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Gonococcal Isolate Surveillance Project (GISP)

The Gonococcal Isolate Surveillance Project (GISP) was established in 1986 to monitor trends in antimicrobial susceptibilities of strains of N. gonorrhoeae in the United States in order to establish a rational basis for the selection of gonococcal therapies. GISP is a collaborative project among selected sexually transmitted diseases (STD) clinics, five regional laboratories, and the Centers for Disease Control and Prevention (CDC).

In GISP, N. gonorrhoeae isolates are collected from up to the first 25 men with urethral gonorrhea attending STD clinics each month in 26 cities in the United States. At regional laboratories, the susceptibilities of these isolates to penicillin, tetracycline, spectinomycin, ciprofloxacin, ceftriaxone, cefixime, and azithromycin are determined by agar dilution. Minimum inhibitory concentrations (MICs) are measured, and values are interpreted according to criteria recommended by the Clinical and Laboratory Standards Institute (CLSI).

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Annual Reports and Profiles

Recent Publications


Sentinel Sites and Regional Laboratories


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Sentinel Sites

  • Albuquerque, NM
  • Atlanta, GA
  • Baltimore, MD
  • Birmingham, AL
  • Boston, MA
  • Buffalo, NY
  • Chicago, IL
  • Cleveland, OH
  • Dallas, TX
  • Greensboro, NC
  • Honolulu, HI
  • Indianapolis, IN
  • Kansas City, MO
  • Las Vegas, NV
  • Los Angeles, CA
  • Minneapolis, MN
  • New Orleans, LA
  • New York, NY
  • Orange County, CA
  • Philadelphia, PA
  • Phoenix, AZ
  • Pontiac, MI
  • Portland, OR
  • San Diego, CA
  • San Francisco, CA
  • Seattle, WA
  • Tripler Army Medical center, Honolulu, HI

Regional Labs

  • Emory University, Atlanta, GA
  • Johns Hopkins University, Baltimore, MD
  • Texas Department of State Health Services, Austin, TX
  • University of Alabama at Birmingham, AL
  • University of Washington, Seattle, WA

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