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U.S. Genome Variation Estimates

FCGR2A Allele and Genotype Frequencies

Available polymorphism(s)

rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs1801274

Ex4-120A>G

His166Arg
His167Arg

TaqMan



Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1801274AGAAAGGG
Non-Hispanic White49.4 (47.6, 51.1)50.6 (48.9, 52.4)0.09624.9 (23.0, 26.9)48.9 (46.8, 51.1)26.2 (24.1, 28.4)0.1270.06
Non-Hispanic Black47.4 (45.8, 49.0)52.6 (51.0, 54.2)21.8 (20.2, 23.5)51.3 (49.5, 53.1)26.9 (25.0, 29.0)0.32
Mexican American48.6 (47.1, 50.1)51.4 (49.9, 52.9)23.7 (22.1, 25.4)49.8 (47.1, 52.5)26.5 (24.3, 28.8)0.50
Total*50.0 (48.5, 51.6)50.0 (48.4, 51.5)25.6 (23.9, 27.3)48.9 (47.4, 50.5)25.5 (23.8, 27.2)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801274AGAAAGGG
12-1952.3 (48.3, 56.4)47.7 (43.6, 51.7)0.16126.6 (22.2, 31.6)51.4 (47.4, 55.3)22.0 (18.0, 26.6)0.014
20-3948.6 (46.6, 50.6)51.4 (49.4, 53.4)24.0 (22.0, 26.2)49.2 (45.7, 52.6)26.8 (23.9, 30.0)
40-5951.5 (48.5, 54.5)48.5 (45.5, 51.5)26.5 (23.0, 30.3)50.0 (45.8, 54.2)23.5 (20.1, 27.4)
>=6049.2 (46.8, 51.7)50.8 (48.3, 53.2)26.7 (24.4, 29.1)45.1 (42.5, 47.8)28.2 (25.1, 31.5)
Total50.0 (48.5, 51.6)50.0 (48.4, 51.5)25.6 (23.9, 27.3)48.9 (47.4, 50.5)25.5 (23.8, 27.2)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801274AGAAAGGG
Male49.0 (46.4, 51.6)51.0 (48.4, 53.6)0.24825.1 (22.4, 28.0)47.9 (45.0, 50.9)27.0 (24.0, 30.3)0.395
Female51.0 (48.9, 53.0)49.0 (47.0, 51.1)26.1 (23.7, 28.5)49.8 (47.7, 52.0)24.1 (22.0, 26.4)
Total50.0 (48.5, 51.6)50.0 (48.4, 51.5)25.6 (23.9, 27.3)48.9 (47.4, 50.5)25.5 (23.8, 27.2)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs1801274AGAAAGGG
Non-Hispanic White12-1952.4 (46.9, 57.9)47.6 (42.1, 53.1)26.4 (20.4, 33.4)52.1 (46.4, 57.8)21.5 (16.2, 27.9)
20-3947.6 (45.0, 50.1)52.4 (49.9, 55.0)23.3 (20.8, 26.1)48.4 (43.6, 53.3)28.2 (24.2, 32.6)
40-5951.4 (48.0, 54.8)48.6 (45.2, 52.0)25.8 (22.0, 29.8)51.3 (46.9, 55.7)22.9 (18.9, 27.5)
>=6048.1 (44.9, 51.2)51.9 (48.8, 55.1)25.7 (22.8, 28.8)44.8 (41.8, 47.8)29.6 (25.8, 33.6)
Non-Hispanic Black12-1950.2 (46.0, 54.5)49.8 (45.5, 54.0)25.1 (20.0, 30.9)50.3 (45.5, 55.2)24.6 (20.5, 29.2)
20-3946.9 (44.1, 49.6)53.1 (50.4, 55.9)20.1 (17.5, 23.0)53.5 (49.0, 57.9)26.4 (22.4, 30.8)
40-5945.8 (42.5, 49.0)54.2 (51.0, 57.5)21.5 (18.5, 25.0)48.4 (42.8, 54.1)30.0 (25.1, 35.4)
>=6048.4 (43.5, 53.4)51.6 (46.6, 56.5)22.9 (18.0, 28.7)51.0 (46.2, 55.7)26.1 (20.8, 32.1)
Mexican American12-1953.3 (51.0, 55.7)46.7 (44.3, 49.0)29.8 (27.0, 32.7)47.1 (42.8, 51.5)23.1 (19.7, 26.9)
20-3947.6 (45.9, 49.4)52.4 (50.6, 54.1)23.1 (20.3, 26.1)49.1 (44.6, 53.5)27.9 (25.2, 30.7)
40-5947.5 (43.5, 51.6)52.5 (48.4, 56.5)21.9 (17.1, 27.5)51.3 (45.8, 56.9)26.8 (22.5, 31.6)
>=6045.8 (39.8, 51.9)54.2 (48.1, 60.2)17.6 (13.2, 23.0)56.5 (50.0, 62.8)26.0 (18.5, 35.2)

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By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs1801274AGAAAGGG
Non-Hispanic WhiteMale48.1 (44.9, 51.3)51.9 (48.7, 55.1)24.1 (20.7, 27.8)47.9 (44.4, 51.5)28.0 (24.3, 32.0)
Female50.6 (48.5, 52.8)49.4 (47.2, 51.5)25.7 (23.3, 28.3)49.8 (47.1, 52.6)24.5 (21.9, 27.2)
Non-Hispanic BlackMale46.8 (44.4, 49.2)53.2 (50.8, 55.6)21.6 (19.3, 24.1)50.3 (47.1, 53.6)28.0 (24.8, 31.5)
Female48.0 (45.9, 50.0)52.0 (50.0, 54.1)21.9 (19.2, 24.8)52.1 (49.2, 55.0)26.0 (23.8, 28.3)
Mexican AmericanMale48.9 (46.7, 51.1)51.1 (48.9, 53.3)24.0 (21.5, 26.7)49.8 (45.8, 53.7)26.2 (23.1, 29.6)
Female48.3 (45.6, 51.0)51.7 (49.0, 54.4)23.4 (21.0, 25.9)49.8 (46.5, 53.1)26.8 (23.2, 30.7)


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