Skip directly to search Skip directly to A to Z list Skip directly to site content
CDC Home

U.S. Genome Variation Estimates

CYP1A2 Allele and Genotype Frequencies

Available polymorphism(s)


  Common Designations  

rs number

Nucleotide change Amino acid change

Genotyping method

rs11854147

5341bp 3' of STP C>T

 

TaqMan

rs2069514

-3859G>A

 

TaqMan

rs4886406

9773bp 3' of STP T>G

 

TaqMan

 

Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs11854147 C T   CC CT TT    
Non-Hispanic White 68.6 (66.9, 70.4) 31.4 (29.6, 33.1) <0.001 49.1 (46.9, 51.4) 39.0 (37.2, 40.8) 11.9 (10.3, 13.6) <0.001 <0.01
Non-Hispanic Black 27.9 (26.1, 29.7) 72.1 (70.3, 73.9) 8.6 (7.1, 10.4) 38.6 (36.8, 40.5) 52.8 (50.5, 55.1) 0.11
Mexican American 38.7 (35.1, 42.3) 61.3 (57.7, 64.9) 16.5 (13.3, 20.2) 44.4 (41.0, 47.8) 39.1 (34.8, 43.7) 0.11
Total* 59.6 (57.2, 61.9) 40.4 (38.1, 42.8)   39.5 (36.8, 42.2) 40.1 (38.6, 41.7) 20.4 (18.2, 22.7)    
rs2069514 A G   AA AG GG    
Non-Hispanic White 1.6 (1.0, 2.5) 98.4 (97.5, 99.0) <0.001 0.1 (0.0, 0.8) 2.9 (1.8, 4.7) 96.9 (95.2, 98.1) <0.001 0.09
Non-Hispanic Black 26.3 (24.9, 27.7) 73.7 (72.3, 75.1) 6.3 (5.3, 7.5) 39.9 (36.8, 43.1) 53.8 (51.0, 56.5) 0.29
Mexican American 33.7 (30.2, 37.4) 66.3 (62.6, 69.8) 12.2 (9.3, 15.9) 42.9 (39.3, 46.6) 44.9 (40.3, 49.6) 0.29
Total* 8.4 (7.0, 10.0) 91.6 (90.0, 93.0)   2.2 (1.7, 2.9) 12.4 (10.2, 15.0) 85.4 (82.6, 87.9)    
rs4886406 G T   GG GT TT    
Non-Hispanic White 27.8 (26.5, 29.2) 72.2 (70.8, 73.5) <0.001 8.4 (7.1, 9.8) 38.9 (37.1, 40.8) 52.7 (50.9, 54.6) 0.001 0.13
Non-Hispanic Black 38.3 (36.0, 40.8) 61.7 (59.2, 64.0) 13.9 (12.1, 16.0) 48.8 (45.9, 51.8) 37.2 (33.8, 40.8) 0.18
Mexican American 26.5 (24.7, 28.5) 73.5 (71.5, 75.3) 7.2 (5.8, 9.0) 38.6 (36.2, 41.1) 54.1 (51.4, 56.9) 0.87
Total* 29.4 (28.1, 30.7) 70.6 (69.3, 71.9)   9.0 (7.9, 10.2) 40.9 (38.9, 42.9) 50.1 (48.1, 52.2)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

Top of Page


 

