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ABCs Report: Streptococcus pneumoniae, 2012

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Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network

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Surveillance Note

Missing race (n=327) data were multiply imputed using sequential regression imputation methods.

ABCs Areas

California (San Francisco County and children < 5 years in Alameda and Contra Costa counties); Colorado (5 county Denver area); Connecticut; Georgia (20 county Atlanta area); Maryland (6 county Baltimore area); Minnesota; New Mexico; New York (15 county Rochester and Albany areas and children <5 years in Erie county); Oregon (3 county Portland area); Tennessee (20 counties)

ABCs Population

The surveillance areas represent 30,356,544 persons.

Source: National Center for Health Statistics bridged‑race vintage 2012 postcensal file

ABCs Case Definition

Invasive pneumococcal disease: isolation of Streptococcus pneumoniae from normally sterile site in resident of a surveillance area in 2012.

ABCs Methodology

ABCs personnel routinely contacted all microbiology laboratories serving acute care hospitals in their area to identify cases. Standardized case report forms that include information on demographic characteristics, clinical syndrome, and outcome of illness were completed for each identified case. Pneumococcal isolates were collected and sent to reference laboratories for susceptibility testing using CLSI methods and serotyping. Regular laboratory audits assessed completeness of active surveillance and detected additional cases.

Rates of invasive pneumococcal disease were calculated using population estimates for 2012. For national estimates, race‑ and age‑specific rates of disease were applied from the aggregate surveillance area to the age and racial distribution of the 2012 U.S. population. Cases with missing data, excluding ethnicity, were multiply imputed using the sequential regression imputation method.

Reported ABCs Profiles


* Cases per 100,000 population for ABCs areas

Age (years)Cases
No. (Rate*)
No. (Rate*)
< 165 (15.7)1 (0.24)
157 (13.6)1 (0.24)
2‑475 (5.9)0 (0.00)
5‑1795 (1.9)7 (0.14)
18-34201 (2.8)7 (0.10)
35-49468 (7.5)37 (0.60)
50‑64942 (15.9)91 (1.53)
≥ 651,136 (29.6)163 (4.24)
Total3,039 (10.0)307 (1.01)

* Cases or deaths per 100,000 population for ABCs areas

Bacteremia without focus511(16.8)
Pneumonia with bacteremia2,101(69.1)

* Percent of cases


Based on reference lab testing of 2,753 isolates
* Susceptible; Intermediate; Resistant based on year 2012 CLSI definitions

National Estimates of Invasive Disease

Cases: 31,600 (10.1/100,000)
Deaths: 3,300 (1.1/100,000)

Healthy People 2020 Update

Objective: Decrease the incidence of invasive pneumococcal infections to 12 per 100,000 persons less than 5 years of age and to 31 per 100,000 persons aged 65 and older.

Age (year)2020 Objective2012 Rate*
< 512/100,0009/100,000
≥ 6531/100,00030/100,000

* Cases per 100,000 U.S. population < 5 years or ≥ 65 years


Centers for Disease Control and Prevention. 2013. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Streptococcus pneumoniae, 2012.


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