|
 |
National Immunization Program
| Title of Project |
Pneumococcal Vaccination Assessment in
Managed Care Settings |
| Category |
Research |
| Objectives and Description |
The objectives of this project are
to (1) develop mechanisms to identify target populations for Pneumococcal vaccination, (2)
assess Pneumococcal vaccination levels, and (3) determine the utility of various methods
of identifying target populations and assessing vaccination levels for a potential HEDIS
measure - in managed care settings. |
| Outcomes: |
|
| Contractor/Project Manager |
American Association of Health Plans
Barbara Lardy, MPH (202) 778-3229 |
| Subcontractor/Principal
Investigator |
Health Partners Research Foundation
James Norden, MD, MPH (612) 883-5087Group
Health Cooperative of Puget Sound
Lisa Jackson, MD, MPH (206) 442-5216
Kaiser Permanente North West
John Mullooly, PhD (503) 335-6768 |
| CDC Project Officer |
Deborah Rogers Mercy (770) 488-8200 |
| CDC Technical Monitor(s) |
Marķa C. Rangel MD, MPH (404) 639-8968 |
| Other CIOs/Agencies Involved |
|
| Annual Extramural Funding |
FY 1997: $300,000 FY 1998: $152,612 |
| Funding Mechanism |
Contract |
| Project Status |
Ongoing |
| Special Populations |
Chronically ill adults or adults >65
years of age |
| Published Abstracts/Articles |
Rangel, MC, Jackson LA, Mullooly JP, Norden J,
Strikas RA, Williams WW, Carste B, Bergsten C, Ahmed F: A Collaborative Effort to Develop
Methodologies to Assess Pneumococcal Vaccination Coverage in Managed Care Settings. Poster
Presentation at 1999 HMO Research Network Conference, Oahu, Hawaii, March 7,
1999.
Jackson LA, Carste BA, Mell LK, Rangel MC:
Pneumococcal Vaccination Assessment in a Managed Care Setting. Accepted for oral
presentation at the 23rd National Immunization Conference. Dallas, Texas, June
23, 1999. |
| Title of Project |
Enhancement of Adolescent Vaccination
Practices in Managed Care Settings |
| Category |
Research |
| Objectives and Description |
The objectives of this project are to (1)
characterize existing policies and administrative practices related to adolescent
vaccination and (2) describe current vaccination practices (e.g., promotion, assessment,
tracking, and record keeping) - in managed care settings. |
| Outcomes: |
|
| Contractor/ Project Manager: |
American Association of Health Plans
Barbara Lardy, MPH (202) 778-3229 |
| Subcontractor/Principal Investigator |
|
| CDC Project Officer |
Deborah Rogers Mercy (770) 488-8200 |
| CDC Technical Monitor(s) |
Marķa C. Rangel MD, MPH (404) 639-8968 |
| Other CIOs/Agencies Involved |
|
| Annual Extramural Funding |
FY 1995: $25,000 |
| Funding Mechanism |
Contract |
| Project Status |
Data analysis and manuscript preparation |
| Special Populations |
Adolescents |
| Published Abstracts/Articles |
Rangel MC, Williams WW, Bergsten C, Joffe A:
Adolescent Vaccination Practices in Managed Care Settings. Abstract presented APHA
1998 Annual Conference.
Rangel MC, Williams WW, Bergsten C, Joffe A:
Adolescent Vaccination Policies and Practices in Managed Care Settings. Abstract accepted NIC
Annual Conference, June 1999. Poster Presentation.Manuscript in preparation: Adolescent Vaccination
Policies and practices in Managed Care Settings |
| Title of Project |
Assessment of Adult Vaccination
Practices in Managed Care Settings |
| Category |
Research |
| Objectives and Description |
The objectives of this project are to
characterize existing policies and administrative practices related to adult vaccination
and use these findings to promote improved adult immunization practices - in managed care
settings. |
| Outcomes: |
|
| Contractors/Project Managers: |
American Association of Health Plans
Barbara Lardy, MPH (202) 778-3229 |
| Subcontractor/Principal
Investigator |
Group Health Cooperative-Puget Sound
Angela Salazar (206) 287-2947 |
| CDC Contract Officer: |
Deborah Rogers Mercy (770) 488-8200 |
| CDC Technical Monitor(s) |
Marķa C. Rangel MD, MPH (404) 639-8968 |
| Other CIOs/Agencies Involved |
|
| Annual Extramural Funding |
FY 1996: $48,859 |
| Funding Mechanism |
Contract |
| Project Status |
Data entry |
| Special Populations |
Adults |
| Published Abstracts/Articles |
Rangel MC, Williams WW, Strikas RA, Bergsten C:
Assessment of Adult Immunization Policies and Practices in Managed Care Settings, 1997.
