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Genomics Day 2005: Genomics Day 2005: Public Health Genomics at CDC

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Group 1: Genetics and Immunity

Immunogenetic factors in chronic beryllium disease
Weston A, Yucesoy B, Luster, M.
Health Effects Laboratory Division, NIOSH, CDC

Poster: Immunogenetic factors in chronic beryllium disease

The development of a Laboratory for Occupational Genomics (NIOSH-LOG) is proposed. The central focus for this laboratory is the identification of genetic susceptibility factors in occupational diseases. The specific aims of the proposed NIOSH-LOG are to: 1) build an occupational biological sample base (DNA, blood, buccal smears, paraffin blocks, other) with which to perform molecular epidemiological genetic association studies based on logical hypotheses in order to identify genetic risk factors of occupational disease. Samples will be available for investigators within the laboratory as well as NIOSH and non-NIOSH investigators that develop appropriate study design. The NIOSH-LOG will take advantage of sample repository facilities at CDC's Lawrenceville, GA, facility and samples will be tracked using the CASPIR system; 2) foster partnerships with academia, industry, other government and international agencies to understand the genetic underpinnings of occupational disease; 3) develop a framework for data analysis that will be available for NIOSH investigators, academics and regulatory agencies. This framework will contain the elements required for meta-analysis, modeling, Monte Carlo analysis and risk assessment. Through this information exchange medium, the NIOSH-LOG will establish collaboration with regulatory agencies, other federal institutions and international organizations involved in occupational and environmental research. These collaborations will include molecular biologists, statisticians, computational biologists and risk assessment modelers; 4) explore ethical challenges surrounding the use of genetic data in occupational health research including protecting confidentiality and appropriate explanation of health-related issues to the workers.



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