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U.S. Genome Variation Estimates

FCGR2A Allele and Genotype Frequencies

 

Available polymorphism(s)

rs number

Common Designations

Nucleotide change                  Amino acid

Genotyping method

rs1801274

Ex4-120A>G

His166Arg
His167Arg

TaqMan



Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity   

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1801274 A G   AA AG GG    
Non-Hispanic White 49.4 (47.6, 51.1) 50.6 (48.9, 52.4) 0.096 24.9 (23.0, 26.9) 48.9 (46.8, 51.1) 26.2 (24.1, 28.4) 0.127 0.06
Non-Hispanic Black 47.4 (45.8, 49.0) 52.6 (51.0, 54.2) 21.8 (20.2, 23.5) 51.3 (49.5, 53.1) 26.9 (25.0, 29.0) 0.32
Mexican American 48.6 (47.1, 50.1) 51.4 (49.9, 52.9) 23.7 (22.1, 25.4) 49.8 (47.1, 52.5) 26.5 (24.3, 28.8) 0.50
Total* 50.0 (48.5, 51.6) 50.0 (48.4, 51.5)   25.6 (23.9, 27.3) 48.9 (47.4, 50.5) 25.5 (23.8, 27.2)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801274 A G   AA AG GG  
12-19 52.3 (48.3, 56.4) 47.7 (43.6, 51.7) 0.161 26.6 (22.2, 31.6) 51.4 (47.4, 55.3) 22.0 (18.0, 26.6) 0.014
20-39 48.6 (46.6, 50.6) 51.4 (49.4, 53.4) 24.0 (22.0, 26.2) 49.2 (45.7, 52.6) 26.8 (23.9, 30.0)
40-59 51.5 (48.5, 54.5) 48.5 (45.5, 51.5) 26.5 (23.0, 30.3) 50.0 (45.8, 54.2) 23.5 (20.1, 27.4)
>=60 49.2 (46.8, 51.7) 50.8 (48.3, 53.2) 26.7 (24.4, 29.1) 45.1 (42.5, 47.8) 28.2 (25.1, 31.5)
Total 50.0 (48.5, 51.6) 50.0 (48.4, 51.5)   25.6 (23.9, 27.3) 48.9 (47.4, 50.5) 25.5 (23.8, 27.2)  

* Includes all participants, regardless of race/ethnicity.

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By Sex* 

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801274 A G   AA AG GG  
Male 49.0 (46.4, 51.6) 51.0 (48.4, 53.6) 0.248 25.1 (22.4, 28.0) 47.9 (45.0, 50.9) 27.0 (24.0, 30.3) 0.395
Female 51.0 (48.9, 53.0) 49.0 (47.0, 51.1) 26.1 (23.7, 28.5) 49.8 (47.7, 52.0) 24.1 (22.0, 26.4)
Total 50.0 (48.5, 51.6) 50.0 (48.4, 51.5)   25.6 (23.9, 27.3) 48.9 (47.4, 50.5) 25.5 (23.8, 27.2)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs1801274 A G AA AG GG
Non-Hispanic White 12-19 52.4 (46.9, 57.9) 47.6 (42.1, 53.1) 26.4 (20.4, 33.4) 52.1 (46.4, 57.8) 21.5 (16.2, 27.9)
20-39 47.6 (45.0, 50.1) 52.4 (49.9, 55.0) 23.3 (20.8, 26.1) 48.4 (43.6, 53.3) 28.2 (24.2, 32.6)
40-59 51.4 (48.0, 54.8) 48.6 (45.2, 52.0) 25.8 (22.0, 29.8) 51.3 (46.9, 55.7) 22.9 (18.9, 27.5)
>=60 48.1 (44.9, 51.2) 51.9 (48.8, 55.1) 25.7 (22.8, 28.8) 44.8 (41.8, 47.8) 29.6 (25.8, 33.6)
Non-Hispanic Black 12-19 50.2 (46.0, 54.5) 49.8 (45.5, 54.0) 25.1 (20.0, 30.9) 50.3 (45.5, 55.2) 24.6 (20.5, 29.2)
20-39 46.9 (44.1, 49.6) 53.1 (50.4, 55.9) 20.1 (17.5, 23.0) 53.5 (49.0, 57.9) 26.4 (22.4, 30.8)
40-59 45.8 (42.5, 49.0) 54.2 (51.0, 57.5) 21.5 (18.5, 25.0) 48.4 (42.8, 54.1) 30.0 (25.1, 35.4)
>=60 48.4 (43.5, 53.4) 51.6 (46.6, 56.5) 22.9 (18.0, 28.7) 51.0 (46.2, 55.7) 26.1 (20.8, 32.1)
Mexican American 12-19 53.3 (51.0, 55.7) 46.7 (44.3, 49.0) 29.8 (27.0, 32.7) 47.1 (42.8, 51.5) 23.1 (19.7, 26.9)
20-39 47.6 (45.9, 49.4) 52.4 (50.6, 54.1) 23.1 (20.3, 26.1) 49.1 (44.6, 53.5) 27.9 (25.2, 30.7)
40-59 47.5 (43.5, 51.6) 52.5 (48.4, 56.5) 21.9 (17.1, 27.5) 51.3 (45.8, 56.9) 26.8 (22.5, 31.6)
>=60 45.8 (39.8, 51.9) 54.2 (48.1, 60.2) 17.6 (13.2, 23.0) 56.5 (50.0, 62.8) 26.0 (18.5, 35.2)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs1801274 A G AA AG GG
Non-Hispanic White Male 48.1 (44.9, 51.3) 51.9 (48.7, 55.1) 24.1 (20.7, 27.8) 47.9 (44.4, 51.5) 28.0 (24.3, 32.0)
Female 50.6 (48.5, 52.8) 49.4 (47.2, 51.5) 25.7 (23.3, 28.3) 49.8 (47.1, 52.6) 24.5 (21.9, 27.2)
Non-Hispanic Black Male 46.8 (44.4, 49.2) 53.2 (50.8, 55.6) 21.6 (19.3, 24.1) 50.3 (47.1, 53.6) 28.0 (24.8, 31.5)
Female 48.0 (45.9, 50.0) 52.0 (50.0, 54.1) 21.9 (19.2, 24.8) 52.1 (49.2, 55.0) 26.0 (23.8, 28.3)
Mexican American Male 48.9 (46.7, 51.1) 51.1 (48.9, 53.3) 24.0 (21.5, 26.7) 49.8 (45.8, 53.7) 26.2 (23.1, 29.6)
Female 48.3 (45.6, 51.0) 51.7 (49.0, 54.4) 23.4 (21.0, 25.9) 49.8 (46.5, 53.1) 26.8 (23.2, 30.7)


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