WHAT is the ABCs Isolate Bank?

The Active Bacterial Core surveillance (ABCs) isolate bank is an extensive collection of group A Streptococcus, group B Streptococcus, and Streptococcus pneumoniae isolates. The ABCs program is an integral part of the Emerging Infections Program (EIP) of the CDC, tracking invasive infections due to group A Streptococcus, group B Streptococcus, Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae since 1995. This national surveillance system operates in ten states, drawing from a population of nearly forty million people. Isolates from approximately 51,800 invasive infections from these pathogens are currently in the Bank.

WHY is it of interest?

Of outstanding value to researchers, the ABCs Isolate Bank contains not only carefully collected and preserved isolates, but crucial laboratory, clinical, and demographic data. These factors can help further in-depth research in a variety of fields, without typical limitations. This isolate bank offers unique research opportunities to investigate scientific questions extending beyond routine surveillance.

WHERE are isolates stored?

Isolates are stored in a restricted-access facility in Lawrenceville, Georgia, with 24-hour monitoring. All specimen storage units are equipped with computerized climate control sensors and are regularly monitored. The shipping and handling process is also executed with maximum professionalism and detailed care.

HOW can my institution or I have access to the isolates?

Request isolates via email at ABCsIsolateBank@cdc.gov, by phone (770-339-5950/5949), or by fax (770-339-5943) to receive official instructions on how to request isolates, along with a description of isolates and parameters.

Requests for isolates are reviewed by the isolate bank custodians (at CDC) prior to approval and release. The CDC strictly enforces a limited distribution policy that prohibits the secondary distribution of ABCs isolates to third-party researchers. Currently, there is a $70 processing fee.

WHICH data are available?

Group A streptococcus

• Year of isolation
• emm type and presence/absence of sof gene
• Presence/absence of severe infections (e.g., necrotizing fasciitis or streptoccal toxic shock syndrome)
• Minimal inhibitory concentration (MIC) testing results to commonly used antibiotics

Group B streptococcus

• Year of isolation
• Perinatal syndrome (early-onset, late-onset, pregnancy-associated)
• Source (CSF, blood, other)
• Age group
• Serotype
• MIC testing results to commonly used antibiotics

Streptococcus pneumoniae

• Year of isolation
• Age groups
• Source (CSF, blood, other)
• Serotype
• MIC testing results to commonly used antibiotics