Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

U.S. Genome Variation Estimates

ADRB2 Allele and Genotype Frequencies

Available polymorphism(s)

Common Designations

rs number

Nucleotide changeAmino acid change

Genotyping method

rs1042713

Ex1+265G>AGly16ArgTaqMan
rs1042714Ex1+298G>CGlu27GlnPyrosequencing

Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1042713AGAAAGGG
Non-Hispanic White38.9 (36.9, 40.9)61.1 (59.1, 63.1)<0.00115.7 (13.4, 18.2)46.4 (43.6, 49.3)37.9 (35.4, 40.4)<0.0010.96
Non-Hispanic Black49.7 (47.7, 51.6)50.3 (48.4, 52.3)25.0 (23.1, 27.1)49.3 (47.0, 51.7)25.6 (23.2, 28.3)0.43
Mexican American41.8 (40.3, 43.2)58.2 (56.8, 59.7)15.6 (14.4, 16.9)52.3 (50.1, 54.4)32.1 (29.9, 34.4)0.14
Total*40.5 (38.9, 42.2)59.5 (57.8, 61.1)16.9 (15.0, 18.9)47.3 (45.0, 49.6)35.8 (33.7, 38.0)
rs1042714CGCCCGGG
Non-Hispanic White58.1 (56.0, 60.1)41.9 (39.9, 44.0)<0.00134.5 (31.6, 37.5)47.3 (44.4, 50.1)18.3 (16.3, 20.4)<0.0010.74
Non-Hispanic Black82.0 (80.4, 83.4)18.0 (16.6, 19.6)67.6 (64.9, 70.2)28.8 (26.2, 31.5)3.7 (2.7, 5.0)0.16
Mexican American78.7 (77.1, 80.2)21.3 (19.8, 22.9)61.4 (58.8, 63.9)34.6 (32.1, 37.2)4.0 (3.1, 5.2)0.66
Total*64.0 (62.1, 65.9)36.0 (34.1, 37.9)42.5 (40.2, 44.8)43.0 (41.0, 45.0)14.5 (12.7, 16.5)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

Top of Page


By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1042713AGAAAGGG
12-1941.8 (38.2, 45.4)58.2 (54.6, 61.8)0.62418.9 (15.5, 22.8)45.8 (40.4, 51.4)35.3 (30.3, 40.7)0.377
20-3940.7 (37.9, 43.5)59.3 (56.5, 62.1)16.7 (13.9, 19.9)48.0 (44.0, 52.1)35.3 (31.5, 39.3)
40-5940.9 (37.9, 43.9)59.1 (56.1, 62.1)17.7 (14.9, 20.9)46.3 (42.7, 50.0)36.0 (32.2, 40.0)
>=6039.0 (36.9, 41.1)61.0 (58.9, 63.1)14.8 (13.3, 16.5)48.3 (46.0, 50.6)36.9 (33.9, 39.9)
Total40.5 (38.9, 42.2)59.5 (57.8, 61.1)16.9 (15.0, 18.9)47.3 (45.0, 49.6)35.8 (33.7, 38.0)
rs1042714CGCCCGGG
12-1965.3 (62.0, 68.6)34.7 (31.4, 38.0)0.01045.2 (41.3, 49.3)40.2 (36.1, 44.4)14.6 (11.2, 18.8)0.038
20-3966.0 (63.8, 68.2)34.0 (31.8, 36.2)45.5 (42.5, 48.6)41.1 (38.4, 43.7)13.4 (11.5, 15.6)
40-5961.7 (58.0, 65.2)38.3 (34.8, 42.0)39.3 (35.1, 43.6)44.9 (40.7, 49.2)15.9 (12.2, 20.4)
>=6062.2 (60.1, 64.3)37.8 (35.7, 39.9)39.0 (36.0, 42.2)46.3 (43.0, 49.6)14.7 (12.6, 16.9)
Total64.0 (62.1, 65.9)36.0 (34.1, 37.9)42.5 (40.2, 44.8)43.0 (41.0, 45.0)14.5 (12.7, 16.5)

* Includes all participants, regardless of race/ethnicity.

