HuGENet™

Publications Bibliography

 

This page contains a list of articles related to HuGENet™ that have been written by our HuGENet™ collaborators. (Access to HuGE Reviews.)

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• Analysis
• Books
• Commentary
• History
• Methods

 

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Analysis

 

• A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions
  Janssens AC, Gwinn M, Bradley LA, Oostra BA, van Duijn CM, Khoury MJ.
  Am J Hum Genet 2008 Mar;82(3):593-9
• The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases
  Janssens AC, Moonesinghe R, Yang Q, Steyerberg EW, van Duijn CM, Khoury MJ.
  Genetics In Medicine 2007; 9(8):528-35
• Claims of sex differences: an empirical assessment in genetic associations
  Patsopoulos NA, Tatsioni A, Ioannidis JP.
  JAMA 2007 Aug 22;298(8):880-93
• Online genetic databases informing human genome epidemiology
  Frodsham AJ, Higgins JP.
  BMC Medical Research Methodology 2007 Jul 4;7:31
• Tools for assessing quality and susceptibility to bias in observational studies in epidemiology: a systematic review and annotated bibliography
  Sanderson S, Tatt ID, Higgins JP.
  International Journal of Epidemiology 2007 Jun;36(3):666-76. Epub 2007 Apr 30
• The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey
  Ioannidis JP, Trikalinos TA.
  Canadian Medical Association Journal, 2007 April 10;176(8):1091-6
• Meta-analysis in genome-wide association datasets: strategies and application in Parkinson disease
  Evangelou E, Maraganore DM, Ioannidis JP.
  PLoS ONE. 2007 Feb 7;2(2):e196
• Most published research findings are false--but a little replication goes a long way
  Moonesinghe R, Khoury MJ, Janssens AC.
  PLoS Medicine (February 2007)
• Concordance of functional in vitro data and epidemiological associations in complex disease genetics
  Ioannidis JP, Kavvoura FK.
  Genetics in Medicine 2006 Sep; 8(9):583-593
• Genomics and Proteomics in Epidemiology: Treasure Trove or "High-Tech Stamp Collecting"?
  Hunter DJ.
  Epidemiology 2006 Sep;17(5):487-489
• Implications of Small Effect Sizes of Individual Genetic Variants on the Design and Interpretation of Genetic Association Studies of Complex Diseases
  Ioannidis JP, Trikalinos TA, Khoury MJ.
  American Journal of Epidemiology 2006; 164(7):609-614
• Predictive testing for complex diseases using multiple genes: fact or fiction?
  Janssens AC, Aulchenko YS, Elefante S, Borsboom GJ, Steyerberg EW, van Duijn CM.
  Genetics in Medicine 2006; 8(7):395-400
• Bayesian meta-analysis and meta-regression for gene-disease associations and deviations from Hardy-Weinberg equilibrium
  Salanti G, Higgins JP, Trikalinos TA, Ioannidis JP.
  Statistics in Medicine 2007; 26(3): 553-567
• Impact of violations and deviations in Hardy-Weinberg equilibrium on postulated gene-disease associations
  Trikalinos TA, Salanti G, Khoury MJ, Ioannidis JP.
  American Journal of Epidemiology 2006;163(4):300-9.
• The case for a global human genome epidemiology initiative
  Khoury MJ.
  Nature Genetics 2004;36(10):1027-8
• Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations
  Little J, Bradley L, Bray MS, Clyne M, Dorman J, Ellsworth, DL, et al.
  American Journal of Epidemiology 2002; 156:300-310
• Genetic test evaluation: information needs of clinicians, policy-makers and the public
  Burke W, Atkins D, Gwinn M, Guttmacher A, Haddow J, Lau J, et al.
  American Journal of Epidemiology2002; 156:311-318

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Books

• Human genome epidemiology: a scientific foundation for using genetic information to improve health and prevent disease
  Book edited by Muin J. Khoury, Julian Little, and Wylie Burke (2004).

