HuGENet™

Archived Reviews

The HuGE Reviews archive is organized by topic category, with the most recent review listed first under each heading.  

• Gene Variant Frequency
• Infectious and Parasitic Diseases
• Neoplasms
• Endocrine, Nutritional and Metabolic Diseases, and Immunity Disorders
• Diseases of the Blood and Blood-Forming Organs Disorders
• Mental Disorders
• Diseases of the Nervous System and Sense Organs 
• Diseases of the Circulatory System
• Diseases of the Respiratory System
• Diseases of the Digestive System
• Diseases of the Genitourinary System
• Complications of Pregnancy, Childbirth and the Puerperium
• Congenital Anomalies
• Diseases Of The Musculoskeletal System And Connective Tissue
• Symptoms, Signs, and Ill-defined Conditions
• Injury and Poisoning

 

Gene Variant Frequency

None at this time.

Infectious and Parasitic Diseases

None at this time.

Neoplasms

• Glutathione S-Transferase M1 (GSTM1) Polymorphisms and Lung Cancer: A Literature-based Systematic HuGE Review and Meta-Analysis.
  (February 2008)
• Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis
  (February 2008)
• The E-cadherin Gene Polymorphism 160C->A and Cancer Risk: A HuGE Review and Meta-Analysis of 26 Case-Control Studies.
  (January 2008)

• Meta- and Pooled Analyses of the Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Gastric Cancer Risk: A Huge-GSEC Review
  (December 2007)

• A Meta-Analysis of the Association of N-Acetyltransferase 2 Gene (NAT2)
  Variants with Breast Cancer
  (August 2007)
• Pooled Analysis and Meta-analysis of the Glutathione S-Transferase P1 Ile 105Val Polymorphism and Bladder Cancer: A HuGE-GSEC Review
  (April 2007)
• Myeloperoxidase G-463A polymorphism and lung cancer: A HuGE Genetic Susceptibility to Environmental Carcinogens pooled analysis
  (February 2007)
• Meta- and Pooled Analyses of the Cytochrome P-450 1B1 Val432Leu Polymorphism and Breast Cancer 
  (October 2006)
• Meta- and Pooled Analysis of GSTT1 and Lung Cancer: A Huge-GSEC Review
  (September 2006)

• Variants in Estrogen Biosynthesis Genes, Sex Steroid Hormone Levels, and
  Endometrial Cancer: A HuGE Review
  (July 2006)

• XRCC3 and XPD/ERCC2 Single Nucleotide Polymorphisms and the Risk of Cancer
  (May 2006)
• Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review
  (November 2005)
• NQO1, MPO, and the Risk of Lung Cancer
  (October 2005)
• Cytochrome P-450 1A1 Gene Polymorphisms and Risk of Breast Cancer
  (May 2005)
• HFE Gene Mutations in Susceptibility to Childhood Leukemia
  (March 2005)
• ERCC2 /XPD Gene Polymorphisms and Lung Cancer
  (January 2005)
• EPHX1 Polymorphisms and the Risk of Lung Cancer
  (January 2005)
• CYP3A4 Polymorphisms—Potential Risk Factors for Breast and Prostate Cancer
  (October 2004)
• Polymorphisms in Genes Involved in Folate Metabolism and Colorectal Neoplasia
  (March 2004)
• Ovarian Cancer and Polymorphisms in the Androgen and Progesterone Receptor Genes
  (February 2004)
• Pooled Analysis of Alcohol Dehydrogenase Genotypes and Head and Neck Cancer
  (January 2004)
• Mutations in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency
  (2004)
• 5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Leukemia Risk
  (April 2003)
• Mismatch Repair Genes hMLH1 and hMSH2 and Colorectal Cancer
  (November 2002)
• Glutathione S-Transferase Polymorphisms and Risk of Ovarian Cancer(August 2002)
• Pooled Analysis of Meta-Analysis GSTM1 and Bladder Cancer
  (July 2002)
• Androgen Receptor (AR) CAG Repeats and Prostate Cancer
  (May 2002)
• GSTM1, GSTT1 and Risk of Squamous Cell Carcinoma of the Head and Neck(2001)
• N-Acetyltransferase Polymorphisms and Colorectal Cancer
  (May 2000)
• Glutathione S Transferase Polymorphisms and Colorectal Cancer
  (January 2000)
• NF1 Gene and Neurofibromatosis Type 1 
  (January 2000)

Top of Page

 

Endocrine, Nutritional and Metabolic Diseases, and Immunity Disorders

• Angiotensin II type 1 receptor polymorphisms and susceptibility to hypertension: A HuGE review
   (August 2008)
• Meta-Analysis of Vitamin D Receptor Polymorphisms and Type 1 Diabetes: A HuGE Review of Genetic Association Studies
  (August 2006)

• CTLA4 Polymorphisms and Type 1 Diabetes Mellitus: A HuGE Gene-disease Association Review
  (July 2005)

