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U.S. Genome Variation Estimates

IL10 Allele and Genotype Frequencies

Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs1800871

-853C>T
-819C>T

TaqMan

rs1800872

-626C>A
-592C>A

TaqMan

rs1800896

-1116A>G
-1082A>G

TaqMan



Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1800871CTCCCTTT
Non-Hispanic White75.8 (73.8, 77.7)24.2 (22.3, 26.2)<0.00158.4 (55.6, 61.1)34.9 (32.4, 37.5)6.7 (5.1, 8.9)<0.0010.06
Non-Hispanic Black60.4 (58.5, 62.2)39.6 (37.8, 41.5)36.3 (33.5, 39.3)48.1 (45.3, 50.9)15.6 (14.0, 17.2)0.66
Mexican American61.9 (58.4, 65.3)38.1 (34.7, 41.6)39.2 (35.2, 43.4)45.4 (43.2, 47.6)15.4 (12.5, 18.8)0.02
Total*71.0 (69.1, 72.9)29.0 (27.1, 30.9)52.2 (49.5, 54.8)37.7 (35.3, 40.3)10.1 (8.4, 12.0)
rs1800872AGAAACCC
Non-Hispanic White24.3 (22.4, 26.4)75.7 (73.6, 77.6)<0.0016.9 (5.1, 9.2)35.0 (32.3, 37.7)58.2 (55.4, 60.9)<0.0010.06
Non-Hispanic Black39.3 (37.4, 41.2)60.7 (58.8, 62.6)15.0 (13.4, 16.8)48.5 (45.4, 51.6)36.5 (33.5, 39.5)0.98
Mexican American37.9 (34.6, 41.4)62.1 (58.6, 65.4)15.1 (12.3, 18.5)45.6 (43.0, 48.3)39.3 (35.2, 43.4)0.03
Total*29.0 (27.1, 31.0)71.0 (69.0, 72.9)10.1 (8.4, 12.1)37.9 (35.3, 40.5)52.1 (49.4, 54.8)
rs1800896AGAAAGGG
Non-Hispanic White53.1 (50.7, 55.5)46.9 (44.5, 49.3)<0.00128.6 (25.6, 31.8)49.0 (46.4, 51.6)22.4 (20.1, 24.8)<0.0010.89
Non-Hispanic Black64.4 (62.5, 66.2)35.6 (33.8, 37.5)40.6 (37.4, 43.8)47.6 (44.3, 50.9)11.8 (10.4, 13.4)0.35
Mexican American69.5 (66.7, 72.2)30.5 (27.8, 33.3)48.7 (43.9, 53.4)41.7 (37.0, 46.5)9.6 (7.8, 11.8)0.36
Total*57.7 (56.0, 59.4)42.3 (40.6, 44.0)34.4 (32.3, 36.6)46.6 (44.3, 48.9)19.0 (17.2, 20.9)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800871CTCCCTTT
12-1969.4 (63.9, 74.4)30.6 (25.6, 36.1)0.16453.1 (45.9, 60.1)32.7 (27.2, 38.7)14.2 (10.3, 19.3)0.081
20-3969.6 (66.8, 72.4)30.4 (27.6, 33.2)49.9 (45.8, 54.1)39.4 (35.1, 43.9)10.7 (8.1, 13.9)
40-5973.3 (70.5, 75.8)26.7 (24.2, 29.5)54.2 (49.8, 58.6)38.1 (34.2, 42.1)7.7 (6.3, 9.4)
>=6071.9 (69.2, 74.4)28.1 (25.6, 30.8)53.1 (49.5, 56.8)37.5 (34.4, 40.8)9.3 (7.3, 11.8)
Total71.0 (69.1, 72.9)29.0 (27.1, 30.9)52.2 (49.5, 54.8)37.7 (35.3, 40.3)10.1 (8.4, 12.0)
rs1800872ACAAACCC
12-1930.7 (25.7, 36.2)69.3 (63.8, 74.3)0.18214.2 (10.4, 19.2)32.9 (27.5, 38.9)52.8 (45.6, 59.9)0.074
20-3930.4 (27.6, 33.4)69.6 (66.6, 72.4)10.7 (8.1, 14.0)39.5 (35.1, 44.0)49.8 (45.6, 54.1)
40-5927.0 (24.3, 29.8)73.0 (70.2, 75.7)7.9 (6.4, 9.7)38.1 (34.5, 42.0)54.0 (49.5, 58.4)
>=6027.9 (25.4, 30.4)72.1 (69.6, 74.6)9.0 (7.0, 11.4)37.8 (34.2, 41.4)53.3 (49.5, 57.0)
