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Reported Tuberculosis in the United States, 2011

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Technical Notes

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National Surveillance for Tuberculosis

Reporting areas (i.e., the 50 states, the District of Columbia, New York City, Puerto Rico, and other U.S. jurisdictions in the Pacific and Caribbean1) report tuberculosis (TB) cases to CDC using a standard case report form, Report of Verified Case of Tuberculosis (RVCT), through 2011. TB cases are verified according to the Tuberculosis Case Definition for Public Health Surveillance in Appendix A . TB cases are reported and counted according to the Recommendations for Reporting and Counting Tuberculosis Cases in Appendix B .

The 2011 Report contains several new features:

  • Race/ethnicity information on TB cases is displayed by origin of birth (U.S.-born or foreign-born) (Table 3).
  • Drug-resistance patterns are displayed in separate tables with drug-resistance trend data by previous TB status and origin of birth (Tables 9 and 10).
  • California now reports HIV test results to CDC, resulting in a significant improvement in the completeness of HIV status reporting in 2011.
  • TB case data are shown by homeless status among those 15 years of age or older by MSA (Table 49).

TB Case Definition

In 2009, the case definition was modified. TB cases are verified according to the following specified laboratory and clinical criteria.

Laboratory criteria for diagnosis

A case may be verified by the laboratory case definition with at least one of the following criteria: 1) isolation of M. tuberculosis complex from a clinical specimen, OR 2) demonstration of M. tuberculosis complex from a clinical specimen by nucleic acid amplification test (NAAT), OR 3) demonstration of acid-fast bacilli (AFB) in a clinical specimen when a culture has not been or cannot be obtained or is falsely negative or contaminated.

Clinical case criteria

A case may be verified by the clinical case definition in the presence of ALL of the following clinical criteria: 1) a positive tuberculin skin test (TST) result or positive interferon gamma release assay (IGRA) result for M. tuberculosis, AND 2) other signs and symptoms compatible with TB (e.g., abnormal chest radiograph, abnormal chest computerized tomography scan or other chest imaging study, or clinical evidence of current disease, AND 3) treatment with two or more anti-TB drugs, AND 4) a completed diagnostic evaluation.

Provider Diagnosis

Provider diagnosis is not a component of the case definition for TB as described in Appendix A. However, when cases of TB are diagnosed but do not meet either the clinical or laboratory case definition, reporting areas have the option of verifying TB cases based on provider diagnosis as described in Appendix B. Through 2008, the RVCT did not collect information on IGRA results. If an IGRA was performed in lieu of the TST, then the RVCT would have indicated that the TST was not performed. Thus, culture- and smear-negative cases without a TST that are diagnosed by a positive IGRA result prior to 2008 were considered to have been confirmed by provider diagnosis. However, starting in 2009, positive results for an IGRA are included as part of the clinical case definition for TB confirmation. Anergic patients with a clinical presentation consistent with TB but without laboratory evidence of M. tuberculosis complex would also be an example of provider diagnosis and one which has not changed over time.

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TB Case Verification Criteria Calculation

The software for TB surveillance developed by CDC includes a calculated variable for TB case verification called “Vercrit,” which was modified in 2009. The new variables, Nucleic Acid Amplification Test Result, Interferon Gamma Release Assay (IGRA) for Mycobacterium tuberculosis at Diagnosis, and Initial Chest CT Scan or Other Chest Imaging Study were added in the Vercrit calculation.

“Vercrit” is calculated by using the following criteria in hierarchical order:

  1. Positive culture
  2. Positive nucleic acid amplification test
  3. Positive acid-fast bacilli test
  4. Clinical case confirmation
  5. Provider diagnosis

Changes in Reporting and Counting TB Cases

In 2009, the Recommendations for Reporting and Counting Tuberculosis Cases in Appendix B were modified. TB cases that are verified but not countable for morbidity statistics can now be reported to CDC as a measure of programmatic and case management burden. However, data on noncountable TB cases are incomplete and not included in this report.

