ABCs Report: Streptococcus pneumoniae, 2008
Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network
California (San Francisco County and children < 5 years in Alameda and Contra Costa counties); Colorado (5 county Denver area); Connecticut; Georgia (20 county Atlanta area); Maryland (6 county Baltimore area); Minnesota; New Mexico; New York (15 county Rochester and Albany areas and children <5 years in Erie county); Oregon (3 county Portland area); Tennessee (11 urban counties)
The surveillance areas represent 28,856,774 persons.
Source: National Center for Health Statistics bridged-race vintage 2008 postcensal file
ABCs Case Definition
Invasive pneumococcal disease: isolation of Streptococcus pneumoniae from normally sterile site in resident of a surveillance area in 2008.
ABCs personnel routinely contacted all microbiology laboratories serving acute care hospitals in their area to identify cases. Standardized case report forms that include information on demographic characteristics, clinical syndrome, and outcome of illness were completed for each identified case. Pneumococcal isolates were collected and sent to reference laboratories for susceptibility testing using NCCLS methods and serotyping. Regular laboratory audits assessed completeness of active surveillance and detected additional cases.
Rates of invasive pneumococcal disease were calculated using population estimates for 2008. For national estimates, race- and age-specific rates of disease were applied from the aggregate surveillance area to the age and racial distribution of the 2008 U.S. population. Cases with unknown race were distributed by area based on reported race distribution for known cases within the eight age categories.
Reported ABCs Profiles
Unknown race (n=700) distributed amongst known
* Cases per 100,000 population for ABCs areas
|<1||164 (36.7)||4 (0.90)|
|1||139 (31.3)||0 (0.00)|
|2-4||154 (11.8)||2 (0.15)|
|5-17||137 (2.8)||2 (0.04)|
|18-34||284 (4.3)||7 (0.11)|
|35-49||849 (13.0)||70 (1.07)|
|50-64||1,121 (21.0)||118 (2.21)|
|≥ 65||1,338 (40.4)||210 (6.35)|
|Total||4,186 (14.5)||413 (1.43)|
*Cases per 100,000 population for ABCs areas
|Bacteremia without focus||788||(18.8)|
|Pneumonia with bacteremia||2,925||(69.9)|
*Percent of cases
Based on reference lab testing of 3,631 isolates
* Susceptible; † Intermediate; ‡ Resistant based on year 2008 CLSI definitions
National Estimates of Invasive Disease
Cases: 44,000 (14.5/100,000)
Deaths: 4,500 (1.5/100,000)
Healthy People 2010 Update
Objective: Decrease the incidence of invasive pneumococcal infections to 46 per 100,000 persons less than 5 years of age and to 42 per 100,000 persons aged 65 and older.
|Age (year)||2010 Objective||2008 Rate*|
*Cases per 100,000 U.S. population < 5 years or ≥ 65 years
Centers for Disease Control and Prevention. 2009. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Streptococcus pneumoniae, 2008.
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