Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

U.S. Genome Variation Estimates


CYP2A6 Allele and Genotype Frequencies

Available polymorphism(s)

Common Designations

rs number

Nucleotide changeAmino acid change

Genotyping method

rs1801272Ex3-15T>ALeu160HisTaqMan

Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1801272ATAAATTT
Non-Hispanic White3.3 (2.8, 3.8)96.7 (96.2, 97.2)<0.0010.1 (0.0, 0.3)6.4 (5.5, 7.4)93.5 (92.5, 94.5)<0.0010.79
Non-Hispanic Black0.6 (0.4, 0.9)99.4 (99.1, 99.6)0.0 (NA)1.2 (0.8, 1.8)98.8 (98.2, 99.2)0.79
Mexican American2.0 (1.6, 2.5)98.0 (97.5, 98.4)0.0 (0.0, 0.3)3.9 (3.2, 4.8)96.0 (95.1, 96.8)0.93
Total*2.7 (2.4, 3.1)97.3 (96.9, 97.6)0.1 (0.0, 0.3)5.3 (4.7, 6.1)94.6 (93.8, 95.3)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

Top of Page


By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801272ATAAATTT
12-192.7 (1.8, 4.1)97.3 (95.9, 98.2)0.1070.2 (0.0, 1.6)5.0 (3.3, 7.6)94.8 (92.2, 96.5)0.026
20-392.4 (1.8, 3.0)97.6 (97.0, 98.2)0.1 (0.0, 0.6)4.6 (3.6, 5.8)95.4 (94.1, 96.4)
40-593.6 (2.7, 4.6)96.4 (95.4, 97.3)0.0 (0.0, 0.1)7.1 (5.5, 9.2)92.9 (90.8, 94.5)
>=602.3 (1.6, 3.4)97.7 (96.6, 98.4)0.0 (NA)4.7 (3.2, 6.8)95.3 (93.2, 96.8)
Total2.7 (2.4, 3.1)97.3 (96.9, 97.6)0.1 (0.0, 0.3)5.3 (4.7, 6.1)94.6 (93.8, 95.3)

* Includes all participants, regardless of race/ethnicity.

Top of Page


By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801272ATAAATTT
Male2.9 (2.2, 3.8)97.1 (96.2, 97.8)0.4780.1 (0.0, 0.5)5.6 (4.3, 7.2)94.3 (92.6, 95.6)0.336
Female2.6 (2.1, 3.1)97.4 (96.9, 97.9)0.0 (NA)5.1 (4.2, 6.2)94.9 (93.8, 95.8)
Total2.7 (2.4, 3.1)97.3 (96.9, 97.6)0.1 (0.0, 0.3)5.3 (4.7, 6.1)94.6 (93.8, 95.3)

* Includes all participants, regardless of race/ethnicity.

Top of Page


By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs1801272ATAAATTT
Non-Hispanic White12-193.9 (2.6, 5.7)96.1 (94.3, 97.4)0.3 (0.0, 2.4)7.1 (4.5, 10.8)92.6 (89.0, 95.1)
20-393.0 (2.3, 4.0)97.0 (96.0, 97.7)0.1 (0.0, 0.9)5.9 (4.5, 7.6)94.0 (92.3, 95.4)
40-594.0 (3.0, 5.3)96.0 (94.7, 97.0)0.0 (NA)8.0 (6.0, 10.6)92.0 (89.4, 94.0)
>=602.4 (1.6, 3.5)97.6 (96.5, 98.4)0.0 (NA)4.7 (3.2, 6.9)95.3 (93.1, 96.8)
Non-Hispanic Black12-190.4 (0.2, 1.2)99.6 (98.8, 99.8)0.0 (NA)0.9 (0.3, 2.4)99.1 (97.6, 99.7)
20-390.4 (0.2, 0.7)99.6 (99.3, 99.8)0.0 (NA)0.8 (0.4, 1.4)99.2 (98.6, 99.6)
40-591.0 (0.5, 2.3)99.0 (97.7, 99.5)0.0 (NA)2.1 (1.0, 4.5)97.9 (95.5, 99.0)
>=600.7 (0.2, 2.1)99.3 (97.9, 99.8)0.0 (NA)1.4 (0.4, 4.1)98.6 (95.9, 99.6)
Mexican American12-191.5 (1.0, 2.4)98.5 (97.6, 99.0)0.0 (NA)3.1 (1.9, 4.9)96.9 (95.1, 98.1)
20-392.3 (1.5, 3.5)97.7 (96.5, 98.5)0.0 (NA)4.6 (3.0, 6.9)95.4 (93.1, 97.0)
40-591.9 (1.3, 2.7)98.1 (97.3, 98.7)0.2 (0.0, 1.5)3.5 (2.4, 5.0)96.4 (94.9, 97.5)
>=601.7 (0.7, 3.8)98.3 (96.2, 99.3)0.0 (NA)3.4 (1.5, 7.5)96.6 (92.5, 98.5)

Top of Page


By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs1801272ATAAATTT
Non-Hispanic WhiteMale3.6 (2.6, 4.8)96.4 (95.2, 97.4)0.2 (0.0, 0.7)6.8 (5.0, 9.1)93.1 (90.7, 94.8)
Female3.0 (2.4, 3.8)97.0 (96.2, 97.6)0.0 (NA)6.0 (4.8, 7.5)94.0 (92.5, 95.2)
Non-Hispanic BlackMale0.6 (0.3, 1.3)99.4 (98.7, 99.7)0.0 (NA)1.2 (0.6, 2.5)98.8 (97.5, 99.4)
Female0.6 (0.3, 1.1)99.4 (98.9, 99.7)0.0 (NA)1.2 (0.6, 2.2)98.8 (97.8, 99.4)
Mexican AmericanMale2.0 (1.4, 2.8)98.0 (97.2, 98.6)0.1 (0.0, 0.6)3.9 (2.8, 5.3)96.1 (94.6, 97.2)
Female2.0 (1.4, 2.8)98.0 (97.2, 98.6)0.0 (NA)4.0 (2.8, 5.6)96.0 (94.4, 97.2)

Top of Page

Error processing SSI file
Top