The recommendations for counting TB cases among immigrants, refugees,, and foreign visitors were revised based on the recommendations in the 2007 Technical Instructions for Tuberculosis Screening and Treatment for Panel Physicians.2 Regardless of of Panel Physician classification or citizenship status, immigrants and refugees examined after arriving in the United States and diagnosed with clinically active TB requiring anti-TB medications should be reported and counted by the locality of their current residence at the time of diagnosis. Foreign visitors diagnosed with TB, receiving anti-TB therapy, and planning to remain in the United States for 90 days or more should be reported and counted by the locality of current residence.

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New and Expanded RVCT Variables

Data on demographic, clinical, laboratory, initial treatment, and treatment outcomes are collected through the RVCT’s three data collection reports:

  1. Report of Verified Case of Tuberculosis: for all patients with a verified case of TB.
  2. Initial Drug Susceptibility Report (Follow-Up Report 1): for all patients who had a culture that was positive for M. tuberculosis complex.
  3. Case Completion Report (Follow-Up Report 2): for all patients who were alive when TB was diagnosed.

In 2009, the RVCT was modified and expanded to include 11 additional variables. Modifications to the RVCT accommodate the changing epidemiology of TB in terms of risk factors, new drug treatments, and enhanced laboratory capacity for diagnostic tests. These new variables will be made available in a future annual report.

The instructions for completing the RVCT forms and the definitions for all data items are available at: CDC. Report of Verified Case of Tuberculosis (RVCT) Instruction Manual. Atlanta, GA: U.S. Department of Health and Human Services, CDC, 2009.

Tabulation and Presentation of TB Data

This report presents summary data for TB cases reported to CDC in 2011. TB cases are tabulated by year in which the reporting area verified that the patient had TB and included the patient in its official annual TB case count. Since 2004, the published report has reflected updated information on the numbers of cases of confirmed TB for each year from 1993 onward. Totals for the United States include data from the 50 states, the District of Columbia (DC), and New York City.

Trend data are presented in Tables 1 through 13, except Table 7, which now only presents number of years in the United States for 2011. Age group tabulations are based on the patient’s age in the month and year the patient was reported to the health department as a suspected TB case. State or metropolitan area data tabulations are based on the patient’s residence at diagnosis of TB.


Rates are expressed as the number of cases reported each calendar year per 100,000 population. Population denominators used in calculating TB rates were based on official census and midyear postcensal estimates from the U.S. Census Bureau. In Tables 1, 19, and 20, the U.S. total populations for 2000–2009 were taken from Annual Estimates of the Resident Population for the United States, Regions, States, and Puerto Rico (April 1, 2000 to July 1, 2009); populations for 2010–2011 were taken from Annual Estimates of the Population for the United States, Regions, States, and Puerto Rico (April 1, 2010 to July 1, 2011). In 2003, two modifications were made to the RVCT form: 1) entries for multiple race (two or more races reported for a person) were allowed, and 2) the previous category of “Asian/Pacific Islander” was divided into “Asian” and “Native Hawaiian or Other Pacific Islander.” To calculate rates in Table 2, denominators for 2000–2011 were obtained from the Annual Estimates of the Resident Population by Sex, Race, and Hispanic Origin for the United States (April 1, 2000 to July 1, 2009) and Annual Estimates of the Resident Population by Sex, Race, and Hispanic Origin for the United States (April 1, 2010 to July 1, 2011). The population source for nativity is the Current Population Survey and is used to calculate case rates for U.S. and foreign-born TB. This population source includes populations for the 50 states and D.C., those born abroad of U.S. parents, and those born in U.S. outlying areas (the U.S.-affiliated areas) as the U.S-born population.

To calculate rates for Table 4, denominators were obtained from the Annual Estimates of the Resident Population by Sex and Five-Year Age Groups for the United States (April 1, 2000 to July 1, 2009) and Annual Estimates of the Resident Population by Sex and Five-Year Age Group for the United States (April 1, 2010 to July 1, 2011). Denominators for computing 2011 rates in Table 15 were obtained from Annual Estimates of the Population by Sex, Race, and Hispanic or Latino Origin for the United States (April 1, 2000 to July 1, 2011). In 2004, the method for calculating the annual percentage change in the TB case rate was modified. Unrounded figures are applied to calculate the percentage change in the case rate.

