ABCs Report: Methicillin-Resistant Staphylococcus aureus, 2005 (Update)†
Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network
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California (3 county San Francisco Bay area); Colorado (5 county Denver area); Connecticut; Georgia (8 county Atlanta area); Maryland (1 Baltimore area county); Minnesota (1 metro Twin City county); New York (1 Rochester county); Oregon (3 county Portland area); Tennessee (1 Nashville county).
The surveillance areas represent 16,489,254 persons.
Source: National Center for Health Statistics bridged-race vintage 2005 postcensal file.
ABCs Case Definition
Invasive methicillin-resistant Staphylococcus aureus (MRSA) disease: isolation of MRSA from a normally sterile site in a resident of the surveillance area in 2005. Cases of disease are classified into one of three epidemiologic classifications. A case is classified as hospital-onset (HO) if the MRSA culture was obtained on or after the fourth calendar day of hospitalization, where admission is hospital day 1; as healthcare-associated community-onset (HACO) if the culture was obtained in an outpatient setting or before the fourth calendar day of hospitalization, and had one or more of the following: 1) a history of hospitalization, surgery, dialysis, or residence in a long term care facility in the previous year, or 2) the presence of a central vascular catheter; and as community-associated (CA) if none of the previously mentioned criteria are met.
ABCs personnel routinely contacted all microbiology laboratories serving acute care hospitals in their area to identify cases. Standardized case report forms that include information on demographic characteristics, clinical syndrome, and outcome of illness were completed for each identified case. Convenience samples of isolates were collected and sent to CDC for routine testing, including: antimicrobial susceptibility testing, toxin testing and SCCmec typing. Regular laboratory audits were performed to ensure completeness of case ascertainment.
Rates of invasive MRSA disease among all patients were calculated using population estimates for 2005. Cases with unknown race were assigned race based on distribution of known race and gender by EIP site. Methodology to make national estimates was modified in January 2012 to adjust for receipt of dialysis, as well as age, race, and gender. Previously reported national estimates were adjusted for age and race only. Confidence intervals for nationally estimated incidence rates of disease and mortality were calculated based on the gamma distribution (Stat Med, 1997 16:791-801).
ABC Racial/Ethnic Profiles
Unknown race (n=691) distributed amongst known
aCases per 100,000 population for ABCs areas (crude rates).
|PFGE Type (%)||% PVL Pos.||Clinda-Ra||T/S-Rb||Levo-Rc|
a% Clindamycin resistant
b% Trimethoprim-sulfamethoxazole resistant
c% Levofloxicin resistant
|MRSA Class||No. (Rate)
|PFGE Type (N,%)d
|PFGE Type (N,%)d
|PFGE Type (N,%)d
|PFGE Type (N,%)d
|CA||966 (5.9)||105 (0.6)||222||56 (23.2)||145 (65.3)||12 (5.4)|
|HCAa||5,064 (30.7)||977 (5.9)||1,248||844 (67.6)||232 (18.9)||83 (6.7)|
|HCA-HO||1,601 (9.7)||418 (2.5)||417||309 (74.1)||69 (13.4)||25 (6.0)|
|HCA-HACO||3,463 (21.0)||559 (3.4)||831||535 (64.4)||176 (21.2)||58 (7.0)|
aHCA: Healthcare-associated invasive MRSA infections; sum of patients that are classified as either HO or HACO.
bn=104; epidemiologic category unknown.
cn=16; epidemiologic category unknown.
disolates were eligible for testing at CDC
|Bloodstream Infection with other syndrome||585||1,676||547|
|Bloodstream Infection with no other syndrome||207||1,427||831|
|Wounds - Surgicalb||4||167||52|
|Wounds - Decubitus/Pressure Ulcers||17||87||36|
aSome case patients had more than one syndrome.
bCombines deep tissue/organ infection and infection of a surgical wound, post operatively.
cCategory includes skin abscess, necrotizing fasciitis, gangrene, non-traumatic wounds.
|Epidemiologic Class||Estimated No.||Incidence Rate
aNational Estimates and Incidence (no. per 100,000 population per year) are adjusted for age, race, gender, and receipt of dialysis treatment using 2005 US Census Data.
b104 cases could not be classified into an epidemiological category or category is unknown and therefore are counted in the overall estimate only.
|Epidemiologic Class||Estimated No.||Mortality Rate
aNational Estimates and Mortality Rate (no. per 100,000 population per year) are adjusted for age, race, gender and receipt of dialysis treatment in the using 2005 US Census Data.
b16 cases epidemiological category or category is unknown and therefore are counted in the overall estimate only.
Surveillance data from 2005 represent the first full year of performing population-based surveillance for invasive MRSA infections through the Emerging Infections Program/Active Bacterial Core Surveillance Activity. In January 2012, tables/figures were added to (1) display age-specific incidence rates by epidemiologic category; and (2) to report national estimates and incidence rates of disease and mortality by epidemiological class. Previous published estimates of 2005 data differ from those in this updated report. Current estimates use slightly different definitions for HACO status(previous documented MRSA colonization or infection is not a determinant in classifying patients) and estimates include initial and subsequent infections in the same patient. Also, HO cases are now defined based on reported calendar dates which also differs from previously published estimates (JAMA, 2007 Oct 17: 298 (15): 1765-71).
Centers for Disease Control and Prevention. 2005. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Methicillin-Resistant Staphylococcus aureus, 2005.
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