By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs11854147 C T   CC CT TT  
12-19 57.9 (51.7, 63.9) 42.1 (36.1, 48.3) 0.199 37.8 (30.9, 45.3) 40.2 (35.8, 44.7) 22.0 (16.8, 28.3) 0.252
20-39 58.1 (54.8, 61.4) 41.9 (38.6, 45.2) 37.0 (33.3, 40.8) 42.3 (40.2, 44.4) 20.7 (17.8, 24.1)
40-59 60.6 (57.4, 63.7) 39.4 (36.3, 42.6) 41.5 (37.5, 45.5) 38.3 (35.1, 41.5) 20.3 (17.5, 23.4)
>=60 62.1 (59.6, 64.5) 37.9 (35.5, 40.4) 42.9 (39.8, 46.0) 38.5 (35.5, 41.6) 18.6 (16.1, 21.4)
Total 59.6 (57.2, 61.9) 40.4 (38.1, 42.8)   39.5 (36.8, 42.2) 40.1 (38.6, 41.7) 20.4 (18.2, 22.7)  
rs2069514 A G   AA AG GG  
12-19 10.5 (7.9, 13.9) 89.5 (86.1, 92.1) 0.003 3.1 (2.2, 4.4) 14.9 (10.8, 20.2) 82.0 (76.2, 86.6) 0.062
20-39 9.7 (7.4, 12.6) 90.3 (87.4, 92.6) 2.4 (1.5, 3.8) 14.6 (10.7, 19.5) 83.1 (77.9, 87.2)
40-59 7.4 (6.1, 8.9) 92.6 (91.1, 93.9) 2.2 (1.5, 3.2) 10.4 (8.7, 12.5) 87.4 (85.0, 89.4)
>=60 5.8 (4.5, 7.6) 94.2 (92.4, 95.5) 1.3 (0.6, 2.9) 9.0 (7.5, 10.7) 89.7 (87.2, 91.7)
Total 8.4 (7.0, 10.0) 91.6 (90.0, 93.0)   2.2 (1.7, 2.9) 12.4 (10.2, 15.0) 85.4 (82.6, 87.9)  
rs4886406 G T   GG GT TT  
12-19 28.7 (25.2, 32.5) 71.3 (67.5, 74.8) 0.822 8.8 (5.4, 14.1) 39.8 (34.5, 45.4) 51.4 (46.6, 56.1) 0.966
20-39 30.0 (27.9, 32.2) 70.0 (67.8, 72.1) 9.1 (7.4, 11.2) 41.8 (39.3, 44.4) 49.1 (46.0, 52.1)
40-59 29.2 (26.9, 31.7) 70.8 (68.3, 73.1) 9.1 (6.8, 12.1) 40.2 (36.1, 44.4) 50.7 (47.1, 54.2)
>=60 28.9 (26.8, 31.1) 71.1 (68.9, 73.2) 8.5 (7.3, 9.9) 40.8 (37.2, 44.5) 50.7 (46.9, 54.5)
Total 29.4 (28.1, 30.7) 70.6 (69.3, 71.9)   9.0 (7.9, 10.2) 40.9 (38.9, 42.9) 50.1 (48.1, 52.2)  

* Includes all participants, regardless of race/ethnicity.

Top of Page


 

By Sex*

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs11854147 C T   CC CT TT  
Male 59.5 (56.5, 62.5) 40.5 (37.5, 43.5) 0.975 39.4 (36.1, 42.8) 40.3 (37.3, 43.3) 20.3 (17.2, 23.8) 0.995
Female 59.6 (56.9, 62.2) 40.4 (37.8, 43.1) 39.6 (35.8, 43.4) 40.0 (37.1, 43.1) 20.4 (18.5, 22.4)
Total 59.6 (57.2, 61.9) 40.4 (38.1, 42.8)   39.5 (36.8, 42.2) 40.1 (38.6, 41.7) 20.4 (18.2, 22.7)  
rs2069514 A G   AA AG GG  
Male 8.9 (7.0, 11.3) 91.1 (88.7, 93.0) 0.166 2.4 (1.7, 3.5) 13.0 (10.1, 16.6) 84.6 (80.5, 88.0) 0.391
Female 7.9 (6.8, 9.1) 92.1 (90.9, 93.2) 2.0 (1.6, 2.6) 11.8 (10.0, 14.0) 86.2 (83.9, 88.1)
Total 8.4 (7.0, 10.0) 91.6 (90.0, 93.0)   2.2 (1.7, 2.9) 12.4 (10.2, 15.0) 85.4 (82.6, 87.9)  
rs4886406 G T   GG GT TT  
Male 29.2 (27.0, 31.6) 70.8 (68.4, 73.0) 0.819 8.7 (7.0, 10.7) 41.2 (38.1, 44.3) 50.2 (46.7, 53.6) 0.845
Female 29.6 (28.0, 31.2) 70.4 (68.8, 72.0) 9.2 (8.1, 10.5) 40.7 (37.0, 44.5) 50.1 (46.8, 53.4)
Total 29.4 (28.1, 30.7) 70.6 (69.3, 71.9)   9.0 (7.9, 10.2) 40.9 (38.9, 42.9) 50.1 (48.1, 52.2)  

* Includes all participants, regardless of race/ethnicity.

