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U.S. Genome Variation Estimates


CYP1A1 Allele and Genotype Frequencies

Available polymorphism(s)


Common Designations
rs number Nucleotide change Amino acid Genotyping method
rs2472299-17961C>T

TaqMan
rs2606345IVS1+606G>T

TaqMan


Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs2472299CTCCCTTT
Non-Hispanic White71.8 (70.3, 73.3)28.2 (26.7, 29.7)<0.00152.8 (50.6, 55.0)37.9 (35.8, 40.0)9.3 (7.9, 10.8)<0.0010.01
Non-Hispanic Black61.5 (59.3, 63.7)38.5 (36.3, 40.7)37.7 (34.7, 40.7)47.8 (45.3, 50.2)14.6 (12.8, 16.6)0.61
Mexican American73.3 (71.1, 75.4)26.7 (24.6, 28.9)53.9 (50.3, 57.4)38.8 (35.7, 42.0)7.3 (6.0, 8.8)0.65
Total*70.2 (68.7, 71.6)29.8 (28.4, 31.3)50.2 (47.8, 52.5)40.0 (37.7, 42.3)9.9 (8.8, 11.0)
rs2606345GTGGGTTT
Non-Hispanic White33.8 (31.8, 35.8)66.2 (64.2, 68.2)<0.00111.2 (9.2, 13.6)45.1 (41.8, 48.5)43.7 (40.7, 46.7)<0.0010.71
Non-Hispanic Black84.1 (81.3, 86.5)15.9 (13.5, 18.7)70.8 (65.8, 75.3)26.6 (22.4, 31.3)2.6 (2.1, 3.4)0.21
Mexican American61.7 (59.1, 64.2)38.3 (35.8, 40.9)38.4 (34.4, 42.6)46.5 (42.5, 50.6)15.1 (13.1, 17.2)0.72
Total*44.0 (41.7, 46.3)56.0 (53.7, 58.3)22.6 (20.5, 24.8)42.8 (40.1, 45.5)34.6 (31.6, 37.8)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs2472299CTCCCTTT
12-1970.7 (67.0, 74.1)29.3 (25.9, 33.0)0.94550.0 (43.9, 56.0)41.5 (35.7, 47.5)8.6 (6.6, 11.2)0.795
20-3969.8 (67.3, 72.1)30.2 (27.9, 32.7)49.4 (46.0, 52.7)40.8 (37.8, 43.9)9.8 (7.8, 12.3)
40-5970.3 (68.0, 72.5)29.7 (27.5, 32.0)51.0 (47.6, 54.4)38.6 (34.9, 42.5)10.4 (8.2, 13.1)
>=6070.3 (68.3, 72.3)29.7 (27.7, 31.7)50.7 (47.2, 54.3)39.2 (35.5, 42.9)10.1 (8.6, 11.8)
Total70.2 (68.7, 71.6)29.8 (28.4, 31.3)50.2 (47.8, 52.5)40.0 (37.7, 42.3)9.9 (8.8, 11.0)
rs2606345GTGGGTTT
12-1948.5 (44.7, 52.4)51.5 (47.6, 55.3)0.00127.8 (22.9, 33.2)41.5 (34.9, 48.4)30.7 (25.9, 36.1)<0.001
20-3945.5 (42.0, 49.0)54.5 (51.0, 58.0)23.4 (20.3, 26.9)44.0 (40.1, 48.0)32.5 (28.1, 37.4)
40-5942.2 (39.5, 45.1)57.8 (54.9, 60.5)22.3 (19.5, 25.4)39.9 (36.5, 43.3)37.8 (34.3, 41.5)
>=6040.3 (37.8, 42.8)59.7 (57.2, 62.2)17.6 (14.8, 20.8)45.4 (41.8, 49.0)37.0 (33.9, 40.3)
Total44.0 (41.7, 46.3)56.0 (53.7, 58.3)22.6 (20.5, 24.8)42.8 (40.1, 45.5)34.6 (31.6, 37.8)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs2472299CTCCCTTT
Male70.3 (68.0, 72.6)29.7 (27.4, 32.0)0.83850.7 (47.3, 54.1)39.2 (36.1, 42.4)10.1 (8.3, 12.3)0.869
Female70.0 (68.1, 71.8)30.0 (28.2, 31.9)49.7 (45.8, 53.5)40.7 (36.3, 45.2)9.6 (8.4, 11.1)
Total70.2 (68.7, 71.6)29.8 (28.4, 31.3)50.2 (47.8, 52.5)40.0 (37.7, 42.3)9.9 (8.8, 11.0)
rs2606345GTGGGTTT
