Many of the news links published in our Weekly Update are temporary, and we cannot guarantee access to stories longer than one or two weeks after the Update is published. We suggest you contact the news source directly for reprints.

These articles report on population prevalence of genotypes, gene-disease associations, gene-environment and gene-gene interactions and evaluation of genetic tests.

p53 polymorphisms in Russia and Belarus: correlation of the 2-1-1 haplotype frequency with longitude
Khrunin AV, et al.
Mol Genet Genomics 2005 Jan

CYP2D6 and CYP1A1 mutations in the Turkish population
Aydin M, et al.
Cell Biochem Funct 2005 Jan

 

Association between tumour necrosis factor gene polymorphisms and the clinical types of patients with chronic hepatitis B virus infection
Xu XW, et al.
Clin Microbiol Infect 2005 Jan;11(1):52-6

 

CYP1A1 alleles in female genital cancers in the Polish population
Seremak-Mrozikiewicz A, et al.
Eur J Obstet Gynecol Reprod Biol 2005 Feb;118(2):246-50

HLA and smoking in prediction and prognosis of small cell lung cancer in autoimmune Lambert-Eaton myasthenic syndrome
Wirtz PW, et al.
J Neuroimmunol 2005 Feb;159(1-2):230-7

HLA polymorphisms are associated with Helicobacter pylori infected gastric cancer in a high risk population, China
Li Z, et al.
Immunogenetics 2005 Jan

Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population
Shaag A, et al.
Hum Mol Genet 2005 Jan

A functional single nucleotide polymorphism of the G-CSF receptor gene predisposes to high-risk myelodysplastic syndrome
Wolfler A, et al.
Blood 2005 Jan

Effect of cytokine genotypes on the hepatitis B virus-hepatocellular carcinoma association
Nieters A, et al.
Cancer 2005 Jan

Methylenetetrahydrofolate reductase polymorphisms/haplotypes and risk of gastric cancer: A case-control analysis in China
Shen H, et al.
Oncol Rep 2005 Feb;13(2):355-60

Human kallikrein-2 gene polymorphism is associated with the occurrence of prostate cancer
Chiang CH, et al.
J Urol 2005 Feb;173(2):429-32

Genetic polymorphisms of GSTs and their association with primary brain tumor incidence
Pinarbasi H, et al.
Cancer Genet Cytogenet 2005 Jan;156(2):144-9

Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study
Li Y, et al.
Breast Cancer Res 2005;7(1):R12-8

 

A 6-year survey of HFE gene test for hemochromatosis diagnosis
Mura C, et al.
Genet Med 2005 Jan-2005 Feb;7(1):68-73

Calpain-10 gene polymorphisms and type 2 diabetes in West Africans: the Africa America Diabetes Mellitus (AADM) Study
Chen Y, et al.
Ann Epidemiol 2005 Feb;15(2):153-9

Ile118Val genetic polymorphism of CYP3A4 and its effects on lipid-lowering efficacy of simvastatin in Chinese hyperlipidemic patients
Wang A, et al.
Eur J Clin Pharmacol 2005 Jan

Haplotypes Produced from Rare Variants in the Promoter and Coding Regions of Angiotensinogen Contribute to Variation in Angiotensinogen Levels
Zhu X, et al.
Hum Mol Genet 2005 Jan

Studies of the Gly482Ser polymorphism of the peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) gene in Danish subjects with the metabolic syndrome
Ambye L, et al.
Diabetes Res Clin Pract 2005 Feb;67(2):175-9

CTLA4 polymorphisms are associated with vitiligo, in patients with concomitant autoimmune diseases
Blomhoff A, et al.
Pigment Cell Res 2005 Feb;18(1):55-8

Association between VDR ApaI Polymorphism and Hip Bone Mineral Density Can Be Modified by Body Mass Index: A Study on Postmenopausal Chinese Women
Deng HW, et al.
Acta Biochim Biophys Sin ( Shanghai ) 2005 Jan;37(1):61-7

Rational approach to genetic testing of cystic fibrosis (CF) in infertile men
Mennicke K, et al.
Andrologia 2005 Jan;37(1):1-9

Searching for haemochromatosis in general practice: testing patients with elevated serum ferritin
Mouland G, et al.
Tidsskr Nor Laegeforen 2005 Jan;125(1):20-2

Familial Mediterranean Fever (FMF) in Turkey: Results of a Nationwide Multicenter Study
Medicine ( Baltimore ) 2005 Jan;84(1):1-11