Top of Page


By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1042713AGAAAGGG
Male40.3 (38.1, 42.5)59.7 (57.5, 61.9)0.70216.0 (13.7, 18.5)48.6 (44.8, 52.4)35.4 (32.1, 38.9)0.424
Female40.8 (38.6, 43.0)59.2 (57.0, 61.4)17.8 (15.5, 20.3)46.1 (43.0, 49.2)36.2 (33.3, 39.2)
Total40.5 (38.9, 42.2)59.5 (57.8, 61.1)16.9 (15.0, 18.9)47.3 (45.0, 49.6)35.8 (33.7, 38.0)
rs1042714CGCCCGGG
Male64.6 (62.1, 67.0)35.4 (33.0, 37.9)0.43542.5 (39.6, 45.5)44.2 (41.2, 47.2)13.3 (10.8, 16.4)0.306
Female63.4 (61.1, 65.8)36.6 (34.2, 38.9)42.5 (39.4, 45.5)42.0 (39.4, 44.5)15.6 (13.5, 17.9)
Total64.0 (62.1, 65.9)36.0 (34.1, 37.9)42.5 (40.2, 44.8)43.0 (41.0, 45.0)14.5 (12.7, 16.5)

* Includes all participants, regardless of race/ethnicity.

Top of Page


By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs1042713AGAAAGGG
Non-Hispanic White12-1940.4 (35.8, 45.2)59.6 (54.8, 64.2)18.1 (13.8, 23.3)44.6 (37.5, 52.0)37.3 (30.6, 44.5)
20-3939.2 (35.3, 43.2)60.8 (56.8, 64.7)15.6 (11.9, 20.1)47.1 (42.0, 52.3)37.3 (32.2, 42.7)
40-5938.6 (35.1, 42.2)61.4 (57.8, 64.9)15.9 (12.6, 20.0)45.4 (41.3, 49.5)38.7 (34.4, 43.3)
>=6037.9 (35.4, 40.5)62.1 (59.5, 64.6)14.1 (12.2, 16.2)47.8 (45.3, 50.2)38.2 (34.8, 41.7)
Non-Hispanic Black12-1947.8 (42.0, 53.7)52.2 (46.3, 58.0)24.6 (19.4, 30.6)46.5 (41.3, 51.8)29.0 (22.3, 36.6)
20-3949.5 (47.0, 52.0)50.5 (48.0, 53.0)25.0 (22.6, 27.5)49.0 (45.7, 52.4)26.0 (22.7, 29.6)
40-5951.6 (46.9, 56.2)48.4 (43.8, 53.1)25.5 (20.2, 31.6)52.2 (47.4, 56.9)22.3 (18.0, 27.4)
>=6049.3 (44.6, 54.1)50.7 (45.9, 55.4)24.8 (20.5, 29.8)49.0 (43.8, 54.2)26.2 (20.6, 32.7)
Mexican American12-1944.3 (40.6, 48.2)55.7 (51.8, 59.4)17.3 (12.7, 23.2)54.1 (48.9, 59.2)28.6 (24.9, 32.6)
20-3941.1 (38.9, 43.4)58.9 (56.6, 61.1)13.9 (12.4, 15.5)54.5 (50.7, 58.2)31.6 (27.9, 35.6)
40-5941.4 (39.0, 43.8)58.6 (56.2, 61.0)18.3 (15.2, 21.8)46.2 (40.1, 52.5)35.5 (31.1, 40.2)
>=6040.1 (35.8, 44.7)59.9 (55.3, 64.2)14.9 (11.0, 20.0)50.4 (43.8, 57.0)34.6 (28.5, 41.4)
rs1042714CGCCCGGG
Non-Hispanic White12-1957.6 (52.7, 62.4)42.4 (37.6, 47.3)35.9 (30.2, 41.9)43.6 (37.7, 49.7)20.6 (15.5, 26.7)
20-3959.5 (56.7, 62.2)40.5 (37.8, 43.3)36.8 (32.9, 40.9)45.3 (41.7, 49.0)17.9 (15.5, 20.5)
40-5956.1 (51.5, 60.6)43.9 (39.4, 48.5)31.4 (26.4, 36.9)49.4 (44.4, 54.3)19.2 (14.7, 24.8)
>=6058.7 (56.6, 60.7)41.3 (39.3, 43.4)33.8 (31.0, 36.8)49.7 (46.2, 53.3)16.5 (14.1, 19.0)
Non-Hispanic Black12-1980.0 (77.2, 82.6)20.0 (17.4, 22.8)64.5 (59.6, 69.1)31.1 (26.1, 36.6)4.4 (2.5, 7.6)
20-3982.7 (79.8, 85.3)17.3 (14.7, 20.2)69.4 (64.5, 74.0)26.5 (22.2, 31.4)4.0 (2.7, 6.0)
40-5981.6 (78.6, 84.3)18.4 (15.7, 21.4)66.7 (61.4, 71.6)29.8 (25.1, 34.9)3.5 (2.3, 5.4)
>=6082.9 (79.5, 85.9)17.1 (14.1, 20.5)67.6 (60.8, 73.7)30.6 (24.2, 37.9)1.8 (0.7, 4.2)
Mexican American12-1979.7 (73.7, 84.7)20.3 (15.3, 26.3)63.2 (54.1, 71.5)33.0 (26.3, 40.6)3.7 (1.6, 8.4)
20-3978.2 (75.9, 80.3)21.8 (19.7, 24.1)60.1 (56.7, 63.4)36.2 (33.3, 39.2)3.7 (2.4, 5.6)
40-5979.6 (74.7, 83.8)20.4 (16.2, 25.3)63.3 (55.3, 70.7)32.6 (26.3, 39.6)4.1 (2.6, 6.4)
>=6076.8 (70.2, 82.3)23.2 (17.7, 29.8)59.7 (49.8, 68.9)34.2 (26.9, 42.2)6.1 (3.6, 10.1)

