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ABCs Report: Haemophilus influenzae, 2010

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Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network

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Surveillance Note

At the start of this surveillance year (2010), missing race (n=69) and deaths (n=3) data were multiply imputed using sequential regression imputation methods. Previously, missing race data were distributed in the same proportion as known cases. For comparison, view the 2010 surveillance report based on the previous method.

ABCs Areas

California (3 county San Francisco Bay area); Colorado (5 county Denver area); Connecticut; Georgia; Maryland; Minnesota; New Mexico; New York (15 county Rochester and Albany areas); Oregon; Tennessee (20 urban counties)

ABCs Population

The surveillance areas represent 41,981,509 persons. Source: National Center for Health Statistics bridged-race vintage 2010 postcensal file

ABCs Case Definition

Invasive Haemophilus influenzae (Hi) disease: isolation of Hi from normally sterile site in a resident of a surveillance area in 2010.

ABCs Methodology

ABCs personnel routinely contacted all microbiology laboratories serving acute care hospitals in their area to identify cases. Standardized case report forms that include information on demographic characteristics, clinical syndrome, and outcome of illness were completed for each identified case. Serotyping was done on Hi isolates at CDC and state laboratories. Regular laboratory audits assessed completeness of active surveillance and detected additional cases.

All rates of invasive Hi disease were calculated using population estimates for 2010. For national estimates, race- and age-specific rates of disease were applied from the aggregate surveillance areas to the race- and age-specific distribution of the 2010 U.S. population. Cases with missing data, excluding ethnicity, were multiply imputed using the sequential regression imputation method.

Reported ABCs Profiles


*Cases per 100,000 population for ABCs areas

No. (%*)
No. (%)
Meningitis46 (6.8)5 (10.9)
Bacteremia without focus193 (28.4)25 (13.0)

*Percent of cases
Deaths per 100 cases

Age (years)B
No. (Rate*)
No. (Rate*)
No. (Rate*)
No. (Rate*)
<12 (0.38)13 (2.45)25 (4.70)8 (1.50)
11 (0.19)5 (0.93)2 (0.37)2 (0.37)
2-42 (0.12)7 (0.42)10 (0.60)3 (0.18)
5-172 (0.03)4 (0.05)24 (0.33)1 (0.01)
18-341 (0.01)6 (0.06)34 (0.35)5 (0.05)
35-490 (0.00)24 (0.27)30 (0.34)9 (0.10)
50-644 (0.05)52 (0.64)63 (0.78)14 (0.17)
≥ 654 (0.08)60 (1.16)215 (4.17)48 (0.93)
Total16 (0.04)171 (0.41)403 (0.96)90 (0.21)

*Cases per 100,000 population for ABCs areas
Non-typeable isolates

National Estimates of Invasive Disease

Cases: 5,080 (1.65/100,000)
Deaths: 840 (0.27/100,000)

Healthy People 2020 Update

Invasive Haemophilus influenzae type B disease

Objective: Decrease the incidence of invasive Haemophilus influenzae type B disease to 0.27 cases per 100,000 persons less than 5 years of age.

Age2020 Objective2010 Rate*

* Cases per 100,000 U.S. population < 5 years


Centers for Disease Control and Prevention. 2012. Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Haemophilus influenza 2010.


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