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ABCs Report: Haemophilus influenzae, 2004

Active Bacterial Core Surveillance (ABCs): Emerging Infections Program Network

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ABCs Areas

California (3 county San Francisco Bay area); Colorado (5 county Denver area); Connecticut; Georgia (20 county Atlanta area); Maryland; Minnesota; New Mexico; New York (15 county Rochester and Albany areas); Oregon; Tennessee (11 urban counties)

ABCs Population

The surveillance areas represent 34,745,429 persons. Source: National Center for Health Statistics bridged-race vintage 2004 postcensal file

ABCs Case Definition

Invasive Haemophilus influenzae (Hi) disease: isolation of Haemophilus influenzae from normally sterile site in a resident of a surveillance area in 2004.

ABCs Methodology

ABCs personnel routinely contacted all microbiology laboratories serving acute care hospitals in their area to identify cases. Standardized case report forms that include information on demographic characteristics, clinical syndrome, and outcome of illness were completed for each identified case. Serotyping was done on Hi isolates at CDC and state laboratories. Regular laboratory audits assessed completeness of active surveillance and detected additional cases.

All rates of invasive Hi disease were calculated using population estimates for 2004. For national projections, race- and age-specific rates of disease were applied from the aggregate surveillance areas to the race- and age-specific distribution of the 2004 U.S. population. Cases with unknown race were distributed by area based on reported race distribution for known cases within the eight age categories.

Reported ABCs Profiles

Race No. (Rate*)
White 350 (1.3)
Black 86 (1.6)
Other 48 (2.0)
Total 484 (1.4)

Unknown race (n=65) distributed amongst known

Syndrome Cases
No. (%*)
Deaths
No. (%)
Meningitis 36 (7.4) 2 (5.6)
Bacteremia without focus 148 (30.6) 30 (21.4)

* Cases per 100,000 population for ABCs areas

*Percent of cases

Deaths per 100 cases with known outcome

Age (years) B
No. (Rate*)
Serotype
Non-B
No. (Rate*)
Serotype
Non-Type
No. (Rate*)
Unknown
No. (Rate*)
<1

3 (0.63)

8 (1.7) 27 (5.6) 4 (0.83)
1

0 (0.0)

5 (1.1) 3 (0.63) 0 (0.0)
2-4 1 (0.07) 7 (0.50) 5 (0.36) 0 (0.0)
5-17 3 (0.05) 6 (0.10) 18 (0.29) 0 (0.0)
18-34 0 (0.0) 6 (0.07) 18 (0.22) 7 (0.09)
35-49 3 (0.04) 11 (0.13) 36 (0.44) 6 (0.07)
50-64 1 (0.02) 28 (0.48) 45 (0.77) 12 (0.20)
≥ 65 4 (0.10) 48 (1.2) 151 (3.8) 18 (0.46)
Total 15 (0.04) 119 (0.34) 303 (0.87) 47 (0.14)

*Cases per 100,000 population for ABCs areas

Non-typeable isolates

National Estimates of Invasive Disease

Cases: 4,150 (1.4/100,000)
Deaths: 725 (0.25/100,000)

Healthy People 2010 Update

Invasive Haemophilus influenzae type B disease

Objective: Decrease the incidence of invasive Haemophilus influenzae type B disease to zero cases per 100,000 persons less than 5 years of age.

Age 2010 Objective 2004 Rate*
<5 0/100,000 0.15/100,000

* Cases per 100,000 U.S. population < 5 years

Citation

Centers for Disease Control and Prevention. 2005 Active Bacterial Core Surveillance Report, Emerging Infections Program Network, Haemophilus influenzae, 2004.

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