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Appendix E: Search Strategy for Literature* Addressing Patient-Important Outcomes† Associated with HCV Testing Among Persons Born During 1945–1965§
|
Outcome |
Search terms |
No. hits |
|---|---|---|
|
All-cause mortality |
Clinical query |
|
|
1. ("hepatitis C" PR HCV) and (mortality) |
123 |
|
|
Search |
||
|
1. Hepatitis C [majr] OR Hepatitis C Antibodies [majr] |
33,186 |
|
|
2. mortality |
480,636 |
|
|
3. #1 AND #2 |
1,857 |
|
|
Sustained virologic response |
Clinical query |
|
|
1. ("hepatitis C" OR HCV) AND ("sustained virologic response" or SVR) |
127 |
|
|
Search |
||
|
1. Hepatitis C [majr] OR Hepatitis C Antibodies [majr] |
33,186 |
|
|
2. "sustained virologic response" OR SVR |
2,849 |
|
|
3. #1 AND #2 |
1,607 |
|
|
Serious adverse events |
Clinical query |
|
|
1. (("hepatitis C" OR HCV) AND ("adverse effects")) |
215 |
|
|
Quality of life |
Clinical query |
|
|
1. (("hepatitis C" OR HCV) AND ("quality of life")) |
45 |
|
|
HCV transmission |
Clinical query |
|
|
1. (("hepatitis C" OR HCV) AND (transmission)) |
166 |
|
|
Search |
||
|
1. Hepatitis C [majr] or Hepatitis C Antibodies [majr] |
33,186 |
|
|
2. transmission |
207,262 |
|
|
3. #1 AND #2 |
4,166 |
|
|
Alcohol use |
Clinical query |
|
|
1. (("hepatitis C" OR HCV) AND ("alcohol use")) |
5 |
|
|
Search |
||
|
1. Hepatitis C [majr] OR Hepatitis C Antibodies [majr] |
33,186 |
|
|
2. Alcohol use |
108,559 |
|
|
3. #1 AND #2 |
1,018 |
|
|
* Literature searches include all types of publications (e.g., conference abstracts, clinical trials, systematic reviews, and meta-analyses), whereas clinical queries include only systematic reviews and meta-analyses. † Although hepatocellular carcinoma (HCC) is considered a patient-important outcome associated with HCV testing, a separate search strategy was used for this outcome (see Appendix H). § The search aimed to answer the following questions: 1) Should HCV testing (versus no testing) be conducted among adults at average risk for infection who were born during 1945–1965? 2) Among persons tested and identified with HCV infection, is treatment-related SVR (versus treatment failure) associated with reduced liver-related morbidity and all-cause mortality? 3) Should HCV testing followed by brief alcohol interventions (versus no intervention) be carried out to reduce or cease drinking among HCV-infected persons? |
||
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