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U.S. Genome Variation Estimates

FAM82A* Allele and Genotype Frequencies

 

Available polymorphism(s)


rs number

Common Designations

Nucleotide change                  Amino acid

Genotyping method

rs163086

IVS10-1363C>T

 

TaqMan

* FAM82A is a hypothetical protein that lies immediately 5' of CYP1B1. This variant may be an intronic polymorphism of FAM82A or a CYP1B1 variant that lies 3’ of the gene



Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs163086 C T   CC CT TT    
Non-Hispanic White 77.2 (75.5, 78.8) 22.8 (21.2, 24.5) <0.001 59.8 (57.0, 62.6) 34.7 (32.0, 37.5) 5.5 (4.3, 6.9) <0.001 0.73
Non-Hispanic Black 80.9 (79.0, 82.6) 19.1 (17.4, 21.0) 65.0 (62.1, 67.8) 31.7 (29.3, 34.2) 3.3 (2.3, 4.6) 0.18
Mexican American 85.5 (83.7, 87.0) 14.5 (13.0, 16.3) 73.4 (70.6, 76.0) 24.1 (21.9, 26.4) 2.5 (1.8, 3.4) 0.18
Total* 78.7 (77.4, 80.0) 21.3 (20.0, 22.6)   62.3 (60.2, 64.2) 32.9 (31.2, 34.8) 4.8 (3.9, 5.9)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age* 

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs163086 C T   CC CT TT  
12-19 74.7 (70.2, 78.6) 25.3 (21.4, 29.8) 0.035 56.0 (49.7, 62.2) 37.2 (32.6, 42.0) 6.7 (4.5, 9.9) 0.036
20-39 78.7 (76.9, 80.5) 21.3 (19.5, 23.1) 62.4 (59.2, 65.5) 32.6 (29.6, 35.8) 5.0 (3.9, 6.3)
40-59 79.1 (76.3, 81.6) 20.9 (18.4, 23.7) 62.6 (58.4, 66.6) 33.0 (29.6, 36.5) 4.5 (3.0, 6.6)
>=60 81.1 (79.3, 82.9) 18.9 (17.1, 20.7)   65.9 (63.0, 68.7) 30.4 (27.7, 33.2) 3.7 (2.5, 5.4)
Total 78.7 (77.4, 80.0) 21.3 (20.0, 22.6)   62.3 (60.2, 64.2) 32.9 (31.2, 34.8) 4.8 (3.9, 5.9)  

* Includes all participants, regardless of race/ethnicity.

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By Sex* 

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs163086 C T   CC CT TT  
Male 78.5 (76.4, 80.5) 21.5 (19.5, 23.6) 0.826 61.6 (58.4, 64.8) 33.8 (30.8, 36.9) 4.6 (3.1, 6.6) 0.615
Female 78.9 (76.9, 80.8) 21.1 (19.2, 23.1) 62.8 (60.1, 65.5) 32.1 (30.1, 34.3) 5.1 (3.7, 6.9)
Total 78.7 (77.4, 80.0) 21.3 (20.0, 22.6)   62.3 (60.2, 64.2) 32.9 (31.2, 34.8) 4.8 (3.9, 5.9)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs163086 C T CC CT TT
Non-Hispanic White 12-19 72.1 (65.7, 77.6) 27.9 (22.4, 34.3) 53.3 (44.5, 61.9) 37.6 (31.3, 44.3) 9.2 (5.9, 14.0)
20-39 76.8 (73.9, 79.5) 23.2 (20.5, 26.1) 59.3 (54.5, 63.9) 35.1 (30.6, 39.8) 5.6 (3.9, 8.0)
40-59 77.5 (74.0, 80.6) 22.5 (19.4, 26.0) 59.7 (54.2, 65.0) 35.5 (30.7, 40.6) 4.8 (3.0, 7.4)
>=60 80.3 (78.0, 82.4) 19.7 (17.6, 22.0) 64.6 (61.2, 67.8) 31.4 (28.6, 34.4) 4.0 (2.6, 6.1)
Non-Hispanic Black 12-19 78.5 (75.0, 81.6) 21.5 (18.4, 25.0) 60.7 (54.9, 66.3) 35.4 (30.2, 41.1) 3.8 (2.2, 6.6)
20-39 81.3 (78.5, 83.8) 18.7 (16.2, 21.5) 65.5 (60.8, 69.9) 31.6 (27.3, 36.2) 2.9 (1.6, 5.3)
40-59 80.7 (78.7, 82.7) 19.3 (17.3, 21.3) 65.6 (62.7, 68.3) 30.3 (27.3, 33.6) 4.1 (2.4, 7.0)
>=60 83.1 (79.5, 86.2) 16.9 (13.8, 20.5) 68.3 (61.2, 74.6) 29.7 (22.9, 37.4) 2.1 (0.8, 5.5)
Mexican American 12-19 86.3 (82.7, 89.4) 13.7 (10.6, 17.3) 74.6 (68.1, 80.1) 23.5 (18.4, 29.5) 1.9 (1.0, 3.5)
20-39 85.0 (83.2, 86.7) 15.0 (13.3, 16.8) 73.1 (70.3, 75.7) 23.9 (21.7, 26.3) 3.0 (2.0, 4.4)
40-59 86.0 (84.1, 87.7) 14.0 (12.3, 15.9) 74.0 (69.4, 78.1) 24.0 (19.1, 29.6) 2.0 (1.1, 3.6)
>=60 84.5 (79.8, 88.3) 15.5 (11.7, 20.2) 71.3 (63.4, 78.1) 26.5 (20.5, 33.5) 2.2 (1.2, 4.3)

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By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs163086 C T CC CT TT
Non-Hispanic White Male 76.8 (74.3, 79.2) 23.2 (20.8, 25.7) 58.8 (54.7, 62.8) 36.0 (32.1, 40.2) 5.1 (3.5, 7.5)
Female 77.5 (74.9, 79.9) 22.5 (20.1, 25.1) 60.8 (57.3, 64.1) 33.5 (30.8, 36.2) 5.7 (3.9, 8.4)
Non-Hispanic Black Male 80.5 (78.3, 82.5) 19.5 (17.5, 21.7) 64.5 (61.0, 67.8) 32.0 (29.0, 35.2) 3.5 (2.3, 5.3)
Female 81.2 (78.4, 83.7) 18.8 (16.3, 21.6) 65.5 (61.0, 69.7) 31.4 (27.9, 35.3) 3.1 (2.0, 4.7)
Mexican American Male 84.9 (82.0, 87.4) 15.1 (12.6, 18.0) 72.2 (67.1, 76.8) 25.3 (21.1, 30.0) 2.5 (1.9, 3.2)
Female 86.1 (84.6, 87.4) 13.9 (12.6, 15.4) 74.7 (71.9, 77.3) 22.8 (19.9, 25.9) 2.5 (1.6, 4.0)


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