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Office of Public Health Genomics
2006 Program Review Book

Table Of Contents

  1. Priorities
    • OPHG Vision
    • OPHG Mission
    • OPHG Goals
      1. Integrate Genomics into Public Health Research
      2. Assess the Role of Family History in Risk Assessment and Disease Prevention
      3. Evaluate the Use of Genetic Tests for Population Health
    • Current Priorities Related to Goals

  2. Major Accomplishments Related to Goals and Priorities
    1. Integrate Genomics into Public Health Research
      • National Health and Nutrition Examination Survey (NHANES) III
        • Major Accomplishments Related to NHANES
      • Develop a Knowledge Base on Genomics and Population Health:  Human Genome Epidemiology (HuGE)
        • Major Accomplishments Related to HuGENet
      • Seed Funding for Public Health Genomics Research
        • Genetic Predictors of Developing Hemolytic-Uremic Syndrome among persons infected with Shiga toxin-producing Escherichia coli (STEC)
        • Microarray Analyses of MHC Genetic Variations in Diisocyanate-induced Occupational Asthma
        • Maternal Smoking, Polymorphisms of Genes Involved with Metabolism of  Tobacco Smoke, and Risk for Gastroschisis and Anorectal Atresia/ Stenosis in the National Birth Defects Prevention Study
        • Identifying Genetic Determinants of Susceptibility to M. tuberculosis
        • Investigation of Immunoglobulin (Ig) GM and KM Gene Polymorphisms in Susceptibility to and Pathogenesis of Malaria and HIV in Children and Pregnant Women in Kenya
        • Effectiveness and Cost-effectiveness of Using Family History of Diabetes for Population–level Health Promotion
        • Should Genetic Testing Be Used to Guide Warfarin Therapy? An Evidence-based Cost-Utility Analysis
        • Effect of Folic Acid Intake on Blood Folate and Homocysteine Levels in Persons Classified by Genotype of Folate-related Genes
        • A Proposal to Evaluate Use of the CDC Web-based Family Healthware™ Assessment Tool Among Specific Public Health Program and Project Healthcare Providers
        • An Early Childhood Mortality Study Using a Newborn Blood Spot Screening Test for Severe Combined Immunodeficiency Disorder (SCID)
        • Osteoporosis: A Multi-determinate Approach to Prevention: Implications for the CDC Health Protection Goal of Living Better and Longer

    2. Assess the Role of Family History in Risk Assessment and Disease Prevention
      • Beta Version of Family Healthware™
      • Family History Controlled Clinical Trial
      • Material Transfer Agreements (MTAs)
      • Surgeon General’s Family History Initiative Resource Packets
      • Major Accomplishments Related to Family History

    3. Evaluate the Use of Genetic Tests for Population Health
      • EGAPP™ Working Group
        • Evidence Reports
        • EGAPP™ Products
        • Evaluation Plan
        • Collaboration between EGAPP™ and the Centers for Genomics and Public Health
        • Moving Toward a Sustainable Process
        • Major Accomplishments Related to EGAPP™

  3. State Examples Related To Goals and Priorities
    • Assess the Role of Family History in Risk Assessment and Disease Prevention
      • Public Health Problem
      • Program Example (Michigan and Utah)
      • Results and Impacts to Date

  4. Future Directions
    • Integrating Genomics into Public Health Investigations:  CDC Influenza Public Health Genomics Initiative
      • Project Goal
      • Anticipated Products and Public Health Impact
    • Beyond Gene Discovery (BGD) Initiative:  Developing a National Genomic Profile for the U.S. Population
    • Applying Genomic Applications to Population Health

  5. Publications

  6. At-A-Glance 2006

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