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U.S. Genome Variation Estimates

CXCL12 Allele and Genotype Frequencies

Available polymorphism(s)

Common Designations

rs number

Nucleotide changeAmino acid change

Genotyping method

rs169097

Ex5+709C>TMGB Eclipse

Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs169097CTCCCTTT
Non-Hispanic White99.7 (99.4, 99.8)0.3 (0.2, 0.6)<0.00199.4 (98.9, 99.7)0.6 (0.3, 1.1)0.0 (0.0, 0.1)<0.001<0.01
Non-Hispanic Black82.8 (80.7, 84.8)17.2 (15.2, 19.3)68.4 (64.7, 71.9)28.9 (25.7, 32.4)2.7 (1.9, 3.8)0.46
Mexican American99.0 (98.6, 99.4)1.0 (0.6, 1.4)98.1 (97.1, 98.7)1.9 (1.3, 2.9)0.0 (NA)0.61
Total*97.5 (96.8, 98.1)2.5 (1.9, 3.2)95.4 (94.1, 96.4)4.3 (3.4, 5.5)0.3 (0.2, 0.5)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs169097CTCCCTTT
12-1996.4 (95.0, 97.4)3.6 (2.6, 5.0)0.00193.2 (90.6, 95.1)6.4 (4.5, 8.9)0.4 (0.2, 0.9)0.013
20-3997.3 (96.2, 98.1)2.7 (1.9, 3.8)95.0 (93.0, 96.5)4.5 (3.2, 6.4)0.5 (0.3, 0.8)
40-5997.9 (97.3, 98.4)2.1 (1.6, 2.7)96.0 (94.9, 96.9)3.8 (2.9, 4.9)0.2 (0.1, 0.4)
>=6098.3 (97.6, 98.8)1.7 (1.2, 2.4)96.7 (95.4, 97.6)3.2 (2.4, 4.4)0.1 (0.0, 0.4)
Total97.5 (96.8, 98.1)2.5 (1.9, 3.2)95.4 (94.1, 96.4)4.3 (3.4, 5.5)0.3 (0.2, 0.5)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs169097CTCCCTTT
Male97.6 (96.9, 98.1)2.4 (1.9, 3.1)0.71695.5 (94.3, 96.5)4.1 (3.2, 5.2)0.4 (0.2, 0.7)0.434
Female97.5 (96.6, 98.1)2.5 (1.9, 3.4)95.2 (93.6, 96.4)4.5 (3.3, 6.1)0.3 (0.2, 0.4)
Total97.5 (96.8, 98.1)2.5 (1.9, 3.2)95.4 (94.1, 96.4)4.3 (3.4, 5.5)0.3 (0.2, 0.5)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs169097CTCCCTTT
Non-Hispanic White12-1999.3 (97.5, 99.8)0.7 (0.2, 2.5)98.6 (95.0, 99.6)1.4 (0.4, 5.0)0.0 (NA)
20-3999.9 (99.4, 100.0)0.1 (0.0, 0.6)99.8 (98.8, 100.0)0.2 (0.0, 1.2)0.0 (NA)
40-5999.6 (99.3, 99.8)0.4 (0.2, 0.7)99.2 (98.5, 99.6)0.7 (0.3, 1.5)0.1 (0.0, 0.5)
>=6099.8 (99.3, 99.9)0.2 (0.1, 0.7)99.6 (98.7, 99.9)0.4 (0.1, 1.3)0.0 (NA)
Non-Hispanic Black12-1982.4 (79.1, 85.3)17.6 (14.7, 20.9)67.5 (62.0, 72.6)29.7 (25.0, 34.9)2.8 (1.5, 5.1)
20-3982.2 (78.7, 85.3)17.8 (14.7, 21.3)68.2 (62.6, 73.4)28.0 (23.6, 32.8)3.8 (2.4, 6.0)
40-5984.0 (81.0, 86.6)16.0 (13.4, 19.0)69.5 (63.7, 74.8)29.0 (23.7, 35.0)1.5 (0.9, 2.5)
>=6083.4 (79.7, 86.5)16.6 (13.5, 20.3)68.0 (61.6, 73.7)30.8 (25.3, 37.0)1.2 (0.3, 4.8)
Mexican American12-1998.4 (97.4, 99.1)1.6 (0.9, 2.6)96.9 (94.8, 98.2)3.1 (1.8, 5.2)0.0 (NA)
20-3999.1 (98.1, 99.6)0.9 (0.4, 1.9)98.2 (96.3, 99.2)1.8 (0.8, 3.7)0.0 (NA)
40-5999.2 (98.8, 99.5)0.8 (0.5, 1.2)98.4 (97.6, 99.0)1.6 (1.0, 2.4)0.0 (NA)
>=6099.6 (99.0, 99.8)0.4 (0.2, 1.0)99.1 (98.0, 99.6)0.9 (0.4, 2.0)0.0 (NA)

By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs169097CTCCCTTT
Non-Hispanic WhiteMale99.6 (99.3, 99.8)0.4 (0.2, 0.7)99.3 (98.7, 99.6)0.7 (0.3, 1.3)0.0 (0.0, 0.3)
Female99.8 (99.3, 99.9)0.2 (0.1, 0.7)99.6 (98.7, 99.9)0.4 (0.1, 1.3)0.0 (NA)
Non-Hispanic BlackMale82.6 (79.9, 85.0)17.4 (15.0, 20.1)68.4 (63.9, 72.5)28.4 (24.5, 32.7)3.2 (1.9, 5.3)
Female83.1 (80.7, 85.2)16.9 (14.8, 19.3)68.4 (64.1, 72.3)29.4 (25.6, 33.5)2.2 (1.6, 3.2)
Mexican AmericanMale98.8 (97.9, 99.3)1.2 (0.7, 2.1)97.5 (95.9, 98.6)2.5 (1.4, 4.1)0.0 (NA)
Female99.3 (98.7, 99.6)0.7 (0.4, 1.3)98.6 (97.5, 99.3)1.4 (0.7, 2.5)0.0 (NA)

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