 (43.2, 50.5) 18.4 (16.3, 20.6) 0.573
Female 57.2 (55.3, 59.1) 42.8 (40.9, 44.7)   34.0 (31.5, 36.6) 46.4 (43.3, 49.6) 19.5 (17.2, 22.1)  
Total 57.7 (56.0, 59.4) 42.3 (40.6, 44.0)   34.4 (32.3, 36.6) 46.6 (44.3, 48.9) 19.0 (17.2, 20.9)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs1800871 C T CC CT TT
Non-Hispanic White 12-19 76.1 (70.1, 81.3) 23.9 (18.7, 29.9) 62.3 (53.3, 70.5) 27.7 (20.6, 36.0) 10.0 (6.6, 14.9)
20-39 74.3 (71.4, 77.0) 25.7 (23.0, 28.6) 56.1 (51.8, 60.3) 36.4 (31.1, 42.0) 7.5 (4.7, 11.8)
40-59 78.2 (74.7, 81.2) 21.8 (18.8, 25.3) 60.5 (54.9, 65.8) 35.4 (30.7, 40.3) 4.2 (2.7, 6.3)
>=60 75.2 (72.2, 77.9) 24.8 (22.1, 27.8) 57.4 (53.2, 61.4) 35.7 (32.1, 39.4) 7.0 (4.9, 9.9)
Non-Hispanic Black 12-19 60.6 (56.4, 64.6) 39.4 (35.4, 43.6) 37.7 (33.2, 42.4) 45.8 (42.2, 49.4) 16.5 (12.6, 21.3)
20-39 61.2 (58.9, 63.5) 38.8 (36.5, 41.1) 37.0 (34.3, 39.7) 48.6 (45.8, 51.4) 14.5 (11.9, 17.5)
40-59 59.1 (55.6, 62.6) 40.9 (37.4, 44.4) 35.4 (29.9, 41.2) 47.5 (41.4, 53.6) 17.2 (14.0, 20.8)
>=60 59.8 (55.4, 64.0) 40.2 (36.0, 44.6) 34.4 (27.1, 42.4) 50.8 (42.1, 59.6) 14.8 (11.1, 19.5)
Mexican American 12-19 62.1 (58.8, 65.3) 37.9 (34.7, 41.2) 39.0 (34.2, 44.1) 46.1 (38.0, 54.5) 14.8 (10.1, 21.3)
20-39 62.9 (58.1, 67.5) 37.1 (32.5, 41.9) 41.2 (35.2, 47.5) 43.4 (40.0, 47.0) 15.3 (12.1, 19.3)
40-59 59.5 (54.8, 64.0) 40.5 (36.0, 45.2) 35.3 (30.3, 40.7) 48.3 (44.8, 51.7) 16.4 (12.3, 21.5)
>=60 61.5 (58.4, 64.5) 38.5 (35.5, 41.6) 37.5 (31.2, 44.3) 48.0 (38.7, 57.3) 14.5 (10.6, 19.6)
rs1800872 A C AA AC CC
Non-Hispanic White 12-19 24.1 (18.9, 30.1) 75.9 (69.9, 81.1) 10.1 (6.7, 14.9) 28.0 (21.0, 36.3) 61.9 (52.9, 70.2)
20-39 25.9 (23.0, 28.9) 74.1 (71.1, 77.0) 7.6 (4.8, 12.0) 36.4 (31.1, 42.0) 55.9 (51.5, 60.3)
40-59 22.2 (19.0, 25.9) 77.8 (74.1, 81.0) 4.5 (3.0, 6.8) 35.4 (31.0, 40.1) 60.1 (54.5, 65.5)
>=60 24.8 (22.2, 27.6) 75.2 (72.4, 77.8) 6.9 (4.8, 9.9) 35.7 (31.7, 40.0) 57.3 (53.2, 61.4)
Non-Hispanic Black 12-19 39.3 (35.6, 43.1) 60.7 (56.9, 64.4) 16.6 (13.2, 20.7) 45.5 (41.7, 49.2) 38.0 (33.5, 42.7)
