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U.S. Genome Variation Estimates

FAM82A* Allele and Genotype Frequencies

Available polymorphism(s)


rs number

Common Designations

Nucleotide change Amino acid

Genotyping method

rs163086

IVS10-1363C>T

TaqMan

* FAM82A is a hypothetical protein that lies immediately 5' of CYP1B1. This variant may be an intronic polymorphism of FAM82A or a CYP1B1 variant that lies 3’ of the gene



Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs163086CTCCCTTT
Non-Hispanic White77.2 (75.5, 78.8)22.8 (21.2, 24.5)<0.00159.8 (57.0, 62.6)34.7 (32.0, 37.5)5.5 (4.3, 6.9)<0.0010.73
Non-Hispanic Black80.9 (79.0, 82.6)19.1 (17.4, 21.0)65.0 (62.1, 67.8)31.7 (29.3, 34.2)3.3 (2.3, 4.6)0.18
Mexican American85.5 (83.7, 87.0)14.5 (13.0, 16.3)73.4 (70.6, 76.0)24.1 (21.9, 26.4)2.5 (1.8, 3.4)0.18
Total*78.7 (77.4, 80.0)21.3 (20.0, 22.6)62.3 (60.2, 64.2)32.9 (31.2, 34.8)4.8 (3.9, 5.9)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs163086CTCCCTTT
12-1974.7 (70.2, 78.6)25.3 (21.4, 29.8)0.03556.0 (49.7, 62.2)37.2 (32.6, 42.0)6.7 (4.5, 9.9)0.036
20-3978.7 (76.9, 80.5)21.3 (19.5, 23.1)62.4 (59.2, 65.5)32.6 (29.6, 35.8)5.0 (3.9, 6.3)
40-5979.1 (76.3, 81.6)20.9 (18.4, 23.7)62.6 (58.4, 66.6)33.0 (29.6, 36.5)4.5 (3.0, 6.6)
>=6081.1 (79.3, 82.9)18.9 (17.1, 20.7)65.9 (63.0, 68.7)30.4 (27.7, 33.2)3.7 (2.5, 5.4)
Total78.7 (77.4, 80.0)21.3 (20.0, 22.6)62.3 (60.2, 64.2)32.9 (31.2, 34.8)4.8 (3.9, 5.9)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs163086CTCCCTTT
Male78.5 (76.4, 80.5)21.5 (19.5, 23.6)0.82661.6 (58.4, 64.8)33.8 (30.8, 36.9)4.6 (3.1, 6.6)0.615
Female78.9 (76.9, 80.8)21.1 (19.2, 23.1)62.8 (60.1, 65.5)32.1 (30.1, 34.3)5.1 (3.7, 6.9)
Total78.7 (77.4, 80.0)21.3 (20.0, 22.6)62.3 (60.2, 64.2)32.9 (31.2, 34.8)4.8 (3.9, 5.9)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs163086CTCCCTTT
Non-Hispanic White12-1972.1 (65.7, 77.6)27.9 (22.4, 34.3)53.3 (44.5, 61.9)37.6 (31.3, 44.3)9.2 (5.9, 14.0)
20-3976.8 (73.9, 79.5)23.2 (20.5, 26.1)59.3 (54.5, 63.9)35.1 (30.6, 39.8)5.6 (3.9, 8.0)
40-5977.5 (74.0, 80.6)22.5 (19.4, 26.0)59.7 (54.2, 65.0)35.5 (30.7, 40.6)4.8 (3.0, 7.4)
>=6080.3 (78.0, 82.4)19.7 (17.6, 22.0)64.6 (61.2, 67.8)31.4 (28.6, 34.4)4.0 (2.6, 6.1)
Non-Hispanic Black12-1978.5 (75.0, 81.6)21.5 (18.4, 25.0)60.7 (54.9, 66.3)35.4 (30.2, 41.1)3.8 (2.2, 6.6)
20-3981.3 (78.5, 83.8)18.7 (16.2, 21.5)65.5 (60.8, 69.9)31.6 (27.3, 36.2)2.9 (1.6, 5.3)
40-5980.7 (78.7, 82.7)19.3 (17.3, 21.3)65.6 (62.7, 68.3)30.3 (27.3, 33.6)4.1 (2.4, 7.0)
>=6083.1 (79.5, 86.2)16.9 (13.8, 20.5)68.3 (61.2, 74.6)29.7 (22.9, 37.4)2.1 (0.8, 5.5)
Mexican American12-1986.3 (82.7, 89.4)13.7 (10.6, 17.3)74.6 (68.1, 80.1)23.5 (18.4, 29.5)1.9 (1.0, 3.5)
20-3985.0 (83.2, 86.7)15.0 (13.3, 16.8)73.1 (70.3, 75.7)23.9 (21.7, 26.3)3.0 (2.0, 4.4)
40-5986.0 (84.1, 87.7)14.0 (12.3, 15.9)74.0 (69.4, 78.1)24.0 (19.1, 29.6)2.0 (1.1, 3.6)
>=6084.5 (79.8, 88.3)15.5 (11.7, 20.2)71.3 (63.4, 78.1)26.5 (20.5, 33.5)2.2 (1.2, 4.3)

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By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs163086CTCCCTTT
Non-Hispanic WhiteMale76.8 (74.3, 79.2)23.2 (20.8, 25.7)58.8 (54.7, 62.8)36.0 (32.1, 40.2)5.1 (3.5, 7.5)
Female77.5 (74.9, 79.9)22.5 (20.1, 25.1)60.8 (57.3, 64.1)33.5 (30.8, 36.2)5.7 (3.9, 8.4)
Non-Hispanic BlackMale80.5 (78.3, 82.5)19.5 (17.5, 21.7)64.5 (61.0, 67.8)32.0 (29.0, 35.2)3.5 (2.3, 5.3)
Female81.2 (78.4, 83.7)18.8 (16.3, 21.6)65.5 (61.0, 69.7)31.4 (27.9, 35.3)3.1 (2.0, 4.7)
Mexican AmericanMale84.9 (82.0, 87.4)15.1 (12.6, 18.0)72.2 (67.1, 76.8)25.3 (21.1, 30.0)2.5 (1.9, 3.2)
Female86.1 (84.6, 87.4)13.9 (12.6, 15.4)74.7 (71.9, 77.3)22.8 (19.9, 25.9)2.5 (1.6, 4.0)


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