Top of Page


 

By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs11854147 C T CC CT TT
Non-Hispanic White 12-19 70.6 (65.2, 75.4) 29.4 (24.6, 34.8) 52.2 (44.3, 59.9) 36.8 (29.8, 44.4) 11.0 (7.5, 15.9)
20-39 68.3 (65.3, 71.2) 31.7 (28.8, 34.7) 48.2 (44.5, 51.9) 40.3 (37.3, 43.4) 11.5 (8.9, 14.7)
40-59 68.5 (65.6, 71.3) 31.5 (28.7, 34.4) 49.2 (45.8, 52.7) 38.6 (35.4, 41.9) 12.2 (9.4, 15.6)
>=60 68.2 (66.5, 69.9) 31.8 (30.1, 33.5) 49.0 (46.2, 51.8) 38.5 (34.8, 42.2) 12.6 (10.6, 14.9)
Non-Hispanic Black 12-19 24.8 (20.3, 29.9) 75.2 (70.1, 79.7) 6.3 (4.4, 9.0) 36.9 (30.2, 44.3) 56.7 (48.4, 64.6)
20-39 29.5 (27.1, 32.0) 70.5 (68.0, 72.9) 9.9 (7.5, 13.1) 39.2 (35.7, 42.7) 50.9 (47.7, 54.1)
40-59 25.9 (23.3, 28.7) 74.1 (71.3, 76.7) 7.8 (5.3, 11.4) 36.3 (32.1, 40.7) 55.9 (52.1, 59.7)
>=60 30.6 (24.8, 37.2) 69.4 (62.8, 75.2) 8.8 (6.1, 12.5) 43.6 (34.2, 53.5) 47.5 (37.1, 58.2)
Mexican American 12-19 37.2 (32.9, 41.6) 62.8 (58.4, 67.1) 15.1 (9.9, 22.3) 44.2 (37.5, 51.1) 40.7 (35.9, 45.7)
20-39 37.3 (34.1, 40.7) 62.7 (59.3, 65.9) 14.9 (12.6, 17.6) 44.9 (40.8, 49.0) 40.2 (35.5, 45.1)
40-59 43.2 (35.9, 50.8) 56.8 (49.2, 64.1) 22.1 (15.3, 30.9) 42.2 (36.3, 48.4) 35.6 (27.7, 44.4)
>=60 38.3 (34.2, 42.6) 61.7 (57.4, 65.8) 14.6 (11.6, 18.1) 47.6 (41.6, 53.6) 37.9 (31.6, 44.6)
rs2069514 A G AA AG GG
Non-Hispanic White 12-19 2.0 (0.8, 5.2) 98.0 (94.8, 99.2) 0.2 (0.0, 1.9) 3.5 (1.2, 9.9) 96.2 (90.0, 98.6)
20-39 1.7 (0.7, 4.1) 98.3 (95.9, 99.3) 0.0 (NA) 3.3 (1.3, 8.2) 96.7 (91.8, 98.7)
40-59 1.2 (0.7, 2.2) 98.8 (97.8, 99.3) 0.4 (0.0, 2.9) 1.7 (0.9, 3.2) 97.9 (96.7, 98.7)
>=60 1.8 (1.3, 2.4) 98.2 (97.6, 98.7) 0.0 (NA) 3.5 (2.7, 4.7) 96.5 (95.3, 97.3)
Non-Hispanic Black 12-19 30.5 (27.2, 34.1) 69.5 (65.9, 72.8) 8.8 (6.0, 12.6) 43.6 (37.7, 49.7) 47.7 (42.1, 53.3)
20-39 24.9 (22.7, 27.3) 75.1 (72.7, 77.3) 5.2 (3.5, 7.7) 39.4 (34.2, 44.8) 55.4 (50.9, 59.9)