• Systematic Review and Meta-Analysis of the Association between ß2-Adrenoceptor Polymorphisms and Asthma
  (March 2005)
• Genetics of leptin and obesity
  (October 2004)
• Familial Hypercholesterolemia and Coronary Heart Disease: A HuGE Association Review 
  (September 2004)
• Familial Hypercholesterolemia, Peripheral Arterial Disease, and Stroke: A HuGE Minireview 
  (September 2004)
• Genetic Causes of Monogenic Heterozygous Familial Hypercholesterolemia: A HuGE Prevalence Review  
  (September 2004)
• Mutations in genes required for T-cell development: IL7R, CD45, IL2RG, JAK3, RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency
  (2004)
• HFE Gene and Hereditary Hemochromatosis
  (2001)
• HLA-DQ Locus of the Human Leukocyte Antigen Complex and Type 1 Diabetes Mellitus
  (May 2000)
• Medium Chain Acyl-coA Dehydrogenase (MCAD) Deficiency
  (December 1999)
  • Update on the epidemiology of MCADD
    (April 2006)

Top of Page

 

Diseases of the Blood and Blood-Forming Organs Disorders

• Sickle Hemoglobin (Hb S) Allele and Sickle Cell Disease
  (May 2000)

Top of Page

 

Mental Disorders

• Association study between interleukin 1β gene and epileptic disorders: a HuGe review and meta-analysis
  (February 2008)
• Meta-Analysis of the Association of the Taq1A Polymorphism with the Risk of Alcohol Dependency: A HuGE Gene-Disease Association Review.
  (November 2007)
• Association study between the NMDA receptor 2B subunit gene (GRIN2B) and schizophrenia: A HuGE review and meta-analysis
  (January 2007)
• Methylenetetrahydrofolate Reductase (MTHFR) Genetic Polymorphisms and Psychiatric Disorders: A HuGE Review 
  (October 2006)

Top of Page

 

Diseases of the Nervous System and Sense  Organs

• HLA-DR15 Haplotype and Multiple Sclerosis: A HuGE Review
  (March 2007)
• Association between Apolipoprotein E Polymorphisms and Age-related Macular Degeneration
  (August 2006)
• Meta-Analysis of the Association of the Cathepsin D Ala224Val Gene Polymorphism with the Risk of Alzheimer's Disease
  (2004)
• GJB2 (Connexin 26) Variants and Nonsyndromic Sensorineural Hearing Loss (August 2002)

Top of Page

 

Diseases of the Circulatory System

• Genetic Variation associated with Ischemic Heart Failure: A HuGE Review and Meta-Analysis
  (July 2007)
• Genetic Effects versus Bias for Candidate Polymorphisms in Myocardial Infarction: Case Study and Overview of Large-Scale Evidence
  (May 2007)
• Endothelial Nitric Oxide Synthase Gene Polymorphisms and Cardiovascular Disease
  (September 2006)
• Factor XIII Val34Leu Variant Is Protective against Venous Thromboembolism
  (July 2006)
• The long QT syndrome family of cardiac ion channelopathies
  (March 2006)
• CYP2C9 Gene Variants and Clinical Outcomes of Warfarin-Treated Patients
  (February 2005)
• Familial Hypercholesterolemia and Coronary Heart Disease: A HuGE Association Review 
  (September 2004)
• Familial Hypercholesterolemia, Peripheral Arterial Disease, and Stroke: A HuGE Minireview 
  (September 2004)
• Apolipoprotein E Polymorphism and Cardiovascular Disease
  (March 2002)

Top of Page

 

Diseases of the Respiratiory System

None at this time.

Diseases of the Digestive System

None at this time.

Diseases of the Genitourinary System

• NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis
  (February 2006)

Top of Page

 

Complications of Pregnancy, Childbirth and the  Puerperium

• Genetic Risk Factors for Placental Abruption: A HuGE Review and Meta-Analysis.
  (March 2008)
• Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview
  (July 2007)
• Genetic variation associated with preterm birth
  (December 2005)

Top of Page

 

Congenital Anomalies

• Association between the Transforming Growth Factor Alpha Gene and
  Nonsyndromic Oral Clefts
  (March 2006)
• FMR1 and the Fragile X Syndrome
  (October 2001)
• 5,10-Methylenetetrahydrofolate Reductase (MTHFR) Gene Variants and Congenital Anomalies
  (August 1999)

Top of Page

 

Diseases Of The Musculoskeletal System and  Connective Tissue

• Estrogen Receptor Gene Polymorphisms and the Genetics of Osteoporosis 
  (February 2005)
• Molecular epidemiology of vitamin D receptor gene variants
  (February 2000)

Top of Page

 

Symptoms, Signs, & Ill-defined Conditions

• CYP17 Gene Polymorphisms: Prevalence and Associations with Hormone Levels and Related Factors
  (October 2004)

Top of Page

 

Injury and Poisoning

• HLA-DPB1 and Chronic Beryllium Disease
  (March 2003)
• NAD(P)H: Quinone Oxidoreductase (NQO1) Polymorphism, Exposure to Benzene, and Predisposition to Disease
  (April 2002)
• d-Aminolevulinic Acid Dehydratase (ALAD) Genotype and Lead Toxicity
  (July 2001)

Top of Page