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Archival Content: 2012

HIV Prevention in the United States

Since the beginning of the epidemic, CDC has been at the forefront of efforts to prevent the spread of HIV by providing national leadership and support for surveillance, prevention research and programs, and the development, implementation, and evaluation of evidence-based interventions serving populations affected by or at risk for HIV infection.

CDC’s HIV prevention activities in the United States include:

  • Prevention Programs: Providing grants, technical assistance, and prevention policy guidance for health departments and community-based organizations that are working to prevent new HIV infections across the United States
  • HIV Surveillance: Coordinating comprehensive national surveillance systems to track the HIV epidemic, risk behaviors, and utilization of health care and prevention services
  • Prevention Research: Supporting biomedical, behavioral, and operational research to develop new HIV prevention strategies and improve existing programs
  • Awareness Raising: Developing communications campaigns and partnerships to ensure that all people know the facts about HIV, find out if they are infected, and understand how to protect themselves

High-Impact Prevention

To maximize its effectiveness, CDC is pursuing an approach it refers to as High-Impact Prevention. By using combinations of scientifically proven, cost-effective, and scalable interventions targeted to the right populations in the right geographic areas, this approach promises to greatly increase the impact of HIV prevention efforts. Five primary considerations drive High-Impact Prevention:

  • Effectiveness and cost: High-Impact Prevention prioritizes proven interventions that are most cost-effective at reducing overall HIV infections.
  • Feasibility of full-scale implementation: Priority is placed on proven interventions that are practical to implement on a large scale, at reasonable cost.
  • Coverage in the target populations: Selection of proven interventions is based in part on how many people can be reached once the intervention is fully implemented.
  • Interaction and targeting: Attention is given to how different proven interventions interact, and how they most effectively can be combined to reach the most-affected populations in a given area.
  • Prioritization: Identify proven interventions that will have the greatest overall potential to reduce infections.

CDC’s High-Impact Prevention approach guides the broad allocation of prevention resources as well as the development of specific prevention strategies for all populations at risk, including gay and bisexual men, communities of color, women, injection drug users, transgender women and men, youth and others.

Working Together

CDC supports and promotes a syndemic approach to prevention by promoting better collaboration between programs and supporting program collaboration and service integration. CDC looks broadly across its programs, and works with our partners, to discover new and innovative ways to collaborate and use resources wisely and efficiently, taking advantage of multiple disciplines and shared knowledge and promoting holistic approaches to health protection.

Statistics for the United States

Additional Information


CDC’s source for information on HIV/AIDS prevention in the United States

Act Against AIDS

A five-year national campaign to combat complacency about HIV/AIDS

Find a test site near you


An interactive tool for accessing CDC data on HIV/AIDS and STDs

CDC National Prevention Information Network

Reference and referral services for information on HIV/AIDS, hepatitis, STDs, and TB in the U.S.

Pre-Exposure Prophylaxis (PrEP)

CDC’s source for information on pre-exposure prophylaxis

CDC Vital Signs™ – Learn about the latest public health data. Read CDC Vital Signs™…CDC Vital Signs

A monthly call to action from CDC on important public health topics, including HIV testing

High-Impact Prevention

CDC's approach to reducing HIV infections in the United States

This CDC Web site is no longer being reviewed or updated and thus is no longer kept current. This site remains to assist researchers or others needing historical content.

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