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U.S. Genome Variation Estimates

CAPN10 Allele and Genotype Frequencies

Available polymorphism(s)

Common Designations

rs number

Nucleotide changeAmino acid change

Genotyping method

rs3792267

IVS3-176G>ATaqMan

Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs3792267AGAAAGGG
Non-Hispanic White25.8 (23.7, 27.9)74.2 (72.1, 76.3)<0.0016.8 (5.8, 8.0)38.0 (35.3, 40.7)55.2 (51.9, 58.6)<0.0010.65
Non-Hispanic Black16.2 (14.3, 18.2)83.8 (81.8, 85.7)2.4 (1.7, 3.4)27.5 (24.5, 30.7)70.1 (66.6, 73.4)0.64
Mexican American27.3 (25.3, 29.5)72.7 (70.5, 74.7)7.3 (6.1, 8.9)40.0 (37.4, 42.6)52.7 (49.5, 55.9)0.42
Total*24.6 (23.1, 26.1)75.4 (73.9, 76.9)6.4 (5.7, 7.3)36.3 (34.4, 38.2)57.3 (54.8, 59.7)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs3792267AGAAAGGG
12-1923.1 (19.8, 26.7)76.9 (73.3, 80.2)0.5466.3 (4.7, 8.4)33.5 (27.4, 40.3)60.2 (53.6, 66.4)0.359
20-3925.5 (23.1, 28.0)74.5 (72.0, 76.9)7.2 (5.7, 9.1)36.5 (33.2, 39.9)56.3 (52.4, 60.1)
40-5923.9 (21.2, 26.8)76.1 (73.2, 78.8)5.7 (4.0, 8.2)36.3 (32.1, 40.8)57.9 (53.3, 62.4)
>=6024.8 (22.3, 27.4)75.2 (72.6, 77.7)5.8 (4.7, 7.1)37.9 (33.9, 42.1)56.3 (51.8, 60.7)
Total24.6 (23.1, 26.1)75.4 (73.9, 76.9)6.4 (5.7, 7.3)36.3 (34.4, 38.2)57.3 (54.8, 59.7)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs3792267AGAAAGGG
Male24.4 (22.2, 26.7)75.6 (73.3, 77.8)0.7496.8 (5.4, 8.5)35.2 (33.0, 37.4)58.0 (54.9, 61.1)0.313
Female24.7 (23.2, 26.4)75.3 (73.6, 76.8)6.1 (5.0, 7.3)37.4 (34.7, 40.1)56.6 (53.8, 59.3)
Total24.6 (23.1, 26.1)75.4 (73.9, 76.9)6.4 (5.7, 7.3)36.3 (34.4, 38.2)57.3 (54.8, 59.7)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs3792267AGAAAGGG
Non-Hispanic White12-1924.5 (19.9, 29.8)75.5 (70.2, 80.1)7.0 (4.6, 10.7)35.0 (27.4, 43.3)58.0 (49.4, 66.1)
20-3926.9 (23.6, 30.4)73.1 (69.6, 76.4)7.9 (5.8, 10.7)37.8 (33.7, 42.1)54.2 (49.1, 59.3)
40-5924.6 (20.9, 28.7)75.4 (71.3, 79.1)5.4 (3.5, 8.4)38.3 (32.4, 44.6)56.3 (49.6, 62.7)
>=6026.2 (23.3, 29.2)73.8 (70.8, 76.7)6.5 (5.2, 8.0)39.5 (34.8, 44.3)54.1 (48.9, 59.2)
Non-Hispanic Black12-1916.2 (13.8, 18.9)83.8 (81.1, 86.2)2.1 (1.0, 4.1)28.3 (23.8, 33.3)69.6 (64.7, 74.2)
20-3916.0 (13.6, 18.7)84.0 (81.3, 86.4)2.5 (1.5, 4.1)27.1 (23.4, 31.2)70.4 (65.9, 74.6)
40-5916.2 (14.0, 18.6)83.8 (81.4, 86.0)2.7 (1.6, 4.5)27.0 (22.5, 32.0)70.3 (65.7, 74.6)
>=6016.5 (13.0, 20.6)83.5 (79.4, 87.0)2.1 (0.9, 4.6)28.8 (22.7, 35.7)69.2 (61.9, 75.6)
Mexican American12-1929.7 (26.7, 33.0)70.3 (67.0, 73.3)7.4 (5.2, 10.4)44.7 (39.1, 50.4)47.9 (42.6, 53.3)
20-3926.3 (24.3, 28.3)73.7 (71.7, 75.7)6.7 (5.5, 8.1)39.2 (36.9, 41.5)54.1 (51.1, 57.1)
40-5928.0 (22.8, 33.8)72.0 (66.2, 77.2)9.2 (6.1, 13.8)37.5 (31.3, 44.2)53.3 (45.0, 61.3)
>=6026.1 (23.9, 28.4)73.9 (71.6, 76.1)6.3 (4.2, 9.3)39.6 (34.9, 44.5)54.1 (50.2, 58.1)

By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs3792267AGAAAGGG
Non-Hispanic WhiteMale25.4 (22.5, 28.5)74.6 (71.5, 77.5)7.3 (5.4, 9.8)36.3 (33.2, 39.4)56.5 (52.1, 60.7)
Female26.1 (24.1, 28.2)73.9 (71.8, 75.9)6.3 (4.8, 8.2)39.6 (35.6, 43.7)54.1 (50.4, 57.8)
Non-Hispanic BlackMale16.3 (14.1, 18.8)83.7 (81.2, 85.9)2.4 (1.5, 3.9)27.9 (24.1, 32.0)69.7 (65.4, 73.8)
Female16.0 (13.8, 18.6)84.0 (81.4, 86.2)2.4 (1.6, 3.7)27.2 (23.8, 31.0)70.4 (66.1, 74.3)
Mexican AmericanMale26.6 (24.5, 28.9)73.4 (71.1, 75.5)7.1 (5.4, 9.2)39.2 (36.6, 41.8)53.8 (50.7, 56.8)
Female28.1 (25.0, 31.3)71.9 (68.7, 75.0)7.6 (6.0, 9.7)40.8 (36.3, 45.5)51.5 (46.3, 56.7)

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