By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs1042713AGAAAGGG
Non-Hispanic WhiteMale38.9 (36.4, 41.4)61.1 (58.6, 63.6)15.0 (12.4, 17.9)47.9 (42.7, 53.1)37.1 (33.0, 41.5)
Female38.9 (36.2, 41.6)61.1 (58.4, 63.8)16.3 (13.8, 19.2)45.1 (41.7, 48.5)38.6 (35.0, 42.3)
Non-Hispanic BlackMale49.7 (46.7, 52.8)50.3 (47.2, 53.3)24.9 (21.8, 28.3)49.7 (45.8, 53.6)25.4 (21.7, 29.6)
Female49.6 (47.3, 52.0)50.4 (48.0, 52.7)25.1 (22.9, 27.5)49.0 (46.0, 52.0)25.8 (22.8, 29.2)
Mexican AmericanMale41.7 (39.7, 43.7)58.3 (56.3, 60.3)15.5 (13.6, 17.7)52.4 (49.4, 55.4)32.1 (29.2, 35.0)
Female41.8 (39.5, 44.1)58.2 (55.9, 60.5)15.7 (13.8, 17.8)52.1 (49.0, 55.3)32.2 (28.8, 35.7)
rs1042714CGCCCGGG
Non-Hispanic WhiteMale58.9 (56.5, 61.4)41.1 (38.6, 43.5)34.8 (31.8, 38.0)48.3 (44.5, 52.1)16.9 (14.0, 20.3)
Female57.3 (54.2, 60.3)42.7 (39.7, 45.8)34.2 (30.2, 38.4)46.3 (42.7, 49.9)19.6 (16.9, 22.6)
Non-Hispanic BlackMale82.5 (80.5, 84.4)17.5 (15.6, 19.5)67.9 (64.8, 70.8)29.3 (26.8, 31.9)2.8 (1.8, 4.4)
Female81.5 (79.7, 83.2)18.5 (16.8, 20.3)67.4 (64.0, 70.6)28.3 (24.9, 32.0)4.3 (3.1, 6.0)
Mexican AmericanMale78.7 (76.8, 80.5)21.3 (19.5, 23.2)61.5 (57.9, 65.0)34.4 (30.5, 38.5)4.1 (2.8, 6.1)
Female78.7 (76.8, 80.4)21.3 (19.6, 23.2)61.2 (58.7, 63.7)34.9 (32.9, 36.9)3.9 (2.6, 5.8)

Top of Page

Top