In Table 5, the populations for U.S.-born and foreign-born persons for 1993 and 1994 were obtained from Quarterly Estimates of the United States Foreign-born and Native Resident Populations: April 1, 1990–July 1, 1999. Denominators for computing the 1995–2011 rates were based on extrapolations from the U.S. Census Current Population Survey (March Supplement).

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Mortality Data

Official TB mortality statistics for the United States are compiled by the National Center for Health Statistics (NCHS), CDC. The annual mortality rate is calculated as the number of deaths due to TB in that year, divided by the estimated population for the year, multiplied by 100,000 (Table 1). The number of deaths for 2009 was obtained from the NCHS, National Vital Statistics Report, Vol. 60, No. 3, December 29, 2011. The finalized numbers of deaths for 2010 and 2011 were not available at the time of this publication.

Race and Ethnicity

Beginning with the 2011 report, Table 3 now includes information on TB cases and percentages by race/ethnicity and origin of birth (U.S.-born or foreign-born).

Drug Resistance

Beginning with the 2011 report, drug-resistance patterns are displayed in separate tables with drug-resistance trend data by previous TB status and origin of birth. Isoniazid (INH) resistance and multidrug resistance (MDR) are shown in Tables 9 and 10, respectively.

Completion of Tuberculosis Therapy

Tables 11, 40, 42, and 43 present rates of completion of TB therapy (COT). Data collected by RVCT Follow Up Report-2 on date and reason therapy stopped (e.g., patient completed therapy) were used to calculate rates of COT. Cases were stratified by the indicated length of therapy, based on American Thoracic Society/CDC/Infectious Diseases Society of America treatment guidelines3 in effect during the period covered, and the patient’s initial drug-susceptibility test results, age, and site of disease.

In Table 40, the first column shows the total number of cases reported during 2009. The remaining columns are grouped under three headings: therapy of 1 year or less indicated therapy, greater than 1 year indicated, and overall. Patients eligible to complete therapy within 1 year had to have been alive at diagnosis, and initiated therapy with at least one drug. Eligible patients did not have rifampin resistance, did not die during therapy, did not move out of country during treatment, and did not have meningeal TB, regardless of age. In addition, TB patients under the age of 15 were not eligible to complete therapy within 1 year if they had disseminated disease (defined as miliary tuberculosis and/or a positive tuberculosis blood culture). Patients with culture-negative disease, those with an unknown culture status, and those with culture-positive disease but unknown initial drug-susceptibility test results were included under the category of 1 year or less of therapy indicated.

In Table 40, each group under an indicated length of therapy has an initial column showing the number of cases in persons who were alive at diagnosis and prescribed an initial regimen of one or more drugs, and who did not die during therapy. This number was used as the denominator in COT rate calculations.

COT rates, shown as percentages, were only calculated for areas reporting reason therapy stopped for at least 90% of cases shown in the overall column. For the group with an indicated length of therapy of 1 year or less, rates are shown for both COT in 1 year or less (COT ≤1 year) and for COT, regardless of duration (i.e., duration of therapy ≤1 year, >1 year, or unknown). For COT ≤1 year, the numerator included only those patients completing therapy in ≤366 days (based on the dates therapy started and stopped). Patients with missing dates were classified as “treatment not completed” for this calculation.

Rates of COT, regardless of duration, were calculated by dividing the number of patients reported as having completed therapy by the number of total eligible patients. Patients with an outcome other than completed therapy (i.e., moved, lost, refused treatment, or other) were classified as “treatment not completed.” Patients with an unknown outcome were also classified as “treatment not completed.” For the remaining two groups of indicated therapy length (greater than 1 year and overall), only rates of COT, regardless of duration, are presented. Table 12 provides rates for COT ≤1 year and for COT, regardless of duration, only for the group with an indicated therapy of 1 year or less. Table 42 presents rates of COT by ethnicity and non-Hispanic race and by state for those in whom therapy less than 1 year was indicated.

Because streptomycin is no longer being used as part of the standard treatment for TB disease, streptomycin has been removed from the calculated variable for initial drug regimen. Consequently, a separate column for the treatment regimen of isoniazid, rifampin, pyrazinamide (IRZ), ethambutol, streptomycin (E/S) is no longer reported in Tables 11 and 35.

