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U.S. Genome Variation Estimates

ADRB3 Allele and Genotype Frequencies

Available polymorphism(s)

Common Designations

rs number

Nucleotide changeAmino acid change

Genotyping method

rs4994

Ex1+387T>CTrp64ArgTaqMan

Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs4994CTCCCTTT
Non-Hispanic White6.9 (5.9, 8.0)93.1 (92.0, 94.1)<0.0010.6 (0.3, 1.1)12.5 (10.8, 14.4)86.9 (84.8, 88.7)<0.0010.27
Non-Hispanic Black11.7 (10.3, 13.1)88.3 (86.9, 89.7)1.4 (0.8, 2.5)20.5 (18.4, 22.7)78.1 (75.7, 80.3)0.78
Mexican American16.6 (14.7, 18.7)83.4 (81.3, 85.3)2.7 (1.9, 3.8)27.7 (24.6, 31.1)69.5 (65.9, 72.9)0.82
Total*8.6 (7.8, 9.5)91.4 (90.5, 92.2)0.9 (0.7, 1.2)15.5 (14.0, 17.0)83.6 (82.0, 85.2)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs4994CTCCCTTT
12-199.4 (6.9, 12.7)90.6 (87.3, 93.1)0.2780.7 (0.3, 1.5)17.4 (12.6, 23.6)81.9 (75.5, 86.8)0.016
20-398.8 (7.4, 10.5)91.2 (89.5, 92.6)0.9 (0.5, 1.5)15.9 (13.1, 19.1)83.3 (80.0, 86.1)
40-599.2 (7.5, 11.1)90.8 (88.9, 92.5)1.4 (0.9, 2.1)15.6 (12.7, 18.9)83.0 (79.5, 86.1)
>=607.0 (6.2, 7.9)93.0 (92.1, 93.8)0.5 (0.2, 1.0)13.0 (11.5, 14.7)86.5 (84.8, 88.0)
Total8.6 (7.8, 9.5)91.4 (90.5, 92.2)0.9 (0.7, 1.2)15.5 (14.0, 17.0)83.6 (82.0, 85.2)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs4994CTCCCTTT
Male8.3 (7.1, 9.7)91.7 (90.3, 92.9)0.4640.9 (0.6, 1.5)14.8 (12.6, 17.4)84.3 (81.6, 86.6)0.736
Female8.9 (7.9, 10.1)91.1 (89.9, 92.1)0.9 (0.6, 1.2)16.1 (14.1, 18.2)83.0 (80.8, 85.0)
Total8.6 (7.8, 9.5)91.4 (90.5, 92.2)0.9 (0.7, 1.2)15.5 (14.0, 17.0)83.6 (82.0, 85.2)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs4994CTCCCTTT
Non-Hispanic White12-196.0 (3.5, 10.2)94.0 (89.8, 96.5)0.4 (0.0, 3.2)11.2 (6.5, 18.7)88.4 (80.6, 93.3)
20-397.0 (5.3, 9.1)93.0 (90.9, 94.7)0.6 (0.2, 1.5)12.9 (9.8, 16.8)86.6 (82.6, 89.8)
40-597.5 (5.5, 10.1)92.5 (89.9, 94.5)0.9 (0.3, 2.4)13.2 (9.6, 17.9)85.9 (81.0, 89.7)
>=606.3 (5.5, 7.2)93.7 (92.8, 94.5)0.5 (0.2, 1.2)11.5 (10.1, 13.2)87.9 (86.3, 89.4)
Non-Hispanic Black12-1911.2 (8.9, 14.0)88.8 (86.0, 91.1)0.8 (0.4, 1.3)20.8 (16.4, 26.1)78.4 (73.0, 83.0)
20-3911.6 (9.4, 14.1)88.4 (85.9, 90.6)1.6 (0.8, 3.2)20.0 (16.9, 23.6)78.4 (74.3, 82.0)
40-5912.6 (10.3, 15.3)87.4 (84.7, 89.7)2.4 (1.0, 5.6)20.4 (16.1, 25.4)77.3 (72.6, 81.3)
>=6011.0 (9.4, 12.9)89.0 (87.1, 90.6)0.2 (0.0, 1.4)21.7 (18.1, 25.7)78.2 (74.3, 81.6)
Mexican American12-1919.8 (17.1, 22.8)80.2 (77.2, 82.9)4.1 (2.4, 7.0)31.4 (25.7, 37.8)64.5 (58.8, 69.7)
20-3915.6 (13.0, 18.5)84.4 (81.5, 87.0)2.4 (1.5, 3.7)26.4 (21.9, 31.5)71.2 (65.9, 76.0)
40-5916.5 (15.1, 17.9)83.5 (82.1, 84.9)2.4 (1.3, 4.3)28.2 (25.1, 31.6)69.4 (66.6, 72.0)
>=6015.1 (12.4, 18.2)84.9 (81.8, 87.6)2.4 (1.5, 3.9)25.3 (20.5, 30.8)72.3 (66.6, 77.3)

By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs4994CTCCCTTT
Non-Hispanic WhiteMale6.8 (5.3, 8.6)93.2 (91.4, 94.7)0.7 (0.3, 1.6)12.1 (9.4, 15.5)87.1 (83.7, 89.9)
Female6.9 (5.8, 8.2)93.1 (91.8, 94.2)0.5 (0.2, 1.1)12.8 (10.7, 15.3)86.7 (84.2, 88.9)
Non-Hispanic BlackMale11.9 (10.0, 14.0)88.1 (86.0, 90.0)1.8 (0.8, 3.8)20.2 (17.0, 23.8)78.0 (74.4, 81.3)
Female11.5 (10.1, 13.1)88.5 (86.9, 89.9)1.1 (0.5, 2.3)20.7 (18.7, 22.9)78.2 (75.6, 80.5)
Mexican AmericanMale17.8 (15.8, 19.9)82.2 (80.1, 84.2)3.1 (2.0, 4.9)29.3 (25.9, 33.0)67.6 (63.9, 71.0)
Female15.4 (13.3, 17.7)84.6 (82.3, 86.7)2.3 (1.4, 3.9)26.1 (22.2, 30.4)71.6 (67.4, 75.5)

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