About Us

10 years of Public Health Genomics at CDC
1997-2007

2.0 Projects of the National Public Health Genomics

Figure: Draft Conceptual Model: Influenza Applied Research and Translation

This graphic shows a draft version of proposed priorities for genomics research on determinants of influenza disease severity and vaccine response and side effects that was presented at the Influenza workshop in January, 2007 that was jointly sponsored by OPHG and NCIRD. On the far left, a vertical box labeled Population contains both Age and Genetic Variation. A first step shown at the top is Modify Environment: Prevent Exposure. Activities in this stage include Develop Vaccine for Influenza Virus using Animal Populations and the use in treatment of Antiviral Drugs.  A second step shown is Modify Immunity: Vaccinate, and the Vaccine is shown above Acquired Immunity for the Influenza Virus. Genetic Variation leads to questions about Innate Immunity in some parts of the population, and to Severe Influenza in other parts of the population. Vaccine Adverse Effects are also shown as a possible outcome from developing the vaccine. Both Vaccine Adverse Effects and Severe Influenza lead to Modify Policy and Systems: Guidelines, Delivery, and Coverage. Finally, all arrows lead to the desired outcome: Reduced Influenza Morbidity and Mortality. 

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