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Commentary

• Reporting of systematic reviews: the challenge of genetic association studies
  Khoury MJ, Little J, Higgins J, Ioannidis JP, Gwinn M.
  PLoS Medicine 2007 Mar 27;4(3):e78.
• Commentary: rare alleles, modest genetic effects and the need for collaboration
  Campbell H, Manolio T.
  International Journal of Epidemiology 2007 April; 36(2):445-8
• Predictive value of testing for multiple genetic variants in multifactorial diseases: implications for the discourse on ethical, legal and social issues [PDF 327 KB]
  Janssens AC, Khoury MJ.
  Italian Journal of Public Health 2007; 4(3):35-41
• Genetic association studies of cancer: where do we go from here?
  Rebbeck TR, Khoury MJ, Potter JD.
  Cancer Epidemiol Biomarkers Prev 2007 May;16(5):864-5
• Genomics and public health
  Gwinn M, Bowen S, Khoury MJ and the Centers for Disease Control and Prevention.
  MMWR Morb Mortal Wkly Rep. 2006 Dec 22;55 Suppl 2:20-1
• The emergence of networks in human genome epidemiology: challenges and opportunities
  Seminara D, Khoury MJ, O'Brien TR, Manolio T, Gwinn ML, Little J, et al
  Epidemiology 2007; 18(1):1-8
• On the synthesis and interpretation of consistent but weak gene–disease associations in the era of genome-wide association studies
  Khoury MJ, Little J, Gwinn M, Ioannidis JP.
  International Journal Epidemiology 2007 Apr;36(2):439-45. Epub 2006 Dec 20
• The integration of genomics into obstetrics and gynecology: A HuGE challenge
  Khoury MJ, Romero R.
  American Journal of Obstetrics and Gynecology 2006; 195:1503-5
• What role for public health in genetics and vice versa?
  Khoury MJ, Gwinn M.
  Community Genetics 2006; 9(4):282
• Genomics, epidemiology and common complex diseases: let's not throw out the baby with the bathwater!
  Khoury MJ, Gwinn M.
  International Journal of Epidemiology 2006; 35(5):1363-1364
• Getting ready for the future: integration of genomics into public health research, policy and practice in Europe and globally
  Brand A, Schroder P, Brand H, Zimmern R.
  Community Genetics 2006; 9(1):67-71
• What is the clinical utility of genetic testing?
  Grosse SD, Khoury MJ.
  Genetics in Medicine 2006; 8(7):448-50
• Commentary: grading the credibility of molecular evidence for complex diseases
  Ioannidis JP.
  International Journal of Epidemiology 2006 Jun;35(3):572-8
• Make it HuGE: human genome epidemiology reviews, population health, and the IJE
  Smith GD, Gwinn M, Ebrahim S, Palmer LJ, Khoury MJ.
  International Journal of Epidemiology 2006; 35(3):507-510
• Genomics and public health in the United States: signposts on the translation highway
  Gwinn M, Khoury MJ
  Community Genetics 2006; 9(1):21-6
• Quantifying the health benefits of genetic tests: the importance of a population perspective
  Khoury MJ, Jones K, Grosse SD.
  Genetics in Medicine 2006; 8(3):191-5
• A road map for efficient and reliable human genome epidemiology
  Ioannidis JP, Gwinn M, Little J, Higgins J, Bernstein JL, Boffetta P,
  Nature Genetics 2006;38:305.
• Journals should publish all "null" results and should sparingly publish "positive" results
  Ioannidis JP.
  Cancer Epidemiology Biomarkers & Prevention 2006;15(1):186
• Do we need genomic research for the prevention of common diseases with environmental causes?
  Khoury MJ, Davis R, Gwinn M, Lindegren ML, Yoon P.
  American Journal of Epidemiology 2006; 161(9):799-805
• Commentary: mendelian randomisation: a new spin or real progress?
  Little J, Khoury MJ.
  Lancet 2003;362(9388):930-1
• The human genome project is now complete. How do we develop a handle for the pump?
  Little J, Khoury MJ, Bradley L, Clyne M, Gwinn M, Lin B, et al.,
  American Journal of Epidemiology 2003; 157:667-673
• Commentary: epidemiology and the continuum from genetic research to genetic testing
  Khoury MJ.
  American Journal of Epidemiology 2002 Aug 15; 156:297-299.
• Human Genome Epidemiology (HuGE): translating advances in human genetics into population-based data for medicine and public health [PDF 142 KB]
  Khoury MJ.
  Genetics in Medicine 1999; 1:71-73