Total29.0 (27.1, 31.0)71.0 (69.0, 72.9)10.1 (8.4, 12.1)37.9 (35.3, 40.5)52.1 (49.4, 54.8)
rs1800896AGAAAGGG
12-1958.0 (54.2, 61.7)42.0 (38.3, 45.8)0.12735.8 (30.5, 41.5)44.4 (38.8, 50.1)19.8 (16.4, 23.7)0.188
20-3959.5 (57.0, 62.0)40.5 (38.0, 43.0)37.3 (33.8, 40.8)44.5 (40.8, 48.3)18.2 (15.6, 21.1)
40-5955.8 (52.6, 58.9)44.2 (41.1, 47.4)31.8 (27.5, 36.3)48.0 (43.2, 52.9)20.2 (16.8, 24.0)
>=6056.6 (54.2, 59.0)43.4 (41.0, 45.8)31.5 (28.2, 34.9)50.3 (46.9, 53.6)18.3 (16.0, 20.8)
Total57.7 (56.0, 59.4)42.3 (40.6, 44.0)34.4 (32.3, 36.6)46.6 (44.3, 48.9)19.0 (17.2, 20.9)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800871CTCCCTTT
Male71.4 (68.7, 74.0)28.6 (26.0, 31.3)0.57452.7 (49.0, 56.5)37.3 (34.4, 40.3)10.0 (8.0, 12.3)0.839
Female70.7 (68.9, 72.5)29.3 (27.5, 31.1)51.6 (48.7, 54.5)38.2 (34.7, 41.8)10.2 (8.3, 12.5)
Total71.0 (69.1, 72.9)29.0 (27.1, 30.9)52.2 (49.5, 54.8)37.7 (35.3, 40.3)10.1 (8.4, 12.0)
rs1800872ACAAACCC
Male28.7 (26.1, 31.5)71.3 (68.5, 73.9)0.6479.9 (7.9, 12.4)37.6 (34.6, 40.7)52.5 (48.7, 56.2)0.898
Female29.3 (27.5, 31.1)70.7 (68.9, 72.5)10.2 (8.2, 12.6)38.2 (34.5, 41.9)51.7 (48.7, 54.7)
Total29.0 (27.1, 31.0)71.0 (69.0, 72.9)10.1 (8.4, 12.1)37.9 (35.3, 40.5)52.1 (49.4, 54.8)
rs1800896AGAAAGGG
Male58.2 (56.2, 60.2)41.8 (39.8, 43.8)0.35334.8 (31.6, 38.1)46.8 (43.2, 50.5)18.4 (16.3, 20.6)0.573
Female57.2 (55.3, 59.1)42.8 (40.9, 44.7)34.0 (31.5, 36.6)46.4 (43.3, 49.6)19.5 (17.2, 22.1)
Total57.7 (56.0, 59.4)42.3 (40.6, 44.0)34.4 (32.3, 36.6)46.6 (44.3, 48.9)19.0 (17.2, 20.9)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs1800871CTCCCTTT
Non-Hispanic White12-1976.1 (70.1, 81.3)23.9 (18.7, 29.9)62.3 (53.3, 70.5)27.7 (20.6, 36.0)10.0 (6.6, 14.9)
20-3974.3 (71.4, 77.0)25.7 (23.0, 28.6)56.1 (51.8, 60.3)36.4 (31.1, 42.0)7.5 (4.7, 11.8)
40-5978.2 (74.7, 81.2)21.8 (18.8, 25.3)60.5 (54.9, 65.8)35.4 (30.7, 40.3)4.2 (2.7, 6.3)
>=6075.2 (72.2, 77.9)24.8 (22.1, 27.8)57.4 (53.2, 61.4)35.7 (32.1, 39.4)7.0 (4.9, 9.9)
Non-Hispanic Black12-1960.6 (56.4, 64.6)39.4 (35.4, 43.6)37.7 (33.2, 42.4)45.8 (42.2, 49.4)16.5 (12.6, 21.3)
20-3961.2 (58.9, 63.5)38.8 (36.5, 41.1)37.0 (34.3, 39.7)48.6 (45.8, 51.4)14.5 (11.9, 17.5)
40-5959.1 (55.6, 62.6)40.9 (37.4, 44.4)35.4 (29.9, 41.2)47.5 (41.4, 53.6)17.2 (14.0, 20.8)
>=6059.8 (55.4, 64.0)40.2 (36.0, 44.6)34.4 (27.1, 42.4)50.8 (42.1, 59.6)14.8 (11.1, 19.5)
Mexican American12-1962.1 (58.8, 65.3)37.9 (34.7, 41.2)39.0 (34.2, 44.1)46.1 (38.0, 54.5)14.8 (10.1, 21.3)