Male44.8 (42.0, 47.7)55.2 (52.3, 58.0)0.22022.7 (20.1, 25.4)44.3 (41.1, 47.5)33.0 (29.4, 36.9)0.171
Female43.2 (40.7, 45.7)56.8 (54.3, 59.3)22.5 (20.0, 25.2)41.4 (38.1, 44.7)36.1 (32.8, 39.6)
Total44.0 (41.7, 46.3)56.0 (53.7, 58.3)22.6 (20.5, 24.8)42.8 (40.1, 45.5)34.6 (31.6, 37.8)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs2472299CTCCCTTT
Non-Hispanic White12-1972.7 (67.2, 77.6)27.3 (22.4, 32.8)54.1 (45.5, 62.5)37.2 (29.9, 45.2)8.7 (6.1, 12.3)
20-3971.4 (68.3, 74.2)28.6 (25.8, 31.7)52.1 (48.2, 55.9)38.5 (35.1, 42.1)9.4 (6.8, 12.8)
40-5971.7 (69.3, 73.9)28.3 (26.1, 30.7)52.9 (49.6, 56.3)37.4 (33.5, 41.6)9.6 (7.2, 12.6)
>=6072.2 (70.0, 74.2)27.8 (25.8, 30.0)53.3 (49.6, 56.9)37.8 (34.1, 41.6)9.0 (7.5, 10.7)
Non-Hispanic Black12-1965.0 (61.6, 68.3)35.0 (31.7, 38.4)40.6 (35.7, 45.8)48.8 (43.8, 54.0)10.5 (7.8, 14.1)
20-3961.8 (59.1, 64.5)38.2 (35.5, 40.9)37.8 (34.2, 41.7)48.0 (43.9, 52.2)14.1 (11.4, 17.5)
40-5959.3 (54.8, 63.6)40.7 (36.4, 45.2)36.1 (30.5, 42.0)46.5 (41.6, 51.4)17.5 (13.6, 22.1)
>=6060.0 (54.1, 65.6)40.0 (34.4, 45.9)36.1 (28.6, 44.3)47.7 (38.4, 57.2)16.2 (10.3, 24.5)
Mexican American12-1972.6 (67.3, 77.2)27.4 (22.8, 32.7)53.5 (46.8, 60.1)38.1 (32.4, 44.1)8.4 (4.8, 14.4)
20-3973.0 (70.6, 75.4)27.0 (24.6, 29.4)53.8 (50.6, 57.0)38.5 (35.8, 41.3)7.7 (5.7, 10.2)
40-5975.5 (71.2, 79.2)24.5 (20.8, 28.8)56.4 (48.6, 63.9)38.2 (30.5, 46.4)5.5 (3.6, 8.2)
>=6071.0 (67.3, 74.5)29.0 (25.5, 32.7)49.0 (43.1, 55.0)43.9 (37.7, 50.3)7.1 (4.4, 11.1)
rs2606345GTGGGTTT
Non-Hispanic White12-1935.7 (31.3, 40.3)64.3 (59.7, 68.7)12.8 (8.9, 18.1)45.7 (36.9, 54.7)41.5 (34.0, 49.4)
20-3933.8 (30.6, 37.2)66.2 (62.8, 69.4)10.5 (7.4, 14.6)46.7 (41.5, 51.9)42.9 (38.2, 47.6)
40-5933.0 (29.6, 36.7)67.0 (63.3, 70.4)12.3 (9.2, 16.2)41.5 (37.9, 45.2)46.2 (41.8, 50.7)
>=6033.6 (31.6, 35.7)66.4 (64.3, 68.4)10.1 (8.2, 12.4)47.0 (43.4, 50.6)42.9 (39.7, 46.2)
Non-Hispanic Black12-1984.3 (81.2, 87.0)15.7 (13.0, 18.8)71.7 (66.1, 76.8)25.2 (20.2, 31.0)3.0 (1.8, 5.2)
20-3983.6 (80.4, 86.4)16.4 (13.6, 19.6)69.8 (64.3, 74.7)27.7 (23.2, 32.7)2.5 (1.4, 4.2)
40-5986.2 (81.9, 89.6)13.8 (10.4, 18.1)74.9 (67.7, 80.9)22.6 (17.4, 28.9)2.5 (1.4, 4.5)
>=6081.3 (76.7, 85.2)18.7 (14.8, 23.3)65.4 (58.4, 71.8)31.8 (26.1, 38.2)2.8 (0.9, 7.9)
Mexican American12-1961.0 (56.0, 65.8)39.0 (34.2, 44.0)38.4 (31.0, 46.3)45.2 (38.0, 52.5)16.5 (12.9, 20.8)
20-3963.0 (60.0, 65.8)37.0 (34.2, 40.0)40.3 (36.5, 44.2)45.3 (42.1, 48.5)14.4 (11.9, 17.2)
40-5961.0 (56.3, 65.5)39.0 (34.5, 43.7)35.6 (27.6, 44.6)50.7 (41.5, 59.9)13.7 (10.5, 17.6)
>=6057.5 (53.7, 61.2)42.5 (38.8, 46.3)34.3 (30.8, 38.0)46.4 (39.6, 53.3)19.3 (13.8, 26.3)