20-39 38.4 (36.2, 40.7) 61.6 (59.3, 63.8) 14.0 (11.5, 16.8) 48.9 (46.1, 51.8) 37.1 (34.5, 39.8)
40-59 40.6 (36.9, 44.5) 59.4 (55.5, 63.1) 16.6 (12.7, 21.2) 48.1 (41.7, 54.6) 35.3 (29.9, 41.2)
>=60 39.6 (35.3, 44.0) 60.4 (56.0, 64.7) 13.6 (9.8, 18.7) 51.9 (42.6, 61.1) 34.5 (27.1, 42.7)
Mexican American 12-19 37.6 (34.4, 40.9) 62.4 (59.1, 65.6) 14.2 (9.7, 20.3) 46.7 (39.0, 54.5) 39.1 (34.3, 44.1)
20-39 36.9 (32.4, 41.6) 63.1 (58.4, 67.6) 15.1 (11.9, 19.0) 43.5 (39.9, 47.2) 41.4 (35.5, 47.5)
40-59 40.6 (36.1, 45.1) 59.4 (54.9, 63.9) 16.3 (12.4, 21.1) 48.5 (44.9, 52.0) 35.2 (30.1, 40.7)
>=60 38.4 (35.3, 41.5) 61.6 (58.5, 64.7) 14.1 (10.2, 19.2) 48.6 (39.7, 57.5) 37.3 (31.3, 43.8)
rs1800896 A G AA AG GG
Non-Hispanic White 12-19 52.9 (46.6, 59.0) 47.1 (41.0, 53.4) 29.2 (21.9, 37.7) 47.4 (40.1, 54.8) 23.4 (17.6, 30.5)
20-39 54.2 (51.8, 56.6) 45.8 (43.4, 48.2) 30.9 (27.7, 34.4) 46.5 (41.9, 51.1) 22.5 (19.4, 26.0)
40-59 51.6 (47.5, 55.7) 48.4 (44.3, 52.5) 26.4 (21.6, 31.9) 50.4 (45.5, 55.2) 23.2 (19.1, 27.9)
>=60 53.4 (50.6, 56.2) 46.6 (43.8, 49.4) 27.3 (23.6, 31.3) 52.3 (48.6, 55.9) 20.4 (17.8, 23.4)
Non-Hispanic Black 12-19 63.3 (59.2, 67.3) 36.7 (32.7, 40.8) 40.2 (34.6, 46.2) 46.1 (40.7, 51.5) 13.7 (10.3, 17.8)
20-39 64.9 (60.8, 68.8) 35.1 (31.2, 39.2) 40.5 (34.0, 47.5) 48.7 (42.8, 54.6) 10.8 (9.0, 12.8)
40-59 64.0 (59.6, 68.2) 36.0 (31.8, 40.4) 40.3 (35.0, 45.8) 47.3 (43.4, 51.3) 12.3 (8.9, 16.8)
>=60 64.8 (60.8, 68.7) 35.2 (31.3, 39.2) 41.5 (34.7, 48.7) 46.6 (39.2, 54.2) 11.8 (8.9, 15.6)
Mexican American 12-19 68.1 (64.6, 71.4) 31.9 (28.6, 35.4) 46.7 (40.3, 53.3) 42.8 (35.1, 50.9) 10.5 (7.4, 14.5)
20-39 69.4 (66.5, 72.2) 30.6 (27.8, 33.5) 48.2 (43.3, 53.1) 42.5 (37.1, 48.1) 9.4 (7.0, 12.4)
40-59 70.9 (63.6, 77.3) 29.1 (22.7, 36.4) 51.5 (41.2, 61.7) 38.8 (30.4, 48.0) 9.7 (5.7, 16.0)
>=60 69.9 (65.0, 74.4) 30.1 (25.6, 35.0) 49.1 (41.4, 56.8) 41.7 (34.4, 49.4) 9.2 (6.3, 13.4)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs1800871 C T CC CT TT