40-59 27.2 (24.3, 30.4) 72.8 (69.6, 75.7) 7.5 (5.5, 10.2) 39.4 (34.3, 44.8) 53.1 (47.9, 58.2)
>=60 23.2 (20.1, 26.7) 76.8 (73.3, 79.9) 4.3 (2.2, 8.2) 37.9 (31.3, 44.9) 57.8 (51.6, 63.8)
Mexican American 12-19 34.5 (27.5, 42.3) 65.5 (57.7, 72.5) 14.4 (9.0, 22.1) 40.3 (31.9, 49.3) 45.3 (35.3, 55.7)
20-39 34.3 (31.9, 36.7) 65.7 (63.3, 68.1) 11.8 (9.4, 14.8) 44.8 (41.7, 48.1) 43.3 (40.4, 46.3)
40-59 32.5 (27.6, 37.9) 67.5 (62.1, 72.4) 10.5 (6.6, 16.4) 43.9 (39.2, 48.8) 45.5 (39.2, 52.0)
>=60 31.1 (25.6, 37.3) 68.9 (62.7, 74.4) 13.7 (9.6, 19.1) 34.9 (28.5, 41.9) 51.4 (43.2, 59.6)
rs4886406 G T GG GT TT
Non-Hispanic White 12-19 26.6 (22.2, 31.4) 73.4 (68.6, 77.8) 7.9 (4.9, 12.5) 37.3 (30.4, 44.7) 54.8 (47.4, 62.0)
20-39 28.5 (26.1, 31.1) 71.5 (68.9, 73.9) 8.8 (6.6, 11.6) 39.4 (36.5, 42.3) 51.8 (48.5, 55.1)
40-59 27.9 (25.3, 30.7) 72.1 (69.3, 74.7) 8.4 (5.6, 12.5) 39.0 (34.5, 43.7) 52.6 (48.8, 56.3)
>=60 27.3 (25.3, 29.3) 72.7 (70.7, 74.7) 7.8 (6.5, 9.4) 38.9 (35.3, 42.6) 53.3 (49.7, 56.8)
Non-Hispanic Black 12-19 34.5 (31.1, 38.1) 65.5 (61.9, 68.9) 9.0 (7.0, 11.3) 51.1 (44.0, 58.1) 40.0 (33.5, 46.9)
20-39 37.2 (34.4, 40.0) 62.8 (60.0, 65.6) 13.6 (11.2, 16.4) 47.1 (43.5, 50.8) 39.3 (35.4, 43.4)
40-59 41.6 (37.2, 46.1) 58.4 (53.9, 62.8) 17.1 (12.9, 22.3) 48.9 (43.3, 54.6) 34.0 (28.5, 40.0)
>=60 41.4 (36.2, 46.8) 58.6 (53.2, 63.8) 15.8 (10.3, 23.5) 51.1 (42.9, 59.3) 33.1 (26.5, 40.3)
Mexican American 12-19 26.0 (22.9, 29.5) 74.0 (70.5, 77.1) 7.8 (5.7, 10.6) 36.5 (30.9, 42.5) 55.7 (49.9, 61.4)
20-39 27.5 (24.9, 30.2) 72.5 (69.8, 75.1) 8.0 (5.7, 11.1) 39.0 (36.3, 41.7) 53.0 (49.7, 56.3)
40-59 24.5 (21.2, 28.1) 75.5 (71.9, 78.8) 5.0 (3.3, 7.6) 38.9 (32.6, 45.6) 56.0 (49.6, 62.3)
>=60 27.6 (24.4, 31.0) 72.4 (69.0, 75.6) 6.9 (4.4, 10.7) 41.2 (37.0, 45.6) 51.8 (47.2, 56.4)

Top of Page


 

