Seasonal Flu Shot
Questions & Answers
On this Page
- What is the flu shot?
- Is there more than one type of flu shot available?
- Who should get vaccinated this season?
- Who should not get a flu shot?
- How effective is the flu shot?
- What are the risks from getting a flu shot?
- What are the side effects that could occur?
- Can severe problems occur?
- What should I do if I have had a serious reaction to seasonal influenza vaccine?
- Can the flu shot give me the flu?
- Why do some people not feel well after getting the flu shot?
- What about people who get a seasonal flu vaccine and still get sick with flu-like symptoms?
Visit What You Should Know for the 2015-2016 Influenza Season for flu and flu vaccine information specific to the 2015-16 flu season.
The flu shot is a vaccine given with a needle, usually in the arm. The seasonal flu shot protects against the three or four influenza viruses that research indicates will be most common during the upcoming season.
There are several flu vaccine options for the 2015-2016 flu season.
Traditional flu vaccines made to protect against three different flu viruses (called “trivalent” vaccines) are available. In addition, flu vaccines made to protect against four different flu viruses (called “quadrivalent” vaccines) also are available.
Trivalent flu vaccine protects against two influenza A viruses (an H1N1 and an H3N2) and an influenza B virus. The following trivalent flu vaccines are available:
- Standard-dose trivalent shots that are manufactured using virus grown in eggs. There are several different flu shots of this type available, and they are approved for people of different ages. Some are approved for use in people as young as 6 months of age. Most flu shots are given with a needle. One standard dose trivalent shot also can be given with a jet injector, for persons aged 18 through 64 years.
- A high-dose trivalent shot, approved for people 65 and older.
- A trivalent shot containing virus grown in cell culture, which is approved for people 18 and older.
- A recombinant trivalent shot that is egg-free, approved for people 18 years and older.
The quadrivalent flu vaccine protects against two influenza A viruses and two influenza B viruses. The following quadrivalent flu vaccines are available:
- A quadrivalent flu shot that is manufactured using virus grown in eggs. There are several different flu shots of this type available, and they are approved for people of different ages. Some are approved for use in people as young as 6 months of age.
- An intradermal quadrivalent shot, which is injected into the skin instead of the muscle and uses a much smaller needle than the regular flu shot. It is approved for people 18 through 64 years of age.
- A quadrivalent nasal spray vaccine, approved for people 2 through 49 years of age.
Everyone 6 months of age and older should get a flu vaccine every season. This recommendation has been in place since February 24, 2010 when CDC’s Advisory Committee on Immunization Practices (ACIP) voted for “universal” flu vaccination in the United States to expand protection against the flu to more people.
Vaccination to prevent influenza is particularly important for people who are at high risk of serious complications from influenza. See People at High Risk of Developing Flu-Related Complications for a full list of age and health factors that confer increased risk.
More information is available at Who Should Get Vaccinated Against Influenza.
Different flu vaccines are approved for use in different groups of people. Factors that can determine a person's suitability for vaccination, or vaccination with a particular vaccine, include a person's age, health (current and past) and any relevant allergies, including an egg allergy.
Nasal Spray Vaccine:
The ability of a flu vaccine to protect a person depends on the age and health status of the person getting the vaccine, and the similarity or “match” between the viruses or virus in the vaccine and those in circulation. For more information, see Vaccine Effectiveness – How well does the Flu Vaccine Work.
You cannot get the flu from a flu shot. The risk of a flu shot causing serious harm or death is extremely small. However, a vaccine, like any medicine, may rarely cause serious problems, such as severe allergic reactions. Almost all people who get influenza vaccine have no serious problems from it.
- Soreness, redness, or swelling where the shot was given
- Fever (low grade)
The intradermal flu shot may cause other additional mild side effects including:
- Toughness and itching where the shot was given
If these problems occur, they begin soon after the shot and usually last one to two days.
Life-threatening allergic reactions are very rare. Signs of serious allergic reaction can include breathing problems, hoarseness or wheezing, hives, paleness, weakness, a fast heartbeat, or dizziness. If they do occur, it is within a few minutes to a few hours after the shot. These reactions can occur among persons who are allergic to something that is in the vaccine, such as egg protein or other ingredients. While severe reactions are uncommon, you should let your doctor, nurse, clinic, or pharmacist know if you have a history of allergy or severe reaction to flu vaccine or any part of flu vaccine, including eggs.