Non-Hispanic White Male 76.0 (73.0, 78.8) 24.0 (21.2, 27.0) 58.9 (54.4, 63.3) 34.1 (30.4, 38.1) 6.9 (5.1, 9.3)
Female 75.7 (73.5, 77.7) 24.3 (22.3, 26.5) 57.9 (55.2, 60.5) 35.6 (32.6, 38.6) 6.6 (4.5, 9.4)
Non-Hispanic Black Male 60.3 (57.6, 63.0) 39.7 (37.0, 42.4) 35.7 (31.6, 40.1) 49.1 (44.7, 53.5) 15.1 (12.8, 17.8)
Female 60.4 (57.9, 62.9) 39.6 (37.1, 42.1) 36.8 (33.3, 40.5) 47.3 (43.8, 50.7) 15.9 (13.7, 18.5)
Mexican American Male 62.1 (57.9, 66.1) 37.9 (33.9, 42.1) 38.6 (34.5, 42.9) 46.9 (44.6, 49.3) 14.5 (10.6, 19.4)
Female 61.7 (58.4, 64.9) 38.3 (35.1, 41.6) 39.8 (35.4, 44.5) 43.8 (40.3, 47.3) 16.4 (14.0, 19.0)
rs1800872 A C AA AC CC
Non-Hispanic White Male 24.2 (21.5, 27.3) 75.8 (72.7, 78.5) 7.1 (5.1, 9.6) 34.4 (30.6, 38.4) 58.6 (54.1, 62.9)
Female 24.4 (22.5, 26.5) 75.6 (73.5, 77.5) 6.7 (4.6, 9.6) 35.5 (32.4, 38.7) 57.8 (55.1, 60.5)
Non-Hispanic Black Male 39.3 (36.8, 41.9) 60.7 (58.1, 63.2) 14.3 (12.1, 17.0) 49.9 (45.2, 54.6) 35.7 (31.6, 40.1)
Female 39.3 (36.8, 41.8) 60.7 (58.2, 63.2) 15.6 (13.4, 18.1) 47.3 (43.6, 51.1) 37.1 (33.5, 40.8)
Mexican American Male 37.8 (33.8, 41.9) 62.2 (58.1, 66.2) 14.1 (10.4, 18.9) 47.3 (44.6, 50.1) 38.5 (34.2, 43.0)
Female 38.1 (35.0, 41.3) 61.9 (58.7, 65.0) 16.1 (13.7, 18.9) 43.9 (40.1, 47.7) 40.0 (35.6, 44.6)
rs1800896 A G AA AG GG
Non-Hispanic White Male 53.9 (51.2, 56.7) 46.1 (43.3, 48.8) 29.2 (25.4, 33.4) 49.4 (45.1, 53.7) 21.4 (18.6, 24.5)
Female 52.3 (49.5, 55.2) 47.7 (44.8, 50.5) 28.0 (24.4, 32.0) 48.6 (44.8, 52.5) 23.3 (20.4, 26.5)
Non-Hispanic Black Male 64.2 (61.5, 66.9) 35.8 (33.1, 38.5) 41.0 (36.8, 45.4) 46.5 (42.2, 50.8) 12.5 (10.4, 15.1)
Female 64.5 (62.0, 66.8) 35.5 (33.2, 38.0) 40.2 (36.4, 44.1) 48.5 (44.4, 52.6) 11.3 (9.3, 13.7)
Mexican American Male 68.4 (64.9, 71.7) 31.6 (28.3, 35.1) 46.2 (40.4, 52.1) 44.3 (38.5, 50.4) 9.4 (7.1, 12.4)
Female 70.7 (68.1, 73.2) 29.3 (26.8, 31.9) 51.2 (47.1, 55.3) 39.0 (35.1, 43.0) 9.8 (7.9, 12.1)


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