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U.S. Genome Variation Estimates

ADH1C Allele and Genotype Frequencies

Available polymorphism(s)

Common Designations
rs number Nucleotide changeAmino acid change

Genotyping method

rs1693482Ex6-14G>AArg272GlnTaqMan
rs698Ex8-56A>GIle350ValTaqMan

Allele and Genotype Frequencies for Subpopulations


By Race/Ethnicity

VariantRace-ethnicityAllele
% (95% CI)
Chi-square
P-value†
Genotype
% (95% CI)
Chi-square
P-value†
HW
P-value‡
rs1693482AGAAAGGG
Non-Hispanic White38.5 (35.4, 41.7)61.5 (58.3, 64.6)<0.00115.5 (13.3, 18.1)45.9 (43.3, 48.4)38.6 (34.5, 42.9)<0.0010.91
Non-Hispanic Black14.6 (12.8, 16.5)85.4 (83.5, 87.2)2.3 (1.5, 3.3)24.6 (21.7, 27.6)73.2 (69.9, 76.2)0.37
Mexican American34.1 (32.5, 35.8)65.9 (64.2, 67.5)11.1 (9.6, 12.9)46.0 (43.3, 48.6)42.9 (40.5, 45.4)0.35
Total*33.8 (31.4, 36.3)66.2 (63.7, 68.6)12.9 (11.1, 15.1)41.7 (39.8, 43.6)45.4 (42.3, 48.5)
rs698AGAAAGGG
Non-Hispanic White60.6 (57.5, 63.5)39.4 (36.5, 42.5)<0.00137.4 (33.4, 41.5)46.4 (43.6, 49.2)16.2 (14.0, 18.7)<0.0010.93
Non-Hispanic Black85.1 (83.2, 86.8)14.9 (13.2, 16.8)72.6 (69.4, 75.6)25.0 (22.2, 28.0)2.4 (1.6, 3.5)0.26
Mexican American68.9 (67.0, 70.7)31.1 (29.3, 33.0)49.2 (46.8, 51.5)39.4 (37.1, 41.7)11.5 (9.7, 13.5)<0.01
Total*65.6 (63.1, 68.0)34.4 (32.0, 36.9)44.8 (41.5, 48.1)41.7 (39.5, 43.9)13.5 (11.7, 15.6)

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

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By Age*

VariantAge (years)Allele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1693482AGAAAGGG
12-1934.7 (29.8, 40.0)65.3 (60.0, 70.2)0.87415.0 (10.1, 21.6)39.5 (34.7, 44.4)45.5 (39.9, 51.3)0.643
20-3933.2 (30.5, 36.1)66.8 (63.9, 69.5)11.8 (9.9, 13.9)42.9 (40.1, 45.8)45.3 (41.4, 49.3)
40-5934.0 (30.3, 37.9)66.0 (62.1, 69.7)13.8 (11.1, 17.1)40.4 (36.7, 44.1)45.8 (40.7, 51.0)
>=6033.9 (31.5, 36.4)66.1 (63.6, 68.5)12.6 (10.3, 15.2)42.6 (39.2, 46.2)44.8 (41.3, 48.3)
Total33.8 (31.4, 36.3)66.2 (63.7, 68.6)12.9 (11.1, 15.1)41.7 (39.8, 43.6)45.4 (42.3, 48.5)
rs698AGAAAGGG
12-1964.9 (59.4, 70.0)35.1 (30.0, 40.6)0.87645.0 (38.9, 51.3)39.7 (34.1, 45.6)15.2 (10.2, 22.1)0.785
20-3966.2 (63.3, 68.9)33.8 (31.1, 36.7)44.8 (41.1, 48.7)42.7 (39.9, 45.5)12.5 (10.4, 14.9)
40-5965.2 (61.2, 69.0)34.8 (31.0, 38.8)44.8 (39.3, 50.4)40.8 (36.8, 45.0)14.4 (11.7, 17.5)
>=6065.5 (63.1, 67.9)34.5 (32.1, 36.9)44.3 (40.9, 47.8)42.4 (39.0, 45.8)13.3 (11.2, 15.7)
Total65.6 (63.1, 68.0)34.4 (32.0, 36.9)44.8 (41.5, 48.1)41.7 (39.5, 43.9)13.5 (11.7, 15.6)

* Includes all participants, regardless of race/ethnicity.

