Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

U.S. Genome Variation Estimates

CCR2 Allele and Genotype Frequencies

Available polymorphism(s)

Common Designations

rs number

Nucleotide changeAmino acid change

Genotyping method

rs1799864

Ex2+241G>AVal64IleTaqMan

Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1799864AGAAAGGG
Non-Hispanic White9.5 (8.1, 11.1)90.5 (88.9, 91.9)<0.0011.2 (0.6, 2.2)16.5 (14.1, 19.3)82.3 (79.4, 84.8)<0.0010.34
Non-Hispanic Black14.5 (13.6, 15.4)85.5 (84.6, 86.4)1.7 (1.1, 2.4)25.7 (24.0, 27.4)72.7 (71.0, 74.3)0.06
Mexican American21.7 (19.8, 23.7)78.3 (76.3, 80.2)4.5 (3.3, 6.2)34.4 (32.1, 36.6)61.1 (58.2, 63.9)0.74
Total*11.2 (10.1, 12.6)88.8 (87.4, 89.9)1.6 (1.0, 2.4)19.3 (17.4, 21.4)79.1 (76.9, 81.2)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

Top of Page


By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1799864AGAAAGGG
12-1912.7 (10.6, 15.1)87.3 (84.9, 89.4)0.0430.8 (0.4, 1.5)23.8 (19.7, 28.5)75.4 (70.7, 79.6)0.066
20-3912.0 (10.3, 13.9)88.0 (86.1, 89.7)2.2 (1.2, 3.9)19.7 (17.1, 22.6)78.2 (75.1, 80.9)
40-599.9 (8.4, 11.8)90.1 (88.2, 91.6)1.4 (0.7, 2.6)17.2 (14.6, 20.0)81.5 (78.4, 84.2)
>=6010.6 (9.2, 12.2)89.4 (87.8, 90.8)1.3 (0.7, 2.6)18.5 (16.3, 21.0)80.1 (77.5, 82.6)
Total11.2 (10.1, 12.6)88.8 (87.4, 89.9)1.6 (1.0, 2.4)19.3 (17.4, 21.4)79.1 (76.9, 81.2)

* Includes all participants, regardless of race/ethnicity.

Top of Page


By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1799864AGAAAGGG
Male10.7 (9.4, 12.0)89.3 (88.0, 90.6)0.4221.8 (1.1, 3.2)17.6 (15.4, 20.2)80.5 (78.1, 82.7)0.227
Female11.8 (9.6, 14.3)88.2 (85.7, 90.4)1.3 (0.9, 2.1)20.9 (17.2, 25.1)77.8 (73.2, 81.8)
Total11.2 (10.1, 12.6)88.8 (87.4, 89.9)1.6 (1.0, 2.4)19.3 (17.4, 21.4)79.1 (76.9, 81.2)

* Includes all participants, regardless of race/ethnicity.

Top of Page


By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs1799864AGAAAGGG
Non-Hispanic White12-1910.3 (7.8, 13.6)89.7 (86.4, 92.2)0.4 (0.1, 2.3)19.8 (15.0, 25.6)79.8 (73.7, 84.7)
20-399.4 (7.4, 11.8)90.6 (88.2, 92.6)1.5 (0.6, 3.9)15.8 (12.4, 19.9)82.7 (78.5, 86.2)
40-599.1 (7.2, 11.4)90.9 (88.6, 92.8)1.2 (0.5, 3.0)15.8 (12.6, 19.5)83.0 (79.0, 86.4)
>=609.7 (8.0, 11.6)90.3 (88.4, 92.0)1.1 (0.5, 2.8)17.0 (14.6, 19.8)81.8 (78.7, 84.6)
Non-Hispanic Black12-1914.0 (11.9, 16.4)86.0 (83.6, 88.1)1.2 (0.4, 3.7)25.6 (21.9, 29.8)73.2 (69.0, 77.0)
20-3915.2 (13.8, 16.8)84.8 (83.2, 86.2)2.0 (1.3, 3.1)26.5 (23.8, 29.4)71.5 (68.6, 74.2)
40-5913.2 (10.9, 16.0)86.8 (84.0, 89.1)1.4 (0.5, 3.9)23.6 (19.7, 28.1)75.0 (70.2, 79.1)
>=6015.1 (12.2, 18.5)84.9 (81.5, 87.8)1.7 (0.8, 3.4)26.9 (21.5, 32.9)71.5 (65.3, 77.0)
Mexican American12-1919.5 (15.8, 23.8)80.5 (76.2, 84.2)3.5 (2.0, 6.1)32.0 (25.2, 39.7)64.5 (56.8, 71.5)
20-3923.6 (21.4, 26.1)76.4 (73.9, 78.6)5.1 (3.5, 7.4)37.1 (34.6, 39.8)57.8 (54.5, 61.0)
40-5920.9 (18.2, 23.9)79.1 (76.1, 81.8)4.9 (2.3, 10.0)32.0 (27.0, 37.4)63.1 (58.9, 67.2)
>=6017.7 (13.9, 22.2)82.3 (77.8, 86.1)3.0 (1.4, 6.4)29.3 (22.8, 36.9)67.6 (60.0, 74.5)

By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs1799864AGAAAGGG
Non-Hispanic WhiteMale8.9 (7.3, 10.9)91.1 (89.1, 92.7)1.6 (0.8, 3.4)14.6 (11.8, 17.9)83.8 (80.5, 86.6)
Female10.0 (7.7, 12.8)90.0 (87.2, 92.3)0.8 (0.4, 1.5)18.4 (14.1, 23.6)80.8 (75.5, 85.3)
Non-Hispanic BlackMale13.6 (12.1, 15.3)86.4 (84.7, 87.9)1.3 (0.9, 2.1)24.5 (21.7, 27.5)74.1 (71.0, 77.0)
Female15.2 (14.0, 16.5)84.8 (83.5, 86.0)1.9 (1.2, 3.0)26.6 (24.1, 29.2)71.5 (69.0, 73.8)
Mexican AmericanMale20.7 (18.3, 23.4)79.3 (76.6, 81.7)4.0 (2.2, 7.2)33.5 (30.5, 36.6)62.5 (59.0, 66.0)
Female22.8 (20.7, 25.1)77.2 (74.9, 79.3)5.1 (3.7, 7.1)35.3 (32.7, 38.0)59.6 (56.3, 62.7)

Top of Page

Error processing SSI file
Top