There is a small possibility that influenza vaccine could be associated with Guillain-Barré syndrome, no more than 1 or 2 cases per million people vaccinated. This is much lower than the risk of severe complications from flu, which can be prevented by flu vaccine.
Call a doctor, or get to a doctor right away.
Tell your doctor what happened, the date and time it happened, and when you got the flu shot.
Ask your doctor, nurse, or health department to file a Vaccine Adverse Event Reporting System (VAERS) form, or call VAERS at 1-800-822-7967.
No, a flu shot cannot give you the flu. Flu vaccines that are administered with a needle are currently made in two ways: the vaccine is made either with a) flu vaccine viruses that have been ‘inactivated’ and are therefore not infectious, or b) with no flu vaccine viruses at all (which is the case for recombinant influenza vaccine). In randomized, blinded studies, where some people got flu shots and others got saltwater shots, the only differences in symptoms was increased soreness in the arm and redness at the injection site among people who got the flu shot. There were no differences in terms of body aches, fever, cough, runny nose or sore throat.
More information about these studies is available at:
- Carolyn Bridges et al. (2000). Effectiveness and cost-benefit of influenza vaccination of healthy working adults: A randomized controlled trial .
- Kristin Nichol et al. (1995). The effectiveness of vaccination against influenza in healthy working adults. New England Journal of Medicine. 333(14): 889-893.
The flu shot can cause mild side effects that are sometimes mistaken for flu. For example, people sometimes experience a sore arm where the shot was given. The needle stick may also cause some soreness at the injection site. Rarely, people who get the flu shot have fever, muscle pain, and feelings of discomfort or weakness. If experienced at all, these effects usually last 1-2 days after vaccination and are much less severe than actual flu illness.
There are several reasons why someone might get flu-like symptoms even after they have been vaccinated against the flu.
- People may be exposed to an influenza virus shortly before getting vaccinated or during the two-week period that it takes the body to gain protection after getting vaccinated. This exposure may result in a person becoming ill with flu before the vaccine begins to protect them.
- People may become ill from other (non-flu) viruses that circulate during the flu season, which can also cause flu-like symptoms (such as rhinovirus).
- A person may be exposed to an influenza virus that is not included in the seasonal flu vaccine. There are many different influenza viruses that circulate every year. The flu shot protects against the 3 or 4 viruses (depending on whether the flu shot is a trivalent or quadrivalent vaccine) that research suggests will be most common.
- Unfortunately, some people can get infected with an influenza vaccine virus despite getting vaccinated. Protection provided by influenza vaccination can vary widely, based in part on health and age factors of the person getting vaccinated. In general, the flu vaccine works best among young healthy adults and older children. Some older people and people with certain chronic illnesses may develop less immunity after vaccination. However, even among people who tend to respond less well to vaccination, the flu vaccine can still help prevent influenza. Vaccination is particularly important for people at high risk of serious flu-related complications and for close contacts of high-risk people. For more information about the effectiveness of the flu vaccine, see How Well Does the Seasonal Flu Vaccine Work?
Lastly, the flu shot can cause mild side effects that are sometimes mistaken for flu. See ‘Why do some people not feel well after getting the flu shot?’ for more information.
People who have ever had a severe allergic reaction to eggs can get recombinant flu vaccine if they are 18 years and older or they should get the regular flu shot (IIV) given by a medical doctor with experience in management of severe allergic conditions. People who have had a mild reaction to egg—that is, one which only involved hives—may get a flu shot with additional safety measures. Recombinant flu vaccines also are an option for people if they are 18 years and older and they do not have any contraindications to that vaccine. Make sure your doctor or health care professional knows about any allergic reactions. Most, but not all, types of flu vaccine contain a small amount of egg.
- Page last reviewed: July 30, 2014
- Page last updated: May 25, 2016
- Content source:
- Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases (NCIRD)
- Page maintained by: Office of the Associate Director for Communication, Digital Media Branch, Division of Public Affairs