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Congenital CMV Infection Trends and Statistics

CMV Infection during Pregnancy

  • Between 30% and 50% of women of childbearing age in the United States have never been infected with CMV.
  • In the United States, about 1%-4% of (1-4 of every 100) uninfected women have a primary (or first) CMV infection during a pregnancy
  • About 33% of (33 of every 100) women who become infected with CMV for the first time during pregnancy pass the virus to their fetuses.


Congenital CMV Infection

  • CMV is the most common viral infection that infants are born with in the United States.
  • About 1 in 150 children is born with congenital (present at birth) CMV infection. This means that in the United States, about 30,000 children are born with congenital CMV infection each year.
  • About 80% of (80 of every 100) babies born with congenital CMV infection never have symptoms or problems.

About 1 in 750 children in the United States is born with or develops permanent problems due to congenital CMV infection. In the United States, more than 5,000 children each year suffer permanent problems caused by CMV infection.

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How Many Babies Are Affected by Congenital CMV Infection?

For every 1000 pregnancies that result in a live birth, about 1 to 2 babies will have permanent CMV-related problems.

Number of babies affected by congenital CMV
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As shown in the chart above, for every 1,000 women whose pregnancies result in a live birth, about 400 will not have had a CMV infection before becoming pregnant. Of these 400 women, about 7 will become infected during pregnancy. Of these 7 infected women, about 2 will have babies with CMV infection. Of the 600 women who had CMV infection before pregnancy, about 2 will have babies with CMV infection. Overall, out of 1,000 live births, about 8 infants (less than 1%) will have congenital CMV infection, of which 1-2 (0.1%) will have permanent problems.

Chart from Cannon MJ. Congenital cytomegalovirus (CMV) epidemiology and awareness. J Clin Virol. 2009;46 [Suppl 4]:S6-10.

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