By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs11854147 C T CC CT TT
Non-Hispanic White Male 68.5 (65.2, 71.6) 31.5 (28.4, 34.8) 48.7 (44.6, 52.9) 39.6 (36.1, 43.1) 11.7 (9.0, 15.1)
Female 68.8 (66.9, 70.6) 31.2 (29.4, 33.1) 49.5 (46.4, 52.6) 38.4 (35.1, 41.9) 12.0 (10.4, 13.9)
Non-Hispanic Black Male 27.7 (25.2, 30.3) 72.3 (69.7, 74.8) 9.2 (7.6, 11.1) 36.9 (33.4, 40.5) 53.9 (49.8, 57.9)
Female 28.1 (25.3, 31.1) 71.9 (68.9, 74.7) 8.0 (5.8, 11.0) 40.1 (37.8, 42.4) 51.9 (48.2, 55.5)
Mexican American Male 39.4 (35.6, 43.2) 60.6 (56.8, 64.4) 17.4 (14.1, 21.3) 43.9 (39.4, 48.5) 38.7 (33.7, 43.9)
Female 37.9 (33.7, 42.4) 62.1 (57.6, 66.3) 15.4 (11.7, 20.1) 44.9 (41.6, 48.3) 39.6 (34.6, 44.9)
rs2069514 A G AA AG GG
Non-Hispanic White Male 2.1 (1.1, 4.0) 97.9 (96.0, 98.9) 0.2 (0.0, 1.8) 3.7 (1.9, 7.1) 96.1 (92.6, 97.9)
Female 1.1 (0.7, 1.9) 98.9 (98.1, 99.3) 0.1 (0.0, 0.4) 2.2 (1.3, 3.7) 97.8 (96.3, 98.7)
Non-Hispanic Black Male 26.3 (24.7, 28.0) 73.7 (72.0, 75.3) 6.4 (4.8, 8.4) 39.8 (36.1, 43.7) 53.8 (50.7, 56.8)
Female 26.2 (24.3, 28.2) 73.8 (71.8, 75.7) 6.2 (4.9, 8.0) 40.0 (35.5, 44.7) 53.7 (49.8, 57.7)
Mexican American Male 32.7 (28.6, 37.1) 67.3 (62.9, 71.4) 11.5 (8.4, 15.5) 42.4 (38.2, 46.6) 46.1 (40.5, 51.9)
Female 34.7 (31.0, 38.6) 65.3 (61.4, 69.0) 13.0 (9.6, 17.3) 43.5 (38.5, 48.6) 43.6 (38.4, 48.8)
rs4886406 G T GG GT TT
Non-Hispanic White Male 27.5 (24.7, 30.5) 72.5 (69.5, 75.3) 7.7 (5.8, 10.3) 39.6 (36.5, 42.8) 52.7 (48.6, 56.7)
Female 28.1 (26.5, 29.7) 71.9 (70.3, 73.5) 9.0 (7.8, 10.2) 38.3 (34.4, 42.3) 52.8 (49.4, 56.1)
Non-Hispanic Black Male 38.8 (35.6, 42.1) 61.2 (57.9, 64.4) 14.1 (12.0, 16.6) 49.4 (44.5, 54.3) 36.5 (31.5, 41.9)
Female 38.0 (35.0, 41.0) 62.0 (59.0, 65.0) 13.8 (11.5, 16.4) 48.4 (44.7, 52.1) 37.8 (33.6, 42.3)
Mexican American Male 26.7 (23.5, 30.2) 73.3 (69.8, 76.5) 6.6 (4.8, 9.0) 40.2 (36.4, 44.2) 53.2 (48.0, 58.3)
Female 26.4 (24.4, 28.5) 73.6 (71.5, 75.6) 7.9 (6.2, 10.0) 37.0 (34.4, 39.6) 55.1 (52.2, 58.0)


Top of Page

 
USA.gov: The U.S. Government's Official Web PortalDepartment of Health and Human Services
Centers for Disease Control and Prevention   1600 Clifton Road Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC–INFO
A-Z Index
  1. A
  2. B
  3. C
  4. D
  5. E
  6. F
  7. G
  8. H
  9. I
  10. J
  11. K
  12. L
  13. M
  14. N
  15. O
  16. P
  17. Q
  18. R
  19. S
  20. T
  21. U
  22. V
  23. W
  24. X
  25. Y
  26. Z
  27. #