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By Sex*

VariantSexAllele
% (95% CI)
Chi-square
P-value
Genotype
% (95% CI)
Chi-square
P-value
rs1693482AGAAAGGG
Male33.5 (30.4, 36.7)66.5 (63.3, 69.6)0.62113.0 (10.9, 15.3)41.1 (37.7, 44.6)45.9 (41.4, 50.5)0.835
Female34.0 (31.9, 36.3)66.0 (63.7, 68.1)12.9 (10.7, 15.6)42.2 (39.9, 44.6)44.8 (42.3, 47.4)
Total33.8 (31.4, 36.3)66.2 (63.7, 68.6)12.9 (11.1, 15.1)41.7 (39.8, 43.6)45.4 (42.3, 48.5)
rs698AGAAAGGG
Male65.9 (62.5, 69.1)34.1 (30.9, 37.5)0.67945.3 (40.3, 50.4)41.1 (36.9, 45.3)13.6 (11.6, 15.8)0.865
Female65.4 (63.2, 67.5)34.6 (32.5, 36.8)44.2 (41.8, 46.7)42.3 (40.1, 44.5)13.5 (11.3, 16.1)
Total65.6 (63.1, 68.0)34.4 (32.0, 36.9)44.8 (41.5, 48.1)41.7 (39.5, 43.9)13.5 (11.7, 15.6)

* Includes all participants, regardless of race/ethnicity.

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By Race/Ethnicity and Age

VariantRace-ethnicityAge (years)Allele
% (95% CI)
Genotype
% (95% CI)
rs1693482AGAAAGGG
Non-Hispanic White12-1941.9 (35.3, 48.8)58.1 (51.2, 64.7)19.0 (12.5, 27.8)45.8 (39.2, 52.5)35.2 (28.1, 43.1)
20-3938.3 (34.5, 42.3)61.7 (57.7, 65.5)14.6 (12.3, 17.3)47.3 (42.9, 51.8)38.1 (32.4, 44.0)
40-5938.0 (33.2, 42.9)62.0 (57.1, 66.8)16.2 (12.9, 20.2)43.5 (39.1, 47.9)40.3 (33.9, 47.0)
>=6037.6 (35.3, 39.9)62.4 (60.1, 64.7)14.2 (11.7, 17.2)46.7 (42.8, 50.6)39.1 (35.8, 42.5)
Non-Hispanic Black12-1913.5 (10.7, 16.7)86.5 (83.3, 89.3)2.1 (0.9, 5.1)22.6 (18.2, 27.7)75.2 (69.8, 79.9)
20-3914.3 (12.4, 16.4)85.7 (83.6, 87.6)2.0 (1.2, 3.1)24.7 (21.3, 28.4)73.4 (69.5, 76.8)
40-5915.0 (12.4, 18.0)85.0 (82.0, 87.6)2.3 (1.1, 4.9)25.3 (21.0, 30.2)72.4 (67.3, 76.9)
>=6016.0 (12.5, 20.2)84.0 (79.8, 87.5)3.3 (1.6, 6.7)25.3 (19.8, 31.7)71.4 (64.5, 77.4)
Mexican American12-1933.8 (30.0, 37.7)66.2 (62.3, 70.0)11.7 (8.7, 15.7)44.1 (38.8, 49.5)44.2 (38.7, 49.9)
20-3934.3 (32.0, 36.6)65.7 (63.4, 68.0)11.2 (9.0, 13.7)46.2 (41.8, 50.7)42.6 (38.8, 46.5)
40-5934.5 (31.2, 37.9)65.5 (62.1, 68.8)10.8 (7.8, 14.6)47.4 (42.8, 52.0)41.8 (37.2, 46.6)
>=6033.0 (28.3, 38.2)67.0 (61.8, 71.7)10.4 (6.9, 15.4)45.3 (39.5, 51.2)44.3 (37.4, 51.4)
rs698AGAAAGGG
Non-Hispanic White12-1957.3 (50.3, 64.1)42.7 (35.9, 49.7)33.9 (26.3, 42.4)46.9 (39.1, 54.7)19.3 (12.6, 28.3)
20-3960.6 (56.9, 64.1)39.4 (35.9, 43.1)36.7 (31.8, 41.9)47.8 (43.8, 51.8)15.5 (12.9, 18.6)
40-5961.0 (55.9, 65.8)39.0 (34.2, 44.1)38.8 (32.1, 45.9)44.4 (39.7, 49.2)16.8 (13.6, 20.5)
>=6061.7 (59.3, 64.1)38.3 (35.9, 40.7)38.5 (35.3, 41.8)46.4 (42.8, 50.0)15.1 (12.6, 18.0)
Non-Hispanic Black12-1985.9 (82.6, 88.8)14.1 (11.2, 17.4)74.5 (69.1, 79.2)22.9 (18.6, 27.8)2.6 (1.2, 5.6)
20-3985.6 (83.5, 87.6)14.4 (12.4, 16.5)73.2 (69.3, 76.8)24.8 (21.3, 28.7)1.9 (1.2, 3.1)
40-5984.5 (81.3, 87.2)15.5 (12.8, 18.7)71.5 (66.2, 76.2)26.0 (21.3, 31.3)2.5 (1.1, 5.7)
>=6083.5 (79.3, 87.0)16.5 (13.0, 20.7)70.3 (63.4, 76.3)26.5 (20.9, 32.9)3.3 (1.6, 6.6)
Mexican American12-1970.6 (66.3, 74.6)29.4 (25.4, 33.7)52.9 (47.2, 58.6)35.3 (30.5, 40.5)11.7 (8.5, 16.0)
20-3968.3 (66.2, 70.3)31.7 (29.7, 33.8)48.4 (45.0, 51.9)39.7 (35.7, 43.9)11.9 (9.9, 14.2)
40-5968.4 (65.0, 71.6)31.6 (28.4, 35.0)47.7 (43.8, 51.5)41.5 (38.8, 44.3)10.8 (8.0, 14.6)
>=6069.3 (64.4, 73.8)30.7 (26.2, 35.6)48.6 (41.4, 55.9)41.4 (34.9, 48.3)10.0 (6.9, 14.2)