20-3962.9 (58.1, 67.5)37.1 (32.5, 41.9)41.2 (35.2, 47.5)43.4 (40.0, 47.0)15.3 (12.1, 19.3)
40-5959.5 (54.8, 64.0)40.5 (36.0, 45.2)35.3 (30.3, 40.7)48.3 (44.8, 51.7)16.4 (12.3, 21.5)
>=6061.5 (58.4, 64.5)38.5 (35.5, 41.6)37.5 (31.2, 44.3)48.0 (38.7, 57.3)14.5 (10.6, 19.6)
rs1800872ACAAACCC
Non-Hispanic White12-1924.1 (18.9, 30.1)75.9 (69.9, 81.1)10.1 (6.7, 14.9)28.0 (21.0, 36.3)61.9 (52.9, 70.2)
20-3925.9 (23.0, 28.9)74.1 (71.1, 77.0)7.6 (4.8, 12.0)36.4 (31.1, 42.0)55.9 (51.5, 60.3)
40-5922.2 (19.0, 25.9)77.8 (74.1, 81.0)4.5 (3.0, 6.8)35.4 (31.0, 40.1)60.1 (54.5, 65.5)
>=6024.8 (22.2, 27.6)75.2 (72.4, 77.8)6.9 (4.8, 9.9)35.7 (31.7, 40.0)57.3 (53.2, 61.4)
Non-Hispanic Black12-1939.3 (35.6, 43.1)60.7 (56.9, 64.4)16.6 (13.2, 20.7)45.5 (41.7, 49.2)38.0 (33.5, 42.7)
20-3938.4 (36.2, 40.7)61.6 (59.3, 63.8)14.0 (11.5, 16.8)48.9 (46.1, 51.8)37.1 (34.5, 39.8)
40-5940.6 (36.9, 44.5)59.4 (55.5, 63.1)16.6 (12.7, 21.2)48.1 (41.7, 54.6)35.3 (29.9, 41.2)
>=6039.6 (35.3, 44.0)60.4 (56.0, 64.7)13.6 (9.8, 18.7)51.9 (42.6, 61.1)34.5 (27.1, 42.7)
Mexican American12-1937.6 (34.4, 40.9)62.4 (59.1, 65.6)14.2 (9.7, 20.3)46.7 (39.0, 54.5)39.1 (34.3, 44.1)
20-3936.9 (32.4, 41.6)63.1 (58.4, 67.6)15.1 (11.9, 19.0)43.5 (39.9, 47.2)41.4 (35.5, 47.5)
40-5940.6 (36.1, 45.1)59.4 (54.9, 63.9)16.3 (12.4, 21.1)48.5 (44.9, 52.0)35.2 (30.1, 40.7)
>=6038.4 (35.3, 41.5)61.6 (58.5, 64.7)14.1 (10.2, 19.2)48.6 (39.7, 57.5)37.3 (31.3, 43.8)
rs1800896AGAAAGGG
Non-Hispanic White12-1952.9 (46.6, 59.0)47.1 (41.0, 53.4)29.2 (21.9, 37.7)47.4 (40.1, 54.8)23.4 (17.6, 30.5)
20-3954.2 (51.8, 56.6)45.8 (43.4, 48.2)30.9 (27.7, 34.4)46.5 (41.9, 51.1)22.5 (19.4, 26.0)
40-5951.6 (47.5, 55.7)48.4 (44.3, 52.5)26.4 (21.6, 31.9)50.4 (45.5, 55.2)23.2 (19.1, 27.9)
>=6053.4 (50.6, 56.2)46.6 (43.8, 49.4)27.3 (23.6, 31.3)52.3 (48.6, 55.9)20.4 (17.8, 23.4)
Non-Hispanic Black12-1963.3 (59.2, 67.3)36.7 (32.7, 40.8)40.2 (34.6, 46.2)46.1 (40.7, 51.5)13.7 (10.3, 17.8)
20-3964.9 (60.8, 68.8)35.1 (31.2, 39.2)40.5 (34.0, 47.5)48.7 (42.8, 54.6)10.8 (9.0, 12.8)
40-5964.0 (59.6, 68.2)36.0 (31.8, 40.4)40.3 (35.0, 45.8)47.3 (43.4, 51.3)12.3 (8.9, 16.8)
>=6064.8 (60.8, 68.7)35.2 (31.3, 39.2)41.5 (34.7, 48.7)46.6 (39.2, 54.2)11.8 (8.9, 15.6)
Mexican American12-1968.1 (64.6, 71.4)31.9 (28.6, 35.4)46.7 (40.3, 53.3)42.8 (35.1, 50.9)10.5 (7.4, 14.5)
20-3969.4 (66.5, 72.2)30.6 (27.8, 33.5)48.2 (43.3, 53.1)42.5 (37.1, 48.1)9.4 (7.0, 12.4)
40-5970.9 (63.6, 77.3)29.1 (22.7, 36.4)51.5 (41.2, 61.7)38.8 (30.4, 48.0)9.7 (5.7, 16.0)
>=6069.9 (65.0, 74.4)30.1 (25.6, 35.0)49.1 (41.4, 56.8)41.7 (34.4, 49.4)9.2 (6.3, 13.4)