Susceptible and Protective Human Leukocyte Antigen Class II Alleles and Haplotypes in Bahraini Type 2 (Non-Insulin-Dependent) Diabetes Mellitus Patients
Motala AA, et al.
Clin Diagn Lab Immunol 2005 Jan;12(1):213-7

Apolipoprotein C-III protein concentrations and gene polymorphisms in Type 1 diabetes; Associations with microvascular disease complications in the DCCT/EDIC cohort
Klein RL, et al.
J Diabetes Complications 2005 Jan-2005 Feb;19(1):18-25

Variation at the paraoxonase gene locus contributes to carotid arterial wall thickness in subjects with familial hypercholesterolemia
Roest M, et al.
Clin Biochem 2005 Feb;38(2):123-7

Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples
Liu Y, et al.
J Hum Genet 2005 Jan

A Functional Polymorphism in the Promoter Region of the Tryptophan Hydroxylase Gene Is Associated With Alcohol Dependence in One Aboriginal Group in Taiwan
Sun HS, et al.
Alcohol Clin Exp Res 2005 Jan;29(1):1-7

Five NOTCH4 polymorphisms show weak evidence for association with schizophrenia: evidence from meta-analyses
Glatt SJ, et al.
Schizophr Res 2005 Mar;73(2-3):281-90

Case-control association study of the close homologue of L1 (CHL1) gene and schizophrenia in the Chinese population
Chen QY, et al.
Schizophr Res 2005 Mar;73(2-3):269-74

Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: A large-scale association study plus meta-analysis
Fan JB, et al.
Biol Psychiatry 2005 Jan;57(2):139-44

Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans
Lee SG, et al.
Hum Genet 2005 Jan

Dopamine D3 Receptor Ser9Gly Polymorphism and Risperidone Response
Lane HY, et al.
J Clin Psychopharmacol 2005 Feb;25(1):6-11

An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia
Zhang B, et al.
Eur Psychiatry 2005 Jan;20(1):45-9

 

Genotypes and haplotypes in the IL-1 gene cluster: analysis of two genetically and diagnostically distinct groups of Alzheimer patients
Seripa D, et al.
Neurobiol Aging 2005 Apr;26(4):455-64

A new promoter polymorphism in the alpha-1-antichymotrypsin gene is a disease modifier of Alzheimer's disease
Licastro F, et al.
Neurobiol Aging 2005 Apr;26(4):449-53

CTLA-4 gene polymorphism is not associated with conventional multiple sclerosis in Japanese
Fukazawa T, et al.
J Neuroimmunol 2005 Feb;159(1-2):225-9

Characterization of a single nucleotide polymorphism in the ZNF9 gene and analysis of association with myotonic dystrophy type II (DM2) in the Italian population
Vallo L, et al.
Mol Cell Probes 2005 Feb;19(1):71-4

Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single gene disease
Soares ML, et al.
Hum Mol Genet 2005 Jan

ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease
Mace S, et al.
Neurobiol Dis 2005 Feb;18(1):119-25

Association of the insertion/deletion polymorphism of the angiotensin I-converting enzyme gene in patients of migraine with aura
Kowa H, et al.
Neurosci Lett 2005 Feb;374(2):129-31

Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease
Jamieson SE, et al.
Neurosci Lett 2005 Feb;374(2):124-8

A functional serotonin transporter gene polymorphism is associated with migraine with aura
Marziniak M, et al.
Neurology 2005 Jan;64(1):157-9

APOE epsilon4 is not a susceptibility gene in idiopathic or diabetic sensory neuropathy
Zhou Z, et al.
Neurology 2005 Jan;64(1):139-41

Cerebral glucose metabolism in patients with AD and different APOE genotypes
Drzezga A, et al.
Neurology 2005 Jan;64(1):102-7

HLA class II alleles are not a general susceptibility factor in Guillain-Barre syndrome
Geleijns K, et al.
Neurology 2005 Jan;64(1):44-9

A Rare Truncating Mutation in ADH1C (G78Stop) Shows Significant Association With Parkinson Disease in a Large International Sample
Buervenich S, et al.
Arch Neurol 2005 Jan;62(1):74-8

Apolipoprotein E, cardiovascular disease and cognitive function in aging women.
Kang JH, et al.
Neurobiol Aging 2005 Apr;26(4):475-84

 

PON1 polymorphism, diabetes mellitus, obesity, and risk of myocardial infarction: Modifying effect of diabetes mellitus and obesity on the association between PON1 polymorphism and myocardial infarction
Li J, et al.
Genet Med 2005 Jan;7(1):58-63

