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National Influenza Vaccine Summit Newsletter

Issue 2 / July 2006

NOTE: This document is provided for historical purposes only and may not reflect the most accurate and up-to-date information on this subject. For current flu information, please visit the CDC Flu Homepage.

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The American Medical Association (AMA) and the Centers for Disease Control and Prevention (CDC) co-sponsor the National Influenza Vaccine Summit (The Summit). The Summit is an action-oriented entity with over 400 members who represent over 100 public and private organizations with an interest in addressing and resolving influenza and influenza vaccine issues.

Second National Influenza Vaccine Summit, June 2006

A second National Influenza Vaccine Summit was convened this year in Chicago, Illinois on June 22. One hundred forty-seven individuals representing seventy-three stakeholder organizations attended and participated in the summit. The goal of this summit meeting was to discuss strategies that may increase utilization of influenza vaccine during the upcoming vaccination season. In addition to considerable discussion among summit members, ten presentations were made by key stakeholders. Presentation slides are available at www.ama-assn.org/ama/pub/category/13732.html.

During the final session of the summit, participants organized six teams that will work to target three populations and address three important objectives for the upcoming influenza season. Each team will develop plans that seek to increase the level of vaccine uptake during the upcoming influenza season. Team leaders are actively recruiting members so that these plans may be developed and implemented by August 31. The six teams are as follows:

  1. Targeting healthcare workers;
  2. Targeting children aged 6 months through 18 years;
  3. Targeting all contacts of high-priority population with an eye towards “universal vaccination;
  4. Extending the vaccination season;
  5. Unifying/creating a provider toolkit; and
  6. Utilizing Partnerships to improve education, reduce barriers to immunizing, and share the fiscal risk of influenza vaccine.

If you are interested in participating in one of these teams, would like a dditional information regarding this and previous Summits, or are interested in other information regarding influenza vaccination during the upcoming influenza season, go to www.ama-assn.org/go/influenzasummit

Influenza Vaccine Supply and Production

The National Influenza Vaccine Summit has made a commitment to provide information on important issues concerning the upcoming influenza season. As part of that effort, we want to let you know about a recent FDA action that concerns influenza vaccine for the 2006-07 season. The links found on the following web sites will provide you with information related to this issue.

The National Influenza Vaccine Summit will continue to monitor the situation and keep you informed of developments.

Projection of the 2006-07 Influenza Vaccine Supply

As of June 9, 2006, influenza vaccine manufacturers project that approximately 110-115 million doses of influenza vaccine will be available in the U.S. for use during the 2006-07 influenza season. This amount represents approximately 16% more doses than were available for the 2005-06 season. An additional 15 million doses may become available if another manufacturer's vaccine is licensed in 2006.

Also as of June 9, 2006, sanofi pasteur projects that up to 8 million doses of thimerosal-free vaccine in pre-filled syringes or vials will be produced for the 2006-07 influenza season. The majority of this vaccine will be in 0.25 mL syringes (indicated for ages 6-35 months) with the remainder in 0.5 mL vials or syringes (indicated for ages 36 months and older). In addition, GSK's influenza vaccine for adults 18 years of age and older is preservative-free (trace thimerosal) vaccine and Novartis (formerly Chiron) has a preservative-free (trace thimerosal) preparation for persons 4 years of age and older. The nasal influenza vaccine, FluMist, also is thimerosal-free

GlaxoSmithKline (GSK) submitted a Biologics License Application (BLA) to the FDA for FluLaval, a seasonal, inactivated influenza vaccine, and hopes to receive approval for use in persons aged 18 years and older in time for the 2006-07 influenza season. If approved, GSK projects up to 15 million doses of FluLaval will be available in the US for the 2006-07 influenza season.

Influenza Vaccine Distribution and Administration

Ordering Influenza Vaccine

Much of the influenza vaccine was pre-booked early this year. Providers should contact distributors and local vendors about remaining supply. Additional doses may be available if a new vaccine is licensed in 2006.

Influenza vaccine preparations and their indications as licensed by the FDA

The table below has been updated with new information provided by GlaxoSmithKline, Inc. since the June 2006 publication of the National Influenza Vaccine Summit newsletter. GlaxoSmithKline, Inc. informed the Summit that the level of Thimerosal in Fluarix ™ inactivated TIV is <1µg Hg/0.5mL dose, preservative free.

Influenza Vaccine Manufacturers for the 2006-07 Influenza Season
Manufacturer
Vaccine
Formulation
Thimerosal preservative
Age indication
sanofi pasteur, Inc.
Fluzone®, Inactivated TIV
Multi-dose vial
Yes
> 6 months
Single-dose pre-filled 0.5 mL syringe or vial
None
> 36 months
Single-dose pre-filled 0.25 mL syringe
None
6-35 months
MedImmune Vaccines, Inc
FluMist™ LAIV
Single-dose sprayer
None
Healthy persons 5-49 years
Novartis Vaccine (formerly Chiron Corporation)
Fluvirin™
Inactivated TIV
Multi-dose vial
Yes
> 4 years
Single-dose 0.5 mL syringe
<1µg Hg/0.5mL dose), preservative free
> 4 years
GlaxoSmithKline, Inc.
Fluarix™ Inactivated TIV
Single-dose pre-filled syringe 0.5 mL
<1µg Hg/0.5mL dose, preservative free
> 18 years

Influenza Vaccine Communications & Resources

Advisory Committee on Immunization Practices (ACIP)

The ACIP met June 29–30, 2006 in Atlanta, Georgia. The agenda included discussion and votes on recommendations for Influenza vaccine, Quadrivalent Human Papillomavirus vaccine (HPV), Tdap vaccine and Varicella vaccine. Other topics for discussion included use of Pneumococcal vaccines to reduce morbidity and mortality in an influenza pandemic, Menactra ® supply and prioritization, Herpes Zoster (Shingles) vaccine, the Adult Immunization Schedule, and the Childhood Immunization Schedule for 2007. Slide presentations from the meeting are currently available at www.cdc.gov/nip/ACIP/slides/mtg-slides-jun06.htm. Meeting minutes will be available at www.cdc.gov/nip/ACIP/minutes.htm later this year.

Morbidity and Mortality Weekly Reports (MMWRs)

To review recently published MMWRs related to influenza, visit the following MMWR links.

Influenza ListServe

The National Influenza Vaccine Summit Newsletter (flu bulletin) is available by e-mail subscription. It's easy to get a copy delivered to your e-mail inbox.

  1. Send an e-mail message to LISTSERV@LISTSERV.CDC.GOV
  2. In the body of the message type the following: SUBSCRIBE FLU-SERVE
  3. You'll receive an e-mail message as a confirmation.

Previous influenza vaccine bulletins are available on the CDC website at www.cdc.gov/flu/professionals/flubulletin.htm

Upcoming Events

Seventh National Conference on Immunization Coalitions, August 9–11, 2006, Denver, Colorado, www.seeuthere.com/rsvp/invitation/invitation.asp?id=/m2c666-455170415278

National Adult Immunization Awareness Week, September 24–30, 2006, Nationwide, www.cdc.gov/nip/events/naiaw/

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