Abstract accepted for oral presentation at 23rd National Immunization Conference,
Dallas Texas, June 1999 |
| Title of Project |
Rapid Influenza Vaccine Effectiveness
Assessment in Managed Care Settings |
| Category |
Research |
| Objectives and Description |
The objectives of this project are to (1)
estimate the effectiveness of the 1996-97 and 1997-98 influenza vaccine in preventing
hospitalization and death from influenza and pneumonia in persons >65 years of
age; (2) use those findings to document the positive impact of influenza vaccine and
promote continued influenza vaccination in high-risk populations; and (3) design a program
of annual vaccine effectiveness studies based on the above experiences - in managed care
settings. |
| Outcomes: |
For the entire 1996-97 influenza season in the
three sites studied, influenza vaccination prevented 22% of all pneumonia and influenza
hospitalizations and 57% of all deaths that would have occured in vaccinated persons, had
they not received influenza vaccine. |
| Contractor/Project Manager |
American Association of Health Plans
Barbara Lardy, MPH (202) 778-3229 |
| Subcontractor/Principal
Investigator |
Health Partners Research Foundation
James Norden, MD, MPH (612) 883-5087Kaiser
Permanente Northwest
John Mullooly, PhD (503) 335-2400
Oxford Health Plan
Sung Poblete and Deborah Wheeler |
| CDC Project Officer |
Deborah Rogers Mercy (770) 488-8200 |
| CDC Technical Monitor(s) |
Raymond A. Strikas, MD (404) 639-8257 |
| Other CIOs/Agencies Involved |
NCID |
| Annual Extramural Funding |
FY 1997: $140,000 FY 1998: $192,463 |
| Funding Mechanism |
Contract |
| Project Status |
Data analysis completed and final report
drafted for 1996-97. Data collection underway for 1997-98. |
| Special Populations |
Adults >65 years of age |
| Published Abstracts/Articles |
Pending |
| Title of Project |
Multi-Site Project to Characterize the
Current Policies and Practices and Assess Interventions for Enhancing the Screening of
Pregnant Women for Vaccine Preventable Diseases |
| Category |
Research |
| Objectives and Description |
The objectives of this project are to (1)
assess the current policies and practices at Group Health Cooperative and affiliated
hospitals related to the screening for and prevention of vaccine preventable diseases in
pregnant women, (2) implement and evaluate an intervention to improve those practices, and
(3) analyze and disseminate the results to a wider audience of hospital policy makers in
an effort to influence them to adopt prenatal screening strategies in their institutions. |
| Outcomes: |
|
| Contractor/Project Manager |
American Association of Health Plans
Barbara Lardy, MPH (202) 778-3229 |
| Subcontractor/Principal
Investigator |
Group Health Cooperative-Puget Sound
Lisa Jackson, MD, MPH (206) 442-5216 |
| CDC Project Officer |
Deborah Rogers Mercy (770) 488-8200 |
| CDC Technical Monitor(s) |
Maria C. Rangel, MD, MPH (404) 639-8969 |
| Other CIOs/Agencies Involved |
|
| Annual Extramural Funding |
FY 1997: $191,795 FY 1998: $190,536 |
| Funding Mechanism |
Contract |
| Project Status |
Ongoing |
| Special Populations |
Adult women |
| Published Abstracts/Articles |
Jackson LA, Carste B, Rebolledo V, Rangel M:
Assessment of Policies and Practices for Prenatal Screening of Women for Vaccine
Preventable Diseases. Poster Presentation at 1999 HMO Research Network Conference, Oahu,
Hawaii, March 7, 1999.
Carste B: Prenatal Screening for Vaccine Preventable Diseases. Oral presentation at 32nd
National Immunization Conference, Dallas, Texas, June 1999. |
| Title of Project |
Vaccine Safety Datalink Project |
| Category |
Research |
| Objectives and Description |
This project will provide comprehensive,
post-licensure, active surveillance for adverse medical events after vaccination in a
managed care population in excess of: 0.5 million children (0-6 years old), 1 million
adolescents, and 3.5 million adults. |
| Contractors/Principal
Investigators: |
Group Health Cooperative of Puget
Sound
Robert S. Thompson, MD (206) 287-2867Harbor UCLA Medical Center
Joel I. Ward, MD (310) 222-2346
Kaiser Foundation Research Institute
Steve Black, MD (510) 267-7534
Kaiser Permanente - Northwest
John P. Mullooly, PhD (503) 335-2400 |
| CDC Project Officer |
Frank DeStefano, MD (404) 639-8256 |
| CDC Technical Monitor(s) |
Frank DeStefano, MD (404) 639-8256 |
| Other CIOs/Agencies Involved |
FDA Center for Biologics Evaluation and
Research |
| Annual Extramural Funding |
FY 1996 and 1997:
$3,970,000 Kaiser Foundation Research Institute$2,308,000 Harbor UCLA Research & Education Inst.