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Site of TB Disease

Miliary disease is classified as both an extrapulmonary and a pulmonary form of TB (Tables 8, 26, and 27). In publications prior to 1997, miliary disease was classified as extrapulmonary TB unless pulmonary disease was reported as the major site of TB disease. Beginning in 2009, miliary disease could not be classified as a site of TB disease because it is a clinical or radiologic finding and should be recorded under Initial Chest Radiograph, Initial Chest CT Scan, or Other Chest Imaging Study.

Reporting of HIV Status

Information on HIV status for persons with TB is shown in Tables 12 and 37; Table 12 additionally shows trend data for persons aged 25–44 years. The completeness of reporting on HIV status among persons with TB has significantly improved to 90% of TB cases tested among persons aged 25–44 years in 2011; however, this variable is still underreported among jurisdictions. Data on the HIV-infection status of persons with reported TB cases should be interpreted with caution. These data are not representative of all TB patients with HIV infection. HIV testing is performed after a patient receives counseling and gives informed consent. TB patients who are tested anonymously may choose not to share the results of HIV testing with their health care provider. TB patients managed in the private sector may receive confidential HIV testing, but results may not be reported to the TB program in the health department. In addition, many factors may influence HIV testing of TB patients, including the extent to which testing is targeted or routinely offered to specific groups (e.g., 25- to 44-year-old males, injecting drug users, homeless persons), and the availability of and access to HIV testing services. These data may overrepresent or underrepresent the proportion of TB patients known to be HIV infected in a reporting area.

Primary Occupation for the Past Year

Table 34 now reflects the new 2009 RVCT variable, Primary Occupation Within the Past Year, which replaces the Occupation Within Past 24 months of TB Diagnosis in previous reports. Following the 2009 RVCT revision, “Multiple Occupation” was removed and the “Retired” and “Not Seeking Employment” categories were added.

Reason Therapy Stopped

Tables 13 and 41 report a new 2009 RVCT data entry option; these tables now include a patient’s adverse reaction to anti-TB drug therapy as an option for the reason therapy stopped. The 2009 RVCT revision removed the option of “Moved” as a valid response to the variable Reason Therapy Stopped; however, in 2009 data, the “Moved” option was still utilized by the following reporting areas: Alaska, California, Georgia, Iowa, and New York City. It is anticipated that future reports will not include the “Moved” option from 2009 forward.

Metropolitan Statistical Areas

Tables 45 through 49 present data by metropolitan statistical areas (MSAs) with an estimated 2011 population of 500,000 or more. MSAs are defined by the federal Office of Management and Budget, and the definitions effective as of December 2009 were used for this publication. Beginning with the 2011 report, Table 49 will show TB cases by homeless status among those 15 years of age or older by MSA.

On June 6, 2003, the OMB announced new MSA definitions based on Census 2000 data, and the information has been updated annually. Some MSAs added or dropped counties and some MSAs merged. The MSA definitions apply to all areas except the six New England states; for these states, the New England County Metropolitan Areas (NECMAs) are used. MSAs are named for a central city in the MSA or NECMA, may include several cities and counties, and may cross state boundaries. For example, the TB cases and case rates presented for the District of Columbia in Table 19 include only persons residing within the geographic boundaries of the District. However, the TB cases and case rates for the Washington, D.C., MSA (Table 45) include persons residing within the several counties in the metropolitan area, including counties in Maryland, Virginia, and West Virginia.

A city/MSA with incomplete or unavailable data was not included in the tables, and some cities’ or MSAs’ total numbers may be underreported owing to missing information.

1Other U.S. jurisdictions include American Samoa, the Commonwealth of the Northern Mariana Islands, the Federated States of Micronesia, Guam, the Republic of the Marshall Islands, the Republic of Palau, and U.S. Virgin Islands.

2CDC. Immigration Requirements: Technical Instructions for Tuberculosis Screening and Treatment, 2007. Atlanta: CDC, Division of Global Migration and Quarantine, revised September 2007;

3CDC. Treatment of Tuberculosis, American Thoracic Society, CDC, and the Infectious Diseases Society of America. MMWR 2003;52(No.RR-11):1-77.

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