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Case Definitions

Patient Under Investigation (PUI)

A patient under investigation (PUI) is a person with the following characteristics:

  • fever (≥38°C, 100.4°F) and pneumonia or acute respiratory distress syndrome (based on clinical or radiological evidence);

AND EITHER

  • history of travel from countries in or near the Arabian Peninsula1 within 14 days before symptom onset;

OR

  • close contact2 with a symptomatic traveler who developed fever and acute respiratory illness (not necessarily pneumonia) within 14 days after traveling from countries in or near the Arabian Peninsula;1

OR

  • is a member of a cluster of patients with severe acute respiratory illness (e.g. fever and pneumonia requiring hospitalization) of unknown etiology in which MERS-CoV is being evaluated, in consultation with state and local health departments.

Confirmed Case

A confirmed case is a person with laboratory confirmation3 of MERS-CoV infection.

Probable Case

A probable case is a PUI with absent or inconclusive4 laboratory results for MERS-CoV infection who is a close contact2 of a laboratory-confirmed MERS-CoV case.

Footnotes


  1. Countries considered in or near the Arabian Peninsula: Bahrain, Iraq, Iran, Israel, Jordan, Kuwait, Lebanon, Oman, Palestinian territories, Qatar, Saudi Arabia, Syria, the United Arab Emirates (UAE), and Yemen.
  2. Close contact is defined as a) any person who provided care for the patient, including a healthcare worker or family member, or had similarly close physical contact; or b) any person who stayed at the same place (e.g. lived with, visited) as the patient while the patient was ill.
  3. Confirmatory laboratory testing requires a positive PCR on at least two specific genomic targets or a single positive target with sequencing on a second.
  4. Examples of laboratory results that may be considered inconclusive include a positive test on a single PCR target, a positive test with an assay that has limited performance data available, or a negative test on an inadequate specimen.
 
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Learn more about MERS and the virus that causes it
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