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By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs1800871CTCCCTTT
Non-Hispanic WhiteMale76.0 (73.0, 78.8)24.0 (21.2, 27.0)58.9 (54.4, 63.3)34.1 (30.4, 38.1)6.9 (5.1, 9.3)
Female75.7 (73.5, 77.7)24.3 (22.3, 26.5)57.9 (55.2, 60.5)35.6 (32.6, 38.6)6.6 (4.5, 9.4)
Non-Hispanic BlackMale60.3 (57.6, 63.0)39.7 (37.0, 42.4)35.7 (31.6, 40.1)49.1 (44.7, 53.5)15.1 (12.8, 17.8)
Female60.4 (57.9, 62.9)39.6 (37.1, 42.1)36.8 (33.3, 40.5)47.3 (43.8, 50.7)15.9 (13.7, 18.5)
Mexican AmericanMale62.1 (57.9, 66.1)37.9 (33.9, 42.1)38.6 (34.5, 42.9)46.9 (44.6, 49.3)14.5 (10.6, 19.4)
Female61.7 (58.4, 64.9)38.3 (35.1, 41.6)39.8 (35.4, 44.5)43.8 (40.3, 47.3)16.4 (14.0, 19.0)
rs1800872ACAAACCC
Non-Hispanic WhiteMale24.2 (21.5, 27.3)75.8 (72.7, 78.5)7.1 (5.1, 9.6)34.4 (30.6, 38.4)58.6 (54.1, 62.9)
Female24.4 (22.5, 26.5)75.6 (73.5, 77.5)6.7 (4.6, 9.6)35.5 (32.4, 38.7)57.8 (55.1, 60.5)
Non-Hispanic BlackMale39.3 (36.8, 41.9)60.7 (58.1, 63.2)14.3 (12.1, 17.0)49.9 (45.2, 54.6)35.7 (31.6, 40.1)
Female39.3 (36.8, 41.8)60.7 (58.2, 63.2)15.6 (13.4, 18.1)47.3 (43.6, 51.1)37.1 (33.5, 40.8)
Mexican AmericanMale37.8 (33.8, 41.9)62.2 (58.1, 66.2)14.1 (10.4, 18.9)47.3 (44.6, 50.1)38.5 (34.2, 43.0)
Female38.1 (35.0, 41.3)61.9 (58.7, 65.0)16.1 (13.7, 18.9)43.9 (40.1, 47.7)40.0 (35.6, 44.6)
rs1800896AGAAAGGG
Non-Hispanic WhiteMale53.9 (51.2, 56.7)46.1 (43.3, 48.8)29.2 (25.4, 33.4)49.4 (45.1, 53.7)21.4 (18.6, 24.5)
Female52.3 (49.5, 55.2)47.7 (44.8, 50.5)28.0 (24.4, 32.0)48.6 (44.8, 52.5)23.3 (20.4, 26.5)
Non-Hispanic BlackMale64.2 (61.5, 66.9)35.8 (33.1, 38.5)41.0 (36.8, 45.4)46.5 (42.2, 50.8)12.5 (10.4, 15.1)
Female64.5 (62.0, 66.8)35.5 (33.2, 38.0)40.2 (36.4, 44.1)48.5 (44.4, 52.6)11.3 (9.3, 13.7)
Mexican AmericanMale68.4 (64.9, 71.7)31.6 (28.3, 35.1)46.2 (40.4, 52.1)44.3 (38.5, 50.4)9.4 (7.1, 12.4)
Female70.7 (68.1, 73.2)29.3 (26.8, 31.9)51.2 (47.1, 55.3)39.0 (35.1, 43.0)9.8 (7.9, 12.1)


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Error processing SSI file
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