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U.S. Genome Variation Estimates

ADRB1 Allele and Genotype Frequencies

Available polymorphism(s)

Common Designations

rs number

Nucleotide changeAmino acid change

Genotyping method

rs1801252

Ex1+231A>GSer49GlyMGB Eclipse

Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1801252AGAAAGGG
Non-Hispanic White86.8 (84.5, 88.8)13.2 (11.2, 15.5)<0.00175.8 (72.2, 79.0)22.0 (19.4, 24.9)2.2 (1.4, 3.6)<0.0010.11
Non-Hispanic Black77.5 (76.0, 79.0)22.5 (21.0, 24.0)60.3 (57.5, 63.1)34.4 (31.2, 37.8)5.2 (4.1, 6.7)0.78
Mexican American72.0 (70.1, 73.8)28.0 (26.2, 29.9)51.8 (48.8, 54.9)40.3 (37.7, 42.9)7.9 (6.8, 9.1)0.83
Total*84.3 (82.3, 86.2)15.7 (13.8, 17.7)71.5 (68.3, 74.5)25.6 (23.3, 28.1)2.8 (2.1, 3.8)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801252AGAAAGGG
12-1983.2 (78.5, 87.0)16.8 (13.0, 21.5)0.24569.3 (61.5, 76.2)27.6 (21.7, 34.5)3.0 (1.8, 5.2)0.364
20-3983.5 (81.4, 85.5)16.5 (14.5, 18.6)70.2 (66.8, 73.4)26.6 (23.6, 29.8)3.2 (2.0, 4.9)
40-5985.4 (82.5, 87.9)14.6 (12.1, 17.5)73.1 (68.2, 77.5)24.6 (20.7, 28.9)2.3 (1.4, 3.8)
>=6085.3 (83.5, 87.0)14.7 (13.0, 16.5)73.5 (69.8, 76.8)23.7 (20.3, 27.5)2.8 (2.2, 3.5)
Total84.3 (82.3, 86.2)15.7 (13.8, 17.7)71.5 (68.3, 74.5)25.6 (23.3, 28.1)2.8 (2.1, 3.8)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1801252AGAAAGGG
Male84.2 (81.7, 86.5)15.8 (13.5, 18.3)0.85871.4 (67.5, 74.9)25.7 (23.1, 28.6)2.9 (1.8, 4.5)0.984
Female84.4 (82.3, 86.4)15.6 (13.6, 17.7)71.7 (68.0, 75.1)25.5 (22.5, 28.8)2.8 (2.1, 3.7)
Total84.3 (82.3, 86.2)15.7 (13.8, 17.7)71.5 (68.3, 74.5)25.6 (23.3, 28.1)2.8 (2.1, 3.8)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs1801252AGAAAGGG
Non-Hispanic White12-1986.9 (80.9, 91.2)13.1 (8.8, 19.1)76.0 (66.5, 83.5)21.8 (15.4, 29.9)2.2 (0.7, 6.4)
20-3986.4 (83.8, 88.7)13.6 (11.3, 16.2)75.4 (71.5, 78.8)22.1 (18.9, 25.8)2.5 (1.1, 5.7)
40-5987.7 (84.9, 90.1)12.3 (9.9, 15.1)76.8 (71.7, 81.3)21.8 (17.5, 26.7)1.4 (0.7, 2.9)
>=6086.0 (84.4, 87.5)14.0 (12.5, 15.6)74.9 (71.7, 77.9)22.2 (19.1, 25.8)2.8 (2.2, 3.6)
Non-Hispanic Black12-1977.9 (74.7, 80.8)22.1 (19.2, 25.3)60.5 (55.3, 65.5)34.8 (30.0, 40.0)4.7 (2.9, 7.5)
20-3976.9 (75.2, 78.6)23.1 (21.4, 24.8)60.0 (56.8, 63.2)33.8 (29.7, 38.1)6.2 (4.3, 8.8)
40-5976.5 (73.6, 79.1)23.5 (20.9, 26.4)58.3 (53.6, 62.8)36.4 (31.9, 41.0)5.3 (3.6, 7.8)
>=6080.8 (77.4, 83.8)19.2 (16.2, 22.6)64.6 (58.2, 70.6)32.4 (26.4, 39.0)3.0 (1.8, 4.9)
Mexican American12-1970.5 (65.6, 75.1)29.5 (24.9, 34.4)50.5 (42.7, 58.3)40.0 (33.2, 47.2)9.4 (7.0, 12.7)
20-3971.9 (69.2, 74.4)28.1 (25.6, 30.8)51.3 (47.0, 55.7)41.0 (37.3, 44.9)7.6 (6.3, 9.1)
40-5973.0 (70.7, 75.2)27.0 (24.8, 29.3)53.3 (49.8, 56.7)39.6 (35.9, 43.4)7.2 (5.2, 9.8)
>=6073.4 (67.2, 78.8)26.6 (21.2, 32.8)54.2 (44.3, 63.8)38.4 (29.8, 47.8)7.4 (4.7, 11.6)

By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs1801252AGAAAGGG
Non-Hispanic WhiteMale86.6 (83.6, 89.0)13.4 (11.0, 16.4)75.3 (70.8, 79.4)22.4 (19.2, 26.1)2.2 (1.1, 4.3)
Female87.0 (84.5, 89.1)13.0 (10.9, 15.5)76.2 (72.1, 79.8)21.6 (18.4, 25.2)2.2 (1.3, 3.8)
Non-Hispanic BlackMale78.1 (76.1, 80.1)21.9 (19.9, 23.9)60.9 (57.6, 64.1)34.4 (31.0, 38.1)4.7 (3.1, 7.0)
Female77.1 (75.2, 78.8)22.9 (21.2, 24.8)59.9 (56.4, 63.3)34.4 (30.6, 38.4)5.7 (4.5, 7.3)
Mexican AmericanMale71.9 (69.8, 73.9)28.1 (26.1, 30.2)52.2 (48.8, 55.6)39.4 (36.3, 42.6)8.4 (7.2, 9.7)
Female72.1 (69.2, 74.8)27.9 (25.2, 30.8)51.5 (46.8, 56.1)41.2 (37.1, 45.5)7.3 (5.8, 9.1)

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