$1,897,000 Group Health Cooperative of Puget
Sound
$1,001,000 Kaiser Permanente - Northwest
FY 1998:
$2,640,000 Kaiser Foundation Research Institute
$1,596,000 Harbor UCLA Research & Education
Inst.
$1,498,000 Group Health Cooperative of Puget
Sound
$1,283,000 Kaiser Permanente Northwest |
| Funding Mechanism |
Contract |
| Project Status |
Ongoing |
| Special Populations |
Children, adolescents, adults, the elderly |
| Published Abstracts/Articles |
For complete listing of publications
contact Frank DeStefano, MD. Recent publications include: 1) Chen RT, Glasser, Rhodes P, et al. The Vaccine Safety
Datalink Project: A New Tool for Improving Vaccine Safety Monitoring in the United States.
Pediatrics 1997;99:765-73.
2)Davis RL, Marcuse E, Black S, Lewis E, Chen R,
et al. MMMR2 at 4-5 Years and 10-11 Years of Age. A Comparison of Adverse Event Rates in
The Vaccine Safety Datalink (VSD) Project. Pediatrics 1997;100:767-771.
3) Black S, Shinefield H, Ray P, Lewis E, Chen
R, Glasser J, et al. Risk of Hospitalization because of Aseptic Meningitis after
Measles-Mumps Rubella Vaccination in One-to-Two Year-Old Children: An Analysis of the
Vaccine Safety Datalink (VSD) Project. Pediatric Infect Dis J 1997; 16:500-3 |
| Title of Project |
Safety and Immunogenicity of 2nd Dose
MMR |
| Category |
Research |
| Objectives and Description |
This project studies the safety and
immunogenicity of a second dose Measles-Mumps-Rubella vaccine administered to children at
4-6 years and 11-13 years. This study was initiated in late 1993; the primary phases have
been completed and the study has been extended to include two and five year
post-vaccination follow-up of participants. |
| Outcomes: |
|
| Contractor/Project Manager |
Marshfield Medical Research Foundation
Bradley Sullivan, PhD, MD (715) 389-3444 |
| Subcontractor/Principal Investigator |
|
| CDC Project Officer |
|
| CDC Technical Monitor(s) |
Charles LeBarron, MD (404) 639-8756 |
| Other CIOs/Agencies Involved |
None |
| Annual Extramural Funding |
FY 1998: 107,243 |
| Funding Mechanism |
Contract |
| Project Status |
Ongoing |
| Special Populations |
Children, adolescents |
| Published Abstracts/Articles |
ICAAC Abstract |
| Title of Project |
Comparison of Response to
Measles-Mumps-Rubella Vaccination in Children at Age 9, 12 and 15 Months |
| Category |
Research |
| Objectives and Description |
The objective of this project is to compare the
response to MMR vaccine given to children at 9, 12 or 15 months of age. It has been
demonstrated that: (1) younger mothers have lower levels of antibody to measles than older
mothers (born before 1962), due to vaccine induced as opposed to wild measles induced
immunity; (2) they pass lower levels of measles antibody to their infants; and (3) their
infants respond better to measles vaccination at a younger age. This study measures the
feasibility of reducing the primary age for MMR vaccination in a population in which a
high proportion of mothers were born after 1962. Currently, infants after being followed
for 2 years after vaccination to assess antibody persistence. |
| Outcomes: |
|
| Contractor/Project Manager |
Health Partners Research Foundation
James Norden, MD, MPH (612) 883-5087 |
| Subcontractor/Principal Investigator |
|
| CDC Project Officer |
|
| CDC Technical Monitor(s) |
Mark Papania, MD, M.P.H. (404) 639-8761 |
| Other CIOs/Agencies Involved |
None |
| Annual Extramural Funding |
FY 1992-1997: $813,046 FY 1998: $ 33,000 |
| Funding Mechanism |
Contract |
| Project Status |
Ongoing |
| Special Populations |
Children 9-18 months |
| Published Abstracts/Articles |
Two abstracts on primary response to measles
vaccination at 9,12 or 15 months presented at Interscience Conference on Antimicrobial
Agents and Chemotherapy (ICAAC, 1994 and 1995). Manuscript in clearance. |
| Title of Project |
Measles Revaccination |
| Category |
Research |
| Objectives and Description |
Approximately 2-5% of susceptible children fail
to respond to primary measles vaccination at age 15 months. This phenomenon, known as
primary vaccine failure, is not completely understood. Previously, this project measured
response to MMR vaccine in children at age 15 months, and provided revaccination for
