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U.S. Genome Variation Estimates

CCL5 Allele and Genotype Frequencies

Available polymorphism(s)

  Common Designations  

rs number

Nucleotide change Amino acid change

Genotyping method

rs2280788

-95C>G   TaqMan

 

Allele and Genotype Frequencies for Subpopulations

 


 

By Race/Ethnicity

Variant Race-ethnicity Allele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs2280788 C G   CC CG GG    
Non-Hispanic White 97.2 (96.8, 97.5) 2.8 (2.5, 3.2) <0.001 94.6 (93.9, 95.2) 5.2 (4.6, 5.9) 0.2 (0.1, 0.5) <0.001 0.04
Non-Hispanic Black 99.3 (98.9, 99.6) 0.7 (0.4, 1.1) 98.7 (97.8, 99.2) 1.3 (0.8, 2.2) 0.0 (NA) 0.79
Mexican American 98.7 (98.3, 99.0) 1.3 (1.0, 1.7) 97.4 (96.6, 98.0) 2.6 (2.0, 3.4) 0.0 (NA) 0.63
Total* 97.4 (97.0, 97.7) 2.6 (2.3, 3.0)   94.9 (94.2, 95.5) 5.0 (4.4, 5.6) 0.1 (0.0, 0.4)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

Variant Age (years) Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs2280788 C G   CC CG GG  
12-19 98.0 (95.5, 99.1) 2.0 (0.9, 4.5) 0.250 96.0 (91.2, 98.2) 4.0 (1.8, 8.8) 0.0 (NA) 0.019
20-39 96.8 (96.1, 97.4) 3.2 (2.6, 3.9) 93.7 (92.4, 94.8) 6.2 (5.2, 7.4) 0.1 (0.0, 0.6)
40-59 97.6 (96.7, 98.2) 2.4 (1.8, 3.3) 95.3 (93.4, 96.6) 4.6 (3.2, 6.6) 0.1 (0.0, 0.8)
>=60 97.9 (97.1, 98.5) 2.1 (1.5, 2.9) 96.0 (94.5, 97.0) 3.8 (2.9, 5.1) 0.2 (0.1, 0.7)
Total 97.4 (97.0, 97.7) 2.6 (2.3, 3.0)   94.9 (94.2, 95.5) 5.0 (4.4, 5.6) 0.1 (0.0, 0.4)  

* Includes all participants, regardless of race/ethnicity.

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By Sex* 

Variant Sex Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs2280788 C G   CC CG GG  
Male 97.8 (97.1, 98.3) 2.2 (1.7, 2.9) 0.172 95.6 (94.4, 96.6) 4.4 (3.4, 5.6) 0.1 (0.0, 0.5) 0.452
Female 97.0 (96.1, 97.7) 3.0 (2.3, 3.9) 94.2 (92.6, 95.5) 5.6 (4.4, 7.1) 0.2 (0.1, 0.6)
Total 97.4 (97.0, 97.7) 2.6 (2.3, 3.0)   94.9 (94.2, 95.5) 5.0 (4.4, 5.6) 0.1 (0.0, 0.4)  

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

Variant Race-ethnicity Age (years) Allele
% (95% CI)
Genotype
% (95% CI)
rs2280788 C G CC CG GG
Non-Hispanic White 12-19 97.9 (95.2, 99.1) 2.1 (0.9, 4.8) 95.9 (90.4, 98.3) 4.1 (1.7, 9.6) 0.0 (NA)
20-39 96.4 (95.5, 97.2) 3.6 (2.8, 4.5) 93.1 (91.4, 94.4) 6.7 (5.4, 8.3) 0.2 (0.0, 0.8)
40-59 97.5 (96.5, 98.2) 2.5 (1.8, 3.5) 95.1 (93.0, 96.6) 4.7 (3.2, 7.0) 0.2 (0.0, 1.0)
>=60 97.7 (96.8, 98.4) 2.3 (1.6, 3.2) 95.7 (94.1, 96.9) 4.0 (3.0, 5.4) 0.2 (0.1, 0.9)
Non-Hispanic Black 12-19 99.5 (98.6, 99.8) 0.5 (0.2, 1.4) 98.9 (97.2, 99.6) 1.1 (0.4, 2.8) 0.0 (NA)
20-39 99.2 (98.4, 99.6) 0.8 (0.4, 1.6) 98.5 (96.8, 99.3) 1.5 (0.7, 3.2) 0.0 (NA)
40-59 99.2 (98.1, 99.7) 0.8 (0.3, 1.9) 98.5 (96.1, 99.4) 1.5 (0.6, 3.9) 0.0 (NA)
>=60 99.7 (98.7, 99.9) 0.3 (0.1, 1.3) 99.4 (97.4, 99.9) 0.6 (0.1, 2.6) 0.0 (NA)
Mexican American 12-19 98.2 (96.2, 99.1) 1.8 (0.9, 3.8) 96.3 (92.5, 98.2) 3.7 (1.8, 7.5) 0.0 (NA)
20-39 98.9 (98.2, 99.4) 1.1 (0.6, 1.8) 97.8 (96.4, 98.7) 2.2 (1.3, 3.6) 0.0 (NA)
40-59 98.7 (98.0, 99.1) 1.3 (0.9, 2.0) 97.3 (95.9, 98.2) 2.7 (1.8, 4.1) 0.0 (NA)
>=60 98.9 (97.5, 99.5) 1.1 (0.5, 2.5) 97.7 (95.1, 99.0) 2.3 (1.0, 4.9) 0.0 (NA)

 

By Race/Ethnicity and Sex

Variant Race-ethnicity Sex Allele
% (95% CI)
Genotype
% (95% CI)
rs2280788 C G CC CG GG
Non-Hispanic White Male 97.4 (96.5, 98.0) 2.6 (2.0, 3.5) 94.9 (93.2, 96.2) 5.0 (3.8, 6.7) 0.1 (0.0, 0.7)
Female 97.0 (96.3, 97.6) 3.0 (2.4, 3.7) 94.3 (93.0, 95.4) 5.4 (4.4, 6.7) 0.3 (0.1, 0.9)
Non-Hispanic Black Male 99.3 (98.6, 99.7) 0.7 (0.3, 1.4) 98.6 (97.1, 99.4) 1.4 (0.6, 2.9) 0.0 (NA)
Female 99.4 (98.8, 99.7) 0.6 (0.3, 1.2) 98.7 (97.6, 99.4) 1.3 (0.6, 2.4) 0.0 (NA)
Mexican American Male 98.9 (97.8, 99.4) 1.1 (0.6, 2.2) 97.7 (95.6, 98.8) 2.3 (1.2, 4.4) 0.0 (NA)
Female 98.5 (97.6, 99.1) 1.5 (0.9, 2.4) 97.1 (95.1, 98.3) 2.9 (1.7, 4.9) 0.0 (NA)

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