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History

• Molecular evidence-based medicine: evolution and integration of information in the genomic era.
  Ioannidis JP.
  European Journal of Clinical Investigation (2007) May;37(5):340-349
• The path from genome-based research to population health: Development of an international public health genomics network
  Burke, W, Khoury, MJ, Stewart, A, Zimmern, RL, for the Bellagio Group.
  Genetics in Medicine 2006; 8(7):451-58
• A network of investigator networks in human genome epidemiology
  Ioannidis JP, Bernstein J, Boffetta P, Danesh J, Dolan S, Hartge P, et al.
  American Journal of Epidemiology 2005; 162(4):302-304
• The emergence of epidemiology in the genomics age
  Khoury MJ, Millikan R, Little J, Gwinn M.
  International Journal of Epidemiology 2004; 33(5):936-944
• Human Genome Epidemiology Information (HuGE) on the Internet: current resources and future prospects
  Marks A, Yoon P. (2002)
• Human genome epidemiologic reviews: the beginning of something HuGE
  Khoury MJ, Little J.
  American Journal of Epidemiology 2000; 151:2-3
• Human Genome Epidemiology (HuGE): translating advances in human genetics into population-based data for medicine and public health
  Khoury MJ.
  Genetics in Medicine 1999;1:71-73.
• The Human Genome Epidemiology Network (HuGENet™)
  Khoury MJ, Dorman JS.
  American Journal of Epidemiology 1998; 198:4

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Methods

• Required sample size and nonreplicability thresholds for heterogeneous genetic associations
  Moonesinghe R, Khoury MJ, Liu T, Ioannidis JP.
  Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):617-22. Epub 2008 Jan 3
• Turning the pump handle: evolving methods for integrating the evidence on gene-disease association
  Higgins J, Little J, Ioannidis JP, Bray MS, Manolio TA, Smeeth L, et al.
  American Journal of Epidemiology 2007; 166(8): 863-866
• Assessment of cumulative evidence on genetic associations: interim guidelines
  Ioannidis JP, Boffetta P, Little J, O'Brien TR, Uitterlinden AG, Vineis P, et al.
  International Journal of Epidemiology 2008 Feb;37(1):120-32
• Genetic and molecular epidemiology
  Ioannidis JP.
  Journal of Epidemiology and Community Health 2007;61:757-758
• HuGE reviews and meta-analysis of gene association studies
  El–Serag H, Associate Editor, Khoury MJ, Centers for Disease Control and Prevention and Lewis JD, Associate Editor
  Gastroenterology 2007; 132(3):839-840
• Bayesian synthesis of epidemiological evidence with different combinations of exposure groups: application to a gene-gene-environment interaction
  Salanti G, Higgins JP, White IR.
  Statistics in Medicine 2006 Dec 30;25(24):4147-63
• Genes, environment and the value of prospective cohort studies
  Manolio TA, Bailey-Wilson JE, Collins FS.
  Nature 2006; 7:812-820
• Family-based versus unrelated case-control designs for genetic associations
  Evangelou E, Trikalinos TA, Salanti G, Ioannidis JP. [link to PubMed only]
  PLoS Genetics 2006; 2(8):e123
• Causal models in epidemiology: Past inheritance and genetic future
  Vineis P, Kriebel D.
  Environmental Health 2006; 5(1):21
• Genetic epidemiological studies of preterm birth: guidelines for research
  Pennell CE, Jacobsson B, Williams SM, Buus RM, Muglia LJ, Dolan SM, et al.
  American Journal of Obstetrics and Gynecology 2006 May 15 [epub ahead of print]
• Tracking the epidemiology of human genes in the literature: the HuGE published literature database
  Lin BK, Clyne M, Walsh M, Gomez O, Yu W, Gwinn M, et al.
  American Journal of Epidemiology 2006; 164(1):1-4
• Genomic epidemiology of complex disease: the need for an electronic evidence-based approach to research synthesis
  Bracken MB.
  American Journal of Epidemiology 2005; 162(4):297-301
• Expanded publishing model for genetic association studies
  Gwinn M, Khoury MJ.
  Cancer Epidemiology Biomarkers & Prevention 2006;15(1):185
• The epidemiologic approach to pharmacogenomics
  Little J, Sharp L, Khoury MJ, Bradley L, Gwinn M.
  American Journal of Pharmacogenomics 2005; 5(1):1-20
• Obstacles and opportunities in meta-analysis of genetic association studies
  Salanti G, Sanderson S, Higgins JP.
  Genetics in Medicine 2005; 7(1):13-20
• Improving the prediction of complex diseases by testing for multiple disease-susceptibility genes
  Yang Q, Khoury MJ, Botto L, Friedman JM, Flanders WD.
  American Journal Human Genetics 2003 Mar;72(3):636-49

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