children with primary vaccine failure to measles vaccine - with serologic testing before
and 4-6 weeks after revaccination. Long term follow-up (to age 5 years) to assess antibody
persistence in vaccinated children is now being funded in one of the two original study
sites. |
| Outcomes: |
|
| Contractor/Project Manager |
Marshfield Medical Research Foundation
Bradley Sullivan, PhD, MD (715 389-3444 |
| Subcontractor/Principal Investigator |
|
| CDC Project Officer |
|
| CDC Technical Monitor(s) |
Jessie Wing, MD (404) 639-8230 |
| Other CIOs/Agencies Involved |
None |
| Annual Extramural Funding |
FY 1990-97: $815,000 |
| Funding Mechanism |
Contract |
| Project Status |
Ongoing |
| Special Populations |
Children 15-18 months |
| Published Abstracts/Articles |
Two abstracts on primary response to measles
vaccination and response to MMR vaccine in mildly ill children presented at Interscience
Conference on Antimicrobial Agents and Chemotherapy (ICAAC, 1993 and 1994). |
| Title of Project |
Health Impact of Pertussis Among Adults |
| Category |
Research |
| Objectives and Description |
This study will characterize the health impact
of pertussis among adults with cough illness lasting more than 7 days. |
| Outcomes: |
|
| Contractor/Project Manager |
Group Health, Minneapolis, MN |
| Subcontractor/Principal Investigator |
|
| CDC Project Officer |
|
| CDC Technical Monitor(s) |
Peter Strebel, MBChB, MPH (404) 639-8252 |
| Other CIOs/Agencies Involved |
None |
| Annual Extramural Funding |
FY 1994: $520,078 |
| Funding Mechanism |
Contract |
| Project Status |
Data analysis and write-up |
| Special Populations |
Adults |
| Published Abstracts/Articles |
Estimated Incidence of Pertussis Among Persons
Aged 10-49 Years, Minnesota, 1995-1996. ICAAC 1997 Abstract K-165. |
| Title of Project |
The Effectiveness and
Cost-Effectiveness of Provider-Based Immunization Assessments in Managed Care Settings |
| Category |
Quality Assurance |
| Objectives and Description |
Immunization assessment is the process of
reviewing vaccination records at individual practices, measuring coverage, identifying
deficient practices, and offering feedback to the provider. This methodology has proved to
be an effective management tool and has contributed to improvements in vaccination
coverage in a variety of public and private provider settings. Its effectiveness and
cost-effectiveness in a managed care environment is less well established. For this
project, we are field testing immunization assessment methodology at several MCO practice
sites to evaluate its feasibility, effectiveness and cost-effectiveness in improving
immunization rates. Data collected for immunization assessment will be compared with
immunization data collected for the Health Plan Employer Data and Information Set (HEDIS),
as well as with administrative (i.e., billing or encounter-form) immunization data. We
will also look at the impact of increased provider awareness of charting tracking, and
missed immunization opportunities, as a result of immunization assessment, on other
childhood prevention services. |
| Outcomes: |
|
| Contractor/Project Manager |
American Association of Health Plans
Barbara Lardy, MPH (202) 778-3229 |
| Subcontractor/Principal
Investigator |
Prudential Center for Health Care Research
Carol McPhillips-Tangum, MPH (770) 801-7880 |
| CDC Project Officer |
Deborah Rogers Mercy (770) 488-8200 |
| CDC Technical Monitor(s) |
Rafael Harpaz, MD, MS (404) 639-8224 |
| Other CIOs/Agencies Involved |
OHCP |
| Annual Extramural Funding |
FY 1995: $200,000 FY 1998: $ 96,631
FY 1999: $1,102,000 |
| Funding Mechanism |
Contract |
| Project Status |
Ongoing |
| Special Populations |
Children |
| Published Abstracts/Articles |
|
| Title of Project |
Surveillance of Rash Illnesses at a
Large Managed Care Organization (MCO) |
| Category |
Research |
| Objectives and Description |
This project will determine: (1) the rate of
febrile rash in a population(i.e., an "AFP analogue"), (2) the usual diagnostic
practices for rash illness in managed care setting, (3) the completeness of reporting of
rash illnesses by providers in a large MCO, (4) whether administrative data can be used to
