HuGENet™ Workshops

HuGENet™ Networks, Genome-Wide Association Studies, and the Knowledge Base on Genetic Variation and Human Health

Thursday, January 24th, and Friday, January 25th, 2008
Tom Harkin Global Communications Center
Building 19, Rooms 245/246

This HuGENet™ Network of Networks workshop reviewed progress on the HuGENet™ Roadmap for human genome epidemiology. Participants discussed approaches for developing the knowledge base on genetic variation and human health, focusing on “field synopses” that summarize genetic associations with specific diseases and a proposal for an online encyclopedia.

Key themes and discussion topics:  

1. Interim Cumulative evidence on genetic associations: applying interim “Venice criteria”
2. Field synopses: reviewing results of pilot studies  
3. Genome-wide association studies: integrating evidence into field synopses
4. Distributed online knowledge base: connecting the dots
5. Linking field synopses with data collections through networks and biobanks

Background document:

• Online encyclopedia global collaboration proposal  (PDF 238KB)

References in packet:

• Ioannidis JP, Gwinn M, Little J, et al. A road map for efficient and reliable human genome epidemiology  (PDF 125KB). Nat Genet 2006;38:3-5.
• Ioannidis JP, Boffetta P, Little, J, et al. Assessment of cumulative evidence on genetic associations: interim guidelines  (PDF 118KB). Int J Epidemiol 2007 Sep 26; [Epub ahead of print]
• NCI-NHGRI Working Group on Replication in Association Studies  (PDF 455KB). Replicating genotype-phenotype associations. Nature 2007;447:655-60.
• Allen NC, Bagade S, McQueen M, et al. Systematic meta-analyses and field synopses of genetic association studies in schizophrenia: the SzGene database. [in press]

 

View the Workshop Agenda and Slides