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Fictional Scenario To Test Your Knowledge of Gene-Environment Interaction: Rheumatoid Arthritis, Herbal Supplements and Fictitious Rheumatoid Arthritis Gene Objectives

This website is archived for historical purposes and is no longer being maintained or updated.

Educational objectives

After reading this case study, you should be able to:

  • Identify key characteristics of the study population (cases and controls) that should be described when reporting results of gene-disease associations and gene-environment interaction.
  • Summarize gene-disease associations and gene-environment interaction in terms of relative and attributable risks.
  • Discuss advantages and disadvantages of case-only analysis for gene-environment interaction.
  • Discuss possible implications of the findings for disease prevention and public health.

Disclaimer for Rheumatoid Arthritis, Herbal Supplements and Fictitious Rheumatoid Arthritis Gene Case Study

The following case study is a completely fictitious scenario presented for educational purposes only. The journal, the gene, the exposures and all the numbers are all made up and are not based on or derived from any existing information or dataset.


  1. Commentary: Facing the challenge of gene-environment interaction: the two-by-four table and beyond.[PDF 177 KB]
    Lorenzo D. Botto and Muin J. Khoury Am J Epidemiol (May 15, 2001)
  2. Epidemiology Book chapter by M. Gwinn, M. J. Khoury - Genetics in Practice (in press)
  3. Genetic Epidemiology Book chapter excerpted by M. Khoury, from Modern Epidemiology, Second Edition (1998)
  4. Rothman KJ. Epidemiology: An Introduction. Oxford University Press, New York, 2002.