accurately assess the rate of febrile rash at MCOs with conventional administrative data
capabilities, and (5) whether and how administrative data can be used for surveillance of
measles and rubella. |
| Outcomes: |
|
| Contractor/Project Manager |
Alliance of Community Health Plans
Michelle Tropper, MPH (732) 220-1388, Ext. 17 |
| Subcontractor/Principal
Investigator |
HealthPartners
James Norden, MD (612) 883-5087 |
| CDC Project Officer |
Deborah Rogers Mercy (770) 488-8200 |
| CDC Technical Monitor(s) |
Rafael Harpaz, MD, MS (404) 639-8230 |
| Other CIOs/Agencies Involved |
|
| Annual Extramural Funding |
FY 1998: $70,000 |
| Funding Mechanism |
Contract |
| Project Status |
Ongoing |
| Special Populations |
None |
| Published Abstracts/Articles |
|
| Title of Project |
Immunization Registry Targeted Research
Projects: Private Provider Recruitment |
| Category |
Information Systems, Capacity Building |
| Objectives and Description |
In this project, we will attempt to determine
how to most effectively secure and maintain the active participation of private providers
in an immunization registry. |
| Outcomes |
The results document factors related to
successful provider recruitment and retention as well as barriers to provider
participation. |
| External Institution/Principal
Investigator |
Group Health Cooperative of Puget Sound
Robert L. Davis, MD, MPH (206) 287-2943 |
| CDC Project Officer |
Jeanne Santoli, MD (404) 639-8807 |
| Other CIOs/Agencies Involved |
|
| Annual Extramural Funding |
FY 1998: $149,632 |
| Funding Mechanism |
Cooperative Agreement |
| Project Status |
Ongoing |
| Special Populations |
Preschool Children |
| Published Abstracts/Articles |
Klebanoff-Hills, Betsy, Group Health
Cooperative of Puget Sound: Evaluation of Private Provider Participation in an
Immunization Registry, CDC Research Grant Concurrent Session Presentation, April 7, 1998,
published in Summary Proceedings, ALL Kids Count Immunization Registry Conference, April
7-8, 1998. p.22. |
| Title of Project |
Immunization Registry Targeted Research
Projects: Cost-Effectiveness |
| Category |
Information Systems and Cost-Effectiveness |
| Objectives and Description |
This project will yield a cost/benefit model
for the development and maintenance of community-based registries in managed care
settings. Both direct and indirect costs will be considered, and a common breakdown
structure adopted to assure consistent data collection across organizations. Data will be
used to model unit costs per child, as well as to identify areas where additional research
is needed. |
| Outcomes |
|
| External Institution/Principal
Investigator |
University of California, San Diego
John Fontanesi, PhD |
| CDC Project Officer |
Lance Rodewald (404) 639-8208 Robert Deuson (404) 639-8674 |
| Other CIOs/Agencies Involved |
|
| Annual Extramural Funding |
FY 1998: $137,213 |
| Funding Mechanism |
Cooperative Agreement |
| Project Status |
Ongoing |
| Special Populations |
Preschool children |
| Published Abstracts/Articles |
|
| Title of Project |
Using HEDIS Criteria to Estimate
Population-Based Preschool Immunization Coverage |
| Category |
Research |
| Objectives and Description |
This project will evaluate the effects of using
HEDIS immunization criteria to estimate population-based preschool immunization coverage.
Existing National Immunization Survey (NIS) data will be analyzed using HEDIS/3.0 criteria
for preschool children. The results should: (1) provide a population-based benchmark for
Medicaid managed care plans, (2) encourage careful comparison of the similarities and
differences between NIS and HEDIS derived data, and (3) stimulate further dialogue on how
NIS and HEDIS immunization measures could be better harmonized in future iterations. |
| Outcomes |
|
| External Institution/Principal Investigator |
National Committee for Quality Assurance |
| CDC Project Officer/Principal Investigator(s): |
Edmond Maes (404) 639-8217 Lance Rodewald (404) 639-8208 |
| Other CIOs/Agencies Involved |
HCFA, EPO |
| Annual Extramural Funding |
|
| Funding Mechanism |
|
| Project Status |
Ongoing |
| Special Populations |
Preschool children |
| Published Abstracts/Articles |
|
|
