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Appendix E: Search Strategy for Literature* Addressing Patient-Important Outcomes Associated with HCV Testing Among Persons Born During 1945–1965§

Outcome

Search terms

No. hits

All-cause mortality

Clinical query

1. ("hepatitis C" PR HCV) and (mortality)

123

Search

1. Hepatitis C [majr] OR Hepatitis C Antibodies [majr]

33,186

2. mortality

480,636

3. #1 AND #2

1,857

Sustained virologic response

Clinical query

1. ("hepatitis C" OR HCV) AND ("sustained virologic response" or SVR)

127

Search

1. Hepatitis C [majr] OR Hepatitis C Antibodies [majr]

33,186

2. "sustained virologic response" OR SVR

2,849

3. #1 AND #2

1,607

Serious adverse events

Clinical query

1. (("hepatitis C" OR HCV) AND ("adverse effects"))

215

Quality of life

Clinical query

1. (("hepatitis C" OR HCV) AND ("quality of life"))

45

HCV transmission

Clinical query

1. (("hepatitis C" OR HCV) AND (transmission))

166

Search

1. Hepatitis C [majr] or Hepatitis C Antibodies [majr]

33,186

2. transmission

207,262

3. #1 AND #2

4,166

Alcohol use

Clinical query

1. (("hepatitis C" OR HCV) AND ("alcohol use"))

5

Search

1. Hepatitis C [majr] OR Hepatitis C Antibodies [majr]

33,186

2. Alcohol use

108,559

3. #1 AND #2

1,018

* Literature searches include all types of publications (e.g., conference abstracts, clinical trials, systematic reviews, and meta-analyses), whereas clinical queries include only systematic reviews and meta-analyses.

Although hepatocellular carcinoma (HCC) is considered a patient-important outcome associated with HCV testing, a separate search strategy was used for this outcome (see Appendix H).

§ The search aimed to answer the following questions: 1) Should HCV testing (versus no testing) be conducted among adults at average risk for infection who were born during 1945–1965? 2) Among persons tested and identified with HCV infection, is treatment-related SVR (versus treatment failure) associated with reduced liver-related morbidity and all-cause mortality? 3) Should HCV testing followed by brief alcohol interventions (versus no intervention) be carried out to reduce or cease drinking among HCV-infected persons?



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**Questions or messages regarding errors in formatting should be addressed to mmwrq@cdc.gov.

 
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