Relationship between In Vitro Lipopolysaccharide-Induced Cytokine Response in Whole Blood, Angiographic In-Stent Restenosis, and Toll-Like Receptor 4 Gene Polymorphisms
Rittersma SZ, et al.
Clin Chem 2005 Jan

C677T mutation of methylenetetrahydrofolate reductase gene and serum homocysteine levels in Turkish patients with coronary artery disease
Yilmaz H, et al.
Cell Biochem Funct 2005 Jan

Haplotype analysis of carnitine transporters and left ventricular mass in human essential hypertension
Tripodi G, et al.
J Ren Nutr 2005 Jan;15(1):2-7

Coagulation Factor XIII VaI34Leu Polymorphism in Patients with Small Vessel Disease or Primary Intracerebral Hemorrhage
Slowik A, et al.
Cerebrovasc Dis 2005 Jan;19(3):165-70

T280M and V249I polymorphisms of fractalkine receptor CX3CR1 and ischemic cerebrovascular disease
Hattori H, et al.
Neurosci Lett 2005 Feb;374(2):132-5

CYP11B2 gene polymorphisms and hypertension in highlanders accustomed to high salt intake
Rajput C, et al.
J Hypertens 2005 Jan;23(1):79-86

Bradykinin B2 receptor gene (-58T/C) polymorphism influences baroreflex sensitivity in never-treated hypertensive patients
Milan A, et al.
J Hypertens 2005 Jan;23(1):63-9

Sequence variation of bradykinin receptors B1 and B2 and association with hypertension
Cui J, et al.
J Hypertens 2005 Jan;23(1):55-62

Hereditary hemochromatosis gene (HFE) mutations C282Y, H63D and S65C in patients with idiopathic dilated cardiomyopathy
Hannuksela J, et al.
Eur J Heart Fail 2005 Jan;7(1):103-8

Polymorphisms of the insertion / deletion ACE and M235T AGT genes and hypertension: surprising new findings and meta-analysis of data
Mondry A, et al.
BMC Nephrol 2005 Jan;6(1):1

Apolipoprotein E, cardiovascular disease and cognitive function in aging women.
Kang JH, et al.
Neurobiol Aging 2005 Apr;26(4):475-84

 

Characterization of genotype-phenotype relationships and stratification by the CARD15 variant genotype for inflammatory bowel disease susceptibility loci using multiple short tandem repeat genetic markers
Crawford NP, et al.
Hum Mutat 2005 Jan;25(2):156-66

 

Is the CAG repeat of mitochondrial DNA polymerase gamma (POLG) associated with male infertility? A multi-centre French study
Aknin-Seifer IE, et al.
Hum Reprod 2005 Jan

 

Cytokine polymorphisms in patients with pemphigus
Eberhard Y, et al.
Arch Dermatol Res 2005 Jan;296(7):309-13Arch

 

A specific haplotype in the 3' end of estrogen-receptor alpha gene is associated with low bone mineral density in premenopausal women and increased risk of postmenopausal osteoporosis
Ongphiphadhanakul B, et al.
Osteoporos Int 2005 Jan

Effect of CYP1A1 Gene Polymorphisms on Estrogen Metabolism and Bone Density
Napoli N, et al.
J Bone Miner Res 2005 Feb;20(2):232-9

Association of mannose binding lectin (MBL) gene polymorphism and serum MBL concentration with characteristics and progression of systemic lupus erythematosus
Takahashi R, et al.
Ann Rheum Dis 2005 Feb;64(2):311-4

No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C260T polymorphisms in susceptibility to ankylosing spondylitis
van der Paardt M, et al.
Ann Rheum Dis 2005 Feb;64(2):235-8

Oral Clefts, Maternal Smoking, and TGFA: A Meta-Analysis of Gene-Environment Interaction.
Zeiger JS, et al.
Cleft Palate Craniofac J 2005 Jan;42(1):58-63

The French congenital central hypoventilation syndrome registry: general data, phenotype, and genotype
Trang H, et al.
Chest 2005 Jan;127(1):72-9

Functional polymorphism of p53 and CCR5 genes in long-livers of a Siberian Region
Vestn Ross Akad Med Nauk 2004(11):25-8

Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1-related gene polymorphisms
Watanabe E, et al.
Crit Care Med 2005 Jan;33(1):89-97

The Association of Interleukin 6 Haplotype Clades With Mortality in Critically Ill Adults
Sutherland AM, et al.
Arch Intern Med 2005 Jan;165(1):75-82

Genetic association analysis of chronic mountain sickness in an Andean high-altitude population
Mejia OM , et al.
Haematologica 2005 Jan;90(1):13-9