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ABCs Report: Neisseria meningitidis, 1999

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Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network

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ABCs Areas

California (3 county San Francisco Bay area); Connecticut; Georgia; Maryland; Minnesota; New York (15 county Rochester/Albany area); Oregon; Tennessee (5 urban counties)

ABCs Population

The surveillance areas represent 31,711,122 persons. Source: U.S. Bureau of the Census, 1999

ABCs Case Definition

Invasive meningococcal disease: isolation of Neisseria meningitidis from normally sterile site in a resident of a surveillance area in 1999.

ABCs Methodology

Project personnel communicated at least monthly with contacts in all microbiology laboratories serving acute care hospitals in their area to identify cases. Standardized case report forms that include information on demographic characteristics, clinical syndrome, and outcome of illness were completed for each identified case. Molecular subtyping was done on meningococcal isolates at CDC. Regular laboratory audits assess completeness of active surveillance and detect additional cases.

All rates of invasive meningococcal disease were calculated using U.S. Bureau of the Census postcensal population estimates for 1999.

For national projections of cases, race- and age-specific rates of disease were applied from the aggregate surveillance area to the age and racial distribution of the 1999 U.S. population.

Cases with unknown race were distributed by area based on reported race distribution for known cases within the eight age categories.

Reported ABCs Profiles

RaceNo.(Rate*)
White247(1.0)
Black85(1.6)
Other15(0.9)
Total347(1.1)

Unknown race (n=40) distributed amongst knowns

* Cases per 100,000 population for ABCs areas

SyndromeCases
No. (%*)
Deaths
No. (Rate)
Meningitis162 (46.7)17 (10.5)
Bacteremia without focus139 (40.1)18 (12.9)

*Percent of cases.

Deaths per 100 cases with known outcome

Serogroups
Age (years)
Serogroups
B
No. (Rate*)
Serogroups
C
No. (Rate*)
Serogroups
Y
No. (Rate*)
Serogroups
Other
No. (Rate*)
<126 (6.0)8 (1.8)16 (3.7)4 (0.9)
14 (0.9)2 (0.5)2 (0.5)1 (0.2)
2-415 (1.2)12 (0.9)3 (0.2)4 (0.3)
5-1715 (0.3)28 (0.5)18 (0.3)3 (0.1)
18-3423 (0.3)26 (0.3)17 (0.2)7 (0.1)
35-4911 (0.1)6 (0.1)14 (0.2)7 (0.1)
50-646 (0.1)2 (0.04)11 (0.2)6 (0.1)
≥ 658 (0.2)7 (0.2)25 (0.7)10 (0.3)
Total108 (0.3)91 (0.3)106 (0.3)42 (0.1)

*Cases per 100,000 population for ABCs areas

Serogroup B Isolates
Serosubtypes
Serogroup B Isolates
No. (%)
Serogroup B Isolates
Serotypes: Serosubtype
Serogroup B Isolates
No. (%)
P1.7,1612 (24)15:P1.7,1611 (22)
P1.22a,149 (18)NT:P1.22a,146 (12)
P1.44 (8)2A:P1.5,23 (6)
P1.5,24 (8)4,7:P1.43 (6)
P1.63 (6)14:NT2 (4)
P1.7,13 (6)4,7:P1.7,12 (4)

*Oregon isolates not included due to continuing increase of P1.7,16

National Projection for Invasive Disease

Cases: 2,957 (1.1/100,000)
Deaths: 316 (0.1/100,000)

Healthy People 2010 Update

Objective: Reduce the incidence of invasive meningococcal disease to 0.9 per 100,000 population.

2010 Objective1999 Rate*
0.9/100,0001.1

*Cases per 100,000 U.S. population

Source:

ABCs/National Electronic Telecommunications System for Surveillance (NETSS)

Citation

Centers for Disease Control and Prevention. 2000. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Neisseria meningitidis, 1999.

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