By Race/Ethnicity and Sex

VariantRace-ethnicitySexAllele
% (95% CI)
Genotype
% (95% CI)
rs1693482AGAAAGGG
Non-Hispanic WhiteMale38.0 (34.1, 42.1)62.0 (57.9, 65.9)15.5 (12.9, 18.6)45.0 (40.8, 49.2)39.5 (34.0, 45.3)
Female38.9 (36.1, 41.8)61.1 (58.2, 63.9)15.6 (13.1, 18.4)46.7 (43.5, 49.9)37.8 (34.0, 41.7)
Non-Hispanic BlackMale15.3 (13.0, 17.9)84.7 (82.1, 87.0)2.2 (1.2, 3.9)26.2 (21.9, 30.9)71.6 (66.9, 75.9)
Female13.9 (11.9, 16.2)86.1 (83.8, 88.1)2.3 (1.4, 3.8)23.2 (20.2, 26.5)74.5 (70.7, 77.9)
Mexican AmericanMale33.0 (30.4, 35.7)67.0 (64.3, 69.6)10.5 (8.1, 13.5)45.0 (41.6, 48.5)44.5 (40.9, 48.1)
Female35.3 (33.2, 37.4)64.7 (62.6, 66.8)11.8 (9.4, 14.8)46.9 (43.0, 50.9)41.3 (38.3, 44.3)
rs698AGAAAGGG
Non-Hispanic WhiteMale61.0 (57.0, 64.9)39.0 (35.1, 43.0)38.2 (32.3, 44.5)45.5 (40.4, 50.7)16.3 (13.7, 19.2)
Female60.1 (57.4, 62.8)39.9 (37.2, 42.6)36.5 (33.2, 40.0)47.2 (44.5, 50.0)16.2 (13.8, 19.0)
Non-Hispanic BlackMale84.1 (81.2, 86.6)15.9 (13.4, 18.8)70.7 (65.5, 75.4)26.8 (22.2, 32.0)2.5 (1.5, 4.2)
Female86.0 (83.7, 87.9)14.0 (12.1, 16.3)74.2 (70.6, 77.5)23.5 (20.6, 26.6)2.3 (1.4, 3.8)
Mexican AmericanMale69.9 (67.5, 72.2)30.1 (27.8, 32.5)50.2 (47.5, 53.0)39.4 (36.1, 42.8)10.4 (7.7, 13.8)
Female67.8 (65.2, 70.2)32.2 (29.8, 34.8)48.1 (44.8, 51.4)39.3 (35.7, 43.1)12.6 (10.0, 15.7)

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Error processing SSI file
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