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By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs2472299CTCCCTTT
Non-Hispanic WhiteMale71.9 (69.0, 74.6)28.1 (25.4, 31.0)53.1 (49.0, 57.1)37.6 (34.0, 41.3)9.3 (7.1, 12.2)
Female71.7 (69.9, 73.4)28.3 (26.6, 30.1)52.6 (48.8, 56.4)38.2 (33.6, 43.0)9.2 (7.7, 11.0)
Non-Hispanic BlackMale61.3 (58.4, 64.2)38.7 (35.8, 41.6)37.5 (33.3, 41.9)47.7 (43.7, 51.8)14.8 (12.4, 17.6)
Female61.7 (58.6, 64.7)38.3 (35.3, 41.4)37.8 (33.6, 42.2)47.8 (44.4, 51.2)14.4 (12.0, 17.1)
Mexican AmericanMale73.4 (69.5, 77.0)26.6 (23.0, 30.5)53.7 (48.4, 58.9)39.5 (35.8, 43.2)6.9 (4.6, 10.1)
Female73.2 (71.1, 75.2)26.8 (24.8, 28.9)54.1 (50.8, 57.4)38.1 (34.9, 41.5)7.8 (6.2, 9.6)
rs2606345GTGGGTTT
Non-Hispanic WhiteMale35.6 (32.3, 39.1)64.4 (60.9, 67.7)12.3 (9.0, 16.6)46.8 (42.4, 51.2)41.0 (36.8, 45.3)
Female32.0 (29.9, 34.1)68.0 (65.9, 70.1)10.2 (8.2, 12.7)43.6 (39.8, 47.4)46.2 (42.9, 49.5)
Non-Hispanic BlackMale84.2 (81.4, 86.7)15.8 (13.3, 18.6)70.8 (65.6, 75.6)26.8 (22.2, 31.9)2.4 (1.6, 3.5)
Female84.0 (80.7, 86.8)16.0 (13.2, 19.3)70.8 (65.0, 76.0)26.4 (21.6, 31.8)2.8 (2.0, 4.1)
Mexican AmericanMale61.1 (58.5, 63.8)38.9 (36.2, 41.5)38.4 (34.1, 42.9)45.4 (40.0, 51.0)16.1 (13.3, 19.5)
Female62.3 (59.3, 65.1)37.7 (34.9, 40.7)38.4 (34.1, 43.0)47.7 (44.0, 51.5)13.9 (12.1, 16.0)

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Error processing SSI file
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