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U.S. Genome Variation Estimates

CCL5 Allele and Genotype Frequencies

Available polymorphism(s)

Common Designations

rs number

Nucleotide changeAmino acid change

Genotyping method

rs2280788

-95C>GTaqMan

Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs2280788CGCCCGGG
Non-Hispanic White97.2 (96.8, 97.5)2.8 (2.5, 3.2)<0.00194.6 (93.9, 95.2)5.2 (4.6, 5.9)0.2 (0.1, 0.5)<0.0010.04
Non-Hispanic Black99.3 (98.9, 99.6)0.7 (0.4, 1.1)98.7 (97.8, 99.2)1.3 (0.8, 2.2)0.0 (NA)0.79
Mexican American98.7 (98.3, 99.0)1.3 (1.0, 1.7)97.4 (96.6, 98.0)2.6 (2.0, 3.4)0.0 (NA)0.63
Total*97.4 (97.0, 97.7)2.6 (2.3, 3.0)94.9 (94.2, 95.5)5.0 (4.4, 5.6)0.1 (0.0, 0.4)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs2280788CGCCCGGG
12-1998.0 (95.5, 99.1)2.0 (0.9, 4.5)0.25096.0 (91.2, 98.2)4.0 (1.8, 8.8)0.0 (NA)0.019
20-3996.8 (96.1, 97.4)3.2 (2.6, 3.9)93.7 (92.4, 94.8)6.2 (5.2, 7.4)0.1 (0.0, 0.6)
40-5997.6 (96.7, 98.2)2.4 (1.8, 3.3)95.3 (93.4, 96.6)4.6 (3.2, 6.6)0.1 (0.0, 0.8)
>=6097.9 (97.1, 98.5)2.1 (1.5, 2.9)96.0 (94.5, 97.0)3.8 (2.9, 5.1)0.2 (0.1, 0.7)
Total97.4 (97.0, 97.7)2.6 (2.3, 3.0)94.9 (94.2, 95.5)5.0 (4.4, 5.6)0.1 (0.0, 0.4)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs2280788CGCCCGGG
Male97.8 (97.1, 98.3)2.2 (1.7, 2.9)0.17295.6 (94.4, 96.6)4.4 (3.4, 5.6)0.1 (0.0, 0.5)0.452
Female97.0 (96.1, 97.7)3.0 (2.3, 3.9)94.2 (92.6, 95.5)5.6 (4.4, 7.1)0.2 (0.1, 0.6)
Total97.4 (97.0, 97.7)2.6 (2.3, 3.0)94.9 (94.2, 95.5)5.0 (4.4, 5.6)0.1 (0.0, 0.4)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs2280788CGCCCGGG
Non-Hispanic White12-1997.9 (95.2, 99.1)2.1 (0.9, 4.8)95.9 (90.4, 98.3)4.1 (1.7, 9.6)0.0 (NA)
20-3996.4 (95.5, 97.2)3.6 (2.8, 4.5)93.1 (91.4, 94.4)6.7 (5.4, 8.3)0.2 (0.0, 0.8)
40-5997.5 (96.5, 98.2)2.5 (1.8, 3.5)95.1 (93.0, 96.6)4.7 (3.2, 7.0)0.2 (0.0, 1.0)
>=6097.7 (96.8, 98.4)2.3 (1.6, 3.2)95.7 (94.1, 96.9)4.0 (3.0, 5.4)0.2 (0.1, 0.9)
Non-Hispanic Black12-1999.5 (98.6, 99.8)0.5 (0.2, 1.4)98.9 (97.2, 99.6)1.1 (0.4, 2.8)0.0 (NA)
20-3999.2 (98.4, 99.6)0.8 (0.4, 1.6)98.5 (96.8, 99.3)1.5 (0.7, 3.2)0.0 (NA)
40-5999.2 (98.1, 99.7)0.8 (0.3, 1.9)98.5 (96.1, 99.4)1.5 (0.6, 3.9)0.0 (NA)
>=6099.7 (98.7, 99.9)0.3 (0.1, 1.3)99.4 (97.4, 99.9)0.6 (0.1, 2.6)0.0 (NA)
Mexican American12-1998.2 (96.2, 99.1)1.8 (0.9, 3.8)96.3 (92.5, 98.2)3.7 (1.8, 7.5)0.0 (NA)
20-3998.9 (98.2, 99.4)1.1 (0.6, 1.8)97.8 (96.4, 98.7)2.2 (1.3, 3.6)0.0 (NA)
40-5998.7 (98.0, 99.1)1.3 (0.9, 2.0)97.3 (95.9, 98.2)2.7 (1.8, 4.1)0.0 (NA)
>=6098.9 (97.5, 99.5)1.1 (0.5, 2.5)97.7 (95.1, 99.0)2.3 (1.0, 4.9)0.0 (NA)

By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs2280788CGCCCGGG
Non-Hispanic WhiteMale97.4 (96.5, 98.0)2.6 (2.0, 3.5)94.9 (93.2, 96.2)5.0 (3.8, 6.7)0.1 (0.0, 0.7)
Female97.0 (96.3, 97.6)3.0 (2.4, 3.7)94.3 (93.0, 95.4)5.4 (4.4, 6.7)0.3 (0.1, 0.9)
Non-Hispanic BlackMale99.3 (98.6, 99.7)0.7 (0.3, 1.4)98.6 (97.1, 99.4)1.4 (0.6, 2.9)0.0 (NA)
Female99.4 (98.8, 99.7)0.6 (0.3, 1.2)98.7 (97.6, 99.4)1.3 (0.6, 2.4)0.0 (NA)
Mexican AmericanMale98.9 (97.8, 99.4)1.1 (0.6, 2.2)97.7 (95.6, 98.8)2.3 (1.2, 4.4)0.0 (NA)
Female98.5 (97.6, 99.1)1.5 (0.9, 2.4)97.1 (95.1, 98.3)2.9 (1.7, 4.9)0.0 (NA)

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