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U.S. Genome Variation Estimates

FGB Allele and Genotype Frequencies

Available polymorphism(s)


rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs1800790

-462G>A

TaqMan



Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1800790AGAAAGGG
Non-Hispanic White19.4 (18.1, 20.7)80.6 (79.3, 81.9)<0.0013.4 (2.6, 4.5)31.9 (30.1, 33.8)64.6 (62.6, 66.6)<0.0010.81
Non-Hispanic Black5.5 (4.6, 6.6)94.5 (93.4, 95.4)0.6 (0.3, 1.3)9.8 (8.0, 11.9)89.6 (87.5, 91.3)0.01
Mexican American15.0 (13.5, 16.6)85.0 (83.4, 86.5)2.5 (2.0, 3.1)24.9 (22.3, 27.8)72.6 (69.6, 75.4)0.82
Total*17.6 (16.2, 19.1)82.4 (80.9, 83.8)3.3 (2.4, 4.4)28.7 (26.8, 30.7)68.0 (65.7, 70.2)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800790AGAAAGGG
12-1917.0 (13.8, 20.8)83.0 (79.2, 86.2)0.3573.3 (1.8, 5.9)27.5 (22.3, 33.4)69.2 (62.9, 74.9)0.163
20-3918.3 (16.3, 20.5)81.7 (79.5, 83.7)3.0 (2.0, 4.5)30.6 (28.0, 33.3)66.4 (63.1, 69.6)
40-5916.4 (14.2, 18.8)83.6 (81.2, 85.8)3.1 (2.1, 4.5)26.6 (22.4, 31.3)70.3 (65.8, 74.5)
>=6018.5 (17.1, 20.0)81.5 (80.0, 82.9)4.0 (2.8, 5.7)29.0 (26.7, 31.3)67.0 (64.7, 69.2)
Total17.6 (16.2, 19.1)82.4 (80.9, 83.8)3.3 (2.4, 4.4)28.7 (26.8, 30.7)68.0 (65.7, 70.2)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1800790AGAAAGGG
Male18.0 (16.4, 19.8)82.0 (80.2, 83.6)0.4473.4 (2.4, 4.8)29.3 (26.7, 32.1)67.3 (64.4, 70.1)0.709
Female17.3 (15.5, 19.2)82.7 (80.8, 84.5)3.2 (2.1, 4.8)28.2 (26.1, 30.4)68.6 (65.9, 71.3)
Total17.6 (16.2, 19.1)82.4 (80.9, 83.8)3.3 (2.4, 4.4)28.7 (26.8, 30.7)68.0 (65.7, 70.2)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs1800790AGAAAGGG
Non-Hispanic White12-1920.4 (15.7, 26.1)79.6 (73.9, 84.3)3.9 (1.9, 7.8)33.0 (25.4, 41.6)63.1 (53.8, 71.6)
20-3919.9 (18.2, 21.8)80.1 (78.2, 81.8)2.8 (2.0, 4.1)34.2 (31.4, 37.0)63.0 (59.8, 66.0)
40-5918.0 (15.7, 20.5)82.0 (79.5, 84.3)3.3 (2.2, 5.0)29.4 (25.2, 34.0)67.3 (62.8, 71.5)
>=6019.8 (18.3, 21.3)80.2 (78.7, 81.7)4.3 (2.9, 6.2)31.0 (28.6, 33.5)64.7 (62.4, 66.9)
Non-Hispanic Black12-196.4 (4.6, 8.9)93.6 (91.1, 95.4)0.4 (0.1, 1.8)12.1 (8.5, 16.9)87.5 (82.7, 91.2)
20-395.5 (4.3, 7.0)94.5 (93.0, 95.7)0.6 (0.2, 1.6)9.9 (7.6, 12.7)89.6 (86.8, 91.8)
40-595.7 (4.2, 7.8)94.3 (92.2, 95.8)0.9 (0.3, 3.0)9.7 (7.2, 12.9)89.4 (86.1, 92.0)
>=604.1 (2.8, 5.9)95.9 (94.1, 97.2)0.6 (0.1, 3.0)6.9 (4.4, 10.5)92.5 (89.1, 94.9)
Mexican American12-1915.8 (13.2, 18.7)84.2 (81.3, 86.8)3.5 (1.8, 6.7)24.7 (19.4, 30.8)71.9 (66.5, 76.7)
20-3915.6 (12.9, 18.6)84.4 (81.4, 87.1)2.4 (1.4, 3.8)26.4 (21.3, 32.3)71.2 (65.4, 76.4)
40-5913.3 (11.6, 15.1)86.7 (84.9, 88.4)2.5 (1.0, 5.7)21.6 (19.4, 24.1)75.9 (73.7, 78.0)
>=6013.6 (11.0, 16.6)86.4 (83.4, 89.0)1.0 (0.3, 3.5)25.1 (21.0, 29.6)73.9 (68.8, 78.4)

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By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs1800790AGAAAGGG
Non-Hispanic WhiteMale19.5 (17.8, 21.3)80.5 (78.7, 82.2)3.2 (2.4, 4.3)32.5 (29.7, 35.5)64.3 (61.2, 67.2)
Female19.3 (17.5, 21.2)80.7 (78.8, 82.5)3.6 (2.3, 5.7)31.4 (29.4, 33.5)65.0 (62.5, 67.4)
Non-Hispanic BlackMale5.7 (4.7, 6.9)94.3 (93.1, 95.3)0.6 (0.2, 2.0)10.3 (8.4, 12.7)89.1 (86.9, 91.0)
Female5.4 (4.0, 7.1)94.6 (92.9, 96.0)0.7 (0.3, 1.6)9.4 (6.9, 12.7)89.9 (86.6, 92.5)
Mexican AmericanMale15.5 (14.0, 17.1)84.5 (82.9, 86.0)2.7 (2.0, 3.8)25.5 (23.4, 27.7)71.7 (69.1, 74.2)
Female14.4 (12.5, 16.4)85.6 (83.6, 87.5)2.2 (1.5, 3.4)24.3 (20.6, 28.4)73.5 (69.5, 77.1)


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